Jun Soo Kwon

Summary

Affiliation: Seoul National University
Country: Korea

Publications

  1. pmc Dysfunction in configural face processing in patients with schizophrenia
    Yong Wook Shin
    Department of Neurosychiatry, Seoul National University Hospital, Seoul, Korea
    Schizophr Bull 34:538-43. 2008
  2. pmc Probable case of neuroleptic malignant syndrome following administration of antituberculotic drugs in a chlorpromazine-treated patient
    GeumSook Shim
    Department of Psychiatry, Seoul National University College of Medicine, Jongno gu, Seoul, Korea
    J Korean Med Sci 23:734-6. 2008
  3. ncbi Weight management program for treatment-emergent weight gain in olanzapine-treated patients with schizophrenia or schizoaffective disorder: A 12-week randomized controlled clinical trial
    Jun Soo Kwon
    Department of Psychiatry, Seoul National University College of Medicine, Chongno Gu, Seoul, Korea
    J Clin Psychiatry 67:547-53. 2006
  4. ncbi Taq1A polymorphism in the dopamine D2 receptor gene as a predictor of clinical response to aripiprazole
    Jun Soo Kwon
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea
    Eur Neuropsychopharmacol 18:897-907. 2008
  5. ncbi A proton MRSI study of brain N-acetylaspartate level after 12 weeks of citalopram treatment in drug-naive patients with obsessive-compulsive disorder
    Joon Hwan Jang
    Department of Psychiatry, Seoul National University College of Medicine, 28 Yeongon dong, Chongno Gu, Seoul, Korea
    Am J Psychiatry 163:1202-7. 2006
  6. ncbi Hippocampal shape deformity analysis in obsessive-compulsive disorder
    Soon Beom Hong
    Department of Psychiatry, Seoul National University College of Medicine, SNUMRC, 28 Yongon Dong, Chongno Gu, 110 744 Seoul, Korea
    Eur Arch Psychiatry Clin Neurosci 257:185-90. 2007
  7. doi Long-term efficacy and safety of aripiprazole in patients with schizophrenia, schizophreniform disorder, or schizoaffective disorder: 26-week prospective study
    Jun Soo Kwon
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea
    Psychiatry Clin Neurosci 63:73-81. 2009
  8. doi Neuroimaging in obsessive-compulsive disorder
    Jun Soo Kwon
    Department of Psychiatry, Seoul National University College of Medicine, 101 Daehak no, Chongno Gu, Seoul, Korea 110 744
    Expert Rev Neurother 9:255-69. 2009
  9. doi Proton magnetic resonance spectroscopy in subjects with high genetic risk of schizophrenia: investigation of anterior cingulate, dorsolateral prefrontal cortex and thalamus
    So Young Yoo
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea
    Schizophr Res 111:86-93. 2009
  10. pmc Phase-specific brain change of spatial working memory processing in genetic and ultra-high risk groups of schizophrenia
    Jung Seok Choi
    Department of Psychiatry, Seoul National University College of Medicine, 101 Daehak no, Chongno Gu, Seoul 110 744, Korea
    Schizophr Bull 38:1189-99. 2012

Collaborators

Detail Information

Publications126 found, 100 shown here

  1. pmc Dysfunction in configural face processing in patients with schizophrenia
    Yong Wook Shin
    Department of Neurosychiatry, Seoul National University Hospital, Seoul, Korea
    Schizophr Bull 34:538-43. 2008
    ....
  2. pmc Probable case of neuroleptic malignant syndrome following administration of antituberculotic drugs in a chlorpromazine-treated patient
    GeumSook Shim
    Department of Psychiatry, Seoul National University College of Medicine, Jongno gu, Seoul, Korea
    J Korean Med Sci 23:734-6. 2008
    ....
  3. ncbi Weight management program for treatment-emergent weight gain in olanzapine-treated patients with schizophrenia or schizoaffective disorder: A 12-week randomized controlled clinical trial
    Jun Soo Kwon
    Department of Psychiatry, Seoul National University College of Medicine, Chongno Gu, Seoul, Korea
    J Clin Psychiatry 67:547-53. 2006
    ..The effects of the weight management program were also assessed with regard to safety and quality of life...
  4. ncbi Taq1A polymorphism in the dopamine D2 receptor gene as a predictor of clinical response to aripiprazole
    Jun Soo Kwon
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea
    Eur Neuropsychopharmacol 18:897-907. 2008
    ..The results suggest an association between the DRD2 Taq1A polymorphism status and the variation in the clinical response to aripiprazole...
