Seung Hoon Lee

Summary

Affiliation: Seoul National University
Country: Korea

Publications

  1. pmc Spontaneous Carotid Cavernous Fistula in a Case with Protein S Deficiency that Newly Developed Ophthalmoplegia after Embolization
    Chi Kyung Kim
    Department of Neurology, Seoul National University Hospital, Seoul, Korea
    J Clin Neurol 7:164-7. 2011
  2. pmc Serum uric acid levels and cerebral microbleeds in patients with acute ischemic stroke
    Wi Sun Ryu
    Department of Neurology, Seoul National University Hospital, Seoul, Republic of Korea
    PLoS ONE 8:e55210. 2013
  3. pmc Branch atheromatous plaque: a major cause of lacunar infarction (high-resolution MRI study)
    Jong Won Chung
    Department of Neurology, Seoul National University Hospital, Seoul, Republic of Korea Clinical Research Center for Stroke, Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
    Cerebrovasc Dis Extra 2:36-44. 2012
  4. pmc Impact of CHADS(2) Score on Neurological Severity and Long-Term Outcome in Atrial Fibrillation-Related Ischemic Stroke
    Dohoung Kim
    Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea
    J Clin Neurol 8:251-8. 2012
  5. pmc Silent microbleeds and hemorrhagic conversion of an embolic infarction
    Beom Joon Kim
    Department of Neurology, Seoul National University Hospital, Seoul, Korea
    J Clin Neurol 3:147-9. 2007
  6. pmc Paradoxical effect of obesity on hemorrhagic transformation after acute ischemic stroke
    Chi Kyung Kim
    Department of Neurology, Seoul National University Hospital, 101 Daehak Ro, Jongno gu, Seoul 110 744, Republic of Korea
    BMC Neurol 13:123. 2013
  7. ncbi request reprint Emodin inhibits vascular endothelial growth factor-A-induced angiogenesis by blocking receptor-2 (KDR/Flk-1) phosphorylation
    Hee Jin Kwak
    Laboratory of Functional Genomics, Korea Institute of Radiological and Medical Sciences, Seoul, Korea
    Int J Cancer 118:2711-20. 2006
  8. ncbi request reprint Increased expression of antioxidant enzymes in radioresistant variant from U251 human glioblastoma cell line
    Hyung Chahn Lee
    Laboratory of Cell Biology, Korea Institute of Radiological Medical Sciences, Seoul, Korea
    Int J Mol Med 13:883-7. 2004
  9. ncbi request reprint Advanced coronary artery calcification is associated with ischemic stroke
    Beom Joon Kim
    Department of Neurology, Seoul National University Hospital, Seoul, South Korea
    Cerebrovasc Dis 30:93-100. 2010
  10. ncbi request reprint Metabolic syndrome as an independent risk factor of silent brain infarction in healthy people
    Hyung Min Kwon
    Department of Neurology, Seoul National University Hospital, Seoul 110 744, Korea
    Stroke 37:466-70. 2006

Collaborators

Detail Information

Publications79

  1. pmc Spontaneous Carotid Cavernous Fistula in a Case with Protein S Deficiency that Newly Developed Ophthalmoplegia after Embolization
    Chi Kyung Kim
    Department of Neurology, Seoul National University Hospital, Seoul, Korea
    J Clin Neurol 7:164-7. 2011
    ..Because spontaneous CCFs are mainly of the dural type, we considered that thrombogenic conditions, such as, protein S deficiency might be associated with CCF...
  2. pmc Serum uric acid levels and cerebral microbleeds in patients with acute ischemic stroke
    Wi Sun Ryu
    Department of Neurology, Seoul National University Hospital, Seoul, Republic of Korea
    PLoS ONE 8:e55210. 2013
    ..We demonstrated that serum uric acid is independently associated with the presence of CMBs. In particular, the relation between uric acid and CMBs was robust in hypertensive patients...
  3. pmc Branch atheromatous plaque: a major cause of lacunar infarction (high-resolution MRI study)
    Jong Won Chung
    Department of Neurology, Seoul National University Hospital, Seoul, Republic of Korea Clinical Research Center for Stroke, Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
    Cerebrovasc Dis Extra 2:36-44. 2012
    ..The authors evaluated the presence of branch atheromatous plaque in parent arteries that supply lacunar infarcts by high-resolution magnetic resonance imaging (HR-MRI)...
  4. pmc Impact of CHADS(2) Score on Neurological Severity and Long-Term Outcome in Atrial Fibrillation-Related Ischemic Stroke
    Dohoung Kim
    Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea
    J Clin Neurol 8:251-8. 2012
    ..However, how the CHADS(2) score is related to stroke severity and outcome in patients with strokes due to atrial fibrillation has not yet been elucidated...
