Jeong Sun Seo

Summary

Affiliation: Seoul National University
Country: Korea

Publications

  1. pmc TIARA: a database for accurate analysis of multiple personal genomes based on cross-technology
    Dongwan Hong
    Genomic Medicine Institute, Medical Research Center, Seoul National University, Seoul 110 799, Korea
    Nucleic Acids Res 39:D883-8. 2011
  2. pmc The first Irish genome and ways of improving sequence accuracy
    Young Seok Ju
    Genomic Medicine Institute, Medical Research Center, Seoul National University, 28 Yongon Dong, Jongno gu, Seoul 110 799, Korea
    Genome Biol 11:132. 2010
  3. pmc Comprehensive genomic analyses associate UGT8 variants with musical ability in a Mongolian population
    Hansoo Park
    Medical Research Center, Genomic Medicine Institute GMI, Seoul National University, Seoul, Korea
    J Med Genet 49:747-52. 2012
  4. pmc Reference-unbiased copy number variant analysis using CGH microarrays
    Young Seok Ju
    Genomic Medicine Institute, Medical Research Center, Seoul National University, Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul 110 799, Korea
    Nucleic Acids Res 38:e190. 2010
  5. pmc TIARA genome database: update 2013
    Dongwan Hong
    Cancer Genomics Branch, Division of Convergence Technology, National Cancer Center, Gyeonggi do 410 769, Korea
    Database (Oxford) 2013:bat003. 2013
  6. pmc The transcriptional landscape and mutational profile of lung adenocarcinoma
    Jeong Sun Seo
    Genomic Medicine Institute GMI, Medical Research Center, Seoul National University, Seoul 110 799, Korea
    Genome Res 22:2109-19. 2012
  7. pmc Discovery of common Asian copy number variants using integrated high-resolution array CGH and massively parallel DNA sequencing
    Hansoo Park
    Genomic Medicine Institute, Medical Research Center, Seoul National University, Seoul, Korea
    Nat Genet 42:400-5. 2010
  8. ncbi request reprint Radiofrequency radiation does not induce stress response in human T-lymphocytes and rat primary astrocytes
    Jae Seon Lee
    Department of Biochemistry and Molecular Biology, ILCHUN Molecular Medicine Institute MRC, Seoul National University College of Medicine, Seoul, Korea
    Bioelectromagnetics 27:578-88. 2006
  9. ncbi request reprint FOXO3a turns the tumor necrosis factor receptor signaling towards apoptosis through reciprocal regulation of c-Jun N-terminal kinase and NF-kappaB
    Hae Young Lee
    Innovative Research Institute for Cell Therapy, Seoul National University Hospital, Seoul, Korea
    Arterioscler Thromb Vasc Biol 28:112-20. 2008
  10. pmc A transforming KIF5B and RET gene fusion in lung adenocarcinoma revealed from whole-genome and transcriptome sequencing
    Young Seok Ju
    Genomic Medicine Institute, Medical Research Center, Seoul National University, Seoul, Korea
    Genome Res 22:436-45. 2012

Collaborators

Detail Information

Publications48

  1. pmc TIARA: a database for accurate analysis of multiple personal genomes based on cross-technology
    Dongwan Hong
    Genomic Medicine Institute, Medical Research Center, Seoul National University, Seoul 110 799, Korea
    Nucleic Acids Res 39:D883-8. 2011
    ..More personal genomes will be archived as more individuals are analyzed by NGS or CGH array. TIARA provides a new approach to the accurate interpretation of personal genomes for genome research...
  2. pmc The first Irish genome and ways of improving sequence accuracy
    Young Seok Ju
    Genomic Medicine Institute, Medical Research Center, Seoul National University, 28 Yongon Dong, Jongno gu, Seoul 110 799, Korea
    Genome Biol 11:132. 2010
    ..Whole-genome sequencing of an Irish person reveals hundreds of thousands of novel genomic variants. Imputation using previous known information improves the accuracy of low-read-depth sequencing...
