Y Surh

Summary

Affiliation: Seoul National University
Country: Korea

Publications

  1. doi request reprint Cancer chemopreventive and therapeutic potential of resveratrol: mechanistic perspectives
    Joydeb Kumar Kundu
    National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shillim Dong, Kwanak gu, Seoul 151 742, Republic of Korea
    Cancer Lett 269:243-61. 2008
  2. ncbi request reprint Cancer preventive phytochemicals as speed breakers in inflammatory signaling involved in aberrant COX-2 expression
    Young Joon Surh
    Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, South Korea
    Curr Cancer Drug Targets 7:447-58. 2007
  3. doi request reprint Xenohormesis mechanisms underlying chemopreventive effects of some dietary phytochemicals
    Young Joon Surh
    College of Pharmacy and Cancer Research Institute, Seoul National University, Seoul, South Korea
    Ann N Y Acad Sci 1229:1-6. 2011
  4. pmc Keap1 cysteine 288 as a potential target for diallyl trisulfide-induced Nrf2 activation
    Sanghyun Kim
    Tumor Microenvironment Global Core Research Center, College of Pharmacy, Seoul National University, Seoul, South Korea
    PLoS ONE 9:e85984. 2014
  5. pmc Janus-faced role of SIRT1 in tumorigenesis
    Na Young Song
    Tumor Microenvironment Global Core Research Center, College of Pharmacy, Seoul National University, Seoul, South Korea
    Ann N Y Acad Sci 1271:10-9. 2012
  6. pmc Docosahexaenoic acid inhibits UVB-induced activation of NF-κB and expression of COX-2 and NOX-4 in HR-1 hairless mouse skin by blocking MSK1 signaling
    Mostafizur Rahman
    Tumor Microenvironment Research Center, College of Pharmacy, Seoul National University, Seoul, South Korea
    PLoS ONE 6:e28065. 2011
  7. ncbi request reprint Cancer chemopreventive effects of curcumin
    Young Joon Surh
    National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, South Korea
    Adv Exp Med Biol 595:149-72. 2007
  8. ncbi request reprint Transcription factors and mitogen-activated protein kinases as molecular targets for chemoprevention with anti-inflammatory phytochemicals
    Young Joon Surh
    College of Pharmacy, Seoul National University, Shinlim Dong, Kwanak Ku, Seoul 151 742, South Korea
    Biofactors 21:103-8. 2004
  9. ncbi request reprint Signal transduction network leading to COX-2 induction: a road map in search of cancer chemopreventives
    Young Joon Surh
    National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Seoul 151 742, Korea
    Arch Pharm Res 28:1-15. 2005
  10. doi request reprint 15-Deoxy-Δ¹²,¹⁴-prostaglandin J₂, an electrophilic lipid mediator of anti-inflammatory and pro-resolving signaling
    Young Joon Surh
    WCU Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul 151 742, South Korea
    Biochem Pharmacol 82:1335-51. 2011

Collaborators

Detail Information

Publications88

  1. doi request reprint Cancer chemopreventive and therapeutic potential of resveratrol: mechanistic perspectives
    Joydeb Kumar Kundu
    National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shillim Dong, Kwanak gu, Seoul 151 742, Republic of Korea
    Cancer Lett 269:243-61. 2008
    ..This review summarizes the diverse molecular targets of resveratrol with a special focus on those involved in fine-tuning of orchestrated intracellular signal transduction...
  2. ncbi request reprint Cancer preventive phytochemicals as speed breakers in inflammatory signaling involved in aberrant COX-2 expression
    Young Joon Surh
    Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, South Korea
    Curr Cancer Drug Targets 7:447-58. 2007
    ....
  3. doi request reprint Xenohormesis mechanisms underlying chemopreventive effects of some dietary phytochemicals
    Young Joon Surh
    College of Pharmacy and Cancer Research Institute, Seoul National University, Seoul, South Korea
    Ann N Y Acad Sci 1229:1-6. 2011
    ....
  4. pmc Keap1 cysteine 288 as a potential target for diallyl trisulfide-induced Nrf2 activation
    Sanghyun Kim
    Tumor Microenvironment Global Core Research Center, College of Pharmacy, Seoul National University, Seoul, South Korea
    PLoS ONE 9:e85984. 2014
    ..In this study, we assessed their relative potency in inducing antioxidant enzyme expression. Among the three organosulfur compounds, DATS was found to be most potent in inducing heme oxygenase-1 (HO-1) and..
  5. pmc Janus-faced role of SIRT1 in tumorigenesis
    Na Young Song
    Tumor Microenvironment Global Core Research Center, College of Pharmacy, Seoul National University, Seoul, South Korea
    Ann N Y Acad Sci 1271:10-9. 2012
    ..Interestingly, SIRT1 displays differential localization in normal cells and cancer cells, which in turn may affect the substrate specificity for its deacetylase activity...
  6. pmc Docosahexaenoic acid inhibits UVB-induced activation of NF-κB and expression of COX-2 and NOX-4 in HR-1 hairless mouse skin by blocking MSK1 signaling
    Mostafizur Rahman
    Tumor Microenvironment Research Center, College of Pharmacy, Seoul National University, Seoul, South Korea
    PLoS ONE 6:e28065. 2011
    ..In conclusion, topically applied DHA inhibits the UVB-induced activation of NF-κB and the expression of COX-2 and NOX-4 by blocking the phosphorylation of MSK1, a kinase downstream of ERK and p38 MAP kinase, in hairless mouse skin...
