Hyo Suk Lee

Summary

Affiliation: Seoul National University
Country: Korea

Publications

  1. ncbi request reprint Therapeutic efficacy of transcatheter arterial chemoembolization as compared with hepatic resection in hepatocellular carcinoma patients with compensated liver function in a hepatitis B virus-endemic area: a prospective cohort study
    Hyo Suk Lee
    Department of Internal Medicine, Liver Research Institute, Seoul National University Hospital, Chongno Gu, Korea
    J Clin Oncol 20:4459-65. 2002
  2. pmc Mathematical modeling of triphasic viral dynamics in patients with HBeAg-positive chronic hepatitis B showing response to 24-week clevudine therapy
    Hwi Young Kim
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea
    PLoS ONE 7:e50377. 2012
  3. pmc Pseudomonas aeruginosa bacteremia in patients with liver cirrhosis: a comparison with bacteremia caused by Enterobacteriaceae
    Ji Hwan Bang
    Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehak ro Jongno gu, 110 744, Seoul, Republic of Korea
    BMC Infect Dis 13:332. 2013
  4. pmc Clinical outcomes of spontaneous bacterial peritonitis due to extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella species: a retrospective matched case-control study
    Kyoung Ho Song
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    BMC Infect Dis 9:41. 2009
  5. ncbi request reprint A 12-week clevudine therapy showed potent and durable antiviral activity in HBeAg-positive chronic hepatitis B
    Hyo Suk Lee
    Seoul National University Hospital, South Korea
    Hepatology 43:982-8. 2006
  6. ncbi request reprint Liver transplantation for hepatocellular carcinoma beyond the Milan criteria: the controversies continue
    Hyo Suk Lee
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Dig Dis 25:296-8. 2007
  7. ncbi request reprint Management of patients with hepatocellular carcinoma and extrahepatic metastasis
    Hyo Suk Lee
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Dig Dis 29:333-8. 2011
  8. ncbi request reprint [The expression of E-cadherin in human and rat hepatic stellate cells: evidence of epithelial-mesenchymal transition]
    Young Suk Lim
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Taehan Kan Hakhoe Chi 8:90-9. 2002
  9. doi request reprint Hepatocellular carcinoma: high hepatitis B viral load and mortality in patients treated with transarterial chemoembolization
    Su Jong Yu
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 101 Daehak Ro, Jongno gu, Seoul, 110 744, Republic of Korea
    Radiology 267:638-47. 2013
  10. ncbi request reprint High rates of progressive hepatic functional deterioration whether lamivudine therapy is continued or discontinued after emergence of a lamivudine-resistant mutant: a prospective randomized controlled study
    Yoon Jun Kim
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 28 Yungun Dong, Chongno Gu, Seoul, 110 744, Korea
    J Gastroenterol 41:240-9. 2006

Detail Information

Publications122 found, 100 shown here

  1. ncbi request reprint Therapeutic efficacy of transcatheter arterial chemoembolization as compared with hepatic resection in hepatocellular carcinoma patients with compensated liver function in a hepatitis B virus-endemic area: a prospective cohort study
    Hyo Suk Lee
    Department of Internal Medicine, Liver Research Institute, Seoul National University Hospital, Chongno Gu, Korea
    J Clin Oncol 20:4459-65. 2002
    ....
  2. pmc Mathematical modeling of triphasic viral dynamics in patients with HBeAg-positive chronic hepatitis B showing response to 24-week clevudine therapy
    Hwi Young Kim
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea
    PLoS ONE 7:e50377. 2012
    ..The aim was to develop a novel method of mathematical modeling to shed light on the dissociation between early and long-term dynamics in previous studies...
  3. pmc Pseudomonas aeruginosa bacteremia in patients with liver cirrhosis: a comparison with bacteremia caused by Enterobacteriaceae
    Ji Hwan Bang
    Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehak ro Jongno gu, 110 744, Seoul, Republic of Korea
    BMC Infect Dis 13:332. 2013
    ..This study was performed to detect risk factors for Pseudomonas aeruginosa bacteremia in patients with liver cirrhosis...
  4. pmc Clinical outcomes of spontaneous bacterial peritonitis due to extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella species: a retrospective matched case-control study
    Kyoung Ho Song
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    BMC Infect Dis 9:41. 2009
    ..Clinical outcomes of spontaneous bacterial peritonitis (SBP) due to extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella species (ESBL-EK) have not been adequately investigated...
  5. ncbi request reprint A 12-week clevudine therapy showed potent and durable antiviral activity in HBeAg-positive chronic hepatitis B
    Hyo Suk Lee
    Seoul National University Hospital, South Korea
    Hepatology 43:982-8. 2006
    ....
  6. ncbi request reprint Liver transplantation for hepatocellular carcinoma beyond the Milan criteria: the controversies continue
    Hyo Suk Lee
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Dig Dis 25:296-8. 2007
    ..Further research on the predictors of benefit of LDLT to HCC patients other than the size and number of HCC such as molecular profiling of HCC are necessary to finally reach a consensus...
  7. ncbi request reprint Management of patients with hepatocellular carcinoma and extrahepatic metastasis
    Hyo Suk Lee
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Dig Dis 29:333-8. 2011
    ..The outcome of ongoing clinical trials of the multidisciplinary approach, combining conventional locoregional therapy and targeted systemic therapy, is pending...
  8. ncbi request reprint [The expression of E-cadherin in human and rat hepatic stellate cells: evidence of epithelial-mesenchymal transition]
    Young Suk Lim
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Taehan Kan Hakhoe Chi 8:90-9. 2002
    ..To further explore the origin and the differentiation of HSCs we studied the expression of E-cadherin, the specific marker of epithelial cells, in human and rat HSCs...
