Seonyang Park

Summary

Affiliation: Seoul National University
Country: Korea

Publications

  1. pmc High-dose versus low-dose cyclophosphamide in combination with G-CSF for peripheral blood progenitor cell mobilization
    Jin Seok Ahn
    Department of Internal Medicine, College of Medicine, Hallym University, Seoul, Korea
    Korean J Intern Med 20:224-31. 2005
  2. pmc Allogeneic stem cell transplantation for patients with advanced hematological malignancies: comparison of fludarabine-based reduced intensity conditioning versus myeloablative conditioning
    Inho Kim
    Department of Internal Medicine, Seoul National University College of Medicine, 28 Yeongeon dong, Jongno gu, Seoul, Korea
    J Korean Med Sci 22:227-34. 2007
  3. pmc Pneumatosis intestinalis with pneumoperitoneum mimicking intestinal perforation in a patient with myelodysplastic syndrome after hematopoietic stem cell transplantation
    Bhumsuk Keam
    Department of Internal Medicine, Seoul National University Hospital, College of Medicine, Seoul National University Seoul, Korea
    Korean J Intern Med 22:40-4. 2007
  4. ncbi request reprint Application of array comparative genomic hybridization in chronic myeloid leukemia
    Seonyang Park
    Department of Internal Medicine, Diagnostic DNA Chip Center, Seoul National University College of Medicine, Seoul, South Korea
    Methods Mol Biol 973:55-68. 2013
  5. ncbi request reprint Treatment outcome of adult acute lymphocytic leukemia with VPD(L) regimen: analysis of prognostic factors
    Sook Ryun Park
    Department of Internal Medicine, Seoul National University College of Medicine, 28, Yongon Dong, Chongno Gu, Seoul 110 744, Korea
    Korean J Intern Med 18:21-8. 2003
  6. ncbi request reprint P2X7 receptor polymorphism and clinical outcomes in HLA-matched sibling allogeneic hematopoietic stem cell transplantation
    Kyung Hun Lee
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Haematologica 92:651-7. 2007
  7. ncbi request reprint Glutathione S-transferase A1 polymorphisms and acute graft-vs.-host disease in HLA-matched sibling allogeneic hematopoietic stem cell transplantation
    Inho Kim
    Department of Internal Medicine, Seoul National University, Seoul, Korea
    Clin Transplant 21:207-13. 2007
  8. doi request reprint RANTES polymorphisms and the risk of graft-versus-host disease in human leukocyte antigen-matched sibling allogeneic hematopoietic stem cell transplantation
    Dong Yeop Shin
    Department of Internal Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul National University College of Medicine, Seoul, Korea
    Acta Haematol 129:137-45. 2013
  9. doi request reprint Comparative analysis between azacitidine and decitabine for the treatment of myelodysplastic syndromes
    Yun Gyoo Lee
    Department of Internal Medicine, Seoul National University Hospital, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Br J Haematol 161:339-47. 2013
  10. doi request reprint Risk factors for poor treatment outcome and central nervous system relapse in diffuse large B-cell lymphoma with bone marrow involvement
    Keun Wook Lee
    Department of Internal Medicine, Seoul National University College of Medicine, Chongno Gu, Seoul, South Korea
    Ann Hematol 88:829-38. 2009

Collaborators

Detail Information

Publications69

  1. pmc High-dose versus low-dose cyclophosphamide in combination with G-CSF for peripheral blood progenitor cell mobilization
    Jin Seok Ahn
    Department of Internal Medicine, College of Medicine, Hallym University, Seoul, Korea
    Korean J Intern Med 20:224-31. 2005
    ....
  2. pmc Allogeneic stem cell transplantation for patients with advanced hematological malignancies: comparison of fludarabine-based reduced intensity conditioning versus myeloablative conditioning
    Inho Kim
    Department of Internal Medicine, Seoul National University College of Medicine, 28 Yeongeon dong, Jongno gu, Seoul, Korea
    J Korean Med Sci 22:227-34. 2007
    ..16). The results of present study indicate that patients with advanced hematological malignancies, even the elderly and those with major organ dysfunctions, might benefit from reduced intensity transplantation...