  3. pmc Comprehensive genomic analyses associate UGT8 variants with musical ability in a Mongolian population
    Hansoo Park
    Medical Research Center, Genomic Medicine Institute GMI, Seoul National University, Seoul, Korea
    J Med Genet 49:747-52. 2012
    ..Specific regions of the brain have been found to be activated by musical stimuli, but these have rarely been extended to the discovery of genes and molecules associated with musical ability...
  4. pmc Reference-unbiased copy number variant analysis using CGH microarrays
    Young Seok Ju
    Genomic Medicine Institute, Medical Research Center, Seoul National University, Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul 110 799, Korea
    Nucleic Acids Res 38:e190. 2010
    ..We found that the CARA remarkably enhanced the accuracy of CGH array in determining absolute CNVs. Our method thus provides a new approach to interpret CGH array data for personalized medicine...
  5. pmc TIARA genome database: update 2013
    Dongwan Hong
    Cancer Genomics Branch, Division of Convergence Technology, National Cancer Center, Gyeonggi do 410 769, Korea
    Database (Oxford) 2013:bat003. 2013
    ..Users can here observe, for example, the expression levels of human genes with allele-specific quantification. Improvements to the TIARA genome browser include the intuitive display of new complex and large-scale data sets...
  6. pmc The transcriptional landscape and mutational profile of lung adenocarcinoma
    Jeong Sun Seo
    Genomic Medicine Institute GMI, Medical Research Center, Seoul National University, Seoul 110 799, Korea
    Genome Res 22:2109-19. 2012
    ..We also found an association between lymph node metastasis and somatic mutations in TP53. These findings broaden our understanding of lung adenocarcinoma and may also lead to new diagnostic and therapeutic approaches...
  7. pmc Discovery of common Asian copy number variants using integrated high-resolution array CGH and massively parallel DNA sequencing
    Hansoo Park
    Genomic Medicine Institute, Medical Research Center, Seoul National University, Seoul, Korea
    Nat Genet 42:400-5. 2010
    ..These common CNVs in Asian populations will be a useful resource for subsequent genetic studies in these populations, and the new method of calling absolute CNVs will be essential for applying CNV data to personalized medicine...
  8. ncbi request reprint Radiofrequency radiation does not induce stress response in human T-lymphocytes and rat primary astrocytes
    Jae Seon Lee
    Department of Biochemistry and Molecular Biology, ILCHUN Molecular Medicine Institute MRC, Seoul National University College of Medicine, Seoul, Korea
    Bioelectromagnetics 27:578-88. 2006
    ..These results indicate that 1763 MHz RF radiation alone did not elicit any stress response, nor did it have any effect on TPA-induced MAPK phosphorylation, under our experimental conditions...
  9. ncbi request reprint FOXO3a turns the tumor necrosis factor receptor signaling towards apoptosis through reciprocal regulation of c-Jun N-terminal kinase and NF-kappaB
    Hae Young Lee
    Innovative Research Institute for Cell Therapy, Seoul National University Hospital, Seoul, Korea
    Arterioscler Thromb Vasc Biol 28:112-20. 2008
    ..We evaluated the full range effects of FOXO3a in endothelial cells (ECs) by microarray analysis and investigated the role of FOXO3a regulating TNF receptor signaling pathway...
  10. pmc A transforming KIF5B and RET gene fusion in lung adenocarcinoma revealed from whole-genome and transcriptome sequencing
    Young Seok Ju
    Genomic Medicine Institute, Medical Research Center, Seoul National University, Seoul, Korea
    Genome Res 22:436-45. 2012
    ..Our data demonstrate that a subset of NSCLCs could be caused by a fusion of KIF5B and RET, and suggest the chimeric oncogene as a promising molecular target for the personalized diagnosis and treatment of lung cancer...
  11. doi request reprint Extensive genomic and transcriptional diversity identified through massively parallel DNA and RNA sequencing of eighteen Korean individuals
    Young Seok Ju
    Genomic Medicine Institute GMI, Medical Research Center, Seoul National University, Seoul, Korea
    Nat Genet 43:745-52. 2011
    ....
