Kyong Soo Park

Summary

Affiliation: Seoul National University
Country: Korea

Publications

  1. pmc Endothelial progenitor cell cotransplantation enhances islet engraftment by rapid revascularization
    Shinae Kang
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea
    Diabetes 61:866-76. 2012
  2. ncbi request reprint Prevention of type 2 diabetes mellitus from the viewpoint of genetics
    Kyong Soo Park
    Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 744, Republic of Korea
    Diabetes Res Clin Pract 66:S33-5. 2004
  3. doi request reprint Effect of ginsam, a vinegar extract from Panax ginseng, on body weight and glucose homeostasis in an obese insulin-resistant rat model
    Soo Lim
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam 463 707, South Korea
    Metabolism 58:8-15. 2009
  4. doi request reprint Enhanced mitochondrial biogenesis contributes to Wnt induced osteoblastic differentiation of C3H10T1/2 cells
    Jee Hyun An
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Bone 47:140-50. 2010
  5. doi request reprint Optimal cut points of waist circumference (WC) and visceral fat area (VFA) predicting for metabolic syndrome (MetS) in elderly population in the Korean Longitudinal Study on Health and Aging (KLoSHA)
    Soo Lim
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea
    Arch Gerontol Geriatr 54:e29-34. 2012
  6. ncbi request reprint Genetic polymorphisms in the transforming growth factor beta-induced gene associated with BMI
    Kyong Soo Park
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Hum Mutat 25:322. 2005
  7. doi request reprint Osteoblast-targeted overexpression of PPARγ inhibited bone mass gain in male mice and accelerated ovariectomy-induced bone loss in female mice
    Sun Wook Cho
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    J Bone Miner Res 26:1939-52. 2011
  8. doi request reprint ATP measurement predicts porcine islet transplantation outcome in nude mice
    Jae Hyeon Kim
    Division of Endocrinology of Metabolism, Department of Internal Medicine, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    Transplantation 87:166-9. 2009
  9. ncbi request reprint The effects of rosiglitazone and metformin on the plasma concentrations of resistin in patients with type 2 diabetes mellitus
    Hye Seung Jung
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul 110 744, Korea
    Metabolism 54:314-20. 2005
  10. ncbi request reprint Genetic polymorphisms in peroxisome proliferator-activated receptor delta associated with obesity
    Hyoung Doo Shin
    Department of Genetic Epidemiology, SNP Genetics, Seoul, Korea
    Diabetes 53:847-51. 2004

Detail Information

Publications130 found, 100 shown here

  1. pmc Endothelial progenitor cell cotransplantation enhances islet engraftment by rapid revascularization
    Shinae Kang
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea
    Diabetes 61:866-76. 2012
    ..These findings might provide a directly applicable tool to enhance the efficacy of islet transplantation in clinical practice...
  2. ncbi request reprint Prevention of type 2 diabetes mellitus from the viewpoint of genetics
    Kyong Soo Park
    Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 744, Republic of Korea
    Diabetes Res Clin Pract 66:S33-5. 2004
    ..Moreover, we can identify people who can get more benefit from prevention and also can provide better and personalized preventive measure based on genetic information...
  3. doi request reprint Effect of ginsam, a vinegar extract from Panax ginseng, on body weight and glucose homeostasis in an obese insulin-resistant rat model
    Soo Lim
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam 463 707, South Korea
    Metabolism 58:8-15. 2009
    ..Our data suggest that ginsam has distinct beneficial effects on glucose metabolism and body weight control in an obese animal model of insulin resistance by changing the expression of genes involved in glucose and fatty acid metabolism...
  4. doi request reprint Enhanced mitochondrial biogenesis contributes to Wnt induced osteoblastic differentiation of C3H10T1/2 cells
    Jee Hyun An
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Bone 47:140-50. 2010
    ..To summarize, mitochodrial biogenesis is upregulated by Wnt signaling and this upregulation contributes to the osteoblastic differentiation of mouse mesenchymal C3H10T1/2 cells...
  5. doi request reprint Optimal cut points of waist circumference (WC) and visceral fat area (VFA) predicting for metabolic syndrome (MetS) in elderly population in the Korean Longitudinal Study on Health and Aging (KLoSHA)
    Soo Lim
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea
    Arch Gerontol Geriatr 54:e29-34. 2012
    ..Compared with the cut points in middle-aged Koreans, the cut points for elderly were lower in men and similar in women...
  6. ncbi request reprint Genetic polymorphisms in the transforming growth factor beta-induced gene associated with BMI
    Kyong Soo Park
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Hum Mutat 25:322. 2005
    ..005) were observed. The present study provides, for the first time, information about genetic polymorphisms in TGFBI and positive associations of those polymorphisms with levels of insulin and BMI in the Korean population...
  7. doi request reprint Osteoblast-targeted overexpression of PPARγ inhibited bone mass gain in male mice and accelerated ovariectomy-induced bone loss in female mice
    Sun Wook Cho
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    J Bone Miner Res 26:1939-52. 2011
    ..In conclusion, in vivo osteoblast-specific overexpression of PPARγ negatively regulates bone mass in male mice and accelerates estrogen-deficiency-related bone loss in female mice...
  8. doi request reprint ATP measurement predicts porcine islet transplantation outcome in nude mice
    Jae Hyeon Kim
    Division of Endocrinology of Metabolism, Department of Internal Medicine, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    Transplantation 87:166-9. 2009
    ..3% and 73.3%, respectively. In conclusion, a simple and a rapid measurement of intraislet ATP content could be a promising substitute for current nude mice islet transplantation studies...