  3. pmc Pneumatosis intestinalis with pneumoperitoneum mimicking intestinal perforation in a patient with myelodysplastic syndrome after hematopoietic stem cell transplantation
    Bhumsuk Keam
    Department of Internal Medicine, Seoul National University Hospital, College of Medicine, Seoul National University Seoul, Korea
    Korean J Intern Med 22:40-4. 2007
    ..The described case supports that a mechanical rather than a bacterial etiology underlies the pathogenesis of PI...
  4. ncbi request reprint Application of array comparative genomic hybridization in chronic myeloid leukemia
    Seonyang Park
    Department of Internal Medicine, Diagnostic DNA Chip Center, Seoul National University College of Medicine, Seoul, South Korea
    Methods Mol Biol 973:55-68. 2013
    ..Here we review the methodological aspects of array-CGH analysis for studying CML and its related data analysis...
  5. ncbi request reprint Treatment outcome of adult acute lymphocytic leukemia with VPD(L) regimen: analysis of prognostic factors
    Sook Ryun Park
    Department of Internal Medicine, Seoul National University College of Medicine, 28, Yongon Dong, Chongno Gu, Seoul 110 744, Korea
    Korean J Intern Med 18:21-8. 2003
    ....
  6. ncbi request reprint P2X7 receptor polymorphism and clinical outcomes in HLA-matched sibling allogeneic hematopoietic stem cell transplantation
    Kyung Hun Lee
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Haematologica 92:651-7. 2007
    ....
  7. ncbi request reprint Glutathione S-transferase A1 polymorphisms and acute graft-vs.-host disease in HLA-matched sibling allogeneic hematopoietic stem cell transplantation
    Inho Kim
    Department of Internal Medicine, Seoul National University, Seoul, Korea
    Clin Transplant 21:207-13. 2007
    ..The identification of glutathione S-transferase A1 genotypes prior to allogeneic stem cell transplantation could allow conditioning regimens and graft-vs.-host disease prophylaxis to be modified to improve outcome...
  8. doi request reprint RANTES polymorphisms and the risk of graft-versus-host disease in human leukocyte antigen-matched sibling allogeneic hematopoietic stem cell transplantation
    Dong Yeop Shin
    Department of Internal Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul National University College of Medicine, Seoul, Korea
    Acta Haematol 129:137-45. 2013
    ..Further larger prospective investigations are needed to establish the role of RANTES polymorphisms in patients treated with allo-HSCT...
  9. doi request reprint Comparative analysis between azacitidine and decitabine for the treatment of myelodysplastic syndromes
    Yun Gyoo Lee
    Department of Internal Medicine, Seoul National University Hospital, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Br J Haematol 161:339-47. 2013
    ..We found that azacitidine and decitabine showed comparable efficacy. Among patients ≥ 65 years of age, survival was significantly better in the azacitidine group (ClinicalTrials.gov Identifier: NCT01409070)...
  10. doi request reprint Risk factors for poor treatment outcome and central nervous system relapse in diffuse large B-cell lymphoma with bone marrow involvement
    Keun Wook Lee
    Department of Internal Medicine, Seoul National University College of Medicine, Chongno Gu, Seoul, South Korea
    Ann Hematol 88:829-38. 2009
    ..Further efforts should be directed toward finding optimal treatment modalities based on the IPI and the extent of BMI by lymphoma. CNS prophylaxis may be considered only in patients with initial elevated LDH levels...
  11. doi request reprint Impact of cytokine gene polymorphisms on risk and treatment outcomes of aplastic anemia
    Yun Gyoo Lee
    Department of Internal Medicine, Seoul National University Hospital, 101 Daehang ro, Jongno gu, Seoul, 110 744, South Korea
    Ann Hematol 90:515-21. 2011
    ..This exploratory study concurred with prior studies indicating that polymorphisms in IFNG are related to AA susceptibility. In addition, it was found that polymorphisms in IFNG and TGFB1 are associated with response to IST...