  9. doi request reprint Hepatocellular carcinoma: high hepatitis B viral load and mortality in patients treated with transarterial chemoembolization
    Su Jong Yu
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 101 Daehak Ro, Jongno gu, Seoul, 110 744, Republic of Korea
    Radiology 267:638-47. 2013
    ..To determine the relationship between hepatitis B virus (HBV) DNA level and the survival of patients with hepatocellular carcinoma treated by means of transarterial chemoembolization (TACE)...
  10. ncbi request reprint High rates of progressive hepatic functional deterioration whether lamivudine therapy is continued or discontinued after emergence of a lamivudine-resistant mutant: a prospective randomized controlled study
    Yoon Jun Kim
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 28 Yungun Dong, Chongno Gu, Seoul, 110 744, Korea
    J Gastroenterol 41:240-9. 2006
    ..The management of patients with lamivudine-resistant mutants remains challenging, and no clear evidence has been presented concerning the discontinuation of lamivudine...
  11. doi request reprint Simple scoring system predicting genotypic resistance during rescue therapy for Lamivudine-resistant chronic hepatitis B
    Jeong Hoon Lee
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea
    J Clin Gastroenterol 46:243-50. 2012
    ..In this study, we aimed to devise a simple scoring system predicting the risk of genotypic resistance (GR) to current rescue therapies for patients with lamivudine (LAM)-resistant chronic hepatitis B...
  12. doi request reprint Negative hepatitis B envelope antigen predicts intrahepatic recurrence in hepatitis B virus-related hepatocellular carcinoma after ablation therapy
    Goh Eun Chung
    Department of Internal Medicine, Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Korea
    J Gastroenterol Hepatol 26:1638-45. 2011
    ..We aimed to evaluate predictors of intrahepatic recurrence and clarify the correlation between viral load and intrahepatic recurrence after percutaneous ablation...
  13. pmc Validation of P2/MS for reflecting hepatic fibrosis in patients with hepatocellular carcinoma
    Su Jong Yu
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Korean J Hepatol 16:389-96. 2010
    ..P2/MS is known as a simple, accurate, and noninvasive marker for determination of the degree of hepatic fibrosis in patients with viral hepatitis. We aimed to validate P2/MS in patients with HCC...
  14. ncbi request reprint Prevalence of naturally occurring surface antigen variants of hepatitis B virus in Korean patients infected chronically
    Byung Cheol Song
    Department of Internal Medicine, College of Medicine, Cheju National University, Jeju, Korea
    J Med Virol 76:194-202. 2005
    ..Second, several novel variants associated with mutations outside the 'a' determinant were detected. Finally, a higher prevalence of MHR variants was associated with HBeAg-negative serostatus and severe liver disease, particularly HCC...
  15. ncbi request reprint Association of TNF-alpha promoter polymorphisms with the clearance of hepatitis B virus infection
    Yoon Jun Kim
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 28 Yungun Dong, Chongno Gu, Seoul 110 744, Korea
    Hum Mol Genet 12:2541-6. 2003
    ..003-0.02). Our findings imply that variations in the genes governing the levels of constitutive and inducible TNF-alpha might be an important factor, which might explain the variable outcome of HBV infection...
  16. ncbi request reprint Anti-apoptotic N-cadherin signaling and its prognostic implication in human hepatocellular carcinomas
    Geum Youn Gwak
    Department of Internal Medicine, Seoul National University College of Medicine, Chongno Gu, Seoul, Republic of Korea
    Oncol Rep 15:1117-23. 2006
    ..Our findings implicate N-cadherin signaling as contributing to HCC progression by exerting anti-apoptotic effects. Thus, we suggest that the selective interruption of this signaling may have therapeutic potential...
  17. doi request reprint Clevudine-induced viral response, associated with continued reduction of HBsAg titer, was durable after the withdrawal of therapy
    Hyo Suk Lee
    Seoul National University Hospital, Seoul, Korea
    J Gastroenterol 46:410-4. 2011
    ..This study was conducted to evaluate the durability of clevudine-induced viral response after the withdrawal of treatment...
  18. pmc Clinical prediction of failure of Lamivudine prophylaxis for hepatitis B virus-infected patients undergoing cytotoxic chemotherapy for malignancy
    In Kyoung Kim
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, South Korea
    Antimicrob Agents Chemother 56:5511-9. 2012
    ..Patients with high viremia, liver cirrhosis, rituximab treatment, and distant metastasis are at high risk of prophylactic failure and need antiviral agents with a greater barrier to resistance...
  19. doi request reprint Caudate lobe hepatocellular carcinoma treated with selective chemoembolization
    Hyo Cheol Kim
    Department of Radiology, Seoul National University College of Medicine Institute of Radiation Medicine Seoul National University Medical Research Center, Seoul, Korea
    Radiology 257:278-87. 2010
    ..To analyze the clinical outcomes of chemoembolization for solitary caudate lobe hepatocellular carcinoma (HCC) found at initial presentation...
  20. doi request reprint Lack of association of RAD51 genetic variations with hepatitis B virus clearance and occurrence of hepatocellular carcinoma in a Korean population
    Charisse Flerida A Pasaje
    Department of Life Science, Sogang University, Seoul, Republic of Korea
    J Med Virol 83:1892-9. 2011
    ..Although studies in other populations are needed to confirm these findings, this preliminary data may contribute to the current knowledge on the pathogenesis of hepatitis...
  21. ncbi request reprint CCND2 polymorphisms associated with clearance of HBV infection
    Tae Joon Park
    Department of Life Science, Sogang University, Shinsu dong, Mapo gu, Seoul, Korea
    J Hum Genet 55:416-20. 2010
    ..429 vs 0.374, P=0.0009). The information identified in this study might provide valuable insights into generating strategies for control of HBV...