  5. pmc Silent microbleeds and hemorrhagic conversion of an embolic infarction
    Beom Joon Kim
    Department of Neurology, Seoul National University Hospital, Seoul, Korea
    J Clin Neurol 3:147-9. 2007
    ..This case suggests that SMBs are indicators of an underlying hemorrhage-prone state...
  6. pmc Paradoxical effect of obesity on hemorrhagic transformation after acute ischemic stroke
    Chi Kyung Kim
    Department of Neurology, Seoul National University Hospital, 101 Daehak Ro, Jongno gu, Seoul 110 744, Republic of Korea
    BMC Neurol 13:123. 2013
    ..In this context, we have investigated the association between obesity and hemorrhagic transformation (HTf) after acute ischemic stroke...
  7. ncbi request reprint Emodin inhibits vascular endothelial growth factor-A-induced angiogenesis by blocking receptor-2 (KDR/Flk-1) phosphorylation
    Hee Jin Kwak
    Laboratory of Functional Genomics, Korea Institute of Radiological and Medical Sciences, Seoul, Korea
    Int J Cancer 118:2711-20. 2006
    ..Based on these data, we propose that an interaction of emodin with KDR/Flk-1 may be involved in the inhibitory function of emodin toward VEGF-A-induced angiogenesis in vitro and responsible for its potent anti-angiogenic in vivo...
  8. ncbi request reprint Increased expression of antioxidant enzymes in radioresistant variant from U251 human glioblastoma cell line
    Hyung Chahn Lee
    Laboratory of Cell Biology, Korea Institute of Radiological Medical Sciences, Seoul, Korea
    Int J Mol Med 13:883-7. 2004
    ..Therefore, radioresistance and cross-resistance to chemotherapeutic agent in RRC might be due to the highly coordinated activation of antioxidant enzymes rather than a single enzyme alone...
  9. ncbi request reprint Advanced coronary artery calcification is associated with ischemic stroke
    Beom Joon Kim
    Department of Neurology, Seoul National University Hospital, Seoul, South Korea
    Cerebrovasc Dis 30:93-100. 2010
    ..However, the association between CAC and ischemic stroke has not been evaluated...
  10. ncbi request reprint Metabolic syndrome as an independent risk factor of silent brain infarction in healthy people
    Hyung Min Kwon
    Department of Neurology, Seoul National University Hospital, Seoul 110 744, Korea
    Stroke 37:466-70. 2006
    ..Moreover, a silent brain infarction (SBI) can predict clinical overt stroke or dementia. We examined the associations between SBI and MetS in apparently healthy individuals...
  11. doi request reprint Dynamics of obesity paradox after stroke, related to time from onset, age, and causes of death
    Beom Joon Kim
    Department of Neurology, Seoul National University Bundang Hospital, Seongnam si, Seoul, Korea
    Neurology 79:856-63. 2012
    ..We aimed to find whether such a relationship exists in ischemic stroke patients, with stratified analyses according to time of death after stroke, age, and cause of death...
  12. ncbi request reprint Arsenic trioxide (As2O3) inhibits invasion of HT1080 human fibrosarcoma cells: role of nuclear factor-kappaB and reactive oxygen species
    Myung Jin Park
    Laboratory of Cell Biology, Korea Institute of Radiological and Medical Sciences, Seoul, Korea
    J Cell Biochem 95:955-69. 2005
    ..In addition, the generation of ROS and subsequent suppression of NF-kappaB activity by As2O3 might partly be responsible for the phenomena. Overall, As2O3 shows potent activity controlling tumor cell invasiveness in vitro...
  13. doi request reprint Secular trends in ischemic stroke characteristics in a rapidly developed country: results from the Korean Stroke Registry Study (secular trends in Korean stroke)
    Keun Hwa Jung
    Department of Neurology, Seoul National University Hospital, Seoul, South Korea
    Circ Cardiovasc Qual Outcomes 5:327-34. 2012
    ..A dynamic change in industry, lifestyle, and healthcare structure brings a corresponding change in disease patterns. Limited data exist with respect to secular trends in stroke epidemiology in Korea, a rapidly developed country...
  14. ncbi request reprint Excessive work and risk of haemorrhagic stroke: a nationwide case-control study
    Beom Joon Kim
    Department of Neurology, Seoul National University Bundang Hospital, Seongnam si, Gyunggi Do, Republic of Korea Department of Neurology, Clinical Research Centre for Stroke, Seoul National University Hospital, Seoul, Republic of Korea
    Int J Stroke 8:56-61. 2013
    ..Adverse effect of excessive work on health has been suggested previously, but it was not documented in cerebrovascular diseases...