  12. doi request reprint Prognosis of secondary acute myeloid leukemia is affected by the type of the preceding hematologic disorders and the presence of trisomy 8
    Youngil Koh
    Department of Internal Medicine, College of Medicine, Seoul National University, Seoul, Republic of Korea
    Jpn J Clin Oncol 40:1037-45. 2010
    ..We also intended to find prognostic factors in secondary acute myeloid leukemia overall...
  13. ncbi request reprint First-line ifosfamide, methotrexate, etoposide and prednisolone chemotherapy +/- radiotherapy is active in stage I/II extranodal NK/T-cell lymphoma
    Keun Wook Lee
    Department of Internal Medicine, Cancer Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Chongno Gu, Seoul, Korea
    Leuk Lymphoma 47:1274-82. 2006
    ..Considering local failure rate after IMEP alone, initial IMEP chemotherapy followed by radiotherapy may be a promising treatment strategy in this subset of NTCL...
  14. doi request reprint GSTT1 copy number gain is a poor predictive marker for escalated-dose imatinib treatment in chronic myeloid leukemia: genetic predictive marker found using array comparative genomic hybridization
    Youngil Koh
    Department of Internal Medicine, Seoul National University Hospital, Seoul National University, 101 Daehagro, Jongno Ku, Seoul 110 744, Korea
    Cancer Genet Cytogenet 203:215-21. 2010
    ..020). We conclude that chromosome regions 16p11.2, 22q11.23, and 17q12 are potential locations related to response in imatinib dose escalation therapy for CML. GSTT1 copy number gain is a genetic change affecting outcome in this setting...
  15. doi request reprint Mitoxantrone, etoposide, cytarabine, and melphalan (NEAM) followed by autologous stem cell transplantation for patients with chemosensitive aggressive non-Hodgkin lymphoma
    Ji Won Kim
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Am J Hematol 87:479-83. 2012
    ..In conclusion, NEAM conditioning with auto-SCT demonstrated considerable efficacy with modest toxicity in patients with chemosensitive aggressive NHL...
  16. doi request reprint Fludarabine, cytarabine, and attenuated-dose idarubicin (m-FLAI) combination therapy for elderly acute myeloid leukemia patients
    Inho Kim
    Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Korea
    Am J Hematol 88:10-5. 2013
    ..In addition, bone-marrow CD117 expression is an independent favorable prognostic factor in elderly AML patients. (ClinicalTrials.gov number, NCT01247493)...
  17. ncbi request reprint Comparative outcomes of reduced intensity and myeloablative allogeneic hematopoietic stem cell transplantation in patients under 50 with hematologic malignancies
    Inho Kim
    Department of Internal Medicine, Seoul National University, College of Medicine, Seoul, Korea
    Clin Transplant 20:496-503. 2006
    ..72). In conclusion, reduced intensity transplantation yielded outcomes comparable with those of myeloablative transplantation in patients under 50 with hematological malignancies...
  18. doi request reprint Different clinical importance of FLT3 internal tandem duplications in AML according to FAB classification: possible existence of distinct leukemogenesis involving monocyte differentiation pathway
    Youngil Koh
    Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea
    Ann Hematol 88:1089-97. 2009
    ..FLT3-ITD is a predictive and prognostic marker only in monocyte lineage patients. This result suggests an existence of distinct subset of monocyte lineage AML with leukemogenesis involving FLT3 activating pathway...
  19. doi request reprint Impact of vitamin D receptor gene polymorphisms on clinical outcomes of HLA-matched sibling hematopoietic stem cell transplantation
    Hyeon Jin Cho
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Clin Transplant 26:476-83. 2012
    ..This study suggests that the genotype and haplotype of VDR in recipient might be associated with clinical outcome of sibling HLA-matched HSCT...
  20. doi request reprint Hypoplastic myelodysplastic syndrome (h-MDS) is a distinctive clinical entity with poorer prognosis and frequent karyotypic and FISH abnormalities compared to aplastic anemia (AA)
    Youngil Koh
    Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea
    Leuk Res 34:1344-50. 2010
    ..Moreover, h-MDS is frequently accompanied by karyotypic and FISH abnormalities and is prone to leukemic conversion. Trisomy 1q and 20q deletion FISH abnormalities may have important prognostic roles in patients with h-MDS...
