Mi Kyung Lee


Affiliation: Sunchon National University
Country: Korea


  1. Ham J, Lee H, Choi R, Sim M, Seo K, Lee M. Anti-steatotic and anti-inflammatory roles of syringic acid in high-fat diet-induced obese mice. Food Funct. 2016;7:689-97 pubmed publisher
    ..SA is likely to be a new natural therapeutic agent for obesity or non-alcoholic liver disease. ..
  2. Ham J, Choi R, Lee H, Lee M. Methoxsalen and Bergapten Prevent Diabetes-Induced Osteoporosis by the Suppression of Osteoclastogenic Gene Expression in Mice. Int J Mol Sci. 2019;20: pubmed publisher
    ..Our data suggest that both bergapten and methoxsalen prevent diabetic osteoporosis by suppressing bone resorption. ..
  3. Kim M, Sim M, Lee H, Ham J, Seo K, Lee M. Dietary umbelliferone attenuates alcohol-induced fatty liver via regulation of PPARα and SREBP-1c in rats. Alcohol. 2014;48:707-15 pubmed publisher
    ..Therefore, UF may provide a promising natural therapeutic strategy against alcoholic fatty liver. ..
  4. Lee H, Lee M. Coordinated regulation of scopoletin at adipose tissue-liver axis improved alcohol-induced lipid dysmetabolism and inflammation in rats. Toxicol Lett. 2015;237:210-8 pubmed publisher
    ..These results indicated that coordinated regulation of scopoletin at the WAT-liver axis may play an important role in improvement of alcohol-induced lipid dysregulation and inflammation. ..
  5. Choi R, Lee H, Ham J, Yee S, Kang K, Lee M. Heshouwu (Polygonum multiflorum Thunb.) ethanol extract suppresses pre-adipocytes differentiation in 3T3-L1 cells and adiposity in obese mice. Biomed Pharmacother. 2018;106:355-362 pubmed publisher
    ..These results demonstrated that PME might relieve obesity that occurs via inhibition of adipogenesis and lipogenesis as well as through lipolysis and fatty acid oxidation in 3T3-L1 cells and HFD-induced obese mice. ..
  6. Choi R, Nam S, Ham J, Lee H, Yee S, Kang K, et al. Anti-adipogenic and anti-diabetic effects of cis-3',4'-diisovalerylkhellactone isolated from Peucedanum japonicum Thunb leaves in vitro. Bioorg Med Chem Lett. 2016;26:4655-4660 pubmed publisher
    ..In addition, cDIVK had potential ?-glucosidase inhibitory activity. These results indicated that cDIVK may act as a natural dual therapeutic agent for diabetes and obesity. ..
  7. Kim Y, Choi J, Ryu R, Lee J, Cho S, Kwon E, et al. Platycodon grandiflorus Root Extract Attenuates Body Fat Mass, Hepatic Steatosis and Insulin Resistance through the Interplay between the Liver and Adipose Tissue. Nutrients. 2016;8: pubmed publisher
    ..PGE can protect from HFD-induced insulin resistance, and hepatic steatosis by controlling lipid and glucose metabolism. ..
  8. Choi R, Ham J, Lee M. Esculetin prevents non-alcoholic fatty liver in diabetic mice fed high-fat diet. Chem Biol Interact. 2016;260:13-21 pubmed publisher
    ..Overall, these results demonstrated that esculetin supplementation could protect against development of non-alcoholic fatty liver in diabetes via regulation of lipids, glucose and inflammation. ..
  9. Choi R, Woo M, Ham J, Lee M. Anti-steatotic and anti-inflammatory effects of Hovenia dulcis Thunb. extracts in chronic alcohol-fed rats. Biomed Pharmacother. 2017;90:393-401 pubmed publisher
    ..These results indicate that both FW and SE play an important role in improvement of alcoholic hepatic steatosis and inflammation via regulation of lipid and inflammation metabolism. ..

More Information


  1. Sim M, Ham J, Lee H, Seo K, Lee M. Long-term supplementation of umbelliferone and 4-methylumbelliferone alleviates high-fat diet induced hypertriglyceridemia and hyperglycemia in mice. Chem Biol Interact. 2014;216:9-16 pubmed publisher
    ..These results indicate that UF and mUF similarly ameliorate hypertriglyceridemia and hyperglycemia partly by modulating hepatic lipid metabolism and the antioxidant defense system along with increasing adiponectin levels. ..
  2. Kwon E, Lee J, Kim Y, Do A, Choi J, Cho S, et al. Seabuckthorn Leaves Extract and Flavonoid Glycosides Extract from Seabuckthorn Leaves Ameliorates Adiposity, Hepatic Steatosis, Insulin Resistance, and Inflammation in Diet-Induced Obesity. Nutrients. 2017;9: pubmed publisher
  3. Sim M, Ham J, Lee M. Young leaves of reed (Phragmites communis) suppress melanogenesis and oxidative stress in B16F10 melanoma cells. Biomed Pharmacother. 2017;93:165-171 pubmed publisher
    ..Overall, these findings indicate that YLR has the potential for use in treatment of skin disorders and skin-whitening. ..
  4. Ham J, Choi R, Yee S, Hwang Y, Kim M, Lee M. Methoxsalen supplementation attenuates bone loss and inflammatory response in ovariectomized mice. Chem Biol Interact. 2017;278:135-140 pubmed publisher
    ..Our study provides valid scientific information regarding the development and application of MTS as a food ingredient, a food supplement or an alternative agent for preventing postmenopausal osteoporosis...