  12. pmc Gene mapping study for constitutive skin color in an isolated Mongolian population
    Seung Hwan Paik
    Department of Dermatology Seoul National University College of Medicine, Seoul 110 799, Korea
    Exp Mol Med 44:241-9. 2012
    ..We were able to discover four possible candidate genes that would be implicated to regulate human skin color: ETS1, UBASH3B, ASAM, and CLTC...
  13. doi request reprint A family-based association study after genome-wide linkage analysis identified two genetic loci for renal function in a Mongolian population
    Hansoo Park
    Genomic Medicine Institute, Medical Research Center, Seoul National University, Seoul, Republic of Korea
    Kidney Int 83:285-92. 2013
    ..Thus, we identified possible loci that determine renal function in an isolated Asian population. Consistent with previous reports, our study found genes linked and associated with renal function in other populations...
  14. doi request reprint Molecular diagnosis of congenital muscular dystrophies with defective glycosylation of alpha-dystroglycan using next-generation sequencing technology
    Byung Chan Lim
    Department of Pediatrics, Seoul National University College of Medicine, Seoul National University Children s Hospital, Seoul, Republic of Korea
    Neuromuscul Disord 23:337-44. 2013
    ..As suboptimal coverage in a small subset of coding regions may affect the sensitivity of the method, complementary Sanger sequencing may be required...
  15. pmc Exomic sequencing of immune-related genes reveals novel candidate variants associated with alopecia universalis
    Seungbok Lee
    Genomic Medicine Institute GMI, Medical Research Center, Seoul National University, Seoul, Korea
    PLoS ONE 8:e53613. 2013
    ..This study provides further evidence for the association of previously reported genes with AA and novel findings such as HLA-DRB5, which might represent a hidden culprit gene for AU...
  16. doi request reprint Diagnostic method for the detection of KIF5B-RET transformation in lung adenocarcinoma
    Heounjeong Go
    Department of Pathology, Seoul National University College of Medicine, Seoul, Republic of Korea
    Lung Cancer 82:44-50. 2013
    ..However, as there may be additional variant of fusion mutation, FISH may be better than PCR method in terms of sensitivity. ..
  17. doi request reprint FX: an RNA-Seq analysis tool on the cloud
    Dongwan Hong
    Genomic Medicine Institute, Medical Research Center, Seoul National University, Seoul
    Bioinformatics 28:721-3. 2012
    ..Unmapped reads not aligned on known transcripts are then mapped on the human genome reference. FX allows analysis of RNA-Seq data on cloud computing infrastructures, supporting access through a user-friendly web interface...
  18. ncbi request reprint Hoyeraal-Hreidarsson syndrome with a DKC1 mutation identified by whole-exome sequencing
    Byung Chan Lim
    Department of Pediatrics, Seoul National University College of Medicine, Seoul National University Children s Hospital, Seoul, Republic of Korea Electronic address
    Gene 546:425-9. 2014
    ..As the genetic background of dyskeratosis congenita or Hoyeraal-Hreidarsson syndrome has expanded rapidly, multiple causative genes and inheritance patterns pose a great challenge to their genetic diagnosis...
  19. ncbi request reprint Identification of radiation-specific responses from gene expression profile
    Woong Yang Park
    ILCHUN Molecular Medicine Institute, Seoul National University, Chongnogu, Seoul, Korea
    Oncogene 21:8521-8. 2002
    ..From these results, we could identify the IR-specific genes from expression profiling, which can be used as radiation biomarkers to screen radiation exposure as well as probing the mechanism of cellular responses to ionizing radiation...
  20. doi request reprint Molecular responses of Jurkat T-cells to 1763 MHz radiofrequency radiation
    Tai Qin Huang
    ILCHUN Genomic Medicine Institute, MRC and Department of Biomedical Sciences, Biochemistry and Molecular Biology, College of Medicine, Seoul, Korea
    Int J Radiat Biol 84:734-41. 2008
    ..In this paper, we monitored cellular and molecular changes in Jurkat human T lymphoma cells after irradiating with 1763 MHz RF radiation to understand the effect on RF radiation in immune cells...