  21. doi request reprint Patient HSP70-hom TG haplotype is associated with decreased transplant-related mortality and improved survival after sibling HLA-matched hematopoietic stem cell transplantation
    Inho Kim
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Clin Transplant 24:459-66. 2010
    ..04; and diplotype, p=0.02). Therefore, our results suggest that HSP70-hom polymorphisms play an important role in the prognosis of patients receiving sibling HLA-matched allogeneic HSCT...
  22. doi request reprint Polymorphisms in genes that regulate cyclosporine metabolism affect cyclosporine blood levels and clinical outcomes in patients who receive allogeneic hematopoietic stem cell transplantation
    Youngil Koh
    Department of Internal Medicine, Seoul National University Hospital, Korea
    Biol Blood Marrow Transplant 18:37-43. 2012
    ....
  23. doi request reprint Comparison of various criteria in predicting treatment response and prognosis of patients with myelodysplastic syndrome treated with azacitidine
    Dae Young Kim
    Department of Hematology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea
    Ann Hematol 89:15-23. 2010
    ..Azacitidine showed similar efficacy in all patient groups, even in patients with poor cytogenetics and in high-risk groups...
  24. ncbi request reprint Doxorubicin-based chemotherapy for diffuse large B-cell lymphoma in elderly patients: comparison of treatment outcomes between young and elderly patients and the significance of doxorubicin dosage
    Keun Wook Lee
    Department of Internal Medicine, Seoul National University Hospital, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea
    Cancer 98:2651-6. 2003
    ..In the current study, treatment outcomes for elderly patients (age > or = 60 years) were analyzed, with emphasis on the dose intensity of doxorubicin...
  25. doi request reprint Phase IV study evaluating efficacy of escalated dose of imatinib in chronic myeloid leukemia patients showing suboptimal response to standard dose imatinib
    Youngil Koh
    Department of Internal Medicine, Seoul National University Hospital, 28 Yongon Dong, Jongno gu, Seoul 110 744, Republic of Korea
    Ann Hematol 89:725-31. 2010
    ..In conclusion, escalated dose imatinib shows considerable efficacy with tolerable toxicity in CML patients showing suboptimal response to standard dose imatinib. EMR is an early predictive marker for positive imatinib response...
  26. pmc A pilot study of bortezomib in Korean patients with relapsed or refractory myeloma
    Keun Wook Lee
    Department of Internal Medicine, Seoul National University College of Medicine, Korea
    J Korean Med Sci 20:598-62. 2005
    ..Overall, bortezomib seems to be effective and feasible. Conduction of larger clinical studies on Korean patients is necessary to characterize clinical efficacy and safety of bortezomib more precisely...
  27. ncbi request reprint Clinical course of non-severe aplastic anemia in adults
    Ji Hyun Kwon
    Department of Internal Medicine, Seoul National University Hospital, College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul, 110 744, Republic of Korea
    Int J Hematol 91:770-5. 2010
    ..White blood cell and absolute neutrophil count at diagnosis and treatment responsiveness of thrombocytopenia were associated with disease progression. Careful monitoring and early management are needed for patients at risk...
  28. ncbi request reprint Polymorphisms of the methylenetetrahydrofolate reductase gene and clinical outcomes in HLA-matched sibling allogeneic hematopoietic stem cell transplantation
    Inho Kim
    Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul, South Korea
    Ann Hematol 86:41-8. 2007
    ..Therefore, patients at high risk of developing hepatic toxicity and with a poor likelihood of survival could be selected by genotyping MTHFR C677T before allogeneic stem cell transplantation...
  29. ncbi request reprint Adult patients with t(8;21) acute myeloid leukemia had no superior treatment outcome to those without t(8;21): a single institution's experience
    Keun Wook Lee
    Department of Internal Medicine, Seoul National University Hospital and College of Medicine, 28 Yongon Dong, Chongno Gu, 110 744 Seoul, Republic of Korea
    Ann Hematol 83:218-24. 2004
    ..3 months (P=NS)]. Similar treatment outcome between patients with and without t(8;21) and non-superior treatment outcome of HDAC consolidative chemotherapy in the t(8;21) AML group in our study is contradictory to previous reports...