  9. ncbi request reprint The effects of rosiglitazone and metformin on the plasma concentrations of resistin in patients with type 2 diabetes mellitus
    Hye Seung Jung
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul 110 744, Korea
    Metabolism 54:314-20. 2005
    ..Considering the potential role of resistin in insulin resistance, decrease in resistin levels may contribute to improving insulin action with rosiglitazone treatment...
  10. ncbi request reprint Genetic polymorphisms in peroxisome proliferator-activated receptor delta associated with obesity
    Hyoung Doo Shin
    Department of Genetic Epidemiology, SNP Genetics, Seoul, Korea
    Diabetes 53:847-51. 2004
    ..The genetic information about PPAR-delta from this study would be useful for further genetic study of obesity, diabetes, and other metabolic diseases...
  11. doi request reprint Pericardial fat amount is an independent risk factor of coronary artery stenosis assessed by multidetector-row computed tomography: the Korean Atherosclerosis Study 2
    Tae Hyuk Kim
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Obesity (Silver Spring) 19:1028-34. 2011
    ..007; 95% CI 1.001-1.014; P = 0.042). In conclusion, an increased pericardial fat volume was an independent risk factor for stenotic CAD and could be helpful in assessing subclinical CADs...
  12. doi request reprint High plasma retinol binding protein-4 and low plasma adiponectin concentrations are associated with severity of glucose intolerance in women with previous gestational diabetes mellitus
    Sung Hee Choi
    Division of Endocrinology and Medicine, Department of Internal Medicine, Seoul National University Bundang Hospital, Bundang Ku, Sungnam City, Gyeonggi do 463 707, South Korea
    J Clin Endocrinol Metab 93:3142-8. 2008
    ..Women with previous gestational diabetes mellitus (pGDM) are at high risk of developing type 2 diabetes mellitus in the future. The role of adipokines in women with pGDM has not been established...
  13. ncbi request reprint Polymorphisms in the leptin receptor (LEPR)--putative association with obesity and T2DM
    Kyong Soo Park
    Genome Research Center for Diabetes and Endocrine Disease, Clinical Research Institute, Seoul National University Hospital, Department of Internal Medicine, Seoul National University College of Medicine, 110 744 Seoul, Korea
    J Hum Genet 51:85-91. 2006
    ..02) and gene dose-dependent genetic effects were observed. The present study provides information about additional genetic polymorphisms in LEPR and positive associations of those polymorphisms with BMI in the Korean population...
  14. ncbi request reprint Relationship between serum adiponectin and leptin concentrations and body fat distribution
    Keun Gyu Park
    Department of Internal Medicine, Keimyung University School of Medicine, Dongsan Medical Center, 194 Dongsan dong, Jung Gu, Daegu 00 712, South Korea
    Diabetes Res Clin Pract 63:135-42. 2004
    ..498, P<0.0001) In conclusion, adiponectin and leptin concentrations, although associated with metabolic parameters, were more strongly influenced by VAT in the case of adiponectin, and by SAT in the case of leptin...
  15. doi request reprint Effect of a peroxisome proliferator-activated receptor gamma sumoylation mutant on neointimal formation after balloon injury in rats
    Soo Lim
    Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, 110 744 Seoul, South Korea
    Atherosclerosis 206:411-7. 2009
    ..These results indicate that desumoylation at K107 in PPARgamma might play an important role against atherosclerosis...
  16. pmc Effect of a dipeptidyl peptidase-IV inhibitor, des-fluoro-sitagliptin, on neointimal formation after balloon injury in rats
    Soo Lim
    Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea
    PLoS ONE 7:e35007. 2012
    ..We investigated the effect of a DPP-IV inhibitor, des-fluoro-sitagliptin, in reducing occurrence of restenosis in carotid artery in response to balloon injury and the related mechanisms...
  17. doi request reprint Factors predicting therapeutic efficacy of combination treatment with sitagliptin and metformin in type 2 diabetic patients: the COSMETIC study
    Soo Lim
    Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea
    Clin Endocrinol (Oxf) 77:215-23. 2012
    ....
  18. pmc Sarcopenic obesity: prevalence and association with metabolic syndrome in the Korean Longitudinal Study on Health and Aging (KLoSHA)
    Soo Lim
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Diabetes Care 33:1652-4. 2010
    ..We investigated the prevalence of sarcopenic obesity (SO) and its relationship with metabolic syndrome in a community-based elderly cohort in Korea...
  19. doi request reprint Polymorphisms of ADIPOR1 and ADIPOR2 are associated with phenotypes of type 2 diabetes in Koreans
    Jin Taek Kim
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Clin Endocrinol (Oxf) 70:66-74. 2009
    ..We investigated whether common polymorphisms of ADIPOR1 and ADIPOR2 are associated with type 2 diabetes or its related phenotypes in Koreans...
  20. pmc Gender differences in diagnostic values of visceral fat area and waist circumference for predicting metabolic syndrome in Koreans
    Hong Il Kim
    Divisions of Endocrinology and Metabolism, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    J Korean Med Sci 26:906-13. 2011
    ..Further studies are necessary to develop a simple clinical parameter that reflects visceral fat in premenopausal women...
  21. doi request reprint Mechanism for antioxidative effects of thiazolidinediones in pancreatic β-cells
    Sung Soo Chung
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea
    Am J Physiol Endocrinol Metab 301:E912-21. 2011
    ..In addition, the expression of catalase is increased by TZDs, and catalase, at least in part, mediates the antioxidant effect of TZDs in pancreatic β-cells...
