Affiliation: Seoul National University
Jang Y, Lee S, Lee B, Jung S, Khalid A, Uchida K, et al
. TRPM2, a Susceptibility Gene for Bipolar Disorder, Regulates Glycogen Synthase Kinase-3 Activity in the Brain. J Neurosci. 2015;35:11811-23 pubmed publisher
..Therefore, abnormal regulation of GSK-3 by hypoactive TRPM2 mutants accounts for the pathology of BD, providing the possible link between BD and TRPM2. ..
Lee B, Cho H, Jung J, Yang Y, Yang D, Oh U. Anoctamin 1 contributes to inflammatory and nerve-injury induced hypersensitivity. Mol Pain. 2014;10:5 pubmed publisher
Chun H, Cho H, Choi J, Lee J, Kim S, Kim H, et al
. Protons inhibit anoctamin 1 by competing with calcium. Cell Calcium. 2015;58:431-41 pubmed publisher
..These findings provide a molecular mechanism underlying the acid-induced inhibition of ANO1, which may contribute to control fluid and electrolyte secretion in the secretory epithelia. ..
Cha J, Wee J, Jung J, Jang Y, Lee B, Hong G, et al
. Anoctamin 1 (TMEM16A) is essential for testosterone-induced prostate hyperplasia. Proc Natl Acad Sci U S A. 2015;112:9722-7 pubmed publisher
..We therefore concluded that ANO1 is essential for the development of prostate hyperplasia and is a potential target for the treatment of BPH. ..
Oh U, Jung J. Cellular functions of TMEM16/anoctamin. Pflugers Arch. 2016;468:443-53 pubmed publisher
..Recently, an X-ray crystal structure of a fungal TMEM16 was reported, which explains a precise molecular gating mechanism as well as ion conduction or phospholipid transport across the plasma membrane. ..
Hong G, Lee B, Wee J, Chun H, Kim H, Jung J, et al
. Tentonin 3/TMEM150c Confers Distinct Mechanosensitive Currents in Dorsal-Root Ganglion Neurons with Proprioceptive Function. Neuron. 2016;91:107-18 pubmed publisher
..Identification of this gene advances our understanding of the various types of mechanosensations, including proprioception. ..