  22. ncbi request reprint Clevudine therapy for 24 weeks further reduced serum hepatitis B virus DNA levels and increased ALT normalization rates without emergence of viral breakthrough than 12 weeks of clevudine therapy
    Kwan Sik Lee
    Yonsei University Hospital, Seoul, Korea
    Intervirology 50:296-302. 2007
    ..The objectives of the study were to evaluate the safety and antiviral activity of 24-week treatment with clevudine 30 mg in HBeAg(+) chronic hepatitis B patients. Biochemical and serological responses were also assessed...
  23. ncbi request reprint Bile acid-mediated thrombospondin-1 induction in hepatocytes leads to transforming growth factor-beta-dependent hepatic stellate cell activation
    Sun Jung Myung
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul 110 744, Republic of Korea
    Biochem Biophys Res Commun 353:1091-6. 2007
    ..These observations imply that bile acids induce thrombospondin-1 expression in hepatocytes, which activates latent TGF-beta leading to HSC activation...
  24. ncbi request reprint Analysis of hepatitis B virus quasispecies distribution in a Korean chronic patient based on the full genome sequences
    Hong Kim
    Department of Microbiology and Immunology, Liver Research Institute and Cancer Research Institute, College of Medicine, Seoul National University, Seoul, Korea
    J Med Virol 79:212-9. 2007
    ....
  25. doi request reprint Improved outcome of adult recipients with a high model for end-stage liver disease score and a small-for-size graft
    Nam Joon Yi
    Department of Surgery, Seoul National University College of Medicine, Seoul, Korea
    Liver Transpl 15:496-503. 2009
    ..7%) (p = 0.072). In conclusion, high MELD score (>25) didn't predict 1-YSR in ALDLT. Improvement of the 1-YSR might be affected by center's experience as well as the selection of patients with low risk of recurrence of HCC...
  26. pmc Identification of a cholangiocarcinoma-like gene expression trait in hepatocellular carcinoma
    Hyun Goo Woo
    Department of Internal Medicine, Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Cancer Res 70:3034-41. 2010
    ..In conclusion, we suggest that the acquisition of cholangiocarcinoma-like expression traits plays a critical role in the heterogeneous progression of HCC...
  27. doi request reprint Retinoic acid and its binding protein modulate apoptotic signals in hypoxic hepatocellular carcinoma cells
    Jeong Hoon Lee
    Department of Internal Medicine, Liver Research Institute, Seoul National University College of Medicine, Chongno Gu, Seoul, Republic of Korea
    Cancer Lett 295:229-35. 2010
    ..Therefore, RA/CRABP-II signal modulation is therapeutically implicated in infiltrative HCCs exposed to hypoxia...
  28. doi request reprint Ursodeoxycholic acid-induced inhibition of DLC1 protein degradation leads to suppression of hepatocellular carcinoma cell growth
    Goh Eun Chung
    Department of Internal Medicine, Gangnam Healthcare Center, Seoul National University Hospital, Seoul, Republic of Korea
    Oncol Rep 25:1739-46. 2011
    ..These observations implicate UDCA as an anti-proliferative agent in HCC...
  29. ncbi request reprint Validation of P2/MS and other noninvasive fibrosis scoring systems in the Korean population with nonalcoholic fatty liver disease
    Su Jong Yu
    Department of Internal Medicine and Healthcare Research Institute, Seoul National University Hospital, Healthcare System Gangnam Center, Korea
    Korean J Gastroenterol 57:19-27. 2011
    ..This study aimed to validate P2/MS and compare it to other noninvasive fibrosis scoring systems in Korean patients with NAFLD...
  30. ncbi request reprint Small single-nodule hepatocellular carcinoma: comparison of transarterial chemoembolization, radiofrequency ablation, and hepatic resection by using inverse probability weighting
    Hyo Joon Yang
    From the Department of Internal Medicine and Liver Research Institute H J Y, J H L, D H L, S J Y, Y J K, J H Y, H S L, Department of Radiology H C K, J M L, J W C, and Department of Surgery N J Y, K W L, K S S, Seoul National University College of Medicine, 103 Daehak Ro, Jongno gu, Seoul 110 744, Korea
    Radiology 271:909-18. 2014
    ....
  31. ncbi request reprint IGF2 polymorphisms are associated with hepatitis B virus clearance and hepatocellular carcinoma
    Yoon Jun Kim
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 28 Yeongeon dong, Chongno Gu, Seoul 110 744, Republic of Korea
    Biochem Biophys Res Commun 346:38-44. 2006
    ..88, 1.68; P=0.04). IGF2 polymorphisms were found to be strongly associated with the clearance of HBV or the occurrence of HCC in patients with chronic HBV infection...
  32. doi request reprint Noninvasive fibrosis indices predict intrahepatic distant recurrence of hepatitis B-related hepatocellular carcinoma following radiofrequency ablation
    Ji Yeon Seo
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Liver Int 33:884-93. 2013
    ..Hence, the aim of this study was to elucidate the correlation between noninvasive fibrosis indices and intrahepatic distant recurrence (IDR) of HCC after RFA...
  33. doi request reprint Hypoxia-inducible adrenomedullin accelerates hepatocellular carcinoma cell growth
    Su Cheol Park
    Department of Internal Medicine, Korea Institute of Radiological and Medical Sciences, Korea Cancer Center Hospital, Seoul, Republic of Korea
    Cancer Lett 271:314-22. 2008
    ..In conclusion, adrenomedullin signaling is hypoxia-inducible and functionally active in HCCs, and its expression may be a prognostic factor...
  34. ncbi request reprint Twenty-four-week clevudine therapy showed potent and sustained antiviral activity in HBeAg-positive chronic hepatitis B
    Byung Chul Yoo
    Samsung Medical Center, Sungkyunkwan University, and Yonsei University Hospital, Seoul, Korea
    Hepatology 45:1172-8. 2007
    ..The incidence of adverse events (AEs) was similar between the clevudine group and the placebo group. No resistance to clevudine was detected with 24 weeks of administration of drug...