  7. ncbi request reprint Cancer chemopreventive effects of curcumin
    Young Joon Surh
    National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, South Korea
    Adv Exp Med Biol 595:149-72. 2007
    ..Sufficient data from pharmacodynamic as well as mechanistic studies are necessary to advocate clinical evaluation of curcumin for its chemopreventive potential...
  8. ncbi request reprint Transcription factors and mitogen-activated protein kinases as molecular targets for chemoprevention with anti-inflammatory phytochemicals
    Young Joon Surh
    College of Pharmacy, Seoul National University, Shinlim Dong, Kwanak Ku, Seoul 151 742, South Korea
    Biofactors 21:103-8. 2004
    ..J. Surh, Nature Reviews Cancer, 3: 768-780, 2003). These include mitogen-activated protein kinases and transcription factors, such as NF-kappaB and AP-1...
  9. ncbi request reprint Signal transduction network leading to COX-2 induction: a road map in search of cancer chemopreventives
    Young Joon Surh
    National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Seoul 151 742, Korea
    Arch Pharm Res 28:1-15. 2005
    ..Thus, unraveling signaling pathways regulating aberrant COX-2 expression and targeted blocking of one or more components of those signal cascades may be exploited in searching chemopreventive agents in the future...
  10. doi request reprint 15-Deoxy-Δ¹²,¹⁴-prostaglandin J₂, an electrophilic lipid mediator of anti-inflammatory and pro-resolving signaling
    Young Joon Surh
    WCU Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul 151 742, South Korea
    Biochem Pharmacol 82:1335-51. 2011
    ..In this context, 15d-PGJ2 and its synthetic derivatives have therapeutic potential for the treatment of inflammatory disorders...
  11. doi request reprint Role of Nrf2-mediated heme oxygenase-1 upregulation in adaptive survival response to nitrosative stress
    Young Joon Surh
    Seoul National University, Korea
    Arch Pharm Res 32:1163-76. 2009
    ....
  12. doi request reprint Nrf2 as a master redox switch in turning on the cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals
    Young Joon Surh
    National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Seoul, South Korea
    Planta Med 74:1526-39. 2008
    ..This review highlights the cytoprotective gene expression induced by some representative dietary chemopreventive phytochemicals with the Nrf2-Keap1 system as a prime molecular target...
  13. ncbi request reprint Cancer chemoprevention with dietary phytochemicals
    Young Joon Surh
    College of Pharmacy, Seoul National University, Shinlim Dong, Kwanak Ku, Seoul 151 742, South Korea
    Nat Rev Cancer 3:768-80. 2003
    ....
  14. ncbi request reprint NF-kappa B and Nrf2 as potential chemopreventive targets of some anti-inflammatory and antioxidative phytonutrients with anti-inflammatory and antioxidative activities
    Young Joon Surh
    Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Shillim Dong, Kwanak gu, Seoul 151 742, South Korea
    Asia Pac J Clin Nutr 17:269-72. 2008
    ..Many antioxidants derived from dietary and medicinal plants have been found to activate this particular redox-sensitive transcription factor, thereby potentiating the cellular antioxidant or detoxification capacity...
  15. ncbi request reprint Bioactivation of benzylic and allylic alcohols via sulfo-conjugation
    Y J Surh
    College of Pharmacy, Seoul National University, South Korea
    Chem Biol Interact 109:221-35. 1998
    ..Besides benzylic sulfonation, sulfuric acid esterification of certain allylic alcohols can produce reactive species...
  16. ncbi request reprint Inhibitory effects of curcumin and capsaicin on phorbol ester-induced activation of eukaryotic transcription factors, NF-kappaB and AP-1
    Y J Surh
    College of Pharmacy, Seoul National University, Kwanak gu, Korea
    Biofactors 12:107-12. 2000
    ..Based on these findings, it is likely that curcumin and capsaicin exert anti-tumor promotional effects through suppression of the tumor promoter-induced activation of transcription factors, NF-kappaB and AP-1...
  17. ncbi request reprint Resveratrol, an antioxidant present in red wine, induces apoptosis in human promyelocytic leukemia (HL-60) cells
    Y J Surh
    Laboratory of Biochemistry and Molecular Toxicology, College of Pharmacy, Seoul National University, South Korea
    Cancer Lett 140:1-10. 1999
    ..Resveratrol treatment resulted in a gradual decrease in the expression of anti-apoptotic Bcl-2. These results, together with previous findings, suggest the cancer therapeutic as well as chemopreventive potential of resveratrol...
  18. ncbi request reprint Molecular mechanisms of chemopreventive effects of selected dietary and medicinal phenolic substances
    Y Surh
    Laboratory of Biochemistry and Molecular Toxicology, College of Pharmacy, Seoul National University, Shinlim Dong, Kwanak gu, Seoul, South Korea
    Mutat Res 428:305-27. 1999
    ..In addition, these compounds have ability to suppress proliferation of human cancer cells via induction of apoptosis...