  22. pmc Control of adipogenesis by the SUMO-specific protease SENP2
    Sung Soo Chung
    Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and Department of Internal Medicine, College of Medicine, Seoul National University, 28 Yongon Dong, Chongno Gu, Seoul 110 744, South Korea
    Mol Cell Biol 30:2135-46. 2010
    ..These results establish a critical role for SENP2 in the regulation of adipogenesis by desumoylation and stabilization of C/EBPbeta and in turn by promoting the expression of its downstream effectors, such as PPARgamma and C/EBPalpha...
  23. pmc Chronic exposure to the herbicide, atrazine, causes mitochondrial dysfunction and insulin resistance
    Soo Lim
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    PLoS ONE 4:e5186. 2009
    ..These results suggest that long-term exposure to the herbicide ATZ might contribute to the development of insulin resistance and obesity, particularly where a high-fat diet is prevalent...
  24. doi request reprint Effect of metabolic syndrome on coronary artery stenosis and plaque characteristics as assessed with 64-detector row cardiac CT
    Soo Lim
    Department of Internal Medicine, Seoul National University College of Medicine and Seoul National University Bundang Hospital, 300 Gumi dong, Seongnam City, Gyeonggi do 463 707, South Korea
    Radiology 261:437-45. 2011
    ....
  25. pmc Association of vitamin D deficiency with incidence of type 2 diabetes in high-risk Asian subjects
    Soo Lim
    Seoul National University College of Medicine, Seongnam, Korea
    Am J Clin Nutr 97:524-30. 2013
    ..However, prospective studies investigating the relation between vitamin D inadequacy and incidence of T2D incorporating obesity and dynamic measures of insulin resistance (IR) and pancreatic β cell function are limited...
  26. pmc EGb761, a Ginkgo biloba extract, is effective against atherosclerosis in vitro, and in a rat model of type 2 diabetes
    Soo Lim
    Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea
    PLoS ONE 6:e20301. 2011
    ..We investigated the effect of EGb761 and its major subcomponents (bilobalide, kaemferol, and quercetin) on preventing atherosclerosis in vitro, and in a rat model of type 2 diabetes...
  27. doi request reprint Associations between polymorphisms in the mitochondrial uncoupling proteins (UCPs) with T2DM
    Hye Ja Lee
    Division of Metabolic Disease, Center for Biomedical Sciences, National Institute of Health, 5 Nokbun dong, Eunpyung Gu, Seoul, 122 701, Republic of Korea
    Clin Chim Acta 398:27-33. 2008
    ..We examined the effect of 23 single nucleotide polymorphisms (SNPs) in the UCP genes on type 2 diabetes mellitus (T2DM) and related phenotypes to identify genetic factors that may be involved in susceptibility to T2DM...
  28. doi request reprint Mitochondrial dysfunction and metabolic syndrome-looking for environmental factors
    Hong Kyu Lee
    Department of Internal Medicine, School of Medicine, Seoul National University, Yongon Dong, Chongno Gu, Seoul 110 744, Republic of Korea
    Biochim Biophys Acta 1800:282-9. 2010
    ..However, further studies are warranted to find more effective therapeutic strategies to treat mitochondrial dysfunction. By doing so, we can also shed light on the path of research for other diseases related to mitochondrial dysfunction...
  29. doi request reprint Lipid profiles and bone mineral density in pre- and postmenopausal women in Korea
    In Kyong Jeong
    Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul, 110 744, Republic of Korea
    Calcif Tissue Int 87:507-12. 2010
    ..We conclude that although there were some weak associations between lipid profiles and BMD, the results of this study hardly support the hypothesis that an atherogenic lipid profile is associated with osteoporosis...
  30. pmc Subsequent pregnancy after gestational diabetes mellitus: frequency and risk factors for recurrence in Korean women
    Soo Heon Kwak
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Diabetes Care 31:1867-71. 2008
    ..The purpose of this study was to determine the frequency of recurrent gestational diabetes mellitus (GDM) and to find risk factors that can predict the recurrence of GDM in Korean women with previous GDM...
  31. doi request reprint Polymorphisms in KCNQ1 are associated with gestational diabetes in a Korean population
    Soo Heon Kwak
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Horm Res Paediatr 74:333-8. 2010
    ..The aim of this study was to investigate whether variants in KCNQ1 are associated with development of gestational diabetes mellitus (GDM) and measures of oral glucose tolerance test (OGTT) at the time of diagnosis of GDM...
  32. pmc Subclinical hypothyroidism has little influences on muscle mass or strength in elderly people
    Min Kyong Moon
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    J Korean Med Sci 25:1176-81. 2010
    ..In conclusion, subclinical hypothyroidism has little influences on muscle mass, strength or quality, and may not be associated with sarcopenia...
  33. pmc Glutathione peroxidase 3 mediates the antioxidant effect of peroxisome proliferator-activated receptor gamma in human skeletal muscle cells
    Sung Soo Chung
    Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 744, South Korea
    Mol Cell Biol 29:20-30. 2009
    ..Collectively, these results suggest that the antioxidant effect of PPARgamma is exclusively mediated by GPx3 and further imply that GPx3 may be a therapeutic target for insulin resistance and diabetes mellitus...