  30. doi request reprint Allogeneic stem cell transplantation in patients with non-Hodgkin lymphoma who experienced relapse or progression after autologous stem cell transplantation
    Ji Won Kim
    Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehak Ro, Jongro Gu, Seoul, 110 744, South Korea
    Ann Hematol 90:1409-18. 2011
    ..In conclusion, despite high TRM, allo-SCT is a viable option for patients with NHL who underwent progression after HDC with auto-SCT...
  31. pmc Utility of ELISA optical density values and clinical scores for the diagnosis of and thrombosis prediction in heparin-induced thrombocytopenia
    Seon Young Kim
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    Korean J Lab Med 31:1-8. 2011
    ..HIT diagnosis is challenging and depends on clinical presentation and laboratory tests. We investigated the usefulness of clinical scores and heparin/PF4 ELISA optical density (OD) as a diagnostic marker and thrombosis predictor in HIT...
  32. doi request reprint Increased copy number of the interleukin-6 receptor gene is associated with adverse survival in multiple myeloma patients treated with autologous stem cell transplantation
    Seon Young Kim
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, South Korea
    Biol Blood Marrow Transplant 17:810-20. 2011
    ..These findings suggest the potential role of IL-6R in myeloma cell growth and therapeutic implications of the IL-6R blocker in the future...
  33. doi request reprint Clinical dissection of multicentric Castleman disease
    Dong Yeop Shin
    Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea
    Leuk Lymphoma 52:1517-22. 2011
    ..4% vs. 10.8% for 5-year OS). MCD might be dissected clinically by the simple parameters of age and presence of splenomegaly...
  34. ncbi request reprint High-dose therapy and autologous stem cell transplantation in Korean patients with aggressive T/NK-cell lymphoma
    Soo Mee Bang
    Department of Internal Medicine, Gachon Medical School, Incheon, Korea
    Leuk Lymphoma 46:1599-1604. 2005
    ..Only CR status after HDT influenced OS (P=0.000). Therefore, an initial approach with effective induction and HDT may result in a better outcome in T/NK-cell lymphoma...
  35. ncbi request reprint Clinical features of Waldenstrom macroglobulinemia in Korea
    Soo Mee Bang
    Department of Internal Medicine, Gachon Medical School, Incheon, Korea
    Korean J Intern Med 19:137-40. 2004
    ..Waldenstrom macroglobulinemia (WM) is a lymphoproliferative disorder characterized by monoclonal IgM. Its rarity makes it difficult to know the clinical manifestations and outcomes of patients with WM...
  36. doi request reprint Higher prognostic value of soluble fibrin complexes than D-dimer and fibrin degradation product for disseminated intravascular coagulation in patients with liver cirrhosis
    Seon Young Kim
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    Blood Coagul Fibrinolysis 24:150-6. 2013
    ..sFC is a powerful diagnostic and prognostic marker of DIC in patient with liver cirrhosis. The use of sFC is expected to enhance the diagnosis and prognosis of DIC, particularly in patients with liver cirrhosis...
  37. doi request reprint Association of human leukocyte antigen class II alleles with response to immunosuppressive therapy in Korean aplastic anemia patients
    Eun Young Song
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    Hum Immunol 71:88-92. 2010
    ..HLA-DR typing may be useful for predicting a response to IST in AA patients...
  38. doi request reprint Correlation between plasma activity of ADAMTS-13 and coagulopathy, and prognosis in disseminated intravascular coagulation
    Jungwon Hyun
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
    Thromb Res 124:75-9. 2009
    ..We determined whether ADAMTS-13 activity showed a significant correlation with the activation status of the coagulation system and hospital mortality in DIC...
  39. doi request reprint Retrospective multicenter study on the development of peripheral lymphocytosis following second-line dasatinib therapy for chronic myeloid leukemia
    Su Jin Lee
    Division of Hematology Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Irwon Dong 50, Gangnam Gu, Seoul, Korea
    Am J Hematol 86:346-50. 2011
    ..002) or MMR (P = 0.003). Further study is necessary to identify which subset of lymphocytes was expanded and to reveal the exact mechanism by which dasatinib induces lymphocyte expansion...