  15. ncbi request reprint Gradient echo magnetic resonance imaging in the prediction of hemorrhagic vs ischemic stroke: a need for the consideration of the extent of leukoariosis
    Dong Eog Kim
    Department of Neurology, Seoul National University Hospital, 28 Yongon Dong, Chongno Gu, Seoul 110 744, South Korea
    Arch Neurol 59:425-9. 2002
    ..However, MSLLs are also known to be associated with leukoariosis; leukoariosis is commonly associated with occlusive-type vascular lesions...
  16. ncbi request reprint Low concentration of serum total cholesterol is associated with multifocal signal loss lesions on gradient-echo magnetic resonance imaging: analysis of risk factors for multifocal signal loss lesions
    Seung Hoon Lee
    Department of Neurology, School of Public Health, Seoul National University, Korea
    Stroke 33:2845-9. 2002
    ..We investigated risk factors of MSLLs and the relationship between lipid profiles and MSLLs on GE-MRI...
  17. ncbi request reprint Obstructive sleep apnea syndrome: a child is not just a small adult
    Ji Ho Choi
    Department of Otorhinolaryngology Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea
    Ann Otol Rhinol Laryngol 119:656-61. 2010
    ..The purpose of this study was to identify the characteristics that distinguish the clinical manifestations and polysomnographic findings of OSAS in children from those in adults...
  18. doi request reprint Validation study of portable device for the diagnosis of obstructive sleep apnea according to the new AASM scoring criteria: Watch-PAT 100
    Ji Ho Choi
    Department of Otorhinolaryngology Head and Neck Surgery, Korea University, Seoul, Korea
    Acta Otolaryngol 130:838-43. 2010
    ..Watch-PAT may provide an accurate and clinically effective portable monitoring method for the diagnosis of obstructive sleep apnea (OSA)...
  19. doi request reprint Efficacy of single-staged modified uvulopalatopharyngoplasty with nasal surgery in adults with obstructive sleep apnea syndrome
    Ji Ho Choi
    Department of Otorhinolaryngology Head and Neck Surgery, Korea University College of Medicine, Seoul, Korea
    Otolaryngol Head Neck Surg 144:994-9. 2011
    ....
  20. ncbi request reprint Effect of successful surgical treatment on changes of position during sleep in adults with obstructive sleep apnea syndrome
    Ji Ho Choi
    Department of Otorhinolaryngology Head and Neck Surgery, Korea University College of Medicine, Seoul, Korea
    Ann Otol Rhinol Laryngol 120:104-9. 2011
    ....
  21. ncbi request reprint Effects of hsp70.1 gene knockout on the mitochondrial apoptotic pathway after focal cerebral ischemia
    Seung Hoon Lee
    Department of Neurology, National University, Seoul, Republic of Korea
    Stroke 35:2195-9. 2004
    ..1 protein after cerebral ischemia. To evaluate the role of HSP70.1 protein in ischemia, we analyzed the mitochondrial apoptotic pathway using hsp70.1 knockout (KO) mice and their wild-type (WT) mice...
  22. pmc Detrimental effects of leptin on intracerebral hemorrhage via the STAT3 signal pathway
    Chi Kyung Kim
    Laboratory for Innovative Biotechnology, Department of Neurology, Biomedical Research Institute, Seoul National University Hospital, Seoul 110 744, Republic of Korea
    J Cereb Blood Flow Metab 33:944-53. 2013
    ..This detrimental effect of leptin on ICH is mediated by the STAT3 signaling pathway in inflammatory cells...
  23. doi request reprint Pentraxin 3: a novel and independent prognostic marker in ischemic stroke
    Wi Sun Ryu
    Department of Neurology, Seoul National University Hospital, Jongno gu, Seoul, Republic of Korea
    Atherosclerosis 220:581-6. 2012
    ..The purpose of the current study was to determine the impact of PTX3 levels on mortality after ischemic stroke...
  24. doi request reprint Elevated leukocyte count in asymptomatic subjects is associated with a higher risk for cerebral white matter lesions
    Chi Kyung Kim
    Department of Neurology, Seoul National University Hospital, Seoul, Republic of Korea
    Clin Neurol Neurosurg 113:177-80. 2011
    ..Cerebral white matter lesions (WMLs) are radiologic markers of small vessel disease in brain, and inflammatory processes were related to WMLs. We propose to determine if elevated leukocyte count was associated with a higher risk of WMLs...
  25. doi request reprint Effects of low serum triglyceride on stroke mortality: a prospective follow-up study
    Wi Sun Ryu
    Clinical Research Center for Stroke, Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
    Atherosclerosis 212:299-304. 2010
    ..We hypothesized that the influence of TG levels on post-stroke mortality varies according to stroke mechanism: cardioembolic (CE) vs. non-CE causes...