  35. doi request reprint Predictors of HBsAg seroclearance in HBeAg-negative chronic hepatitis B patients
    Min Sun Kwak
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Digestion 84:23-8. 2011
    ..The aim of this study was to evaluate the annual HBsAg seroclearance rate and its predictors including serum HBV DNA levels in HBeAg-negative chronic hepatitis B patients...
  36. ncbi request reprint Low P2/MS value is an independent risk factor for early recurrence of hepatocellular carcinoma after radiofrequency ablation therapy
    Min Sun Kwak
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Hepatogastroenterology 58:147-52. 2011
    ..We aimed to evaluate the relationship between P2/MS value and hepatocellular carcinoma recurrence after radiofrequency ablation therapy in this study...
  37. doi request reprint Hypoxia and retinoic acid-inducible NDRG1 expression is responsible for doxorubicin and retinoic acid resistance in hepatocellular carcinoma cells
    Eun Uk Jung
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea
    Cancer Lett 298:9-15. 2010
    ..Thus, the selective interruption of NDRG1 signaling may prove to be therapeutically useful in HCCs, particularly in the advanced infiltrative type of tumors exposed to hypoxic environments...
  38. doi request reprint Inhibition of hypoxia-inducible carbonic anhydrase-IX enhances hexokinase II inhibitor-induced hepatocellular carcinoma cell apoptosis
    Su Jong Yu
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul 110 744, Korea
    Acta Pharmacol Sin 32:912-20. 2011
    ..Carbonic anhydrase-IX (CA-IX) is an enzyme lowering pH. This study is to examine whether hypoxia induces CA-IX in hepatocellular carcinoma (HCC) cells, and to evaluate its clinical implication in HCC patients...
  39. doi request reprint Hepatic steatosis index: a simple screening tool reflecting nonalcoholic fatty liver disease
    Jeong Hoon Lee
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 744, Republic of Korea
    Dig Liver Dis 42:503-8. 2010
    ..To optimize management of nonalcoholic fatty liver disease (NAFLD), a simple screening tool is necessary. In this study, we aimed to devise a simple index of NAFLD...
  40. doi request reprint Sodium taurocholate cotransporting polypeptide mediates dual actions of deoxycholic acid in human hepatocellular carcinoma cells: enhanced apoptosis versus growth stimulation
    Eun Sun Jang
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul National University Hospital, 101 Daehakro, Chongno Gu, Seoul, 110 744, Republic of Korea
    J Cancer Res Clin Oncol 140:133-44. 2014
    ..We investigated DC-induced alterations in HCC cell growth, with a particular focus on the effect of the expression of bile acid (BA)-transporting Na(+)-dependent taurocholic cotransporting polypeptides (NTCPs)...
  41. ncbi request reprint Identification of variants in NFKBIA and association analysis with hepatocellular carcinoma risk among chronic HBV patients
    Lyoung Hyo Kim
    Department of Genetic Epidemiology, SNP Genetics, Inc, 11th Floor, MaeHun B D, 13 Chongro 4 Ga, Chongro Gu, Seoul, Korea
    Hum Mutat 21:652-3. 2003
    ..As a conclusion, we could not find any significant association of NFKBIA variants with development of HCC among chronic hepatitis B patients...
  42. ncbi request reprint SPP1 polymorphisms associated with HBV clearance and HCC occurrence
    Hyoung Doo Shin
    Department of Genetic Epidemiology, SNP Genetics, Inc, Rm 1407, 14th Floor, Complex B, WooLim Lion s Valley, 371 28, Gasan Dong, Geumcheon gu, Seoul, 153 803, Republic of Korea
    Int J Epidemiol 36:1001-8. 2007
    ..We investigated the genetic polymorphisms in SPP1 to determine whether it is a potential candidate gene for a host genetic study of hepatitis B virus (HBV) clearance and HCC occurrence...
  43. ncbi request reprint Guggulsterone attenuates activation and survival of hepatic stellate cell by inhibiting nuclear factor kappa B activation and inducing apoptosis
    Bo Hyun Kim
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea Center for Liver Cancer, National Cancer Center, Goyang, Gyeonggi Do, Korea
    J Gastroenterol Hepatol 28:1859-68. 2013
    ..Guggulsterone has recently been shown to induce apoptosis in several cell lines. Thus, the aim of this study was to evaluate whether guggulsterone has antifibrotic activities by reducing the activation and survival of HSCs...
  44. ncbi request reprint Clinical outcome of bacteremic spontaneous bacterial peritonitis due to extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae
    Cheol In Kang
    Departments of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Korean J Intern Med 19:160-4. 2004
    ..This study was conducted to evaluate the risk factors for infection and clinical outcomes of bacteremic spontaneous bacterial peritonitis (SBP) due to ESBL-producing E. coli and K. pneumoniae, in patients with advanced liver cirrhosis...
  45. ncbi request reprint Diffuse infiltrative hepatocellular carcinomas in a hepatitis B-endemic area: diagnostic and therapeutic impediments
    Sun Jung Myung
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea
    Hepatogastroenterology 53:266-70. 2006
    ..Thus, in the present study, we were to assess the risk factors, mode of diagnosis and prognosis of D-HCCs in a hepatitis B virus-endemic area...
  46. ncbi request reprint Eupatilin attenuates bile acid-induced hepatocyte apoptosis
    Su Cheol Park
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 28 Yungun dong Chongno gu, Seoul 110 744, Republic of Korea
    J Gastroenterol 41:772-8. 2006
    ..This study was undertaken to examine if eupatilin modulates bile acid-induced hepatocyte apoptosis...