  19. ncbi request reprint Chemopreventive effects of 2-(allylthio)pyrazine on hepatic lesion, mutagenesis and tumorigenesis induced by vinyl carbamate or vinyl carbamate epoxide
    Y J Surh
    Seoul National University College of Pharmacy, South Korea
    Carcinogenesis 19:1263-7. 1998
    ..2-AP also inhibited the mutagenicity of VC in the Salmonella-microsome assay. Taken together, these findings suggest that 2-AP is a potential chemopreventive agent...
  20. ncbi request reprint Chemoprotective properties of some pungent ingredients present in red pepper and ginger
    Y J Surh
    College of Pharmacy, Seoul National University, Shinlim Dong, Kwanak gu, Seoul 151 742, South Korea
    Mutat Res 402:259-67. 1998
    ..Some pungent constituents present in ginger and other zingiberaceous plants have potent antioxidant and anti-inflammatory effects, and some of them exhibit anti-tumor promotional activity in experimental carcinogenesis...
  21. ncbi request reprint Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation
    Y J Surh
    College of Pharmacy, Seoul National University, Shinlim Dong, Kwanak Ku, Seoul 151 742, South Korea
    Mutat Res 480:243-68. 2001
    ....
  22. pmc Molecular mechanisms underlying anti-tumor promoting activities of heat-processed Panax ginseng C.A. Meyer
    Y J Surh
    College of Pharmacy, Seoul National University, Seoul, Korea
    J Korean Med Sci 16:S38-41. 2001
    ....
  23. ncbi request reprint Iron enhancement of oxidative DNA damage and neuronal cell death induced by salsolinol
    Young Joon Surh
    Laboratory of Biochemistry and Molecular Toxicology, College of Pharmacy, Seoul National University, South Korea
    J Toxicol Environ Health A 65:473-88. 2002
    ..Exposure of PC12 cells to SAL produced concentration-dependent reduction in viability, which was exacerbated by iron and ameliorated by deferoxamine...
  24. ncbi request reprint Anti-tumor promoting potential of selected spice ingredients with antioxidative and anti-inflammatory activities: a short review
    Young Joon Surh
    Laboratory of Biochemistry and Molecular Toxicology, College of Pharmacy, Seoul National University, 151 742, Seoul, South Korea
    Food Chem Toxicol 40:1091-7. 2002
    ....
  25. ncbi request reprint Inhibitory effects of isopropyl-2-(1,3-dithietane-2-ylidene)-2- [N-(4-methylthiazol-2-yl)carbamoyl]acetate (YH439) on benzo[a]pyrene-induced skin carcinogenesis and micronucleated reticulocyte formation in mice
    Y J Surh
    College of Pharmacy, Seoul National University, Shinlim Dong, Kwanak gu, Seoul 151 742, South Korea
    Mutat Res 423:149-53. 1999
    ..Likewise, diallyl sulfide, a major volatile thioether present in garlic, also protected against B[a]P-induced skin tumorigenesis and micronucleated reticulocyte formation in mice...
  26. ncbi request reprint Oxidative DNA damage and cytotoxicity induced by copper-stimulated redox cycling of salsolinol, a neurotoxic tetrahydroisoquinoline alkaloid
    Y Jung
    Laboratory of Biochemistry and Molecular Toxicology, College of Pharmacy, Seoul National University, Seoul, South Korea
    Free Radic Biol Med 30:1407-17. 2001
    ....
  27. ncbi request reprint Breaking the relay in deregulated cellular signal transduction as a rationale for chemoprevention with anti-inflammatory phytochemicals
    Joydeb Kumar Kundu
    National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shinlim Dong, Kwanak gu, Seoul 151 742, South Korea
    Mutat Res 591:123-46. 2005
    ..Modulation of cellular signaling involved in chronic inflammatory response by anti-inflammatory phytochemicals may comprise a rational and pragmatic strategy in molecular target-based chemoprevention...
  28. ncbi request reprint [6]-Gingerol prevents UVB-induced ROS production and COX-2 expression in vitro and in vivo
    Jin Kyoung Kim
    Department of Dermato Immunology, College of Medicine, Catholic Research Institute of Medical Science, The Catholic University of Korea, Seoul, South Korea
    Free Radic Res 41:603-14. 2007
    ..These results suggest that [6]-gingerol could be an effective therapeutic agent providing protection against UVB-induced skin disorders...
  29. ncbi request reprint Intracellular signaling network as a prime chemopreventive target of (-)-epigallocatechin gallate
    Hye Kyung Na
    National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Seoul, South Korea
    Mol Nutr Food Res 50:152-9. 2006
    ....
  30. ncbi request reprint 4-Hydroxyestradiol induces oxidative stress and apoptosis in human mammary epithelial cells: possible protection by NF-kappaB and ERK/MAPK
    Zhi Hua Chen
    National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shinlim Dong, Kwanak Ku, Seoul 151 742, South Korea
    Toxicol Appl Pharmacol 208:46-56. 2005
    ..A pharmacological inhibitor of ERK aggravated the 4-OHE2-induced cytotoxicity, supporting the pivotal role of ERK in protecting against catechol estrogen-induced oxidative cell death...
  31. ncbi request reprint Vitamin C and cancer chemoprevention: reappraisal
    Ki Won Lee
    Department of Food Science and Technology, School of Agricultural Biotechnology, Seoul National University, Seoul, South Korea
    Am J Clin Nutr 78:1074-8. 2003
    ..In this article, we discuss issues of contention and some controversies related to the potential chemopreventive effects of vitamin C in carcinogenesis...