  26. doi request reprint Functional recovery after spinal cord injury in dogs treated with a combination of Matrigel and neural-induced adipose-derived mesenchymal Stem cells
    Sung Su Park
    Department of Veterinary Surgery, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea
    Cytotherapy 14:584-97. 2012
    ..In this study, we investigated whether a combination of Matrigel and neural-induced mesenchymal stem cells (NMSC) improved hindlimb function in dogs with SCI, and what mechanisms were involved...
  27. doi request reprint Effect of upper airway surgery on heart rate variability in patients with obstructive sleep apnoea syndrome
    Ji Ho Choi
    Department of Otorhinolaryngology Head and Neck Surgery, Korea University College of Medicine, Seoul, Korea
    J Sleep Res 21:316-21. 2012
    ..No significant changes were observed in the unsuccessful surgical group. Successful UA surgery may improve cardiac sympathetic and parasympathetic modulation in patients with OSAS...
  28. doi request reprint Geldanamycin protects rat brain through overexpression of HSP70 and reducing brain edema after cerebral focal ischemia
    Hyung Min Kwon
    Department of Neurology, Seoul National University Boramae Hospital, Seoul, Korea
    Neurol Res 30:740-5. 2008
    ..We hypothesized that GA would protect brain from focal ischemia via induction of HSP70 and MMP suppression in vivo...
  29. doi request reprint Risk factors and tumor response associated with hydrocephalus after gamma knife radiosurgery for vestibular schwannoma
    Seung Hoon Lee
    Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon dong, Gangnam Gu, Seoul, 135 710, Korea
    Acta Neurochir (Wien) 154:1679-84. 2012
    ..This study was designed to investigate the clinical characteristics and risk factors of hydrocephalus after gamma knife radiosurgery (GKRS) for vestibular schwannoma...
  30. doi request reprint Association of obesity with cerebral microbleeds in neurologically asymptomatic elderly subjects
    Chi Kyung Kim
    Department of Neurology, Seoul National University Hospital, Seoul, Republic of Korea
    J Neurol 259:2599-604. 2012
    ..Based on our findings, we postulate that obesity is associated with the presence of subclinical and bleeding-prone cerebrovascular disease in the elderly...
  31. doi request reprint Significant association of metabolic syndrome with silent brain infarction in elderly people
    Hyung Min Kwon
    Department of Neurology, Seoul National University Boramae Hospital, Seoul, South Korea
    J Neurol 256:1825-31. 2009
    ..MetS was found to be significantly associated with SBI in neurologically healthy elderly people. The positive trend between the number of MetS components and SBI could be used as a diagnostic tool to predict and prevent future stroke...
  32. ncbi request reprint Clinical and radiologic differences between primary intracerebral hemorrhage with and without microbleeds on gradient-echo magnetic resonance images
    Sang Wuk Jeong
    Department of Neurology, Ilsan Paik Hospital, Inje University, Ilsan, Korea
    Arch Neurol 61:905-9. 2004
    ..The microbleeds are frequently detected in patients with primary intracerebral hemorrhage (PICH). However, some patients do not have microbleeds...
  33. doi request reprint Secondary prevention by stroke subtype: a nationwide follow-up study in 46 108 patients after acute ischaemic stroke
    Dohoung Kim
    Department of Neurology, Seoul National University Hospital, 101 Daehak Ro, Jongno gu, Seoul 110 744, Republic of Korea
    Eur Heart J 34:2760-7. 2013
    ..Although use of antithrombotic agents is recommended after ischaemic stroke or transient ischaemic attack (TIA), long-term outcome of secondary prevention between stroke subtypes has not yet been explored...
  34. doi request reprint Enforced physical training promotes neurogenesis in the subgranular zone after focal cerebral ischemia
    Seung Hoon Lee
    Department of Neurology, Seoul National University Hospital, Seoul, Republic of Korea
    J Neurol Sci 269:54-61. 2008
    ..We examined whether enforced physical training (EPT) influences neurogenesis in the SVZ and SGZ after cerebral ischemia...
  35. doi request reprint The impacts of open-mouth breathing on upper airway space in obstructive sleep apnea: 3-D MDCT analysis
    Eun Joong Kim
    Department of Otorhinolaryngology Head and Neck Surgery, Korea University College of Medicine, Seoul, Korea
    Eur Arch Otorhinolaryngol 268:533-9. 2011
    ..Results suggest that the more elongated and narrow upper airway during open-mouth breathing may aggravate the collapsibility of the upper airway and, thus, negatively affect OSA severity...
  36. ncbi request reprint Correlation of coronary and cerebral atherosclerosis: difference between extracranial and intracranial arteries
    Hee Joon Bae
    Department of Neurology, Eulji General Hospital, Eulji University School of Medicine, Seoul National University Hospital, Seoul, Korea
    Cerebrovasc Dis 21:112-9. 2006
    ....
