Hyung Sik Kim


Affiliation: Sungkyunkwan University
Country: Korea


  1. Won A, Kim S, Kim Y, Kim K, Choi W, Kacew S, et al. Discovery of urinary metabolomic biomarkers for early detection of acute kidney injury. Mol Biosyst. 2016;12:133-44 pubmed publisher
    ..Therefore, low urinary or high serum 3-IS levels may be more useful for early detection of AKI than conventional biomarkers. ..
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    Tripathy S, De U, Dehury N, Laha P, Panda M, Kim H, et al. Cyclometallated iridium complexes inducing paraptotic cell death like natural products: synthesis, structure and mechanistic aspects. Dalton Trans. 2016;45:15122-15136 pubmed
    ..An intimate relationship between p53, ROS production and extent of cell death has also been established using p53 wild, null and mutant type cancer cells. ..
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    Choi A, Kim J, Woo Y, Cheon J, Kim H, Yoon S. Co-treatment of LY294002 or MK-2206 with AZD5363 Attenuates AZD5363-induced Increase in the Level of Phosphorylated AKT. Anticancer Res. 2016;36:5849-5858 pubmed
    ..Our findings contribute to the development of AZD5363-based sensitization therapies for patients with cancer. ..
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    Choi A, Kim J, Cheon J, Kim H, Yoon S. Attenuation of Colchicine Toxicity in Drug-resistant Cancer Cells by Co-treatment with Anti-malarial Drugs. Anticancer Res. 2016;36:5859-5866 pubmed
    ..These findings provide important information regarding the prevention of COL toxicity in COL-resistant cells and indicate that CHL, PRI and MEF may contribute to sensitization in COL-resistant cells. ..
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    Cheon J, Lee B, Kim H, Yoon S. Highly Halaven-resistant KBV20C Cancer Cells Can Be Sensitized by Co-treatment with Fluphenazine. Anticancer Res. 2016;36:5867-5874 pubmed
    ..These findings provide important information regarding the sensitization of HAL-resistant cells and indicate that FLU, THIO and MEF may have similar sensitization effects in highly HAL-resistant cells. ..
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    Lim J, Park Y, Lee B, Kim H, Yoon S. Co-treatment with Celecoxib or NS398 Strongly Sensitizes Resistant Cancer Cells to Antimitotic Drugs Independent of P-gp Inhibition. Anticancer Res. 2016;36:5063-5070 pubmed
    ..These findings provide important information regarding the sensitization of drug-resistant cells and indicate that COX-2 inhibitors may be used for potentially resistant cancer patients, without the toxic effects of P-gp inhibition. ..
  7. De U, Son J, Jeon Y, Ha S, Park Y, Yoon S, et al. Plumbagin from a tropical pitcher plant (Nepenthes alata Blanco) induces apoptotic cell death via a p53-dependent pathway in MCF-7 human breast cancer cells. Food Chem Toxicol. 2019;123:492-500 pubmed publisher
    ..This study thus identifies a new anticancer mechanism of plumbagin against p53-dependent breast cancer cells and suggests a novel strategy for overcoming of breast cancer therapy. ..
  8. Sachan R, Kundu A, Jeon Y, Choi W, Yoon K, Kim I, et al. Afrocyclamin A, a triterpene saponin, induces apoptosis and autophagic cell death via the PI3K/Akt/mTOR pathway in human prostate cancer cells. Phytomedicine. 2018;51:139-150 pubmed publisher
    ..In an in vivo xenograft model, afrocyclamin A inhibited the growth of DU145 cells. Afrocyclamin A has anticancer activity via the PI3K/Akt/mTOR pathway, which leads to cell death. ..
  9. De U, Son J, Sachan R, Park Y, Kang D, Yoon K, et al. A New Synthetic Histone Deacetylase Inhibitor, MHY2256, Induces Apoptosis and Autophagy Cell Death in Endometrial Cancer Cells via p53 Acetylation. Int J Mol Sci. 2018;19: pubmed publisher
    ..These results suggest that MHY2256 exerts its anticancer activity through p53 acetylation in endometrial cancer and can be used for targeting hormone-related cancers. ..

More Information


  1. Kim T, Kim H, Kang Y, Yoon S, Lee J, Choi W, et al. Psammaplin A induces Sirtuin 1-dependent autophagic cell death in doxorubicin-resistant MCF-7/adr human breast cancer cells and xenografts. Biochim Biophys Acta. 2015;1850:401-10 pubmed publisher
    ..The results of this study suggest that PsA is sufficient to overcome multidrug-resistant cancer via SIRT1-mediated autophagy in MCF-7/adr breast cancer cells, indicating that PsA has therapeutic potential for clinical use. ..
  2. Kim M, Kwack S, Lim S, Kim Y, Roh T, Choi S, et al. Toxicological evaluation of isopropylparaben and isobutylparaben mixture in Sprague-Dawley rats following 28 days of dermal exposure. Regul Toxicol Pharmacol. 2015;73:544-51 pubmed publisher
    ..These data suggest that the mixture of IPP and IBP showed a synergistic dermal toxicity in rats and should be considered for future use in consumer products. ..
  3. Kim K, Lim H, Lim J, Son J, Lee J, Lee B, et al. Curcumin ameliorates cadmium-induced nephrotoxicity in Sprague-Dawley rats. Food Chem Toxicol. 2018;114:34-40 pubmed publisher
    ..The administration of curcumin provided a significant protective effect against Cd-induced nephrotoxicity. ..
  4. Lee E, Shin Y, Park E, Kim N, Moon A, Kwack S, et al. Selenium-binding protein 1: a sensitive urinary biomarker to detect heavy metal-induced nephrotoxicity. Arch Toxicol. 2017;91:1635-1648 pubmed publisher
    ..Thus, urinary excretion of SBP1 might be a sensitive and specific biomarker to detect early stages of kidney injury. ..
  5. Cheon J, Kim K, Yadav D, Kim M, Kim H, Yoon S. The JAK2 inhibitors CEP-33779 and NVP-BSK805 have high P-gp inhibitory activity and sensitize drug-resistant cancer cells to vincristine. Biochem Biophys Res Commun. 2017;490:1176-1182 pubmed publisher
    ..These findings indicate that inhibition of JAK2 may be a promising target in the treatment of cancers that are resistant to anti-mitotic drugs. ..
  6. Cho Y, Nguyen T, Park S, Kim K, Kim H, Jeong H, et al. Bromopropane Compounds Increase the Stemness of Colorectal Cancer Cells. Int J Mol Sci. 2017;18: pubmed publisher
    ..These results demonstrate for the first time that BP compounds have the potential to promote cancer stemness. ..
  7. Kim J, Kim A, Kim H, Kim H, Park Y, You J, et al. Rhamnus davurica leaf extract inhibits Fyn activation by antigen in mast cells for anti-allergic activity. BMC Complement Altern Med. 2015;15:80 pubmed publisher
    ..Therefore, this study provides scientific evidence for LERD to be used as an herbal medicine or health food for patients with allergic diseases. ..