  21. pmc Fine-scale mapping of meiotic recombination in Asians
    Thomas Bleazard
    Genomic Medicine Institute GMI, Medical Research Center, Seoul National University, Seoul, South Korea
    BMC Genet 14:19. 2013
    ..There have been several reports that recombination hotspot usage differs between human populations. But while fine-scale genetic maps exist for European and African populations, none have been constructed for Asians...
  22. doi request reprint Combined linkage and association analyses identify a novel locus for obesity near PROX1 in Asians
    Hyun Jin Kim
    Genomic Medicine Institute GMI, Medical Research Center, Seoul National University, Seoul, Republic of Korea Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Republic of Korea
    Obesity (Silver Spring) 21:2405-12. 2013
    ..Our objective was to identify the novel candidates for obesity in Asian populations by using genemapping strategies that combine linkage and association analyses...
  23. pmc A highly annotated whole-genome sequence of a Korean individual
    Jong Il Kim
    Genomic Medicine Institute, Medical Research Center, Seoul National University, Seoul 110 799, Korea
    Nature 460:1011-5. 2009
    ..The integration of several human whole-genome sequences derived from several ethnic groups will assist in understanding genetic ancestry, migration patterns and population bottlenecks...
  24. ncbi request reprint Effect of radiofrequency radiation exposure on mouse skin tumorigenesis initiated by 7,12-dimethybenz[alpha]anthracene
    Tai Qin Huang
    ILCHUN Molecular Medicine Institute MRC, and Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul
    Int J Radiat Biol 81:861-7. 2005
    ..To study if RF radiation has a tumor promoting effect, we exposed mice with skin tumorigenesis initiated by 7,12-dimethybenz[a]anthracene (DMBA) to RF radiation...
  25. ncbi request reprint Differential expression of two stress-inducible hsp70 genes by various stressors
    Jae Seon Lee
    Department of Biochemistry and Molecular Biology, ILCHUN Molecular Medicine Institute MRC, Seoul National University College of Medicine, Korea
    Exp Mol Med 34:131-6. 2002
    ..1 gene expression in the M-1 cell line. Hsp70 accumulation by H2O2 and NaCl treatment was mainly due to hsp70.1 expression. Our studies demonstrated that two hsp70 genes respond differentially to types of stress...
  26. doi request reprint Linkage and association scan for tanning ability in an isolated Mongolian population
    Seung Hwan Paik
    Institute of Dermatological Science, Seoul National University College of Medicine, Korea
    BMB Rep 44:741-6. 2011
    ..3 and 12q13.2, having 6 and 7 significant single nucleotide polymorphisms (SNPs), respectively. Those significant SNPs were located in or adjacent to potential candidate genes related to tanning ability: GRM6, ATF1, WNT1, and SILV/Pmel17...
  27. pmc Analysis of genetic and non-genetic factors that affect the QTc interval in a Mongolian population: the GENDISCAN study
    Sun Wha Im
    Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul 110 799, Korea
    Exp Mol Med 41:841-8. 2009
    ..A genetic effect for the QTc interval was identified based on familial correlation with a heritability value of 0.31. In a whole genome linkage analysis, we identified the four potential linkage regions 7q31-34, 5q21, 4q28, and 2q36...
  28. ncbi request reprint Gene expression profile of megakaryocytes from human cord blood CD34(+) cells ex vivo expanded by thrombopoietin
    Jeong Ah Kim
    Departments of Biochemistry, College of Medicine, Ewha Womans University, Seoul, Korea
    Stem Cells 20:402-16. 2002
    ..These gene expression profiles will be useful to understand megakaryocytopoiesis at the molecular level, including apoptosis and related signal transduction pathways...
  29. doi request reprint Epidemiologic characteristics of intraocular pressure in the Korean and Mongolian populations: the Healthy Twin and the GENDISCAN study
    Mi Kyeong Lee
    Department of Epidemiology and Institute of Environment and Health, School of Public Health, Seoul National University, Seoul, Korea
    Ophthalmology 119:450-7. 2012
    ..The purpose of this study was to demonstrate a negative association between intraocular pressure (IOP) and age in 2 Asian populations. In addition, we evaluated genetic and nongenetic factors associated with IOP...