  47. doi request reprint Add-on adefovir is superior to a switch to entecavir as rescue therapy for Lamivudine-resistant chronic hepatitis B
    Goh Eun Chung
    Department of Internal Medicine, Gangnam Healthcare Center, Seoul National University Hospital, Seoul, Republic of Korea
    Dig Dis Sci 56:2130-6. 2011
    ..We validated the optimum treatment strategy for LAM-resistant patients by means of a comparative study of add-on adefovir (ADV) and a switch to entecavir (ETV)...
  48. doi request reprint Non-alcoholic fatty liver disease across the spectrum of hypothyroidism
    Goh Eun Chung
    Department of Internal Medicine, Healthcare Research Institute, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, South Korea
    J Hepatol 57:150-6. 2012
    ..The aim of this study was to characterize the relationship between the broad spectrum of hypothyroidism and NAFLD...
  49. doi request reprint Enhancement of hexokinase II inhibitor-induced apoptosis in hepatocellular carcinoma cells via augmenting ER stress and anti-angiogenesis by protein disulfide isomerase inhibition
    Su Jong Yu
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 101 Daehak Ro, Jongno gu, Seoul 110 744, Republic of Korea
    J Bioenerg Biomembr 44:101-15. 2012
    ..Thus, blockage of PDI activity in combination with HK II inhibitor may be therapeutically useful in HCCs...
  50. ncbi request reprint Enhanced epidermal growth factor receptor activation in human cholangiocarcinoma cells
    Jung Hwan Yoon
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul 110 744, South Korea
    J Hepatol 41:808-14. 2004
    ..However, the characteristics of EGFR signaling in cholangiocarcinoma cells have not been characterized. Thus, we attempted to more fully characterize EGF/EGFR signaling in human cholangiocarcinoma cells...
  51. doi request reprint Visceral obesity and insulin resistance as risk factors for colorectal adenoma: a cross-sectional, case-control study
    Hyoun Woo Kang
    Department of Internal Medicine, Liver Research Institute, Seoul National University College of Medicine, Korea
    Am J Gastroenterol 105:178-87. 2010
    ..The aim of this study was to examine VAT area and insulin resistance as risk factors of colorectal adenoma...
  52. doi request reprint Survival of infiltrative hepatocellular carcinoma patients with preserved hepatic function after treatment with transarterial chemoembolization
    Eun Sun Jang
    Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnamsi, Gyeonggido, Republic of Korea
    J Cancer Res Clin Oncol 139:635-43. 2013
    ..In this study, we aimed to document whether patients with infiltrative HCC would benefit from TACE...
  53. doi request reprint Long-term prognosis of combined hepatocellular and cholangiocarcinoma after curative resection comparison with hepatocellular carcinoma and cholangiocarcinoma
    Jeong Hoon Lee
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul, Republic of Korea
    J Clin Gastroenterol 45:69-75. 2011
    ..In this study, we attempted to evaluate the prognosis of combined hepatocellular and cholangiocarcinoma (cHCC-CC) with comparison to hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (CC)...
  54. ncbi request reprint Hepatitis B virus infection and B-cell non-Hodgkin's lymphoma in a hepatitis B endemic area: a case-control study
    Jee Hyun Kim
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul 110 744, South Korea
    Jpn J Cancer Res 93:471-7. 2002
    ..The present study suggests that the risk of B-cell non-Hodgkin's lymphoma is increased in HBV carriers and warrants further investigation of the possible role of hepatitis B virus in the pathogenesis of B-cell non-Hodgkin's lymphoma...
  55. pmc Efficacy of adefovir-based combination therapy for patients with Lamivudine- and entecavir-resistant chronic hepatitis B virus infection
    Yun Bin Lee
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea
    Antimicrob Agents Chemother 57:6325-32. 2013
    ..Further study is warranted to evaluate the efficacy of a more potent tenofovir-based regimen in such patients. ..
  56. pmc Aberrant CpG island hypermethylation along multistep hepatocarcinogenesis
    Sun Lee
    Department of Pathology, Seoul National University College of Medicine, Seoul, Korea
    Am J Pathol 163:1371-8. 2003
    ..CpG island methylation of E-cadherin or GSTP1 might serve as a potential biomarker for prognostication of HCC patients...
  57. ncbi request reprint Molecular epidemiology of hepatitis B virus (HBV) genotypes and serotypes in patients with chronic HBV infection in Korea
    Hong Kim
    Department of Microbiology and Immunology, Liver Research Institute and Cancer Research Institute, College of Medicine, Seoul National University, Seoul, Korea
    Intervirology 50:52-7. 2007
    ..Although hepatitis B virus (HBV) is endemic to Korea, no large-scale survey of HBV genotypes and serotypes based on sequence analysis has been performed...
  58. ncbi request reprint Wnt signaling enhances the activation and survival of human hepatic stellate cells
    Sun Jung Myung
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea
    FEBS Lett 581:2954-8. 2007
    ..Particularly, caspase 3 was more activated in sFRP1 over-expressing cells following TRAIL and Wnt3A treatment. These observations imply that Wnt signaling promotes hepatic fibrosis by enhancing HSC activation and survival...
  59. pmc Association of polymorphism in pri-microRNAs-371-372-373 with the occurrence of hepatocellular carcinoma in hepatitis B virus infected patients
    Min Sun Kwak
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea
    PLoS ONE 7:e41983. 2012
    ..Our study investigated whether pri-miRNAs-371-373 polymorphisms are associated with the risk of HCC occurrence and HBV clearance...
  60. doi request reprint Prognostic implications of tumor vascularity and its relationship to cytokeratin 19 expression in patients with hepatocellular carcinoma
    Goh Eun Chung
    Department of Internal Medicine, Gangnam Healthcare Center, Seoul National University Hospital, South Korea
    Abdom Imaging 37:439-46. 2012
    ..Cytokeratin 19 (CK19) is a marker for the biliary phenotype reflecting a poor prognosis. We assessed the prognostic implications of tumor vascularity and its association with CK19 expression in HCC...
