Research Topics

Dong Chan Oh


Affiliation: Seoul National University
Country: Korea


  1. Park S, Julianti E, Ahn S, Kim D, Lee S, Noh M, et al. Phenalenones from a Marine-Derived Fungus Penicillium Sp. Mar Drugs. 2019;17: pubmed publisher
  2. Kwon O, Kim D, Kim H, Lee Y, Lee H, Sim C, et al. Bromopyrrole Alkaloids from the Sponge Agelas kosrae. Mar Drugs. 2018;16: pubmed publisher
    ..The sceptrin alkaloids exhibited weak cytotoxicity against cancer cells. Compounds 1 and 2 also moderately exhibited anti-angiogenic and isocitrate lyase-inhibitory activities, respectively. ..
  3. You M, Liao L, Hong S, Park W, Kwon D, Lee J, et al. Lumazine peptides from the marine-derived fungus Aspergillus terreus. Mar Drugs. 2015;13:1290-303 pubmed publisher
    ..In addition, the compounds exhibited fluorescence changes upon binding to DNA, demonstrating their potential applications to DNA sequence recognition. ..
  4. Won T, Kim C, Lee S, Rho B, Lee S, Oh D, et al. Amino Acid-Derived Metabolites from the Ascidian Aplidium sp. Mar Drugs. 2015;13:3836-48 pubmed publisher
    ..The absolute configuration of the amino acid residue in 1 was determined by advanced Marfey's analysis. Several of these compounds exhibited moderate cytotoxicity and significant inhibition against Na+/K+-ATPase (4). ..
  5. Choi H, Oh D. Considerations of the chemical biology of microbial natural products provide an effective drug discovery strategy. Arch Pharm Res. 2015;38:1591-605 pubmed publisher
  6. Kim D, Lee E, Lee J, Leutou A, Shin Y, Choi B, et al. Antartin, a Cytotoxic Zizaane-Type Sesquiterpenoid from a Streptomyces sp. Isolated from an Antarctic Marine Sediment. Mar Drugs. 2018;16: pubmed publisher
    ..Antartin (1) showed cytotoxicity against A549, H1299, and U87 cancer cell lines by causing cell cycle arrest at the G1 phase. ..
  7. Kwon Y, Byun W, Kim B, Song M, Bae M, Yoon Y, et al. Depsidomycins B and C: New Cyclic Peptides from a Ginseng Farm Soil-Derived Actinomycete. Molecules. 2018;23: pubmed publisher
    ..Depsidomycins B and C displayed significant antimetastatic activities against metastatic breast cancer cells (MDA-MB-231). ..
  8. Bae M, Chung B, Oh K, Shin J, Oh D. Hormaomycins B and C: New Antibiotic Cyclic Depsipeptides from a Marine Mudflat-Derived Streptomyces sp. Mar Drugs. 2015;13:5187-200 pubmed publisher
    ..These hormaomycins exhibited significant inhibitory effects against various pathogenic Gram-positive and Gram-negative bacteria. ..
  9. Ahn J, Pei Y, Chae H, Kim S, Kim Y, Choi Y, et al. Spiroketones and a Biphenyl Analog from Stems and Leaves of Larrea nitida and Their Inhibitory Activity against IL-6 Production. Molecules. 2018;23: pubmed publisher
    ..Of them, compounds 1, 3-6 showed potent anti-inflammatory activity, with IC50 values of 12.8, 17.5, 14.9, 22.9, and 17.8 ┬ÁM, respectively. ..

More Information


  1. Um S, Pyee Y, Kim E, Lee S, Shin J, Oh D. Thalassospiramide G, a new ?-amino-acid-bearing peptide from the marine bacterium Thalassospira sp. Mar Drugs. 2013;11:611-22 pubmed publisher
    ..Thalassospiramides A and D (2-3) inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated mouse macrophage RAW 264.7 cells, with IC(50) values of 16.4 and 4.8 ?M, respectively. ..
  2. Bae M, Park S, Kwon Y, Lee S, Shin J, Nam J, et al. QM-HiFSA-Aided Structure Determination of Succinilenes A-D, New Triene Polyols from a Marine-Derived Streptomyces sp. Mar Drugs. 2017;15: pubmed publisher
    ..The absolute configurations of succinilenes A-D (1-4) were established through J-based configuration analysis, the modified Mosher's method following methanolysis, and CD spectral analysis. ..
  3. Kim J, Shin D, Kim S, Park W, Shin Y, Kim W, et al. Borrelidins C-E: New Antibacterial Macrolides from a Saltern-Derived Halophilic Nocardiopsis sp. Mar Drugs. 2017;15: pubmed publisher
    ..Borrelidins C and D displayed inhibitory activity, particularly against the Gram-negative pathogen Salmonella enterica, and moderate cytotoxicity against the SNU638 and K562 carcinoma cell lines. ..
  4. Kim T, Shin Y, Lee H, Kim J, Choe J, Jang J, et al. Ohmyungsamycins promote antimicrobial responses through autophagy activation via AMP-activated protein kinase pathway. Sci Rep. 2017;7:3431 pubmed publisher
    ..Collectively, these data show that OMS is a promising candidate for new anti-mycobacterial therapeutics by activating antibacterial autophagy via AMPK-dependent signaling and suppressing excessive inflammation during Mtb infections. ..