  32. ncbi request reprint Protective effect of resveratrol on beta-amyloid-induced oxidative PC12 cell death
    Jung Hee Jang
    Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151 742, South Korea
    Free Radic Biol Med 34:1100-10. 2003
    ..Resveratrol attenuated beta-amyloid-induced cytotoxicity, apoptotic features, and intracellular ROI accumulation. Beta-amyloid transiently induced activation of NF-kappaB in PC12 cells, which was suppressed by resveratrol pretreatment...
  33. ncbi request reprint [6]-Gingerol inhibits COX-2 expression by blocking the activation of p38 MAP kinase and NF-kappaB in phorbol ester-stimulated mouse skin
    Sue Ok Kim
    College of Pharmacy, Seoul National University, Seoul 151 742, South Korea
    Oncogene 24:2558-67. 2005
    ..Taken together, our data suggest that [6]-gingerol inhibits TPA-induced COX-2 expression in mouse skin in vivo by blocking the p38 MAP kinase-NF-kappaB signaling pathway...
  34. ncbi request reprint beta-Amyloid induces oxidative DNA damage and cell death through activation of c-Jun N terminal kinase
    Jung Hee Jang
    College of Pharmacy, Seoul National University, Shinlim Dong, Kwanak Ku, Seoul 151 742, Korea
    Ann N Y Acad Sci 973:228-36. 2002
    ..These findings suggest that production of ROS and subsequent activation of JNK play an important role in beta-amyloid-induced apoptotic cell death...
  35. ncbi request reprint 2-Hydroxyestradiol induces oxidative DNA damage and apoptosis in human mammary epithelial cells
    Yeon Jin Hurh
    Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, Korea
    J Toxicol Environ Health A 67:1939-53. 2004
    ..These findings, taken together, suggest that 2-OHE2-induced oxidative DNA damage and apoptosis in MCF-10A cells might be mediated by ROS generated via the redox cycling of this catechol estrogen...
  36. ncbi request reprint Protective effects of green tea polyphenol extracts against ethanol-induced gastric mucosal damages in rats: stress-responsive transcription factors and MAP kinases as potential targets
    Jeong Sang Lee
    College of Pharmacy, Seoul National University, Seoul 151 742, South Korea
    Mutat Res 579:214-24. 2005
    ..Inactivation of MAPKs, especially p38 and ERKl/2, by GTE might be responsible for inhibition of ethanol-induced expression of COX-2 and iNOS...
  37. ncbi request reprint Signal transduction pathways regulating cyclooxygenase-2 expression: potential molecular targets for chemoprevention
    Kyung Soo Chun
    Laboratory of Biochemistry and Molecular Toxicology, College of Pharmacy, Seoul National University, 151 742, South Korea
    Biochem Pharmacol 68:1089-100. 2004
    ..The present review covers the signal transduction pathways responsible for regulating COX-2 expression as novel molecular targets of chemopreventive agents with celecoxib as a specific example...
  38. ncbi request reprint Bcl-2 attenuation of oxidative cell death is associated with up-regulation of gamma-glutamylcysteine ligase via constitutive NF-kappaB activation
    Jung Hee Jang
    Laboratory of Biochemistry and Molecular Toxicology, College of Pharmacy, Seoul National University, Shinlim Dong, Kwanak Ku, Seoul 151 742, South Korea
    J Biol Chem 279:38779-86. 2004
    ..These results suggest that NF-kappaB plays a role in bcl-2-mediated protection against H(2)O(2)-induced apoptosis in PC12 cells through augmentation of antioxidant capacity...
  39. ncbi request reprint Redox-sensitive transcription factors as prime targets for chemoprevention with anti-inflammatory and antioxidative phytochemicals
    Young Joon Surh
    National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Seoul 151 742, South Korea
    J Nutr 135:2993S-3001S. 2005
    ..The modulation of cellular signaling by anti-inflammatory phytochemicals hence provides a rational and pragmatic strategy for molecular target-based chemoprevention...
  40. ncbi request reprint Inhibitory effects of the ginsenoside Rg3 on phorbol ester-induced cyclooxygenase-2 expression, NF-kappaB activation and tumor promotion
    Young Sam Keum
    College of Pharmacy, Seoul National University, Shinlim Dong, Kwanak Ku, Seoul 151 742, South Korea
    Mutat Res 523:75-85. 2003
    ..Based on these findings, it is likely that the anti-tumor promoting activity of Rg(3) is mediated possibly through down-regulation of NF-kappaB and AP-1 transcription factors...
  41. ncbi request reprint Curcumin inhibits phorbol ester-induced expression of cyclooxygenase-2 in mouse skin through suppression of extracellular signal-regulated kinase activity and NF-kappaB activation
    Kyung Soo Chun
    College of Pharmacy, College of Medicine, Seoul National University, Seoul 151 741, South Korea
    Carcinogenesis 24:1515-24. 2003
    ....