  40. pmc Korean guidelines for the prevention of venous thromboembolism
    Soo Mee Bang
    Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea
    J Korean Med Sci 25:1553-9. 2010
    ..These guidelines establish low-, moderate-, and high-risk groups, and recommend appropriate thromboprophylaxis for each group...
  41. doi request reprint Therapeutic plasma exchange in patients with thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: the 10-year experience of a single center
    Ji Won Kim
    Department of Internal Medicine, the Ilchun Molecular Research Center, Seoul, Korea
    Hematology 16:73-9. 2011
    ..Therapeutic plasma exchange (TPE) has been used for the treatment of patients with thrombotic thrombocytopenic purpura-hemolytic uremic syndrome (TTP-HUS). We report the 10-year treatment results along with the risk factors analyses...
  42. pmc Clinical features and survival outcomes of patients with diffuse large B-cell lymphoma: analysis of web-based data from the Korean Lymphoma Working Party Registry
    Hyeon Gyu Yi
    Department of Internal Medicine, Inha University Hospital, Inha University College of Medicine, Incheon, Korea Korean Society of Hematology Lymphoma Working Party, Korea
    Blood Res 48:115-20. 2013
    ..This study aimed to survey the clinical spectrum of diffuse large B-cell lymphoma (DLBCL) in terms of epidemiology, pathologic subtypes, stage, and prognostic index as well as treatment outcomes...
  43. ncbi request reprint Influence of coagulation and anticoagulant factors on global coagulation assays in healthy adults
    Seon Young Kim
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    Am J Clin Pathol 139:370-9. 2013
    ..The synchronized plasma levels of vitamin K-dependent proteins with opposite functionalities may compensate a propensity to hyper- or hypocoagulability in a normal population...
  44. pmc Cost analysis of iron-related complications in a single institute
    Ki Hwan Kim
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Korean J Intern Med 24:33-6. 2009
    ..The financial burden of caring for iron-related complications (IRCs) is an emerging medical problem in Korea, as in Western countries. We produced a preliminary estimate of the costs of treating patients for IRCs...
  45. ncbi request reprint Non-A type nucleophosmin 1 gene mutation predicts poor clinical outcome in de novo adult acute myeloid leukemia: differential clinical importance of NPM1 mutation according to subtype
    Youngil Koh
    Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea
    Int J Hematol 90:1-5. 2009
    ..001). The type of mutation of NPM1 is important for prognosis in de novo AML lacking FLT3-ITD. Non-A type NPM1 mutation is a poor prognostic factor...
  46. ncbi request reprint Allogeneic stem cell transplantation in patients with de novo diffuse large B-cell lymphoma who experienced relapse or progression after autologous stem cell transplantation: a Korea-Japan collaborative study
    Ji Won Kim
    Department of Internal Medicine, Seoul National University Hospital, 101 Daehak Ro, Jongno gu, Seoul, 110 744, South Korea
    Ann Hematol 93:1345-51. 2014
    ..Our data suggest that allo-SCT could be a viable treatment option if patients have fewer lines of prior chemotherapy, chemo-sensitive disease, and/or good PS. ..
  47. ncbi request reprint Extramedullary relapse confirmed by fluorescence in situ hybridization study of an ear mass in acute promyelocytic leukemia
    Keun Wook Lee
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Int J Hematol 79:462-4. 2004
    ..FISH performed on the ear mass revealed t(15;17). To our knowledge, this case is the first reported case of extramedullary relapse of APL confirmed by FISH study of a biopsy specimen of extramedullary tissue...
  48. pmc A prospective multicenter observational study of decitabine treatment in Korean patients with myelodysplastic syndrome
    Je Hwan Lee
    Department of Hematology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    Haematologica 96:1441-7. 2011
    ..Decitabine was evaluated for its efficacy and safety in Korean patients with myelodysplastic syndrome with IPSS score of 0.5 or over...
  49. ncbi request reprint [Usefulness of silica clotting time for detection of lupus anticoagulants]
    Hye Ryun Lee
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    Korean J Lab Med 29:497-504. 2009
    ..Also, we analyzed differences in the thrombotic features and the characteristics of antiphospholipid antibodies between dRVVT and SCT...