  34. doi request reprint Endothelial colony-forming cell coating of pig islets prevents xenogeneic instant blood-mediated inflammatory reaction
    Jae Hyeon Kim
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    Cell Transplant 20:1805-15. 2011
    ..In conclusion, the coating of pig islets with ECFCs completely prevented all components of xenogeneic IBMIR. ECFCs may be a better source of protection against xenogeneic IBMIR than are mature ECs...
  35. pmc S-Adenosyl-L-methionine ameliorates TNFalpha-induced insulin resistance in 3T3-L1 adipocytes
    Min Kyong Moon
    Department of Internal Medicine, Eulji University School of Medicine, Seoul 139 872, Korea
    Exp Mol Med 42:345-52. 2010
    ..These results suggest that SAM can alleviate TNFalpha mediated-insulin resistance by inhibiting the IKK-beta/NF-kappaB pathway and thus can have a beneficial role in the treatment of type 2 diabetes mellitus...
  36. doi request reprint Association between body composition and pulmonary function in elderly people: the Korean Longitudinal Study on Health and Aging
    Soo Lim
    Department of Internal Medicine, Seoul National University College of Medicine and Seoul National University Bundang Hospital, Seongnam, Korea
    Obesity (Silver Spring) 19:631-8. 2011
    ..Augmentation of muscle in the trunk and low extremity in men, and reduction of fat in the trunk and upper body in men and women may be helpful in maintaining lung function in the elderly population...
  37. pmc Android fat depot is more closely associated with metabolic syndrome than abdominal visceral fat in elderly people
    Seon Mee Kang
    Department of Internal Medicine, Seoul National University College of Medicine and Seoul National University Bundang Hospital, Seongnam, Korea
    PLoS ONE 6:e27694. 2011
    ..The incremental utility of measuring regional fat deposition in association with metabolic syndrome (MS) has not been well described particularly in an elderly population...
  38. doi request reprint Vitamin D inadequacy is associated with significant coronary artery stenosis in a community-based elderly cohort: the Korean Longitudinal Study on Health and Aging
    Soo Lim
    Department of Internal Medicine, Seoul National University College of Medicine and Seoul National University Bundang Hospital, 300 Gumi dong, Bundang gu, Seongnam 463 707, Korea
    J Clin Endocrinol Metab 97:169-78. 2012
    ..Recent studies suggest an association between vitamin D activity and cardiometabolic risk...
  39. doi request reprint Tauroursodeoxycholate (TUDCA), chemical chaperone, enhances function of islets by reducing ER stress
    Yeon Yi Lee
    Department of Biomedical Science, Seoul National University College of Medicine, Seoul, Republic of Korea
    Biochem Biophys Res Commun 397:735-9. 2010
    ..42+/-0.15 vs. 1.92+/-0.12, n=12, p<0.05). Taken together, we suggest that TUDCA could be a useful agent for islet protection in islet isolation for transplantation...
  40. doi request reprint Retinol binding protein-4 elevation is associated with serum thyroid-stimulating hormone level independently of obesity in elderly subjects with normal glucose tolerance
    Sung Hee Choi
    Department of Internal Medicine, Bundang Hospital, Seoul National University College of Medicine, 300 Gumi dong, Bundang Ku, Seongnam si, Gyeonggi Do, South Korea
    J Clin Endocrinol Metab 93:2313-8. 2008
    ..Subclinical hypothyroidism (SCH) has also been associated with CVD; however, the factors linking SCH to CVD are not clear...
  41. doi request reprint Clinical and genetic risk factors for type 2 diabetes at early or late post partum after gestational diabetes mellitus
    Soo Heon Kwak
    Department of Internal Medicine, Seoul National University Hospital, Seoul, 110 744, Korea
    J Clin Endocrinol Metab 98:E744-52. 2013
    ..Women with a history of gestational diabetes mellitus (GDM) are at increased risk of type 2 diabetes (T2DM). However, the time to progression to diabetes differs individually...
  42. pmc Effect of the combination of metformin and fenofibrate on glucose homeostasis in diabetic Goto-Kakizaki rats
    Tae Jung Oh
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Exp Mol Med 45:e30. 2013
    ..In conclusion, fenofibrate did not confer any beneficial effect on glucose homeostasis but reduced metformin's glucose-lowering activity in GK rats, thus discouraging the addition of fenofibrate to metformin to improve glycemic control. ..
  43. doi request reprint Subclinical atherosclerosis in a community-based elderly cohort: the Korean Longitudinal Study on Health and Aging
    Soo Lim
    Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea
    Int J Cardiol 155:126-33. 2012
    ..We evaluated subclinical atherosclerosis using various methods in a population-based cohort study, the Korean Longitudinal Study on Health and Aging (KLoSHA)...
  44. ncbi request reprint Changes in ghrelin and ghrelin receptor expression according to feeding status
    Min Seon Kim
    Department of Internal Medicine, University of Ulsan College of Medicine, Seoul, Korea
    Neuroreport 14:1317-20. 2003
    ..Such as enhanced ghrelin receptor expression could contribute to the amplification of ghrelin action in a negative-energy balance state...
  45. ncbi request reprint Polymorphisms in the ghrelin gene are associated with serum high-density lipoprotein cholesterol level and not with type 2 diabetes mellitus in Koreans
    Hyung Jin Choi
    Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 744, Korea
    J Clin Endocrinol Metab 91:4657-63. 2006
    ..Ghrelin is known to play a role in glucose metabolism and in beta-cell function. There are controversies regarding the role of ghrelin polymorphisms in diabetes and diabetes-related phenotypes...