  37. doi request reprint Association between changes in lipid profiles and progression of symptomatic intracranial atherosclerotic stenosis: a prospective multicenter study
    Dong Eog Kim
    Department of Neurology, Dongguk University College of Medicine, Dongguk University Ilsan Hospital, 814 Siksa dong, Goyang, Korea, 410 773
    Stroke 43:1824-30. 2012
    ..We investigated whether poststroke changes in lipid profiles would affect the prognosis of symptomatic intracranial atherosclerotic stenosis...
  38. doi request reprint Effectiveness of nasal surgery alone on sleep quality, architecture, position, and sleep-disordered breathing in obstructive sleep apnea syndrome with nasal obstruction
    Ji Ho Choi
    Department of Otorhinolaryngology Head and Neck Surgery, Korea University College of Medicine, Seoul, Korea
    Am J Rhinol Allergy 25:338-41. 2011
    ....
  39. pmc Optimal continuous positive airway pressure level in korean patients with obstructive sleep apnea syndrome
    Ji Ho Choi
    Department of Otorhinolaryngology Head and Neck Surgery, Korea University College of Medicine, Seoul, Korea
    Clin Exp Otorhinolaryngol 3:207-11. 2010
    ....
  40. ncbi request reprint Body mass index, initial neurological severity and long-term mortality in ischemic stroke
    Wi Sun Ryu
    Clinical Research Center for Stroke, Clinical Research Institute and Department of Neurology, Seoul National University Hospital, 28 Yongon Dong, Jongno gu, Seoul, Republic of Korea
    Cerebrovasc Dis 32:170-6. 2011
    ..The aim of this study was to evaluate the independent association between BMI and long-term mortality after ischemic stroke...
  41. ncbi request reprint Topographical distribution of pontocerebellar microbleeds
    Seung Hoon Lee
    Department of Neurology, Seoul National University and Neuroscience Research Institute, SNUMRC and Clinical Research Institute, Seoul National University Hospital, Korea
    AJNR Am J Neuroradiol 25:1337-41. 2004
    ..The purpose of this study was to evaluate the distribution of MBs in the pontocerebellar region and to compare it with the distribution of ICHs reported in the literature...
  42. ncbi request reprint Advanced coronary artery calcification and cerebral small vessel diseases in the healthy elderly
    Beom Joon Kim
    Department of Neurology, Seoul National University Hospital, Seoul, Republic of Korea
    Circ J 75:451-6. 2011
    ....
  43. ncbi request reprint Optimal level of continuous positive airway pressure: auto-adjusting titration versus titration with a predictive equation
    Ji Ho Choi
    Department of Otorhinolaryngology Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea
    Ann Otol Rhinol Laryngol 122:339-43. 2013
    ..We also investigated the reliability of the two methods in patients with obstructive sleep apnea syndrome (OSAS)...
  44. doi request reprint Effects of human neural stem cell transplantation in canine spinal cord hemisection
    Seung Hoon Lee
    Department of Neurology, Seoul National University and Seoul National University Hospital, Seoul, Korea
    Neurol Res 31:996-1002. 2009
    ..In the present work, the authors sought to determine whether the transplantation of human NSCs improves functional outcome in a canine SCI model and whether transplanted NSCs survive and differentiate...
  45. doi request reprint Adipocytokines and ischemic stroke: differential associations between stroke subtypes
    Beom Joon Kim
    Department of Neurology and Clinical Research Center for Stroke, Seoul National University Hospital, Seoul, Republic of Korea
    J Neurol Sci 312:117-22. 2012
    ..We hypothesized that the strength of the associations between adipocytokines and stroke would differ between ischemic stroke subtypes...
  46. pmc A Quantitative Comparison of the Vertebral Artery and Transverse Foramen Using CT Angiography
    Chulho Kim
    Department of Neurology, Hallym University Sacred Heart Hospital, Chuncheon, Korea
    J Clin Neurol 8:259-64. 2012
    ..Most studies of these structures have focused on anatomical anomalies. Therefore, we investigated quantitatively the association between the relative sizes of the TF and VA...
  47. doi request reprint Ischemic stroke during sleep: its association with worse early functional outcome
    Beom Joon Kim
    Department of Neurology, Seoul National University Hospital, 101 Daehang ro, Jongno gu, 110 744, Seoul, Republic of Korea
    Stroke 42:1901-6. 2011
    ..Approximately one fourth of stroke occur during sleep. Despite the clinical and radiological similarities between wake-up stroke (WUS) and non-WUS, the functional outcomes of WUS are largely unknown...
