Ki Won Lee


Affiliation: Seoul National University
Country: Korea


  1. Shin J, Kim J, Pak K, Kang J, Kim T, Lee S, et al. A Combination of Soybean and Haematococcus Extract Alleviates Ultraviolet B-Induced Photoaging. Int J Mol Sci. 2017;18: pubmed publisher
    ..These results highlight the potential for SHM to be developed as a therapeutic agent to prevent UVB-induced skin wrinkling. ..
  2. Jung S, Lee M, Lim D, Kim J, Singh P, Lee S, et al. Isoliquiritigenin induces apoptosis and inhibits xenograft tumor growth of human lung cancer cells by targeting both wild type and L858R/T790M mutant EGFR. J Biol Chem. 2014;289:35839-48 pubmed publisher
    ..Taken together, ILQ suppresses NSCLC cell growth by directly targeting wild type or mutant EGFR. ..
  3. Lim T, Kim J, Lee S, Park J, Yeom M, Chen H, et al. The daidzein metabolite, 6,7,4'-Trihydroxyisoflavone, is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1. Int J Mol Sci. 2014;15:21419-32 pubmed publisher
    ..Overall, we elucidated the inhibitory effect of 6,7,4'-THIF on sUV-induced MMPs and suggest PKCα as its direct molecular target. ..
  4. Byun S, Lim S, Mun J, Kim K, Ramadhar T, Farrand L, et al. Identification of a Dual Inhibitor of Janus Kinase 2 (JAK2) and p70 Ribosomal S6 Kinase1 (S6K1) Pathways. J Biol Chem. 2015;290:23553-62 pubmed publisher
    ..These findings provide rationale for dual targeting of JAK2 and S6K1 in cancer for a combinatorial therapeutic approach. ..
  5. Kang S, Kim J, Li Y, Jung S, Song N, Thimmegowda N, et al. Hirsutenone in Alnus extract inhibits akt activity and suppresses prostate cancer cell proliferation. Mol Carcinog. 2015;54:1354-62 pubmed publisher
    ..Our results show that hirsutenone suppresses human prostate cancer by targeting Akt1 and 2 as a key component to explain for anti-cancer activity of Alnus species. ..
  6. Park G, Baek S, Kim J, Lim T, Lee C, Yang H, et al. Flt3 is a target of coumestrol in protecting against UVB-induced skin photoaging. Biochem Pharmacol. 2015;98:473-83 pubmed publisher
    ..These findings suggest that coumestrol is a novel dietary compound with potential application in preventing and improving UVB-associated skin aging. ..
  7. Son J, Jeong H, Kim H, Kim Y, Lee E, Lee H, et al. Pelargonidin attenuates PDGF-BB-induced aortic smooth muscle cell proliferation and migration by direct inhibition of focal adhesion kinase. Biochem Pharmacol. 2014;89:236-45 pubmed publisher
  8. Cho H, Lim D, Kwon G, Kim J, Huang Z, Song H, et al. Benzyl Isothiocyanate Inhibits Prostate Cancer Development in the Transgenic Adenocarcinoma Mouse Prostate (TRAMP) Model, Which Is Associated with the Induction of Cell Cycle G1 Arrest. Int J Mol Sci. 2016;17:264 pubmed publisher
    ..These results indicate that inhibition of cell cycle progression contributes to the inhibition of prostate cancer development in TRAMP mice treated with BITC. ..
  9. Kang H, Lee C, Kim J, Kwon J, Son M, Kim J, et al. Theobroma cacao extract attenuates the development of Dermatophagoides farinae-induced atopic dermatitis-like symptoms in NC/Nga mice. Food Chem. 2017;216:19-26 pubmed publisher
    ..CE also significantly alleviated transepidermal water loss and increased skin hydration. These results suggest that CE, a natural phytochemical-rich food, has potential therapeutic efficacy for the treatment of AD. ..

