Dong Chan Oh
Affiliation: Seoul National University
- Um S, Pyee Y, Kim E, Lee S, Shin J, Oh D. Thalassospiramide G, a new ?-amino-acid-bearing peptide from the marine bacterium Thalassospira sp. Mar Drugs. 2013;11:611-22 pubmed publisher..Thalassospiramides A and D (2-3) inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated mouse macrophage RAW 264.7 cells, with IC(50) values of 16.4 and 4.8 ?M, respectively. ..
- Bae M, Park S, Kwon Y, Lee S, Shin J, Nam J, et al. QM-HiFSA-Aided Structure Determination of Succinilenes A-D, New Triene Polyols from a Marine-Derived Streptomyces sp. Mar Drugs. 2017;15: pubmed publisher..The absolute configurations of succinilenes A-D (1-4) were established through J-based configuration analysis, the modified Mosher's method following methanolysis, and CD spectral analysis. ..
- Kim J, Shin D, Kim S, Park W, Shin Y, Kim W, et al. Borrelidins C-E: New Antibacterial Macrolides from a Saltern-Derived Halophilic Nocardiopsis sp. Mar Drugs. 2017;15: pubmed publisher..Borrelidins C and D displayed inhibitory activity, particularly against the Gram-negative pathogen Salmonella enterica, and moderate cytotoxicity against the SNU638 and K562 carcinoma cell lines. ..
- Kim T, Shin Y, Lee H, Kim J, Choe J, Jang J, et al. Ohmyungsamycins promote antimicrobial responses through autophagy activation via AMP-activated protein kinase pathway. Sci Rep. 2017;7:3431 pubmed publisher..Collectively, these data show that OMS is a promising candidate for new anti-mycobacterial therapeutics by activating antibacterial autophagy via AMPK-dependent signaling and suppressing excessive inflammation during Mtb infections. ..