  46. doi request reprint Thigh muscle attenuation measured by computed tomography was associated with the risk of low bone density in community-dwelling elderly population
    Jung Hee Kim
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Clin Endocrinol (Oxf) 78:512-7. 2013
    ..We investigated the effects of muscle strength and muscle fat infiltration, as a measure of muscle quality, adjusted for muscle mass on femoral neck BMD in Korean elderly cohort...
  47. doi request reprint F-box only protein 9 is required for adipocyte differentiation
    Kyeong Won Lee
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
    Biochem Biophys Res Commun 435:239-43. 2013
    ..These results suggest that FBXO9 is required for adipocyte differentiation, and C/EBPβ plays a role in the effect of FBXO9 on adipogenesis...
  48. ncbi request reprint Plasma retinol-binding protein-4 concentrations are elevated in human subjects with impaired glucose tolerance and type 2 diabetes
    Young Min Cho
    Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul, 110 744, Korea
    Diabetes Care 29:2457-61. 2006
    ..Here, we examined the relation between plasma RBP4 concentrations and various metabolic parameters in humans...
  49. ncbi request reprint Ghrelin stimulates proliferation and differentiation and inhibits apoptosis in osteoblastic MC3T3-E1 cells
    Sang Wan Kim
    Department of Internal Medicine, Seoul National University College of Medicine, 28 Yungun Dong, Chongno Gu, Seoul 110 744, South Korea
    Bone 37:359-69. 2005
    ..These results suggest that ghrelin promotes proliferation and differentiation and inhibits apoptosis of osteoblasts...
  50. doi request reprint The effects of chronic exercise on the inflammatory cytokines interleukin-6 and tumor necrosis factor-α are different with age
    Min Kyong Moon
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Appl Physiol Nutr Metab 37:631-6. 2012
    ....
  51. doi request reprint Analysis of hemodialysis-associated hypoglycemia in patients with type 2 diabetes using a continuous glucose monitoring system
    Hye Seung Jung
    Division of Endocrinology and Metabolism, Seoul National University College of Medicine, Seoul, Republic of Korea
    Diabetes Technol Ther 12:801-7. 2010
    ..The object of this study was to describe glucose profiles and hypoglycemia associated with HD in diabetes patients using a CGM system...
  52. doi request reprint Persistent organic pollutants, mitochondrial dysfunction, and metabolic syndrome
    Soo Lim
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Ann N Y Acad Sci 1201:166-76. 2010
    ..We propose that the mitochondrial paradigm for the etiology of metabolic syndrome will facilitate the prevention and treatment of this major health problem...
  53. pmc Herpesvirus-associated ubiquitin-specific protease (HAUSP) modulates peroxisome proliferator-activated receptor γ (PPARγ) stability through its deubiquitinating activity
    Kyeong Won Lee
    From the Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongnogu, Seoul 110 744
    J Biol Chem 288:32886-96. 2013
    ..Our results demonstrate that the stability and activity of PPARγ are modulated by the deubiquitinating activity of HAUSP, which may be a target for the development of anti-diabetic drugs. ..
  54. pmc Differential proteome profiling using iTRAQ in microalbuminuric and normoalbuminuric type 2 diabetic patients
    Jonghwa Jin
    Department of Biomedical Sciences, Seoul National University College of Medicine, 28 Yongon Dong, Seoul 110 799, Republic of Korea
    Exp Diabetes Res 2012:168602. 2012
    ....
  55. doi request reprint SUMO modification selectively regulates transcriptional activity of peroxisome-proliferator-activated receptor γ in C2C12 myotubes
    Sung Soo Chung
    Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 744, Korea
    Biochem J 433:155-61. 2011
    ..In conclusion, these results indicate that SENP2 de-SUMOylates PPARγ in myotubes, and de-SUMOylation of PPARγ selectively increases the expression of some PPARγ target genes...
  56. pmc Bisphenol A impairs mitochondrial function in the liver at doses below the no observed adverse effect level
    Min Kyong Moon
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    J Korean Med Sci 27:644-52. 2012
    ..In conclusion, doses of BPA below the NOAEL induce mitochondrial dysfunction in the liver, and this is associated with an increase in oxidative stress and inflammation...
  57. doi request reprint Effect of S-adenosylmethionine on neointimal formation after balloon injury in obese diabetic rats
    Soo Lim
    Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul, Korea 110 744
    Cardiovasc Res 90:383-93. 2011
    ..However, the role of SAM in the development of restenosis has not been explored. Therefore, we investigated the effects of SAM on neointimal formation after balloon injury in obese diabetic rats and cultured cells...
  58. doi request reprint Activation of PPARgamma negatively regulates O-GlcNAcylation of Sp1
    Sung Soo Chung
    Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 744, Republic of Korea
    Biochem Biophys Res Commun 372:713-8. 2008
    ....
  59. pmc MCP-1 and RANTES polymorphisms in Korean diabetic end-stage renal disease
    Kwon Wook Joo
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    J Korean Med Sci 22:611-5. 2007
    ..Prospective studies with clearly-defined, homogenous cohorts are needed to confirm the effect of these genetic polymorphisms on DN...
  60. doi request reprint Taurine supplementation restored the changes in pancreatic islet mitochondria in the fetal protein-malnourished rat
    Yun Yong Lee
    Department of Internal Medicine, Korea Cancer Center Hospital, Seoul, South Korea
    Br J Nutr 106:1198-206. 2011
    ..The lack of taurine may be a key causative factor for these dysfunctional mitochondrial changes...