  48. doi request reprint Metformin reduces TGF-β1-induced extracellular matrix production in nasal polyp-derived fibroblasts
    Il Ho Park
    Department of Otorhinolaryngology Head and Neck Surgery, Korea University College of Medicine, Seoul, Korea
    Otolaryngol Head Neck Surg 150:148-53. 2014
    ....
  49. ncbi request reprint Ischemic intensity influences the distribution of delayed infarction and apoptotic cell death following transient focal cerebral ischemia in rats
    Seung Hoon Lee
    Department of Neurology, College of Medicine, Seoul National University, Neuroscience Research Institute, Chongno Gu, Seoul, 110 744, South Korea
    Brain Res 956:14-23. 2002
    ..These findings suggest that ischemic severity may influence the distribution of delayed infarction, and that apoptosis is the underlying pathophysiologic mechanism...
  50. doi request reprint Low level of low-density lipoprotein cholesterol increases hemorrhagic transformation in large artery atherothrombosis but not in cardioembolism
    Beom Joon Kim
    Department of Neurology, Seoul National University Hospital, Jongno gu, Seoul, Republic of Korea
    Stroke 40:1627-32. 2009
    ..However, the associations of hemorrhagic transformation (HTf) after acute ischemic stroke and the low levels of total cholesterol (TC) or low-density lipoprotein cholesterol (LDLC) are largely undiscovered...
  51. doi request reprint The relation between chronic kidney disease and cerebral microbleeds: difference between patients with and without diabetes
    Wi Sun Ryu
    Department of Neurology, Seoul National University Hospital, Seoul, Korea
    Int J Stroke 7:551-7. 2012
    ..Cerebral microbleeds are an important radiologic marker of bleeding-prone brain and have been reported to be associated with the increased risk of intracerebral haemorrhage...
  52. doi request reprint Risk for leptomeningeal seeding after resection for brain metastases: implication of tumor location with mode of resection
    Jun Hyong Ahn
    Department of Neurosurgery, Seoul National University College of Medicine, National Cancer Center, Goyang, Korea
    J Neurosurg 116:984-93. 2012
    ..In this paper, the authors' goal was to define the factors related to the development of LMS and to evaluate the difference according to tumor location...
  53. ncbi request reprint The pneumonia score: a simple grading scale for prediction of pneumonia after acute stroke
    Hyung Min Kwon
    Department of Neurology, Seoul National University Hospital, Chongno Gu, Republic of Korea
    Am J Infect Control 34:64-8. 2006
  54. doi request reprint Cerebral microbleeds are a risk factor for warfarin-related intracerebral hemorrhage
    Seung Hoon Lee
    Department of Neurology, Seoul National University Hospital, Jongno gu, Seoul, Republic of Korea
    Neurology 72:171-6. 2009
    ..In this study, we investigated whether microbleeds are associated with the incidence of warfarin-related ICH...
  55. doi request reprint Does glycated hemoglobin have clinical significance in ischemic stroke patients?
    Sung Hyuk Heo
    Clinical Research Center for Stroke, Clinical Research Institute, Seoul National University Hospital, Republic of Korea
    Clin Neurol Neurosurg 112:98-102. 2010
    ..However, an association between HbA1c and stroke has not yet been determined. In this study, our purpose was to examine whether HbA1c was independently associated with various types of cerebral vascular lesions in stroke patients...
  56. doi request reprint Cilostazol in Acute Ischemic Stroke Treatment (CAIST Trial): a randomized double-blind non-inferiority trial
    Yong Seok Lee
    Seoul National University Boramae Medical Center, Seoul, Korea
    Cerebrovasc Dis 32:65-71. 2011
    ..Aspirin is a proven antiplatelet agent in acute ischemic stroke, and there are no current guidelines for other antiplatelet treatments. We aimed to compare the efficacy and safety of cilostazol with aspirin in acute stroke...
  57. doi request reprint Public awareness of stroke in Korea: a population-based national survey
    Young Seo Kim
    Department of Neurology, Seoul National University Hospital, 101 Daehak ro Jongno gu Seoul, 110 744, Republic of Korea
    Stroke 43:1146-9. 2012
    ..To date, no large study has been conducted to investigate baseline stroke awareness within a nationally representative sample of the Korean population...
  58. ncbi request reprint Cerebral microbleeds in patients with hypertensive stroke. Topographical distribution in the supratentorial area
    Seung Hoon Lee
    Department of Neurology, Seoul National University Hospital, 28 Yongon Dong, Jongno gu Seoul 110 744, Korea
    J Neurol 251:1183-9. 2004
    ..To analyse the topography of cerebral microbleeds (CMBs) visualized by T2*-weighted gradient-echo MR imaging in the supratentorial brain area, based on the anatomical classification of the regions and the arterial territories...