  42. ncbi request reprint Inhibition of phorbol ester-induced COX-2 expression by epigallocatechin gallate in mouse skin and cultured human mammary epithelial cells
    Joydeb Kumar Kundu
    College of Pharmacy, Seoul National University, Seoul 151 742, South Korea
    J Nutr 133:3805S-3810S. 2003
    ..In addition, EGCG inhibited the catalytic activity of ERK and p38 MAPK, suggesting that these signal-transducing enzymes could be potential targets for previously reported antitumor promoting activity of EGCG...
  43. ncbi request reprint Potential roles of NF-kappaB and ERK1/2 in cytoprotection against oxidative cell death induced by tetrahydropapaveroline
    Mi Hyun Shin
    Laboratory of Biochemistry and Molecular Toxicology, College of Pharmacy, Seoul National University, Seoul 151 742, South Korea
    Free Radic Biol Med 36:1185-94. 2004
    ..In conclusion, THP induces apoptosis in PC12 cells by generating ROS. THP-mediated oxidative stress was accompanied by differential activation of intracellular signaling kinases and NF-kappaB...
  44. ncbi request reprint Peroxisome proliferator-activated receptor gamma (PPARgamma) ligands as bifunctional regulators of cell proliferation
    Hye Kyung Na
    Laboratory of Biochemistry and Molecular Toxicology, College of Pharmacy, Seoul National University, Shinlim Dong, Kwanak Ku, Seoul 151 742, South Korea
    Biochem Pharmacol 66:1381-91. 2003
    ..This commentary focuses on dual effects of the typical PPARgamma agonist 15d-PGJ(2) on cell proliferation and growth, and its possible involvement in the NSAID-induced COX-2 expression and apoptosis...
  45. doi request reprint Inflammation: gearing the journey to cancer
    Joydeb Kumar Kundu
    National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Cancer Research Institute, Seoul National University, Seoul 151 742, South Korea
    Mutat Res 659:15-30. 2008
    ..The present article highlights the role of various proinflammatory mediators in carcinogenesis and their promise as potential targets for chemoprevention of inflammation-associated carcinogenesis...
  46. ncbi request reprint Nrf2-mediated heme oxygenase-1 induction confers adaptive survival response to tetrahydropapaveroline-induced oxidative PC12 cell death
    So Hyun Park
    National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Seoul, South Korea
    Antioxid Redox Signal 9:2075-86. 2007
    ..Taken together, these findings suggest that HO-1 induction via Nrf2 activation may confer a cellular adaptive response against THP-mediated cell death...
  47. ncbi request reprint Nrf2 as a novel molecular target for chemoprevention
    Jeong Sang Lee
    National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shinlim Dong, Kwanak Ku, Seoul 151 742, South Korea
    Cancer Lett 224:171-84. 2005
    ....
  48. ncbi request reprint Epigallocatechin gallate inhibits phorbol ester-induced activation of NF-kappa B and CREB in mouse skin: role of p38 MAPK
    Joydeb Kumar Kundu
    College of Pharmacy, Seoul National University, Shillim Dong, Kwanak Ku, Seoul 151 742, Korea
    Ann N Y Acad Sci 1095:504-12. 2007
    ..Taken together, EGCG inhibited TPA-induced DNA binding of NF-kappaB and CREB by blocking activation of p38 MAPK, which may provide a molecular basis of COX-2 inhibition by EGCG in mouse skin in vivo...
  49. ncbi request reprint Curcumin attenuates dimethylnitrosamine-induced liver injury in rats through Nrf2-mediated induction of heme oxygenase-1
    E Olatunde Farombi
    Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151 742, Republic of Korea
    Food Chem Toxicol 46:1279-87. 2008
    ..Taken together, these findings suggest that curcumin protects against DMN-induced hepatotoxicity, at least in part, through ARE-driven induction of HO-1 expression...
  50. ncbi request reprint Possible role of NF-kappaB in Bcl-X(L) protection against hydrogen peroxide-induced PC12 cell death
    Jung Hee Jang
    Laboratory of Biochemistry and Molecular Toxicology, College of Pharmacy, Seoul National University, Seoul, South Korea
    Redox Rep 9:343-8. 2004
    ..These results suggest that the redox-sensitive transcription factor NF-kappaB may play a role in bcl-X(L)-mediated protection against oxidative cell death...
  51. ncbi request reprint Protective effects of oligomers of grape seed polyphenols against beta-amyloid-induced oxidative cell death
    Mei Hua Li
    Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Shinlim Dong, Kwanak Ku, Seoul 151 742, South Korea
    Ann N Y Acad Sci 1030:317-29. 2004
    ..Moreover, Abeta transiently induced the activation of nuclear factor kappaB in PC12 cells, which was suppressed by pretreatment with Oligonol...
  52. ncbi request reprint Celecoxib induces apoptosis in cervical cancer cells independent of cyclooxygenase using NF-kappaB as a possible target
    Su Hyeong Kim
    Cancer Research Institute, College of Medicine Seoul National University, Seoul, Korea
    J Cancer Res Clin Oncol 130:551-60. 2004
    ..Recently, many studies have shown that celecoxib induces apoptosis in various cancer cells by different mechanisms depending on the cell type. This study examined the apoptotic effect of celecoxib in cervical cancer cells and its mechanism...
  53. ncbi request reprint Resveratrol inhibits TCDD-induced expression of CYP1A1 and CYP1B1 and catechol estrogen-mediated oxidative DNA damage in cultured human mammary epithelial cells
    Zhi Hua Chen
    College of Pharmacy, Seoul National University, Seoul 151 742, South Korea
    Carcinogenesis 25:2005-13. 2004
    ....