  61. ncbi request reprint Lack of association between serum leptin levels and hepatic steatosis, fibrosis or response to antiviral therapy in Korean chronic hepatitis C patients
    Geum Youn Gwak
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 28 Yungun dong Chongno gu, Seoul 110 744, Republic of Korea
    Hepatogastroenterology 54:844-8. 2007
    ..In this study, we examined whether serum leptin levels are correlated with clinical, virological, and histological features, and with response to antiviral therapy in Korean CHC patients...
  62. ncbi request reprint Bile acid-mediated induction of cyclooxygenase-2 and Mcl-1 in hepatic stellate cells
    Kang Mo Kim
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul 110 744, South Korea
    Biochem Biophys Res Commun 342:1108-13. 2006
    ..These results imply that the bile acid-mediated inductions of COX-2 and Mcl-1 may lead to HSC survival in cholestatic liver diseases...
  63. doi request reprint Transarterial chemoembolization can be safely performed in patients with hepatocellular carcinoma invading the main portal vein and may improve the overall survival
    Goh Eun Chung
    Department of Internal Medicine, Gangnam Healthcare Center, Seoul National University Hospital, 28 Yungun Dong, Chongno Gu, Seoul 110 744, Korea
    Radiology 258:627-34. 2011
    ..To determine the efficacy and safety of transarterial chemoembolization (TACE) in patients with hepatocellular carcinoma (HCC) and main portal vein (MPV) invasion...
  64. ncbi request reprint Switch of cadherin expression from E- to N-type during the activation of rat hepatic stellate cells
    Young Suk Lim
    Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, 388 1 Pungnap 2dong, Songpa Gu, Seoul, 138 736, South Korea
    Histochem Cell Biol 127:149-60. 2007
    ..These results suggest that HSC activation represents transdifferentiation from an epithelial to a mesenchymal phenotype...
  65. ncbi request reprint Hepatocellular carcinoma with internal mammary artery supply: feasibility and efficacy of transarterial chemoembolization and factors affecting patient prognosis
    Hyo Cheol Kim
    Department of Radiology, Seoul National University College of Medicine, Institute of Radiation Medicine, Seoul National University Medical Research Center, and Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
    J Vasc Interv Radiol 18:611-9; quiz 620. 2007
    ..To determine technical feasibility, therapeutic efficacies, and identify prognostic factors in patients with hepatocellular carcinoma (HCC) treated by transarterial chemoembolization via the internal mammary artery...
  66. ncbi request reprint Modulation of cytokeratin expression during in vitro cultivation of human hepatic stellate cells: evidence of transdifferentiation from epithelial to mesenchymal phenotype
    Young Suk Lim
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 28 Yungun Dong, Chongno Gu, Seoul 110 744, Korea
    Histochem Cell Biol 118:127-36. 2002
    ..Our results suggest that HSCs may be of epithelial origin, and that they undergo the transdifferentiation from epithelial to mesenchymal phenotype during an activation process in vitro...
  67. ncbi request reprint Hypoxia stimulates proliferation of human hepatoma cells through the induction of hexokinase II expression
    Geum Youn Gwak
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 28 Yungun Dong, Chongno Gu, Seoul 110 744, South Korea
    J Hepatol 42:358-64. 2005
    ..This study was to evaluate if hexokinase II is participating in HCC cell survival in a hypoxic state, and to analyze the mechanism of cell death caused by hexokinase II-specific inhibition...
  68. ncbi request reprint [Efficacy of percutaneous ethanol injection therapy in Korean with hepatocellular carcinoma]
    Hyoun Woo Kang
    Department of Internal Medicine, Seoul National University College of Medicine, Jongno gu, Seoul, Korea
    Korean J Gastroenterol 42:502-9. 2003
    ..Thus, this study was to assess its efficacy and prognostic factors affecting tumor-free survival following PEIT in Korean HCC patients...
  69. ncbi request reprint Hepatic resection compared to percutaneous ethanol injection for small hepatocellular carcinoma using propensity score matching
    Yong Beom Cho
    Department of Surgery, Seoul National University College of Medicine, Seoul, Korea
    J Gastroenterol Hepatol 22:1643-9. 2007
    ..There have been several studies comparing hepatic resection (HR) and percutaneous ethanol injection (PEI) for the treatment of HCC. However, there is still disagreement about the best treatment modality...
  70. ncbi request reprint Bile acid-induced TGR5-dependent c-Jun-N terminal kinase activation leads to enhanced caspase 8 activation in hepatocytes
    Jong In Yang
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul 110 744, Republic of Korea
    Biochem Biophys Res Commun 361:156-61. 2007
    ..These observations suggest therapeutic applications for TGR5 signaling blockage in cholestasis...
  71. doi request reprint Transarterial chemoembolization with additional cisplatin infusion for hepatocellular carcinoma invading the hepatic vein
    Hyo Cheol Kim
    Department of Radiology, Seoul National University College of Medicine, Institute of Radiation Medicine, Seoul National University Medical Research Center, and Clinical Research Institute, Chongno Gu, Seoul 110 744, Korea
    J Vasc Interv Radiol 24:274-83. 2013
    ....
  72. ncbi request reprint Polymorphisms near interleukin 28B gene are not associated with hepatitis B virus clearance, hepatitis B e antigen clearance and hepatocellular carcinoma occurrence
    Dong Hyeon Lee
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea
    Intervirology 56:84-90. 2013
    ..In this study, we aimed to determine whether these polymorphisms could affect natural courses of HBV infection...