  30. pmc Gene flow between the Korean peninsula and its neighboring countries
    Jongsun Jung
    Syntekabio Inc, Seoul, Korea
    PLoS ONE 5:e11855. 2010
    ....
  31. pmc Targeted disruption of hsp70.1 sensitizes to osmotic stress
    Eun Hee Shim
    Department of Biochemistry and ILCHUN Molecular Medicine Institute MRC, Seoul National University College of Medicine, Korea
    EMBO Rep 3:857-61. 2002
    ..Taken together, our results demonstrate that differential expression of hsp70 genes contributes to the stress response and that the hsp70.1 gene plays a critical role in osmotolerance...
  32. ncbi request reprint Selection of neural differentiation-specific genes by comparing profiles of random differentiation
    Min Su Lee
    Department of Computer Science and Engineering, Ewha Womans University, Seoul, Korea
    Stem Cells 24:1946-55. 2006
    ....
  33. ncbi request reprint Caveolin-1 inhibits neurite growth by blocking Rac1/Cdc42 and p21-activated kinase 1 interactions
    Min Ji Kang
    Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul, Korea
    Neuroreport 17:823-7. 2006
    ..From these results, we suggest that the up-regulated caveolin-1 in neuronal cells can inhibit the bFGF signaling pathway from small GTPases to PAK1 by directly binding to PAK1...
  34. doi request reprint Genetic diagnosis of Duchenne and Becker muscular dystrophy using next-generation sequencing technology: comprehensive mutational search in a single platform
    Byung Chan Lim
    Department of Pediatrics, Seoul National University College of Medicine, Seoul National University Children s Hospital, Seoul, Korea
    J Med Genet 48:731-6. 2011
    ....
  35. pmc A genome-wide Asian genetic map and ethnic comparison: the GENDISCAN study
    Young Seok Ju
    Department of Biochemistry and Molecular Biology, College of Medicine, Seoul National University, Seoul, Korea
    BMC Genomics 9:554. 2008
    ..Different ethnic groups may have different recombination rates as a result of genomic variations, which would generate misspecification of the genetic map and reduce the power of linkage analyses...
  36. doi request reprint Parthenogenetic embryonic stem cells with H19 siRNA-mediated knockdown as a potential resource for cell therapy
    Minhye Kwak
    ILCHUN Genomic Medicine Institute, MRC, Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul 110 799, Republic of Korea
    Int J Mol Med 29:257-62. 2012
    ..These results indicate that the ESH cells may be a source of cell-based therapy for conditions such as muscular atrophy...
  37. ncbi request reprint Targeting efficiency of a-1,3-galactosyl transferase gene in pig fetal fibroblast cells
    Dong Il Jin
    ILCHUN Molecular Medicine Institute, Medical Research Center, Seoul National University, Korea
    Exp Mol Med 35:572-7. 2003
    ..Double selection method with Neo' and HSV-tk genes could be useful for gene targeting in somatic cells for production of cloned animals carrying targeted endogenous genes...
  38. pmc Targeted resequencing of candidate genes reveals novel variants associated with severe Behçet's uveitis
    Sang Jin Kim
    1 Department of Ophthalmology, Seoul National University College of Medicine, Seoul, South Korea 2 Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
    Exp Mol Med 45:e49. 2013
    ..In conclusion, this study showed that target enrichment and next-generation sequencing technologies can provide valuable information on the genetic predisposition for Behçet's uveitis. ..
  39. pmc Copy number variation of age-related macular degeneration relevant genes in the Korean population
    Jung Hyun Park
    Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea
    PLoS ONE 7:e31243. 2012
    ..Copy number variation (CNV) may be an additional type of genetic variation that contributes to AMD pathogenesis. This study investigated CNV in 4 AMD-relevant genes in Korean AMD patients and control subjects...
  40. pmc Targeted sequencing of cancer-related genes in colorectal cancer using next-generation sequencing
    Sae Won Han
    Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea
    PLoS ONE 8:e64271. 2013
    ..Targeted sequencing platform using NGS technology is feasible for clinical use and provides comprehensive genetic alteration data...
