Chang Young Jang

Summary

Affiliation: Sookmyung Women's University
Country: Korea

Publications

  1. ncbi Mitotic kinases regulate MT-polymerizing/MT-bundling activity of DDA3
    Chang Young Jang
    Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
    Biochem Biophys Res Commun 408:174-9. 2011
  2. ncbi DDA3 associates with MCAK and controls chromosome congression
    Chang Young Jang
    School of Pharmacy, Sookmyung Women s University, Seoul 140 742, Republic of Korea
    Biochem Biophys Res Commun 407:610-4. 2011
  3. ncbi DDA3 recruits microtubule depolymerase Kif2a to spindle poles and controls spindle dynamics and mitotic chromosome movement
    Chang Young Jang
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    J Cell Biol 181:255-67. 2008
  4. ncbi Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entry
    Akiko Seki
    Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
    Science 320:1655-8. 2008
  5. ncbi Aurora A regulates the activity of HURP by controlling the accessibility of its microtubule-binding domain
    Jim Wong
    Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
    Mol Biol Cell 19:2083-91. 2008
  6. ncbi Plk1- and beta-TrCP-dependent degradation of Bora controls mitotic progression
    Akiko Seki
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    J Cell Biol 181:65-78. 2008
  7. ncbi The N-terminal domain of DDA3 regulates the spindle-association of the microtubule depolymerase Kif2a and controls the mitotic function of DDA3
    Chang Young Jang
    Department of Biological Sciences, Stanford University, Stanford, CA, USA
    Cell Cycle 8:3165-71. 2009
  8. ncbi FAM29A promotes microtubule amplification via recruitment of the NEDD1-gamma-tubulin complex to the mitotic spindle
    Hui Zhu
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    J Cell Biol 183:835-48. 2008
  9. ncbi Phospho-regulation of DDA3 function in mitosis
    Chang Young Jang
    Department of Biological Sciences, Stanford University, CA 94305 5020, USA
    Biochem Biophys Res Commun 393:259-63. 2010
  10. ncbi Plk1 and Aurora A regulate the depolymerase activity and the cellular localization of Kif2a
    Chang Young Jang
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    J Cell Sci 122:1334-41. 2009

Collaborators

  • Guowei Fang
  • Hui Zhu
  • Akiko Seki
  • John R Yates
  • Jim Wong
  • Judith A Coppinger
  • Haining Du
  • Robert Lerrigo

Detail Information

Publications10

  1. ncbi Mitotic kinases regulate MT-polymerizing/MT-bundling activity of DDA3
    Chang Young Jang
    Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
    Biochem Biophys Res Commun 408:174-9. 2011
    ..We conclude that kinases control the function of DDA3 in the cell cycle by regulating its MT-polymerizing/bundling activities through sequential phosphorylation...
  2. ncbi DDA3 associates with MCAK and controls chromosome congression
    Chang Young Jang
    School of Pharmacy, Sookmyung Women s University, Seoul 140 742, Republic of Korea
    Biochem Biophys Res Commun 407:610-4. 2011
    ..On the other hand, the localization of chromosomal passenger complex (CPC) and the kinase activity of Aurora B are normal in DDA3-depleted cells. We conclude that MCAK and CENP-E are involved in DDA3-mediated chromosome congression...
  3. ncbi DDA3 recruits microtubule depolymerase Kif2a to spindle poles and controls spindle dynamics and mitotic chromosome movement
    Chang Young Jang
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    J Cell Biol 181:255-67. 2008
    ..Thus, DDA3 represents a new class of MT-destabilizing protein that controls spindle dynamics and mitotic progression by regulating MT depolymerases...
  4. ncbi Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entry
    Akiko Seki
    Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
    Science 320:1655-8. 2008
    ..Thus, Bora and Aur-A control mitotic entry, which provides a mechanism for one of the most important yet ill-defined events in the cell cycle...
  5. ncbi Aurora A regulates the activity of HURP by controlling the accessibility of its microtubule-binding domain
    Jim Wong
    Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
    Mol Biol Cell 19:2083-91. 2008
    ..We concluded that phosphorylation of HURP by Aurora A provides a regulatory mechanism for the control of spindle assembly and function...
  6. ncbi Plk1- and beta-TrCP-dependent degradation of Bora controls mitotic progression
    Akiko Seki
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    J Cell Biol 181:65-78. 2008
    ..We conclude that tight regulation of the Bora protein by its synthesis and degradation is critical for cell cycle progression...
  7. ncbi The N-terminal domain of DDA3 regulates the spindle-association of the microtubule depolymerase Kif2a and controls the mitotic function of DDA3
    Chang Young Jang
    Department of Biological Sciences, Stanford University, Stanford, CA, USA
    Cell Cycle 8:3165-71. 2009
    ..The C-terminal domain confers its ability to associate with the mitotic spindle, while the regulatory N-terminal domain controls the microtubule-binding by the C-terminal domain and determines the cellular activity of the DDA3 protein...
  8. ncbi FAM29A promotes microtubule amplification via recruitment of the NEDD1-gamma-tubulin complex to the mitotic spindle
    Hui Zhu
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    J Cell Biol 183:835-48. 2008
    ..Our study provides a biochemical mechanism for MT-dependent MT amplification and for the maturation of kinetochore fibers in mammalian cells...
  9. ncbi Phospho-regulation of DDA3 function in mitosis
    Chang Young Jang
    Department of Biological Sciences, Stanford University, CA 94305 5020, USA
    Biochem Biophys Res Commun 393:259-63. 2010
    ..We conclude that the mitotic function of DDA3 is regulated by phosphorylation on the Ser225 residue...
  10. ncbi Plk1 and Aurora A regulate the depolymerase activity and the cellular localization of Kif2a
    Chang Young Jang
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    J Cell Sci 122:1334-41. 2009
    ....