  59. ncbi request reprint Retinopathy as an indicator of silent brain infarction in asymptomatic hypertensive subjects
    Hyung Min Kwon
    Department of Neurology, Kyunghee University East West Neo Medical Center, Seoul, Republic of Korea
    J Neurol Sci 252:159-62. 2007
    ..The purpose of this study is to investigate the relation between hypertensive retinopathy (HTR) and SBI in subjects without a history of stroke or transient ischemic attack...
  60. pmc Dynamic temporal change of cerebral microbleeds: long-term follow-up MRI study
    Seung Hoon Lee
    Department of Neurology, Seoul National University College of Medicine, Seoul, Republic of Korea
    PLoS ONE 6:e25930. 2011
    ..Cerebral microbleeds (MBs) are understood as an important radiologic marker of intracerebral hemorrhage. We sought to investigate the temporal changes of MBs and clinical factors associated with the changes using long-term follow-up MRI...
  61. ncbi request reprint Cortico-subcortical distribution of microbleeds is different between hypertension and cerebral amyloid angiopathy
    Seung Hoon Lee
    Department of Neurology, Seoul National University Hospital, 28 Yongon Dong, Jongno gu, Seoul, 110 744, Republic of Korea
    J Neurol Sci 258:111-4. 2007
    ..Distributions within the cortico-subcortical (CSC) area have not been compared between the diseases, and remain poorly understood...
  62. doi request reprint High serum alkaline phosphatase in relation to cerebral small vessel disease
    Wi Sun Ryu
    Department of Neurology, Dongguk University Ilsan Hospital, Goyang, Republic of Korea
    Atherosclerosis 232:313-8. 2014
    ..Vascular calcification is related with cerebral small vessel disease. We investigated whether alkaline phosphatase (ALP), a marker of vascular calcificiation, is related to cerebral small vessel disease...
  63. doi request reprint High-resolution magnetic resonance imaging reveals hidden etiologies of symptomatic vertebral arterial lesions
    Jong Won Chung
    Department of Neurology, Seoul National University Hospital, Seoul, Republic of Korea Clinical Research Center for Stroke, Department of Neurology, Seoul National University Hospital, Seoul, Republic of Korea
    J Stroke Cerebrovasc Dis 23:293-302. 2014
    ..The underlying histopathology of symptomatic intracranial VA disease has only been studied at postmortem, and no in vivo imaging investigation has been conducted despite the increased sophistication of imaging techniques...
  64. ncbi request reprint Effects of celecoxib on volumes of hematoma and edema in patients with primary intracerebral hemorrhage
    Hee Kwon Park
    Department of Neurology, Seoul National University Hospital, Seoul, South Korea
    J Neurol Sci 279:43-6. 2009
    ..These results suggest that celecoxib may be safe and efficacious in patients with primary ICH. To confirm this notion, a large-sized prospective study should be performed...
  65. doi request reprint Impact of smoking cessation on the risk of subarachnoid haemorrhage: a nationwide multicentre case control study
    Chi Kyung Kim
    Department of Neurology, Seoul National University Hospital, 28 Yeongeon dong, Jongno gu, Seoul 110 744, Republic of Korea
    J Neurol Neurosurg Psychiatry 83:1100-3. 2012
    ..Subarachnoid haemorrhage (SAH) is the most devastating cerebrovascular disease. Cigarette smoking is one of the established risk factors for SAH, but the risk of SAH has not been properly elucidated in relation to smoking cessation...
  66. ncbi request reprint Reduced neurogenesis after suppressed inflammation by minocycline in transient cerebral ischemia in rat
    Beom Joon Kim
    Department of Neurology, Seoul National University Hospital, Jongno gu, Seoul, Republic of Korea
    J Neurol Sci 279:70-5. 2009
    ..Infarct size and behavioral tests were not different. Our results indicate that minocycline may reduce immediate post-ischemic neurogenesis despite adequately suppressed inflammation...
  67. ncbi request reprint Effects of microbleeds on hemorrhage development in leukoaraiosis patients
    Seung Hoon Lee
    Department of Neurology, Seoul National University, Seoul, Republic of Korea
    Hypertens Res 28:895-9. 2005
    ..02), but their predictive value for ICH was not high (positive, 52.3%; negative, 75.0%). Our results indicated that CMBs may be used to predict the risk of ICH in hypertensive patients with advanced LA...
  68. doi request reprint Age-independent association of pulse pressure with cerebral white matter lesions in asymptomatic elderly individuals
    Chi Kyung Kim
    Department of Neurology, Seoul National University Hospital, Seoul, Republic of Korea
    J Hypertens 29:325-9. 2011
    ..WMLs may be age-related degenerative change, but few studies have addressed the relationship between vascular aging and WMLs. In this study, we assessed whether brachial PP is associated with the presence of WMLs in the elderly...