  73. doi request reprint The efficacy of adefovir plus entecavir combination therapy in patients with chronic hepatitis B refractory to both lamivudine and adefovir
    Yuri Cho
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul, 110 744, Republic of Korea
    Dig Dis Sci 58:1363-70. 2013
    ..We aimed to evaluate the efficacy of ADV plus ETV as compared to that of lamivudine (LAM) plus ADV in the patients with antiviral refractoriness to sequential LAM monotherapy and then ADV monotherapy...
  74. pmc Serum bilirubin levels are inversely associated with nonalcoholic fatty liver disease
    Min Sun Kwak
    Department of Internal Medicine, Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Korea
    Clin Mol Hepatol 18:383-90. 2012
    ..The aim of this study was thus to elucidate the association between serum total bilirubin levels and NAFLD...
  75. pmc Nonalcoholic fatty liver disease is associated with coronary artery calcification
    Donghee Kim
    Department of Internal Medicine, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Korea
    Hepatology 56:605-13. 2012
    ..28, 95% CI, 1.04-1.59; P = 0.023) independent of visceral adiposity...
  76. doi request reprint Risk factors, clinical features, and prognosis of the hepatocellular carcinoma with peritoneal metastasis
    Min Sun Kwak
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 28 Yungun Dong, Chongno Gu, Seoul 110 744, Korea
    Dig Dis Sci 57:813-9. 2012
    ..The clinical features and prognosis of hepatocellular carcinoma (HCC) with peritoneal metastasis have not been fully evaluated...
  77. ncbi request reprint TGFBR3 polymorphisms and its haplotypes associated with chronic hepatitis B virus infection and age of hepatocellular carcinoma occurrence
    Jeong Hyun Kim
    Department of Life Science, Sogang University, Seoul, Korea
    Dig Dis 29:278-83. 2011
    ..This study investigated whether TGFBR3 polymorphisms might be associated with HBV clearance and HCC occurrence...
  78. ncbi request reprint Characterization of two hepatitis B virus populations in a single Korean hepatocellular carcinoma patient with an HBeAg-negative serostatus: a novel X-Gene-deleted strain with inverted duplication sequences of upstream enhancer site II
    Hong Kim
    Department of Microbiology and Immunology, College of Medicine, Seoul National University, Seoul, Korea
    Intervirology 50:273-80. 2007
    ..The aim of the study was to elucidate mutation patterns related to hepatocarcinogenesis in a Korean hepatocellular carcinoma (HCC) patient...
  79. ncbi request reprint Long-term survival after pulmonary metastatectomy of hepatocellular carcinoma; treatment outcome or natural history?
    Geum Youn Gwak
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea
    Hepatogastroenterology 51:1428-33. 2004
    ..To evaluate the role of pulmonary metastatectomy in hepatocellular carcinoma...
  80. doi request reprint Antiviral efficacy of combination therapy with entecavir and adefovir for entecavir/lamivudine-resistant hepatitis B virus with or without adefovir resistance
    Hyo Joon Yang
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea
    J Med Virol 84:424-30. 2012
    ..Therefore, ETV/ADV combination therapy could be a useful therapeutic option for ETV- and LAM-resistant HBV without prior ADV resistance...
  81. doi request reprint The prevalence of hepatitis B virus preS deletions occurring naturally in Korean patients infected chronically with genotype C
    Ho Suk Mun
    Department of Microbiology and Immunology, Liver Research Institute and Cancer Research Institute, College of Medicine, Seoul National University, Seoul, South Korea
    J Med Virol 80:1189-94. 2008
    ..Specific deletion of the type disrupting preS1 start codon may play important roles in hepatocarcinogenesis, at least in Korean patients with chronic HBV infection...
  82. ncbi request reprint High expression of microRNA-15b predicts a low risk of tumor recurrence following curative resection of hepatocellular carcinoma
    Goh Eun Chung
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Oncol Rep 23:113-9. 2010
    ..These results indicate that miR-15b expression in HCC tissues may predict a low risk of HCC recurrence. In addition, the modulation of miR-15b expression may be useful as an apoptosis-sensitizing strategy for HCC treatment...
  83. doi request reprint Relative etiological role of prior hepatitis B virus infection and nonalcoholic fatty liver disease in the development of non-B non-C hepatocellular carcinoma in a hepatitis B-endemic area
    Eun Ju Cho
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Digestion 84:17-22. 2011
    ....
  84. doi request reprint Absence of symptom and intact liver function are positive prognosticators for patients undergoing radiotherapy for lymph node metastasis from hepatocellular carcinoma
    Kyubo Kim
    Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Republic of Korea
    Int J Radiat Oncol Biol Phys 78:729-34. 2010
    ..The positive role of radiotherapy for patients with lymph node (LN) metastasis from hepatocellular carcinoma has recently been reported. The outcome and prognostic factors for these patients were analyzed...
  85. doi request reprint Antituberculosis drug-induced liver injury in chronic hepatitis and cirrhosis
    Wan Beom Park
    Department of Internal Medicine, Seoul National University College of Medicine, 39 Boramae Road, Seoul, Republic of Korea
    J Infect 61:323-9. 2010
    ..To evaluate the incidence, risk factors and outcomes for anti-tuberculosis (TB) drug-induced liver injury (DILI) in patients with chronic liver disease including cirrhosis...
  86. ncbi request reprint [Analysis of prognostic factors after curative resection for combined hepatocellular and cholangiocarcinoma]
    Won Kim
    Department of Internal Medicine, Seoul National University College of Medicine, National University Hospital, 29 Yeongeon dong, Jong no gu, Seoul, Korea
    Korean J Gastroenterol 49:158-65. 2007
    ..The aim of this study was to evaluate the prognostic factors of combined HCC-CC after curative resection...