  5. ncbi A proton MRSI study of brain N-acetylaspartate level after 12 weeks of citalopram treatment in drug-naive patients with obsessive-compulsive disorder
    Joon Hwan Jang
    Department of Psychiatry, Seoul National University College of Medicine, 28 Yeongon dong, Chongno Gu, Seoul, Korea
    Am J Psychiatry 163:1202-7. 2006
    ..The authors used proton magnetic resonance spectroscopic imaging ((1)H-MRSI) to investigate regional N-acetylaspartate level abnormalities and changes after 12 weeks of pharmacotherapy with citalopram in drug-naive OCD patients...
  6. ncbi Hippocampal shape deformity analysis in obsessive-compulsive disorder
    Soon Beom Hong
    Department of Psychiatry, Seoul National University College of Medicine, SNUMRC, 28 Yongon Dong, Chongno Gu, 110 744 Seoul, Korea
    Eur Arch Psychiatry Clin Neurosci 257:185-90. 2007
    ..Also, further considering the hippocampal neural connections specific to its surface topography, these surface deformities may reflect developmental alterations in these patients with regard to the neural circuitry involving hippocampus...
  7. doi Long-term efficacy and safety of aripiprazole in patients with schizophrenia, schizophreniform disorder, or schizoaffective disorder: 26-week prospective study
    Jun Soo Kwon
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea
    Psychiatry Clin Neurosci 63:73-81. 2009
    ..The aim of the present study was therefore to investigate the long-term efficacy, safety and tolerability of aripiprazole in a large number of patients with schizophrenia, schizophreniform disorder, or schizoaffective disorder in Korea...
  8. doi Neuroimaging in obsessive-compulsive disorder
    Jun Soo Kwon
    Department of Psychiatry, Seoul National University College of Medicine, 101 Daehak no, Chongno Gu, Seoul, Korea 110 744
    Expert Rev Neurother 9:255-69. 2009
    ..The limitations of traditional imaging techniques and recent developments to overcome them will also be discussed...
  9. doi Proton magnetic resonance spectroscopy in subjects with high genetic risk of schizophrenia: investigation of anterior cingulate, dorsolateral prefrontal cortex and thalamus
    So Young Yoo
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea
    Schizophr Res 111:86-93. 2009
    ....
  10. pmc Phase-specific brain change of spatial working memory processing in genetic and ultra-high risk groups of schizophrenia
    Jung Seok Choi
    Department of Psychiatry, Seoul National University College of Medicine, 101 Daehak no, Chongno Gu, Seoul 110 744, Korea
    Schizophr Bull 38:1189-99. 2012
    ..Our findings suggest that functional deficits associated with spatial WM processing emerge in the UHR before the onset of schizophrenia and compensatory neural processes exist in the GHR with genetic liability to schizophrenia...
  11. doi The relationship between antipsychotic D2 occupancy and change in frontal metabolism and working memory : A dual [(11)C]raclopride and [(18) F]FDG imaging study with aripiprazole
    Euitae Kim
    Department of Psychiatry, Seoul National University College of Medicine, 28 Yeongon dong, Chongno Gu, Seoul, 110 744, South Korea
    Psychopharmacology (Berl) 227:221-9. 2013
    ..This prompts the necessity of using an intermediate biomarker relating the drug effect on the brain to change in cognitive function...
  12. doi Impairment of source memory in patients with obsessive-compulsive disorder: equivalent current dipole analysis
    Young Youn Kim
    BK21 Research Division of Human Life Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea
    Psychiatry Res 165:47-59. 2009
    ..These results indicate that OCD patients have preserved item memory about content, but impaired source memory about context...
  13. ncbi Increased water diffusivity in the frontal and temporal cortices of schizophrenic patients
    Yong Wook Shin
    Clinical Cognitive Neuroscience Center, SNU MRC, Seoul, Republic of Korea
    Neuroimage 30:1285-91. 2006
    ..These findings contribute towards integrating micro and macrostructural abnormalities and syndromes of schizophrenia...
  14. ncbi Cortical network dynamics during source memory retrieval: current density imaging with individual MRI
    Young Youn Kim
    BK21 Research Division of Human Life Sciences, Seoul National University College of Medicine, Seoul, Korea
    Hum Brain Mapp 30:78-91. 2009
    ..These results indicate that multiple neural systems may underlie the ability to recollect context...