  54. ncbi request reprint Inhibition of mouse skin tumor promotion by anti-inflammatory diarylheptanoids derived from Alpinia oxyphylla Miquel (Zingiberaceae)
    Kyung Soo Chun
    Research Institute of Pharnaceutical Sciences, College of Pharmacy, Seoul National University, Shinlim Dong, South Korea
    Oncol Res 13:37-45. 2002
    ..These findings indicate that pungent diarylheptanoids from A. oxyphylla Miquel have an antitumor promotional activity that might be related to their anti-inflammatory properties...
  55. ncbi request reprint Celecoxib inhibits phorbol ester-induced expression of COX-2 and activation of AP-1 and p38 MAP kinase in mouse skin
    Kyung Soo Chun
    College of Pharmacy, Seoul National University, Seoul, Korea
    Carcinogenesis 25:713-22. 2004
    ....
  56. ncbi request reprint Molecular basis of chemoprevention by resveratrol: NF-kappaB and AP-1 as potential targets
    Joydeb Kumar Kundu
    Laboratory of Biochemistry and Molecular Toxicology, College of Pharmacy, Seoul National University, Shinlim Dong, Kwanak Ku, Seoul 151 742, South Korea
    Mutat Res 555:65-80. 2004
    ..This review aims to update the molecular mechanisms underlying chemoprevention by resveratrol with special focus on its effect on cellular signaling cascades mediated by NF-kappaB and AP-1...
  57. ncbi request reprint Inhibitory effects of [6]-gingerol on PMA-induced COX-2 expression and activation of NF-kappaB and p38 MAPK in mouse skin
    Sue Ok Kim
    College of Pharmacy, Seoul National University, Seoul 151 742, South Korea
    Biofactors 21:27-31. 2004
    ..In addition, [6]-gingerol inhibited the phoshorylation of p38 mitogen-activated protein kinase which may account for its inactivation of NF-kappaB and suppression of COX-2 expression...
  58. ncbi request reprint Inhibition of phorbol ester-induced COX-2 expression by some edible African plants
    Hye Kyung Na
    Laboratory of Biochemistry and Molecular Toxicology, College of Pharmacy, Seoul National University, South Korea
    Biofactors 21:149-53. 2004
    ..Based on above findings, CB and BB are likely to inhibit TPA-induced COX-2 expression through suppression of DNA binding of NF-kappaB, which may contribute to the chemopreventive or chemoprotective activity of these African plants...
  59. ncbi request reprint Potentiation of cellular antioxidant capacity by Bcl-2: implications for its antiapoptotic function
    Jung Hee Jang
    Laboratory of Biochemistry and Molecular Toxicology, College of Pharmacy, Seoul National University, Shinlim Dong, Kwanak Ku, Seoul 151 742, South Korea
    Biochem Pharmacol 66:1371-9. 2003
    ..The role of Bcl-2 in regulation of nuclear factor kappaB signaling pathways and possible cross-talk with mitogen-activated protein kinases are also discussed...
  60. ncbi request reprint Induction of cyclooxygenase-2 and peroxisome proliferator-activated receptor-gamma during nitric oxide-induced apoptotic PC12 cell death
    So Young Lim
    Laboratory of Biochemistry and Molecular Toxicology, College of Pharmacy, Seoul National University, Seoul 151 742, Korea
    Ann N Y Acad Sci 1010:648-58. 2003
    ..Taken together, the above findings suggest that the proinflammatory mediators such as PGE(2) and PPARgamma may regulate the nitrosative stress-induced apoptotic cell death...
  61. ncbi request reprint Capsaicin induces heme oxygenase-1 expression in HepG2 cells via activation of PI3K-Nrf2 signaling: NAD(P)H:quinone oxidoreductase as a potential target
    Eun Joo Joung
    Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, South Korea
    Antioxid Redox Signal 9:2087-98. 2007
    ..This, in turn, would trigger the activation of Akt via phosphorylation, increase the nuclear translocation and ARE binding of Nrf2, and upregulate the expression of HO-1...
  62. ncbi request reprint Inhibitory effects of the extracts of Sutherlandia frutescens (L.) R. Br. and Harpagophytum procumbens DC. on phorbol ester-induced COX-2 expression in mouse skin: AP-1 and CREB as potential upstream targets
    Joydeb Kumar Kundu
    Laboratory of Biochemistry and Molecular Toxicology, College of Pharmacy, Seoul National University, Shinlim Dong, Kwanak Ku, Seoul 151 742, South Korea
    Cancer Lett 218:21-31. 2005
    ..In another study, topical application of TPA induced DNA binding of cyclic AMP response element binding (CREB) protein in mouse skin in vivo, which was abrogated by pretreatment with either CB or DC...
  63. ncbi request reprint Effects of selected ginsenosides on phorbol ester-induced expression of cyclooxygenase-2 and activation of NF-kappaB and ERK1/2 in mouse skin
    Young Joon Surh
    Laboratory of Biochemistry and Molecular Toxicology, College of Pharmacy, Seoul National University, Seoul 151 742, South Korea
    Ann N Y Acad Sci 973:396-401. 2002
    ..Of the ginsenosides tested, Rg(3) was found to be most effective in terms of inhibiting TPA-induced ear edema, COX-2 expression, and NF-kappaB activation...