  50. pmc Allogeneic hematopoietic cell transplantation for acute leukemia in first relapse or second remission
    Je Hwan Lee
    Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    Korean J Hematol 45:95-101. 2010
    ..The role of pre-transplant salvage chemotherapy has been controversial in relapsed acute leukemia...
  51. ncbi request reprint Poor prognosis of hypocoagulability assessed by thrombin generation assay in disseminated intravascular coagulation
    Kyunghoon Lee
    aDepartment of Laboratory Medicine bCancer Research Institute cDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea Kyunghoon Lee and Ji Eun Kim contributed equally to this work
    Blood Coagul Fibrinolysis 25:241-7. 2014
    ..ETP and peak thrombin well reflect DIC severity. Hypocoagulability manifesting as prolonged lag time and time to peak is expected to be an independent prognostic marker in DIC. ..
  52. pmc High dose therapy followed by autologous peripheral blood stem cell transplantation as a first line treatment for multiple myeloma: a Korean Multicenter Study
    Soo Mee Bang
    Department of Internal Medicine, Gachon Medical School, University of Ulsan Medical School, Incheon, Korea
    J Korean Med Sci 18:673-8. 2003
    ..This study verifies the efficacy and feasibility of high dose melphalan therapy with autologous stem cell transplantation in newly diagnosed multiple myeloma...
  53. pmc Identification of two novel NPM1 mutations in patients with acute myeloid leukemia
    Yongbum Jeon
    Department of Laboratory Medicine, Seoul National University Hospital, Seoul, Korea
    Ann Lab Med 33:60-4. 2013
    ..Genetic abnormalities in adult AML are caused most frequently by somatic mutations in exon 12 of the NPM1 gene, which is observed in approximately 35% of AML patients and up to 60% of patients with cytogenetically normal AML (CN-AML)...
  54. ncbi request reprint Plasma level of stromal derived factor-1 (SDF-1) is increased in disseminated intravascular coagulation patients who have poor outcomes: in vitro effect of SDF-1 on coagulopathy
    Hyun Kyung Kim
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
    Thromb Res 120:559-66. 2007
    ..These findings suggest that plasma SDF-1 might be closely associated with hypercoagulability though its action as a platelet activator...
  55. doi request reprint Clinical predictors of recurrent venous thromboembolism: a single institute experience in Korea
    Tae Min Kim
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Thromb Res 123:436-43. 2009
    ..Moreover, predictors for recurrent VTE were not identified in Asians. Thus, this study was undertaken to investigate risk factors for recurrent VTE events in Korean people...
  56. doi request reprint Prognostic values of the factor Xa-activated clotting time and endogenous thrombin potential in patients suspected of having disseminated intravascular coagulation
    Ji Weon Seo
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    Thromb Res 123:565-72. 2009
    ....
  57. ncbi request reprint Multicentric Castleman's disease complicated by tumor lysis syndrome
    Ki Deok Lee
    Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, 110 744, Seoul, South Korea
    Ann Hematol 83:722-5. 2004
    ..This suggests that the possibility of tumor lysis syndrome should be considered when treating Castleman's disease with a large disease burden...
  58. doi request reprint Cytotoxic effects of novel phytosphingosine derivatives, including N,N-dimethylphytosphingosine and N-monomethylphytosphingosine, in human leukemia cell line HL60
    Sook Ryun Park
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
    Leuk Lymphoma 51:132-45. 2010
    ..Furthermore, DMPH displayed synergistic cytotoxicity with daunorubicin in a sequence-dependent manner. Our findings indicate that DMPH has potential as an effective cytotoxic agent for leukemia...
  59. ncbi request reprint Case of complete recovery of pancytopenia after treatment of hypopituitarism
    Dae Young Kim
    Department of Internal Medicine, Seoul National University College of Medicine, Yongon Dong, Jongro Gu, 110 744, Seoul, Korea
    Ann Hematol 83:309-12. 2004
    ....
  60. ncbi request reprint Utility of the fibrinogen/C-reactive protein ratio for the diagnosis of disseminated intravascular coagulation
    Hyun Kyung Kim
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    Acta Haematol 117:34-9. 2007
    ..The results of our study suggest that replacement of fibrinogen by the fibrinogen/CRP ratio for calculating the DIC score may lead to enhance diagnostic and prognostic power for DIC...