  69. doi request reprint Morphine-sensitive paroxysmal sympathetic storm in pontine intracerebral hemorrhage
    Sang Bae Ko
    Department of Neurology, Clinical Research Center for Stroke, Clinical Research Institute, College of Medicine, Seoul National University Hospital, Seoul
    Neurologist 16:384-5. 2010
    ..We report a classic case of PSS after spontaneous pontine hemorrhage in which the patient's fluctuating blood pressure and body temperature were dramatically stabilized using morphine...
  70. doi request reprint High levels of serum uric acid are associated with silent brain infarction
    Sung Hyuk Heo
    Department of Neurology, Kyunghee University College of Medicine, Seoul, Republic of Korea
    J Neurol Sci 297:6-10. 2010
    ..We sought to determine whether increased levels of uric acid are associated with the presence of silent brain infarction (SBI)...
  71. pmc Stroke awareness decreases prehospital delay after acute ischemic stroke in Korea
    Young Seo Kim
    Department of Neurology, Seoul National University Hospital, Seoul, Republic of Korea
    BMC Neurol 11:2. 2011
    ..Our study aimed to investigate factors associated with prehospital delay after acute ischemic stroke in Korea...
  72. doi request reprint Ceria nanoparticles that can protect against ischemic stroke
    Chi Kyung Kim
    Department of Neurology, Seoul National University Hospital, Seoul 110 744, Korea
    Angew Chem Int Ed Engl 51:11039-43. 2012
    ..PEGylated ceria nanoparticles showed protective effects against ROS-induced cell death in vitro. Optimal doses of ceria nanoparticles reduced infarct volumes and the rate of ischemic cell death in vivo...
  73. doi request reprint Carotid cavernous fistula with cervical myelopathy
    Sang Bae Ko
    Department of Neurology, Clinical Research Center for Stroke, Clinical Research Institute, College of Medicine, Seoul National University Hospital, Yongon dong 28, Chongno Gu, Seoul, 110 744, Korea
    J Clin Neurosci 16:1350-3. 2009
    ..Stereotactic gamma-knife radiosurgery was performed as an alternative treatment, and effectively obliterated the CCF. However, the patient remained disabled due to cervical cord atrophy associated with long-standing venous hypertension...
  74. doi request reprint Atorvastatin enhances hypothermia-induced neuroprotection after stroke
    Seung Hoon Lee
    Department of Neurology, Seoul National University Hospital, Seoul, Republic of Korea
    J Neurol Sci 275:64-8. 2008
    ..Both statin and hypothermia protect the brain from focal cerebral ischemia. In this study, we sought to determine whether statin pretreatment enhances the efficacy of hypothermia and extends the therapeutic time window of hypothermia...
  75. ncbi request reprint Silent microbleeds are associated with volume of primary intracerebral hemorrhage
    Seung Hoon Lee
    Department of Neurology, Neuroscience Research Institute, SNUMRC, Seoul National University Hospital, Seoul, Republic of Korea
    Neurology 66:430-2. 2006
    ..Moreover, the presence of microbleeds was an independent risk factor for large-sized hemorrhage. These data show that microbleeds may be associated with a larger ICH volume...
  76. ncbi request reprint Differential expression of HSP70 mRNA in the mouse brain after treatment with geldanamycin
    Hyung Min Kwon
    Department of Neurology, Seoul National University Boramae Hospital, Chongno Gu, Seoul, Republic of Korea
    Neurol Res 31:541-4. 2009
    ..The induction of specific heat shock protein (HSP) isoforms by GA has not been studied in detail. The aim of this work was to identify the HSP70 genes that become up-regulated in the mouse brain after GA administration...
  77. doi request reprint Radiotherapy followed by adjuvant temozolomide with or without neoadjuvant ACNU-CDDP chemotherapy in newly diagnosed glioblastomas: a prospective randomized controlled multicenter phase III trial
    Il Han Kim
    Department of Radiation Oncology, Cancer Research Institute, Seoul National University Hospital, 28 Yeongeon dong, Jongno gu, Seoul 110 744, Korea
    J Neurooncol 103:595-602. 2011
    ..Future studies should aim to identify a subpopulation at reduced risk for ACNU-CDDP toxicity so that the potential of this protocol can be realized...
  78. doi request reprint Effects of admission glucose level on mortality after subarachnoid hemorrhage: a comparison between short-term and long-term mortality
    Seung Hoon Lee
    Department of Neurology, Seoul National University Hospital, Seoul, Republic of Korea
    J Neurol Sci 275:18-21. 2008
    ..The purpose of this study was to assess whether the admission glucose level in patients with SAH is associated with short- and/or long-term mortality...