  64. ncbi request reprint Modulation of Nrf2-mediated antioxidant and detoxifying enzyme induction by the green tea polyphenol EGCG
    Hye Kyung Na
    National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shinlim Dong, Kwanak Ku, Seoul 151 742, South Korea
    Food Chem Toxicol 46:1271-8. 2008
    ..This review summarizes the molecular basis of chemoprevention and cytoprotection afforded by EGCG with emphasis on its ability to modulate Nrf2-mediated cellular events...
  65. ncbi request reprint Ergothioneine rescues PC12 cells from beta-amyloid-induced apoptotic death
    Jung Hee Jang
    Laboratory of Biochemistry and Molecular Toxicology, College of Pharmacy, Seoul National University, Seoul 151 742, South Korea
    Free Radic Biol Med 36:288-99. 2004
    ..The importance of diet-derived antioxidants in the management of Alzheimer's disease and other neurodegenerative disorders is discussed...
  66. ncbi request reprint Curcumin suppresses activation of NF-kappaB and AP-1 induced by phorbol ester in cultured human promyelocytic leukemia cells
    Seong Su Han
    Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151 742, South Korea
    J Biochem Mol Biol 35:337-42. 2002
    ..Likewise, the TPA-induced DNA binding of the activator protein-1 (AP-1) was inhibited by curcumin pretreatment...
  67. ncbi request reprint Suppression of phorbol ester-induced NF-kappaB activation by capsaicin in cultured human promyelocytic leukemia cells
    Seong Su Han
    Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Korea
    Arch Pharm Res 25:475-9. 2002
    ..Methylation of the phenolic hydroxyl group of capsaicin abolished its inhibitory effect on NF-kappaB DNA binding. Likewise, TPA-induced activation of AP-1 was mitigated by capsaicin treatment...
  68. ncbi request reprint Hirsutenone inhibits phorbol ester-induced upregulation of COX-2 and MMP-9 in cultured human mammary epithelial cells: NF-kappaB as a potential molecular target
    Jung Hwan Kim
    College of Pharmacy, Seoul National University, Shillim Dong, Kwanak gu, Seoul 151 742, Republic of Korea
    FEBS Lett 580:385-92. 2006
    ..In summary, hirsutenone inhibits the TPA-induced upregulation of COX-2 and MMP-9 in human breast epithelial cells, possibly by targeting NF-kappaB, which may contribute to its chemopreventive effects...
  69. ncbi request reprint Molecular basis of heme oxygenase-1 induction: implications for chemoprevention and chemoprotection
    Auemduan Prawan
    National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Seoul 151 742, South Korea
    Antioxid Redox Signal 7:1688-703. 2005
    ..The scope of this review is limited to focus on molecular mechanisms underlying HO-1 expression and the significance of targeted induction of HO-1 as a strategy to achieve chemoprevention and chemoprotection...
  70. ncbi request reprint Inhibitory effects of the standardized extract (DA-9601) of Artemisia asiatica Nakai on phorbol ester-induced ornithine decarboxylase activity, papilloma formation, cyclooxygenase-2 expression, inducible nitric oxide synthase expression and nuclear transc
    Hyo Joung Seo
    College of Pharmacy, Seoul National University, Seoul, South Korea
    Int J Cancer 100:456-62. 2002
    ..DA-9601 also significantly suppressed TPA-induced ODC activity and papilloma formation in mouse skin. Taken together, these findings suggest that DA-9601 derived from A. asiatica possesses potential chemopreventive activities...
  71. ncbi request reprint Resveratrol modulates phorbol ester-induced pro-inflammatory signal transduction pathways in mouse skin in vivo: NF-kappaB and AP-1 as prime targets
    Joydeb Kumar Kundu
    National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shinlim 9 dong, Kwanak gu, Seoul 151 742, South Korea
    Biochem Pharmacol 72:1506-15. 2006
    ....
  72. ncbi request reprint Induction of cyclooxygenase-2 in Ras-transformed human mammary epithelial cells undergoing apoptosis
    Hye Kyung Na
    Laboratory of Biochemistry and Molecular Toxicology, College of Pharmacy, Seoul National University, Seoul 151 742, Korea
    Ann N Y Acad Sci 973:153-60. 2002
    ..Taken together, the above findings suggest that COX-2 up-regulation does not necessarily confer the resistance to apoptosis in ras-transformed cells, but rather may sensitize these cells to apoptotic death...
  73. ncbi request reprint Roles of JNK-1 and p38 in selective induction of apoptosis by capsaicin in ras-transformed human breast epithelial cells
    Hye Jung Kang
    College of Pharmacy, Duksung Women s University, 4129 Ssangmun dong, Tobong ku, Seoul 132 714, Korea
    Int J Cancer 103:475-82. 2003
    ....
  74. ncbi request reprint Effects of yakuchinone A and yakuchinone B on the phorbol ester-induced expression of COX-2 and iNOS and activation of NF-kappaB in mouse skin
    Kyung Soo Chun
    Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, South Korea
    J Environ Pathol Toxicol Oncol 21:131-9. 2002
    ..These findings suggest that diarylheptanoids contained in Alpinia oxyphylla down-regulate COX-2 and iNOS expression through suppression of NF-kappaB activation in the TPA-treated mouse skin...