  61. ncbi request reprint Changes of mitochondrial DNA content in the male offspring of protein-malnourished rats
    Hyeong Kyu Park
    Department of Internal Medicine, Soonchunhyang University College of Medicine, Seoul, Korea
    Ann N Y Acad Sci 1011:205-16. 2004
    ..Our findings imply that protein malnutrition in utero causes changes in mtDNA content, impaired beta-cell development, and insulin secretion, which may contribute to the development of type 2 diabetes in later life...
  62. ncbi request reprint PPARgamma gene transfer sustains apoptosis, inhibits vascular smooth muscle cell proliferation, and reduces neointima formation after balloon injury in rats
    Soo Lim
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, 110 744, Korea
    Arterioscler Thromb Vasc Biol 26:808-13. 2006
    ..There is still debate as to whether antiatherosclerotic effect of PPARgamma ligands is dependant on PPARgamma gene itself or some other pathway...
  63. doi request reprint Effects of aerobic exercise training on C1q tumor necrosis factor α-related protein isoform 5 (myonectin): association with insulin resistance and mitochondrial DNA density in women
    Soo Lim
    Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea
    J Clin Endocrinol Metab 97:E88-93. 2012
    ..We recently found that the C1q TNFα-related protein isoform 5 (C1QTNF5 or myonectin) level was increased in insulin-resistant rodents and mitochondrial DNA (mtDNA)-depleted myocytes...
  64. doi request reprint Derivation of a new equation for estimating creatinine clearance by using fat-free mass and serum creatinine concentration in Korean patients with type 2 diabetes mellitus
    Eun Kyung Lee
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
    Diabetes Res Clin Pract 83:44-9. 2009
    ..We aimed to determine the serum creatinine (Scr) concentrations that indicate renal insufficiency and formulate a new equation to estimate Ccr by a function of FFM in Korean type 2 diabetic patients...
  65. pmc Clinical characteristics of the responders to dipeptidyl peptidase-4 inhibitors in Korean subjects with type 2 diabetes
    Tae Jung Oh
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    J Korean Med Sci 28:881-7. 2013
    ..In conclusion, better response to DPP4i would be expected in Korean patients with type 2 diabetes who have higher baseline HbA1c and creatinine levels with shorter duration of diabetes...
  66. doi request reprint Verification of multimarkers for detection of early stage diabetic retinopathy using multiple reaction monitoring
    Kyunggon Kim
    Department of Biomedical Engineering, Institute of Medical and Biological Engineering, Medical Research Center, Seoul National University College of Medicine, 28 Yongon Dong, Seoul 110 799, Korea
    J Proteome Res 12:1078-89. 2013
    ..0. We concluded that MRM is a fast, robust approach of multimarker panel determination and an assay platform that provides improved specificity compared with single biomarker assay systems...
  67. doi request reprint Effect of seasonal changes on the transition between subclinical hypothyroid and euthyroid status
    Tae Hyuk Kim
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul 110 744, Korea
    J Clin Endocrinol Metab 98:3420-9. 2013
    ..The widespread use of thyroid tests in asymptomatic individuals identifies many patients with transient subclinical hypothyroidism...
  68. pmc Increasing prevalence of metabolic syndrome in Korea: the Korean National Health and Nutrition Examination Survey for 1998-2007
    Soo Lim
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Diabetes Care 34:1323-8. 2011
    ....
  69. doi request reprint Ghrelin inhibits early osteogenic differentiation of C3H10T1/2 cells by suppressing Runx2 expression and enhancing PPARgamma and C/EBPalpha expression
    Sang Wan Kim
    Department of Internal Medicine, Seoul National University, College of Medicine, Seoul, South Korea
    J Cell Biochem 106:626-32. 2009
    ..Moreover, ghrelin inhibited early osteogenic differentiation, as shown by alkaline phosphatase activity and staining, and inhibited osteoblast-specific genes expression by altering Runx2, PPARgamma, and C/EBPalpha protein expression...
  70. doi request reprint Serum FGF21 concentration is associated with hypertriglyceridaemia, hyperinsulinaemia and pericardial fat accumulation, independently of obesity, but not with current coronary artery status
    Yenna Lee
    Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Clin Endocrinol (Oxf) 80:57-64. 2014
    ..We investigated the associations between serum FGF21 concentrations and glucose/lipid metabolism, CAD, and pericardial fat deposition in subjects strictly matched for obesity parameters...
  71. doi request reprint Regulatory effect of common promoter polymorphisms on the expression of the 11beta-hydroxysteroid dehydrogenase type 1 gene
    Yun Hyi Ku
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Horm Res 72:25-32. 2009
    ..In this study, we examined the association between HSD11B1 polymorphisms and type 2 diabetes and metabolic phenotypes in Koreans...
  72. ncbi request reprint S-adenosyl-L-methionine increases skeletal muscle mitochondrial DNA density and whole body insulin sensitivity in OLETF rats
    Cheng Ji Jin
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul 110 744, Korea
    J Nutr 137:339-44. 2007
    ..752, P<0.001). In conclusion, SAM treatment increased mtDNA density in the skeletal muscle, improved whole body insulin sensitivity, and prevented body weight gain in OLETF rats...
  73. ncbi request reprint Visceral fatness and insulin sensitivity in women with a previous history of gestational diabetes mellitus
    Soo Lim
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 300 Gumi dong Bundang gu, Seongnam City, South Korea 463 707
    Diabetes Care 30:348-53. 2007
    ..The purpose of this study was to investigate the insulin sensitivity and visceral fatness in women with previous gestational diabetes mellitus (GDM), who are prone to develop type 2 diabetes...
