Affiliation: Seoul National University
Lee B, Lee S, Lee S, Lee J. The LIM-homeobox transcription factor Isl1 plays crucial roles in the development of multiple arcuate nucleus neurons. Development. 2016;143:3763-3773 pubmed
..Our results identify Isl1 as a crucial transcription factor that plays essential roles in the gene regulatory program directing development of multiple arcuate neuronal subpopulations. ..
Lee B, Kim J, An T, Kim S, Patel E, Raber J, et al
. Dlx1/2 and Otp coordinate the production of hypothalamic GHRH- and AgRP-neurons. Nat Commun. 2018;9:2026 pubmed publisher
..Together, our study demonstrates that the identity of GHRH- and AgRP-neurons is synchronously specified and segregated by the Dlx1/2-Otp gene regulatory axis. ..
Seo S, Lee B, Lee S. Critical Roles of the LIM Domains of Lhx3 in Recruiting Coactivators to the Motor Neuron-Specifying Isl1-Lhx3 Complex. Mol Cell Biol. 2015;35:3579-89 pubmed publisher
..Our results suggest that the Lhx3-LIM domains play critical roles in transactivation of the Isl1-Lhx3 complex by not only directing the assembly of the Isl1-Lhx3 complex but also recruiting coactivators to the complex. ..
Nam H, Lee S. Identification of STAM1 as a novel effector of ventral projection of spinal motor neurons. Development. 2016;143:2334-43 pubmed publisher
..Our results reveal a crucial regulatory axis for the ventral axonal trajectory of developing spinal MNs, consisting of the ISL1-LHX3 complex, STAM1 and CXCR4. ..
Clovis Y, Seo S, Kwon J, Rhee J, Yeo S, Lee J, et al
. Chx10 Consolidates V2a Interneuron Identity through Two Distinct Gene Repression Modes. Cell Rep. 2016;16:1642-1652 pubmed publisher
..This dual activity enables Chx10 to effectively separate the V2a and MN pathways. Our study uncovers a widely applicable gene regulatory principle for segregating related cell fates. ..
Lee S, Shen R, Cho H, Kwon R, Seo S, Lee J, et al
. STAT3 promotes motor neuron differentiation by collaborating with motor neuron-specific LIM complex. Proc Natl Acad Sci U S A. 2013;110:11445-50 pubmed publisher
..Together, our studies uncover crucial gene regulatory mechanisms that couple MN-hexamer and STAT-activating extracellular signals to promote motor neuron differentiation in vertebrate spinal cord. ..
Kim D, Kim J, Kwon J, Sandhu J, Tontonoz P, Lee S, et al
. Critical Roles of the Histone Methyltransferase MLL4/KMT2D in Murine Hepatic Steatosis Directed by ABL1 and PPAR?2. Cell Rep. 2016;17:1671-1682 pubmed publisher
..Our results uncover a murine hepatic steatosis regulatory axis consisting of ABL1-PPAR?2-MLL4, which may serve as a target of anti-steatosis drug development. ..