  75. ncbi request reprint 15-deoxy-Delta12,14-prostaglandin J2 as a potential endogenous regulator of redox-sensitive transcription factors
    Eun Hee Kim
    National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shinlim Dong, Kwanak Ku, Seoul 151 742, South Korea
    Biochem Pharmacol 72:1516-28. 2006
    ..This commentary describes the biological and physiological functions of 15d-PGJ(2) and underlying biochemical and molecular mechanisms with emphasis on the modulation of redox-sensitive transcription factors and their regulators...
  76. doi request reprint (-)-Epigallocatechin gallate induces Nrf2-mediated antioxidant enzyme expression via activation of PI3K and ERK in human mammary epithelial cells
    Hye Kyung Na
    National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Seoul 151 742, South Korea
    Arch Biochem Biophys 476:171-7. 2008
    ....
  77. ncbi request reprint Selenium regulates cyclooxygenase-2 and extracellular signal-regulated kinase signaling pathways by activating AMP-activated protein kinase in colon cancer cells
    Jin Taek Hwang
    Department of Biochemistry and Molecular Biology, Medical Research Center for Bioreaction to Reactive Oxygen Species, Kyung Hee University College of Medicine, Seoul, South Korea
    Cancer Res 66:10057-63. 2006
    ..We propose that AMPK is a novel and critical regulatory component in selenium-induced cancer cell death, further implying AMPK as a prime target of tumorigenesis...
  78. ncbi request reprint Bcl-2 protects against Abeta(25-35)-induced oxidative PC12 cell death by potentiation of antioxidant capacity
    Jung Hee Jang
    Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Shinlim Dong, Kwanak Ku, Seoul 151 742, South Korea
    Biochem Biophys Res Commun 320:880-6. 2004
    ..These results suggest that NF-kappaB plays a role in bcl-2-mediated protection against Abeta-induced apoptosis in PC12 cells through augmentation of cellular antioxidant capacity...
  79. ncbi request reprint Resveratrol inhibits phorbol ester-induced expression of COX-2 and activation of NF-kappaB in mouse skin by blocking IkappaB kinase activity
    Joydeb Kumar Kundu
    National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Seoul 151 742
    Carcinogenesis 27:1465-74. 2006
    ..Taken together, the above findings suggest that resveratrol targets IKK in blocking TPA-induced NF-kappaB activation and COX-2 expression in mouse skin in vivo...
  80. ncbi request reprint L-ascorbic acid represses constitutive activation of NF-kappaB and COX-2 expression in human acute myeloid leukemia, HL-60
    Seong Su Han
    Samsung Medical Center, and Sungkyunkwan University School of Medicine, Seoul 135 710, Korea
    J Cell Biochem 93:257-70. 2004
    ..In conclusion, our data suggest that LAA exerts its anti-tumor activity through downregulation of NF-kappaB activity and COX-2 expression, and these inhibitory effects can be enhanced by co-treatment with As2O3...
  81. ncbi request reprint In vitro evidence of the role of COX-2 in attenuating gastric inflammation and promoting gastric carcinogenesis
    Ki Baik Hahm
    Department of Gastroenterology, Ajou University School of Medicine, Suwon, Korea
    J Environ Pathol Toxicol Oncol 21:165-76. 2002
    ..In conclusion, COX-2 expression seems to be induced to attenuate the degree of atrophic gastritis, the initial event in gastric carcinogenesis, and promote gastric carcinogenesis...
  82. ncbi request reprint Chemoprevention of Helicobacter pylori-associated gastric carcinogenesis in a mouse model: is it possible?
    Ki Baik Hahm
    Chemoprevention Agent Development Research Group, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Biochem Mol Biol 36:82-94. 2003
    ..pylori or lessening the inflammation provoked by H. pylori infection in high risk group...
  83. ncbi request reprint Zerumbone, a sesquiterpene in subtropical ginger, suppresses skin tumor initiation and promotion stages in ICR mice
    Akira Murakami
    Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto, Japan
    Int J Cancer 110:481-90. 2004
    ....
  84. ncbi request reprint Chemopreventive potential of epigallocatechin gallate and genistein: evidence from epidemiological and laboratory studies
    Ock Jin Park
    Applied Sciences, College of Natural Sciences, Hannam University, Daejeon 306 791, South Korea
    Toxicol Lett 150:43-56. 2004
    ....
  85. ncbi request reprint Dietary and medicinal antimutagens and anticarcinogens: molecular mechanisms and chemopreventive potential--highlights of a symposium
    Young Joon Surh
    Mutat Res 523:1-8. 2003
    ..This special issue features some of the highlights of the conference on this topic that was held in Seoul on October 17-19, 2001...
  86. ncbi request reprint Oxidative DNA damage and glioma cell death induced by tetrahydropapaveroline
    Yunjo Soh
    Department of Neuroscience, Graduate School of East West Medical Science, Kyung Hee University, Yongin si, Kyungki do, South Korea
    Mutat Res 544:129-42. 2003
    ..Furthermore, pretreatment with inhibitors of JNK and p38 MAPK rescued the glioma cells from THP-induced cytotoxicity, suggestive of the involvement of these kinases in THP-induced C6 glioma cell damage...