  15. doi Longitudinal patterns of social functioning and conversion to psychosis in subjects at ultra-high risk
    Joon Hwan Jang
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea
    Aust N Z J Psychiatry 45:763-70. 2011
    ..The effect of pharmacotherapy on the course of social dysfunction was also examined...
  16. pmc Cortical thickness reduction in individuals at ultra-high-risk for psychosis
    Wi Hoon Jung
    Department of Psychiatry and Behavioral Sciences, Seoul National University College of Medicine, 101 Daehak no, Chongno Gu, Seoul, South Korea
    Schizophr Bull 37:839-49. 2011
    ..These structural abnormalities might reflect functional decline at the prodromal stage of schizophrenia, and there may be progressive thinning of GM cortex over time...
  17. doi Pre-attentive auditory processing in ultra-high-risk for schizophrenia with magnetoencephalography
    Kyung Soon Shin
    Interdisciplinary Program in Cognitive Science, Seoul National University, Seoul, Korea
    Biol Psychiatry 65:1071-8. 2009
    ..Pre-attentive auditory deficits, which represent a core feature of schizophrenia, were investigated in individuals at UHR for schizophrenia...
  18. ncbi Neural correlates of clinical symptoms and cognitive dysfunctions in obsessive-compulsive disorder
    Jun Soo Kwon
    BK 21 Human Life Sciences, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 744, South Korea
    Psychiatry Res 122:37-47. 2003
    ..In particular, the frontal-subcortical circuits might mediate not only symptomatic expression but also cognitive expression in patients with OCD...
  19. ncbi Neuropsychological correlates of P300 abnormalities in patients with schizophrenia and obsessive-compulsive disorder
    Myung Sun Kim
    Department of Psychiatry, Seoul National University College of Medicine and Clinical Research Institute, Seoul National University Hospital, Seoul, South Korea
    Psychiatry Res 123:109-23. 2003
    ..The neurophysiological mechanisms underlying P300 abnormalities observed in schizophrenic and OCD patients are discussed...
  20. doi Taq1A polymorphism in the dopamine D2 receptor gene predicts brain metabolic response to aripiprazole in healthy male volunteers
    Euitae Kim
    Department of Psychiatry, Seoul National University College of Medicine, and Department of Clinical Pharmacology and Clinical Trial Center, Seoul National University Hospital, Seoul, Korea
    Pharmacogenet Genomics 18:91-7. 2008
    ..We investigated the metabolic response of glucose in the brain to aripiprazole in relation to the DRD2 Taq1A polymorphism...
  21. ncbi Functional disconnection between the prefrontal and parietal cortices during working memory processing in schizophrenia: a[15(O)]H2O PET study
    Jae Jin Kim
    Department of Psychiatry and Nuclear Medicine, College of Medicine, Seoul National University Hospital, 28 Yongun dong, Chongno Gu, Seoul, Korea 110 744
    Am J Psychiatry 160:919-23. 2003
    ..The purpose of this study was to use direct neuroimaging to address whether interregional correlation in the prefrontal-parietal circuits is impaired in schizophrenia...
  22. doi Multi-level comparison of empathy in schizophrenia: an fMRI study of a cartoon task
    Seung Jae Lee
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, South Korea
    Psychiatry Res 181:121-9. 2010
    ....
  23. ncbi Effect of cognitive training focusing on organizational strategies in patients with obsessive-compulsive disorder
    Hee Soo Park
    Department of Psychiatry, Seoul National University College of Medicine and Neuroscience Institute, SNU MRC, Korea
    Psychiatry Clin Neurosci 60:718-26. 2006
    ..Therefore, cognitive training, focusing on the improvement of organizational strategies, could be an effective treatment modality for patients with OCD...
  24. ncbi Integration of cross-modal emotional information in the human brain: an fMRI study
    Ji Young Park
    Interdisciplinary Program in Cognitive Science, Seoul National University, Seoul, Republic of Korea
    Cortex 46:161-9. 2010
    ..These emotion-specific activations suggest that each emotion uses a separate network to integrate bimodal information and shares a common network for cross-modal integration...
  25. doi Reduced prefrontal functional connectivity in the default mode network is related to greater psychopathology in subjects with high genetic loading for schizophrenia
    Joon Hwan Jang
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea
    Schizophr Res 127:58-65. 2011
    ..We sought to identify putative genetic vulnerability markers by examining whether aberrant DMN connectivity was present in GHR subjects with high genetic loading...