  41. ncbi request reprint Inhibitory effect of Hsp70 on angiotensin II-induced vascular smooth muscle cell hypertrophy
    Ying Zheng
    ILCHUN Molecular Medicine Institute, Seoul National University College of Medicine, Seoul 110 799, Korea
    Exp Mol Med 38:509-18. 2006
    ..This inhibitory effect of Hsp70 appears to be partly due to extracellular signal-regulated kinase (ERK1/2) inactivation, which in turn, may possibly result from the accumulation of MAP kinase phosphatase-1 (MKP-1)...
  42. ncbi request reprint The signature from messenger RNA expression profiling can predict lymph node metastasis with high accuracy for non-small cell lung cancer
    Naeyun Choi
    Cancer Research Division, Center for Clinical Research, Samsung Biomedical Research Institute, Seoul, Korea
    J Thorac Oncol 1:622-8. 2006
    ..The authors attempted to deduce a group of genes from the analysis of mRNA expression profiles of the tumor tissues of NSCLC patients with or without LN metastasis, and make a classification model for better prediction of LN metastasis...
  43. ncbi request reprint HSP70 deficiency results in activation of c-Jun N-terminal Kinase, extracellular signal-regulated kinase, and caspase-3 in hyperosmolarity-induced apoptosis
    Jae Seon Lee
    ILCHUN Molecular Medicine Institute, Medical Research Center and Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine and BK21 Human Life Science, Seoul National University, Seoul, Korea
    J Biol Chem 280:6634-41. 2005
    ....
  44. pmc Effect of thermal preconditioning before excimer laser photoablation
    Joon Mo Kim
    Department of Ophthalmology, College of Medicine, Seoul National University, Korea
    J Korean Med Sci 19:437-46. 2004
    ..Induced Hsps also seemed to play an important role in rapid wound healing, and decreased corneal and lens opacity after excimer laser ablation...
  45. ncbi request reprint Association of interleukin-6 promoter variant with bone mineral density in pre-menopausal women
    Hye Won Chung
    Department of Obstetrics and Gynecology, College of Medicine, Ewha Woman s University, 158 710, Seoul, Korea
    J Hum Genet 48:243-8. 2003
    ..58+/-0.19), and intermediate in heterozygotes (0.64+/-0.21). In the present study, we describe a variant in the IL6 promoter region that shows positive association with higher BMD in a gene-dose-dependent manner in pre-menopausal women...
  46. ncbi request reprint Forkhead factor, FOXO3a, induces apoptosis of endothelial cells through activation of matrix metalloproteinases
    Hae Young Lee
    Innovative Research Institute for Cell Therapy, Seoul National University Hospital, Seoul, Korea
    Arterioscler Thromb Vasc Biol 28:302-8. 2008
    ..However, its effects on extracellular matrices (ECM), which are important in EC survival, remained unknown. Here, we evaluated the role of FOXO3a on EC-ECM interaction...
  47. ncbi request reprint Overexpression of tumor necrosis factor receptor-associated protein 1 (TRAP1), leads to mitochondrial aberrations in mouse fibroblast NIH/3T3 cells
    Chang Nim Im
    Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine ILCHUN Molecular Medicine Institute MRC, Seoul 110 799 Department of Biochemistry, The Catholic University of Korea College of Medicine, Seoul 137 701, Korea
    BMB Rep 47:280-5. 2014
    ..This study suggests that overexpression of TRAP1 might be a critical link between mitochondrial disturbances and carcinogenesis...
  48. doi request reprint Characterization of biological effect of 1763 MHz radiofrequency exposure on auditory hair cells
    Tai Qin Huang
    ILCHUN Genomic Medicine Institute, MRC and Department of Biochemistry and Molecular Biology, College of Medicine, Seoul, Korea
    Int J Radiat Biol 84:909-15. 2008
    ..We chose HEI-OC1 immortalized mouse auditory hair cells to characterize the cellular response to 1763 MHz RF exposure, because auditory cells could be exposed to mobile phone frequencies...