More Information


  1. Kim J, Lee K. Silkworm Thorn Stem Extract Targets RSK2 and Suppresses Solar UV-Induced Cyclooxygenase-2 Expression. Int J Mol Sci. 2015;16:25096-107 pubmed publisher
    ..These results suggest a potential for SWE to be developed as a cosmeceutical material and functional food constituent for the promotion of skin health. ..
  2. Park S, Kwon S, Lim S, Kim J, Lee K, Park J. Licoricidin, an Active Compound in the Hexane/Ethanol Extract of Glycyrrhiza uralensis, Inhibits Lung Metastasis of 4T1 Murine Mammary Carcinoma Cells. Int J Mol Sci. 2016;17: pubmed publisher
    ..The present study demonstrates that the licoricidin in HEGU inhibits lung metastasis of 4T1 mammary carcinoma cells, which may be mediated via inhibition of cancer cell migration, tumor angiogenesis, and lymphangiogenesis. ..
  3. Kang H, Lee C, Kim J, Kwon J, Seo S, Han J, et al. Chlorella vulgaris Attenuates Dermatophagoides Farinae-Induced Atopic Dermatitis-Like Symptoms in NC/Nga Mice. Int J Mol Sci. 2015;16:21021-34 pubmed publisher
    ..In addition, CV treatment downregulated mRNA expression levels of IL-4 and IFN-γ. Taken together, these results suggest that CV extract may have potential as a nutraceutical ingredient for the prevention of AD. ..
  4. Kim H, Kang Y, Lee J, Chang H, Lee K, Apostolidis E, et al. The Postprandial Anti-Hyperglycemic Effect of Pyridoxine and Its Derivatives Using In Vitro and In Vivo Animal Models. Nutrients. 2018;10: pubmed publisher
    ..Therefore, pyridoxal may have the potential to be used as a food ingredient for the prevention of prediabetes progression to type 2 diabetes. ..
  5. Kim J, Song D, Kim J, Choi J, Kim J, Yoon H, et al. Oral Supplementation with Cocoa Extract Reduces UVB-Induced Wrinkles in Hairless Mouse Skin. J Invest Dermatol. 2016;136:1012-1021 pubmed publisher
    ..These results suggest that cacao extract may offer a protective effect against photoaging by inhibiting the breakdown of dermal matrix, which leads to an overall reduction in wrinkle formation. ..
  6. Kim J, Shim J, Lee S, Cho W, Hong E, Lee J, et al. Rg3-enriched ginseng extract ameliorates scopolamine-induced learning deficits in mice. BMC Complement Altern Med. 2016;16:66 pubmed publisher
    ..e., phosphorylation of p65) in the hippocampus. These findings suggest that Rg3GE may stabilize scopolamine-induced memory deficits through the inhibition of acetylcholinesterase activity and NF-κB signaling in the hippocampus. ..
  7. Song N, Kim J, Park J, Kim J, Kang H, Lee E, et al. Licochalcone A, a polyphenol present in licorice, suppresses UV-induced COX-2 expression by targeting PI3K, MEK1, and B-Raf. Int J Mol Sci. 2015;16:4453-70 pubmed publisher
    ..Collectively, these results provide insight into the biological action of LicoA, which may have potential for development as a skin cancer chemopreventive agent. ..
  8. Lee C, Dudonné S, Dubé P, Desjardins Y, Kim J, Kim J, et al. Comprehensive phenolic composition analysis and evaluation of Yak-Kong soybean (Glycine max) for the prevention of atherosclerosis. Food Chem. 2017;234:486-493 pubmed publisher
    ..YK has promising potential for further development as a functional food source targeted at atherosclerosis prevention. ..
  9. Byun S, Lee E, Lee K. Therapeutic Implications of Autophagy Inducers in Immunological Disorders, Infection, and Cancer. Int J Mol Sci. 2017;18: pubmed publisher
    ..This review covers recent developments in the understanding of autophagy and discusses potential therapeutic interventions that may alter the outcomes of certain diseases. ..
  10. Lee C, Dudonné S, Kim J, Kim J, Dubé P, Kim J, et al. A major daidzin metabolite 7,8,4'-trihydroxyisoflavone found in the plasma of soybean extract-fed rats attenuates monocyte-endothelial cell adhesion. Food Chem. 2018;240:607-614 pubmed publisher
    ..Therefore, 7,8,4'-THI, a highly bioavailable hydroxylated isoflavone metabolite, has potential anti-atherosclerotic effect via inhibiting monocyte-endothelial adhesion. ..
  11. Kim J, Lee S, Jang M, Choi H, Kim J, Chen H, et al. Coumestrol Epigenetically Suppresses Cancer Cell Proliferation: Coumestrol Is a Natural Haspin Kinase Inhibitor. Int J Mol Sci. 2017;18: pubmed publisher
    ..These findings suggest that the anti-cancer effect of coumestrol is due to the direct targeting of haspin kinase. Coumestrol has considerable potential for further development as a novel anti-cancer agent. ..
  12. Lee C, Kim J, Kim J, Oh Y, Han S, Park J, et al. 5-(3',4'-Dihydroxyphenyl-γ-valerolactone), a Major Microbial Metabolite of Proanthocyanidin, Attenuates THP-1 Monocyte-Endothelial Adhesion. Int J Mol Sci. 2017;18: pubmed publisher
    ..We suggested that DHPV has higher potentiality in prevention of atherosclerosis among the proanthocyanidin metabolites. ..
  13. Kim J, Lee E, Friedline R, Suk S, Jung D, Dagdeviren S, et al. Endoplasmic reticulum chaperone GRP78 regulates macrophage function and insulin resistance in diet-induced obesity. FASEB J. 2017;: pubmed publisher
    ..Noh, H. L., Kwon, J. Y., Nambu, A., Huh, J. R., Han, M. S., Davis, R. J., Lee, A. S., Lee, K. W., Kim, J. K. Endoplasmic reticulum chaperone GRP78 regulates macrophage function and insulin resistance in diet-induced obesity...
  14. Choi J, Seo M, Shin K, Lee K, Oh D. Synergistic production of 20(S)-protopanaxadiol from protopanaxadiol-type ginsenosides by ?-glycosidases from Dictyoglomus turgidum and Caldicellulosiruptor bescii. AMB Express. 2017;7:219 pubmed publisher
    ..Thus, DT-bgl combined with CB-bgl completely converted PPD-type ginsenosides to APPD with the highest volumetric and specific productivities reported thus far. ..