  87. doi request reprint Enhanced interleukin-2 diphtheria toxin conjugate-induced growth suppression in retinoic acid-treated hypoxic hepatocellular carcinoma cells
    Bo Hyun Kim
    Department of Internal Medicine and the Liver Research Institute, Seoul National University College of Medicine, 28 Yungun Dong, Chongno Gu, Seoul 110 744, Republic of Korea
    Cancer Lett 274:259-65. 2009
    ..Therefore, denileukin diftitox and RA may be therapeutically implicated in infiltrative HCCs which are exposed to hypoxic environments...
  88. ncbi request reprint Do young hepatocellular carcinoma patients with relatively good liver function have poorer outcomes than elderly patients?
    Soo Jeong Cho
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea
    J Gastroenterol Hepatol 22:1226-31. 2007
    ..The aim of this study was to compare the tumor characteristics and survival rates of young and old HCC patients, with respect to tumor stage...
  89. ncbi request reprint Putative association of Fas and FasL gene polymorphisms with clinical outcomes of hepatitis B virus infection
    Yong Jin Jung
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Intervirology 50:369-76. 2007
    ..This study was performed to determine whether Fas and FasL promoter polymorphisms are associated with clinical outcome in chronic HBV infection...
  90. ncbi request reprint Clevudine is highly efficacious in hepatitis B e antigen-negative chronic hepatitis B with durable off-therapy viral suppression
    Byung Chul Yoo
    Sungkyunkwan University Samsung Medical Center, Seoul, South Korea
    Hepatology 46:1041-8. 2007
    ..0006). ALT normalization in the clevudine group was well-maintained during the post-treatment follow-up period. The incidence of adverse events was similar in the 2 groups. No resistance to clevudine was detected during treatment...
  91. ncbi request reprint Association of transforming growth factor-beta1 gene polymorphisms with a hepatocellular carcinoma risk in patients with chronic hepatitis B virus infection
    Yoon Jun Kim
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul 110 744, Korea
    Exp Mol Med 35:196-202. 2003
    ....
  92. pmc Protein induced by vitamin K absence or antagonist-II production is a strong predictive marker for extrahepatic metastases in early hepatocellular carcinoma: a prospective evaluation
    Hyun Mi Bae
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea
    BMC Cancer 11:435. 2011
    ..We investigated the pretreatment predictors of extrahepatic metastases in HCC patients...
  93. ncbi request reprint Apoptosis-inducing antitumor efficacy of hexokinase II inhibitor in hepatocellular carcinoma
    Won Kim
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Mol Cancer Ther 6:2554-62. 2007
    ..Therefore, HK II inhibitors may be therapeutically useful for the treatment of advanced infiltrative hypovascular HCCs, which are growing in a hypoxic environment...
  94. ncbi request reprint Successful treatment for hepatocellular carcinoma with main portal vein tumor thrombi by 3-dimensional conformal radiation therapy combined with transarterial chemoembolization
    Geum Youn Gwak
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 28 Yungun dong Chongno gu, Seoul 110 744, Republic of Korea
    Hepatogastroenterology 55:673-6. 2008
    ..Therefore, although 3D-CRT combined with TAE cannot be routinely recommended because of anticipated hepatic functional deterioration, it can be cautiously considered for patients with MPV tumor thrombi...
  95. doi request reprint Gene expression-based recurrence prediction of hepatitis B virus-related human hepatocellular carcinoma
    Hyun Goo Woo
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Clin Cancer Res 14:2056-64. 2008
    ....
  96. ncbi request reprint Production of C-reactive protein in Escherichia coli-infected patients with liver dysfunction due to liver cirrhosis
    Wan Beom Park
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul 110 744, Republic of Korea
    Diagn Microbiol Infect Dis 51:227-30. 2005
    ..1-1.2) in patients without acute infection (P < 0.001). Our data suggest that, although CRP levels are reduced in response to acute infection, production is nevertheless maintained even in patients with advanced liver dysfunction...
  97. pmc Transcatheter arterial chemoembolization of hepatocellular carcinoma: prevalence and causative factors of extrahepatic collateral arteries in 479 patients
    Jin Wook Chung
    Department of Radiology, Seoul National University Hospital, Chongno Gu, Seoul, Korea
    Korean J Radiol 7:257-66. 2006
    ..We wanted to investigate the prevalence and causative factors of extrahepatic arterial blood supply to hepatocellular carcinoma (HCC) at its initial presentation and during chemoembolization...
  98. doi request reprint [Nonalcoholic fatty liver disease as a risk factor of cardiovascular disease: relation of non-alcoholic fatty liver disease to carotid atherosclerosis]
    Su Yeon Choi
    Seoul National University Hospital Healthcare System Gangnam Center, Healthcare Research Institute, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Korean J Hepatol 14:77-88. 2008
    ..The aim of the present study was to elucidate whether NAFLD is associated with carotid atherosclerosis...
  99. ncbi request reprint Hepatitis B virus X mutations occurring naturally associated with clinical severity of liver disease among Korean patients with chronic genotype C infection
    Hyun Ju Kim
    Department of Microbiology and Immunology, Liver Research Institute and Cancer Research Institute, College of Medicine, Seoul National University, Seoul, Korea
    J Med Virol 80:1337-43. 2008
    ..In particular, a novel mutation type (V5M/L) discovered firstly during the present study was found to be associated significantly with HCC...
  100. ncbi request reprint [A case of infiltrative hepatocellular carcinoma with main portal vein tumor thrombosis successfully treated by transarterial chemoembolization]
    Sun Jung Myung
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Korean J Hepatol 12:107-11. 2006
    ....
  101. doi request reprint [Clinical features of hepatic tuberculosis in biopsy-proven cases]
    Sung Wook Hwang
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Korean J Hepatol 15:159-67. 2009
    ..With the ever-increasing number of immunocompromised patients, it is expected that hepatic tuberculosis will occur more frequently. The aim of the present study was to establish the clinical manifestations and course of the disease...