  26. doi Social cognition and neurocognition as predictors of conversion to psychosis in individuals at ultra-high risk
    Hee Sun Kim
    Clinical Cognitive Neuroscience Center, Neuroscience Institute, SNU MRC, Seoul, Republic of Korea
    Schizophr Res 130:170-5. 2011
    ..We examined longitudinally the social-cognitive and neurocognitive function of individuals at ultra-high risk for schizophrenia who developed psychosis later as predictive markers...
  27. doi The relationship between psychosocial functioning and resilience and negative symptoms in individuals at ultra-high risk for psychosis
    Kyung Ran Kim
    Department of Psychiatry, Yonsei University College of Medicine, Severance Hospital, Seoul, South Korea
    Aust N Z J Psychiatry 47:762-71. 2013
    ..We aimed to investigate whether psychosocial functioning is impaired in individuals in the putative prodromal phase of schizophrenia, and, if so, to identify factors associated with compromised psychosocial functioning...
  28. ncbi Electrophysiological correlates of behavioral response inhibition in patients with obsessive-compulsive disorder
    Myung Sun Kim
    Department of Psychology, Sungshin Women s University, Seoul, Korea
    Depress Anxiety 24:22-31. 2007
    ..In addition, NoGo-N2 seems to result in more accurate response inhibition measurements in patients with OCD than does NoGo-P3...
  29. ncbi Shape deformity of the corpus striatum in obsessive-compulsive disorder
    Jung Seok Choi
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea
    Psychiatry Res 155:257-64. 2007
    ....
  30. pmc Population pharmacokinetic modelling of aripiprazole and its active metabolite, dehydroaripiprazole, in psychiatric patients
    Jung Ryul Kim
    Department of Pharmacology, Seoul National University College of Medicine, Seoul, Korea
    Br J Clin Pharmacol 66:802-10. 2008
    ....
  31. ncbi Effects of DRD2 and CYP2D6 genotypes on delta EEG power response to aripiprazole in healthy male volunteers: a preliminary study
    Euitae Kim
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea
    Hum Psychopharmacol 21:519-28. 2006
    ..Our results demonstrate a need for further evaluation of the CYP2D6 genotypic effect on the pharmacodynamics of aripiprazole...
  32. ncbi Cortical thinning in obsessive compulsive disorder
    Yong Wook Shin
    Clinical Cognitive Neuroscience Center, SNU MRC, Seoul, Korea
    Hum Brain Mapp 28:1128-35. 2007
    ..Most thinned regions were located in the left ventral cortex system, providing a new perspective that this ventral cortical system may be involved in the pathophysiology of OCD...
  33. pmc The effect of meditation on brain structure: cortical thickness mapping and diffusion tensor imaging
    Do Hyung Kang
    Department of Psychiatry, Seoul National University College of Medicine, Seoul 110 744, Republic of Korea
    Soc Cogn Affect Neurosci 8:27-33. 2013
    ..Our findings suggest that long-term meditators have structural differences in both gray and white matter...
  34. doi Regional cortical thinning in subjects with high genetic loading for schizophrenia
    Min Soo Byun
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea
    Schizophr Res 141:197-203. 2012
    ..The effect of genetic loading on cortical thinning was also measured by comparing GHR subgroups according to the levels of genetic loading...
  35. doi Clinical and neurocognitive profiles of subjects at high risk for psychosis with and without obsessive-compulsive symptoms
    Ji Won Hur
    Department of Brain and Cognitive Sciences World Class University Program, College of Natural Sciences, Seoul National University, Seoul, Republic of Korea
    Aust N Z J Psychiatry 46:161-9. 2012
    ..However, few studies on the clinical and neurocognitive implications of OCS in individuals at ultra-high risk for psychosis (UHR) have been conducted...
  36. doi BOLD response during visual perception of biological motion in obsessive-compulsive disorder : an fMRI study using the dynamic point-light animation paradigm
    Wi Hoon Jung
    Interdisciplinary Program in Brain Science and in Cognitive Science, Seoul National University, Seoul, Korea
    Eur Arch Psychiatry Clin Neurosci 259:46-54. 2009
    ..We used functional magnetic resonance imaging (fMRI) to investigate neural activity associated with the perception of biological motion in OCD patients...
