Seog Bae Oh
Affiliation: Seoul National University
Jang I, Davies A, Akimoto N, Back S, Lee P, Na H, et al
. Acute inflammation reveals GABAA receptor-mediated nociception in mouse dorsal root ganglion neurons via PGE2 receptor 4 signaling. Physiol Rep. 2017;5: pubmed publisher
Won J, Lee P, Oh S. Alpha 2 adrenoceptor agonist guanabenz directly inhibits hyperpolarization-activated, cyclic nucleotide-modulated (HCN) channels in mesencephalic trigeminal nucleus neurons. Eur J Pharmacol. 2019;: pubmed publisher
..Our study demonstrates that guanabenz can directly inhibit HCN channels in addition to its primary role of activating α2A-adrenoceptors. ..
Davies A, Kim H, González Cano R, Choi J, Back S, Roh S, et al
. Natural Killer Cells Degenerate Intact Sensory Afferents following Nerve Injury. Cell. 2019;176:716-728.e18 pubmed publisher
Won J, Kim J, Oh S. Molecular expression of Mg2+ regulator TRPM7 and CNNM4 in rat odontoblasts. Arch Oral Biol. 2018;96:182-188 pubmed publisher
..Colocalization of TRPM7 and CNNM4 in the odontoblastic process suggest functional coupling of these two molecules to maintain Mg2+ homeostasis. ..
Kwon M, Baek S, Park C, Chung G, Oh S. Single-cell RT-PCR and immunocytochemical detection of mechanosensitive transient receptor potential channels in acutely isolated rat odontoblasts. Arch Oral Biol. 2014;59:1266-71 pubmed publisher
..Given that TRPM7 is a mechanosensitive ion channel with a kinase activity that plays a role in Mg(2+) homeostasis, it is possible that TRPM7 expressed in odontoblasts might play a central role in mineralization during dentin formation. ..
Lee D, Cho P, Lee H, Lee S, Jung S, Oh S. Trans-activation of TRPV1 by D1R in mouse dorsal root ganglion neurons. Biochem Biophys Res Commun. 2015;465:832-7 pubmed publisher
..These results provide evidence that the trans-activation of TRPV1 following D1R activation may contribute to the modulation of pain signaling in nociceptive sensory neurons. ..
Lee P, Yoon S, Kim H, Yeo J, Kim Y, Oh S. Peripheral GABAA receptor-mediated signaling facilitates persistent inflammatory hypersensitivity. Neuropharmacology. 2018;135:572-580 pubmed publisher
Yoon S, Lee J, Roh D, Oh S. Pharmacopuncture With Scolopendra subspinipes Suppresses Mechanical Allodynia in Oxaliplatin-Induced Neuropathic Mice and Potentiates Clonidine-induced Anti-allodynia Without Hypotension or Motor Impairment. J Pain. 2018;: pubmed publisher
..The combination of SSP and low-dose clonidine might provide a novel strategy for the management of chemotherapy-induced peripheral neuropathy. ..
Jeong H, Kim Y, Lee Y, Jung S, Oh S. TRPM2 contributes to LPC-induced intracellular Ca2+ influx and microglial activation. Biochem Biophys Res Commun. 2017;485:301-306 pubmed publisher
..Taken together, our results suggest that LPC induces intracellular Ca2+ influx and increases phosphorylation of p38 MAPK via TRPM2, which in turn activates microglia. ..