  74. doi request reprint Serum fibroblast growth factor-21 concentration is associated with residual renal function and insulin resistance in end-stage renal disease patients receiving long-term peritoneal dialysis
    Seung Hyeok Han
    Division of Nephrology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea
    Metabolism 59:1656-62. 2010
    ..These findings suggest that FGF-21 may play a role in insulin resistance in patients with end-stage renal disease...
  75. ncbi request reprint Relationship of 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase gene polymorphisms with metabolic syndrome and type 2 diabetes
    Seong Su Moon
    Department of Internal Medicine, Dongguk University School of Medicine, Gyeongju, South Korea
    Endocr J 58:949-59. 2011
    ..In conclusion, HSD11B1 and H6PD polymorphisms may not be associated with type 2 diabetes and metabolic syndrome. Further investigation of the role of these gene polymorphisms on the pathogenesis of metabolic syndrome is required...
  76. doi request reprint Regulation of Wnt/β-catenin signaling by CCAAT/enhancer binding protein β during adipogenesis
    Sung Soo Chung
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Obesity (Silver Spring) 20:482-7. 2012
    ..These results suggest a dual function of C/EBPβ: stimulating expression of adipogenic genes and inhibiting Wnt signaling...
  77. pmc A genome-wide association study of gestational diabetes mellitus in Korean women
    Soo Heon Kwak
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Diabetes 61:531-41. 2012
    ..In conclusion, we have confirmed that genetic variants in CDKAL1 and near MTNR1B are strongly associated with GDM in Korean women. There seems to be a shared genetic basis between GDM and type 2 diabetes...
  78. pmc Microarray analysis of thyroid stimulating hormone, insulin-like growth factor-1, and insulin-induced gene expression in FRTL-5 thyroid cells
    You Jin Lee
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea
    J Korean Med Sci 22:883-90. 2007
    ....
  79. ncbi request reprint Acylated ghrelin secretion is acutely suppressed by oral glucose load or insulin-induced hypoglycemia independently of basal growth hormone secretion in humans
    Sang Wan Kim
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Horm Res 67:211-9. 2007
    ..However, the effects of endogenous ghrelin on GH secretion and changes in ghrelin levels during dynamic changes in GH levels are not well understood...
  80. ncbi request reprint Susceptible alleles of the CD40 and CTLA-4 genes are not associated with the relapse after antithyroid withdrawal in Graves' disease
    Kyung Won Kim
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Thyroid 17:1229-34. 2007
    ..These findings suggest that the genetic markers associated with the development of GD cannot be used to predict the relapse of GD patients in place of clinical parameters...
  81. pmc Accumulation of autophagosomes contributes to enhanced amyloidogenic APP processing under insulin-resistant conditions
    Sung Min Son
    Department of Biochemistry and Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea
    Autophagy 8:1842-4. 2012
    ..Therefore, we propose that insulin resistance-induced autophagosome accumulation becomes a potential linker between AD and T2DM...
  82. pmc Mesenchymal stem cells transfer mitochondria to the cells with virtually no mitochondrial function but not with pathogenic mtDNA mutations
    Young Min Cho
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea
    PLoS ONE 7:e32778. 2012
    ..Elucidation of the mechanism of mitochondrial transfer will help us create a potential cell therapy-based mitochondrial restoration or mitochondrial gene therapy for human diseases caused by mitochondrial dysfunction...
  83. doi request reprint Insulin-sensitizing effects of exercise on adiponectin and retinol-binding protein-4 concentrations in young and middle-aged women
    Soo Lim
    Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 28 Yongon dong Chongno gu, Seoul, Korea
    J Clin Endocrinol Metab 93:2263-8. 2008
    ..Exercise training enhances insulin sensitivity. Changes in retinol-binding protein-4 (RBP4) and adiponectin levels are linked to insulin resistance...
  84. doi request reprint Lower bone mineral density is associated with higher coronary calcification and coronary plaque burdens by multidetector row coronary computed tomography in pre- and postmenopausal women
    Sung Hee Choi
    Seoul National University College of Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul, Korea
    Clin Endocrinol (Oxf) 71:644-51. 2009
    ..Coronary multidetector row computed tomography (MDCT) is a noninvasive tool developed to evaluate coronary status precisely. We used MDCT to evaluate this association...
  85. doi request reprint Cerebral white matter hyperintensity is mainly associated with hypertension among the components of metabolic syndrome in Koreans
    Hoon Sung Choi
    Department of Internal Medicine, Seoul National University College of Medicine, Chongno Gu, Seoul, South Korea
    Clin Endocrinol (Oxf) 71:184-8. 2009
    ..In this study we examined the association between cerebral WMH and metabolic syndrome, a cluster of hypertension, glucose intolerance, abdominal obesity and dyslipidaemia...
  86. doi request reprint Detection of differential proteomes associated with the development of type 2 diabetes in the Zucker rat model using the iTRAQ technique
    Dohyun Han
    Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea
    J Proteome Res 10:564-77. 2011
    ..With these novel proteins, our proteomics study could provide valuable clues for better understanding the underlying mechanisms associated with the dynamic transition of obesity to T2D...
  87. doi request reprint Differences in donor CXCR4 expression levels are correlated with functional capacity and therapeutic outcome of angiogenic treatment with endothelial colony forming cells
    Bae Jun Oh
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    Biochem Biophys Res Commun 398:627-33. 2010
    ....