  61. doi request reprint Prognostic implications of the immunophenotype in biphenotypic acute leukemia
    Je Hwan Lee
    Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    Leuk Lymphoma 49:700-9. 2008
    ..6% vs. 88.0%, P = 0.039) and lower overall survival (0% vs. 33.9% at 5 years, P = 0.028) than those with M + B phenotype. Our results suggest that immunophenotype has prognostic implications in adult patients with BAL...
  62. pmc Hematopoietic stem cell transplantation after posttransplant lymphoproliferative disorder
    Min Joo Kim
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    J Korean Med Sci 25:781-4. 2010
    ..Fourteen months after liver transplantation, she received a second HSCT due to engraftment failure, and PTLD resolved completely. The second HSCT can serve as cellular therapy for PTLD...
  63. pmc Acute lymphoblastic leukemia in elderly patients: a single institution's experience
    Dong Yeop Shin
    Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea
    Korean J Intern Med 26:328-39. 2011
    ..We investigated the clinical characteristics and prognosis of elderly patients with acute lymphoblastic leukemia (ALL)...
  64. doi request reprint Seasonal variation in the occurrence of venous thromboembolism: a report from the Korean Venous Thromboembolism Working Party
    Moon Ju Jang
    Department of Internal Medicine, School of Medicine, CHA University, Korea
    Thromb Res 130:e199-202. 2012
    ..The monthly occurrence rate peaked in December and was at its lowest in July (P=0.004). In conclusion, our study provides evidence that there is an increased risk for VTE in Korean population in the winter season...
  65. doi request reprint Polymorphisms of platelet ADP receptor P2RY12 in the risk of venous thromboembolism in the Korean population
    Moon Ju Jang
    Department of Internal Medicine, School of Medicine, CHA University, Seongnam, Korea
    Clin Appl Thromb Hemost 18:416-20. 2012
    ..2%, 30.1%, and 1.7%, respectively. T744C P2RY12 polymorphism did not significantly affect the risk of VTE. Our study shows that T744C P2RY12 polymorphism did not significantly affect the risk of VTE in the Korean population...
  66. doi request reprint A meta-analysis of the effects of interleukin-6 -174 G>C genetic polymorphism on acute graft-versus-host disease susceptibility
    Boyoon Choi
    College of Pharmacy, Seoul National University, Seoul, Korea
    Clin Ther 34:295-304. 2012
    ..However, previous studies have yielded inconclusive results as to its role in patient susceptibility to aGVHD, and no study to date has systematically analyzed this polymorphism...
  67. pmc Hematological manifestations of human immunodeficiency virus infection and the effect of highly active anti-retroviral therapy on cytopenia
    Se Youn Choi
    Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea
    Korean J Hematol 46:253-7. 2011
    ..The aim of this study is to investigate the hematological manifestations of human immunodeficiency virus (HIV) infection, the risk factors for cytopenia, and the effect of highly active anti-retroviral therapy (HAART) on cytopenia...
  68. pmc Central pontine myelinolysis in a patient with acute lymphoblastic leukemia after hematopoietic stem cell transplantation: a case report
    Kyu Hyoung Lim
    Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, 28 Yeongeon dong, Jongno gu, Seoul, Korea
    J Korean Med Sci 23:324-7. 2008
    ..We report a rare case in which hepatic dysfunction due to graft-versus-host disease has a strong association with CPM after HSCT...
  69. ncbi request reprint Production and characterization of monoclonal antibodies to mesenchymal stem cells derived from human bone marrow
    Hyun Jung Yoo
    Department of Internal Medicine, National Research Lab for Rheumatic Diseases, Clinical Research Institute, Medical Research Center, Seoul National University College of Medicine, Seoul, Korea
    Hybridoma (Larchmt) 24:92-7. 2005
    ..YS08 and YS14 showed specific bands in Western blotting. In conclusion, we developed three monoclonal antibodies, YS08, YS14, and YS18, that recognize human MSC cell surface antigen...