  88. doi request reprint Life-threatening hypoglycemia induced by a tyrosine kinase inhibitor in a patient with neuroendocrine tumor: a case report
    Yenna Lee
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul 110 744, Republic of Korea
    Diabetes Res Clin Pract 93:e68-70. 2011
    ..Administration of small dose of prednisolone could prevent severe hypoglycemia and improve glucose homeostasis...
  89. ncbi request reprint Association of adiponectin and resistin with cardiovascular events in Korean patients with type 2 diabetes: the Korean atherosclerosis study (KAS): a 42-month prospective study
    Soo Lim
    Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul, 110 744, Republic of Korea
    Atherosclerosis 196:398-404. 2008
    ..A low level of adiponectin, not resistin, was a significant risk factor for the development of cardiovascular events in these Korean patients with type 2 diabetes...
  90. doi request reprint The ginsenoside Rg3 has a stimulatory effect on insulin signaling in L6 myotubes
    Min Kim
    Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 744, Republic of Korea
    Biochem Biophys Res Commun 389:70-3. 2009
    ..In conclusion, these results suggest that Rg3 improves insulin signaling and glucose uptake primarily by stimulating the expression of IRS-1 and GLUT4...
  91. ncbi request reprint Dynamic changes in mitochondrial biogenesis and antioxidant enzymes during the spontaneous differentiation of human embryonic stem cells
    Young Min Cho
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
    Biochem Biophys Res Commun 348:1472-8. 2006
    ..Therefore, the HESCs would serve as a good model to examine the mitochondrial biology during the early human differentiation...
  92. pmc Polymorphisms of the reg1α gene and early onset type 2 diabetes in the korean population
    Bo Kyung Koo
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Korean Diabetes J 34:229-36. 2010
    ..As human Reg1α is homologous with murine Reg1, we investigated whether common variants in Reg1α are associated with type 2 diabetes in the Korean population...
  93. ncbi request reprint Genetic factors related to mitochondrial function and risk of diabetes mellitus
    Young Min Cho
    Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon dong Chongno gu, Seoul 110 744, Korea
    Diabetes Res Clin Pract 77:S172-7. 2007
    ..Elucidation of genetic factors regulating mitochondrial function would be of help to understand how mitochondrial dysfunction is linked to the pathogenesis of type 2 diabetes...
  94. ncbi request reprint The effect of composite pig islet-human endothelial cell grafts on the instant blood-mediated inflammatory reaction
    Hyoung Il Kim
    Xenotransplantation Research Center, Seoul 110 744, Republic of Korea
    Cell Transplant 18:31-7. 2009
    ..If the optimal endothelial cell-islet coculture method could be identified, human endothelial cell coating of pig islets would offer new strategies to improve xenogenic islet transplantation outcomes...
  95. doi request reprint Association of variations in TPH1 and HTR2B with gestational weight gain and measures of obesity
    Soo Heon Kwak
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Obesity (Silver Spring) 20:233-8. 2012
    ..However, further replication studies in a different population are required to confirm our findings...
  96. doi request reprint Thiazolidinediones inhibit the growth of PC12 cells both in vitro and in vivo
    Sang Wan Kim
    Department of Internal Medicine, Seoul National University, College of Medicine, 28 Yungun Dong, Chongno Gu, Seoul 110 774, Republic of Korea
    Biochem Biophys Res Commun 371:197-202. 2008
    ..Finally, rat PHEO growth generated by subcutaneous injection of PC12 cells was slowed in an RGZ-treated mouse. These data suggest that TZDs may be a promising therapeutic approach for medical treatment for PHEO...
  97. doi request reprint Silent corticotroph adenomas have unique recurrence characteristics compared with other nonfunctioning pituitary adenomas
    Hwa Young Cho
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Clin Endocrinol (Oxf) 72:648-53. 2010
    ..Our goal was to compare the clinical characteristics and natural history between patients with SCAs and non-SCAs...
  98. pmc Hemoglobin A1c as a diagnostic tool for diabetes screening and new-onset diabetes prediction: a 6-year community-based prospective study
    Sung Hee Choi
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Diabetes Care 34:944-9. 2011
    ..We evaluated the usefulness of A1C levels when screening for undiagnosed diabetes and as a predictor of 6-year incident diabetes in a prospective, population-based cohort study...
  99. pmc The clinical characteristics of normoalbuminuric renal insufficiency in Korean type 2 diabetic patients: a possible early stage renal complication
    Jee Hyun An
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    J Korean Med Sci 24:S75-81. 2009
    ..The association with a shorter duration of the diabetes and a lower prevalence of retinopathy suggests that it might be an early stage renal complication...
  100. ncbi request reprint Rapidly increasing diabetes-related mortality with socio-environmental changes in South Korea during the last two decades
    Young Ju Choi
    Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon dong Chongno gu, Seoul 110 744, Republic of Korea
    Diabetes Res Clin Pract 74:295-300. 2006
    ..To counter increasing prevalence of diabetes and its related mortality in South Korea, multidirectional efforts including lifestyle modification should be mandatory features of future public health policy...
  101. pmc Predictive factors associated with the reversibility of post-transplantation diabetes mellitus following liver transplantation
    Hwa Young Ahn
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    J Korean Med Sci 24:567-70. 2009
    ..0 vs. 9.4%, P<0.05), and use of mycophenolate mofetil (59.5 vs. 28.1%, P<0.05). Among these risk factors, age at the time of transplantation is the single independent predictive factor associated with the reversibility of PTDM...