  37. doi Neuropsychological correlates of N400 anomalies in patients with schizophrenia: A preliminary report
    Kyung Soon Shin
    Interdisciplinary Program in Cognitive Science, Seoul National University, Seoul, Republic of Korea
    Neurosci Lett 448:226-30. 2008
    ..In addition, we concluded that the N400 amplitude is a candidate for an endophenotype marker of schizophrenia by revealing its relationship to neuropsychological deficits...
  38. doi General intellectual functioning as a buffer against theory-of-mind deficits in individuals at ultra-high risk for psychosis
    Ji Won Hur
    Department of Brain and Cognitive Sciences, World Class University Program, College of Natural Sciences, Seoul National University, Seoul, Republic of Korea
    Schizophr Res 149:83-7. 2013
    ..Our findings are discussed in relation to the role of neurocognitive abilities in ToM-related impairments in UHR individuals...
  39. pmc Aberrant auditory processing in schizophrenia and in subjects at ultra-high-risk for psychosis
    Kyung Soon Shin
    Neuroscience Institute, Seoul National University Medical Research Center, Seoul, Korea
    Schizophr Bull 38:1258-67. 2012
    ..Deficits in auditory sensory memory, on the other hand, may be similarly impaired in both groups...
  40. doi Do pathological gambling and obsessive-compulsive disorder overlap? a neurocognitive perspective
    Ji Won Hur
    Department of Brain and Cognitive Sciences, Seoul National University, Seoul, Korea
    CNS Spectr 17:207-13. 2012
    ..Pathological gambling (PG) is a severe and persistent pattern of problem gambling that has been aligned with obsessive-compulsive disorder (OCD). However, no study has compared the neurocognitive profiles of individuals with PG and OCD...
  41. ncbi Neuromagnetic auditory response and its relation to cortical thickness in ultra-high-risk for psychosis
    Kyung Soon Shin
    Clinical Cognitive Neuroscience Center, Neuroscience Institute, SNU MRC, Seoul, Republic of Korea
    Schizophr Res 140:93-8. 2012
    ..However, little is known about the relationship between perceptual processing and structural deficits in ultra-high-risk for psychosis...
  42. doi Influence of brain-derived neurotrophic factor and catechol O-methyl transferase polymorphisms on effects of meditation on plasma catecholamines and stress
    Ye Ha Jung
    Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea
    Stress 15:97-104. 2012
    ..This is the first evidence that meditation produces different effects on plasma catecholamines according to BDNF or COMT polymorphisms...
  43. pmc Reduced cortical folding of the anterior cingulate cortex in obsessive-compulsive disorder
    GeumSook Shim
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea
    J Psychiatry Neurosci 34:443-9. 2009
    ..We hypothesized that patients with OCD would show reduced cortical folding of the ACC compared with controls...
  44. doi Do organizational strategies mediate nonverbal memory impairment in drug-naïve patients with obsessive-compulsive disorder?
    Na Young Shin
    Interdisciplinary Cognitive Science Program, Seoul National University, Seoul, Korea
    Neuropsychology 24:527-33. 2010
    ..The present study aimed to examine nonverbal memory and organizational skill functions in psychotropic-naïve patients with OCD...
  45. ncbi White matter neuroplastic changes in long-term trained players of the game of "Baduk" (GO): a voxel-based diffusion-tensor imaging study
    Boreom Lee
    Clinical Cognitive Neuroscience Center, Neuroscience Institute, Seoul National University Medical Research Center, Seoul, Republic of Korea
    Neuroimage 52:9-19. 2010
    ....
  46. ncbi Fractal dimension of cerebral cortical surface in schizophrenia and obsessive-compulsive disorder
    Tae Hyon Ha
    Department of Psychiatry, Seoul National University College of Medicine and Hospital, 28 Yongon Dong, Chongno Gu, Seoul 110 744, Korea
    Neurosci Lett 384:172-6. 2005
    ..Further studies to explore regional FD changes in mental disorders and clinical implications of the FD including diagnostic value should be performed in the future...
  47. ncbi Impairment of recognition memory in schizophrenia: event-related potential study using a continuous recognition task
    Myung Sun Kim
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea
    Psychiatry Clin Neurosci 58:465-72. 2004
    ..All of these results suggest that schizophrenic patients have recognition memory impairment, the cause of which may range from early encoding, and memory search to late retrieval...
  48. doi An MEG study of alpha modulation in patients with schizophrenia and in subjects at high risk of developing psychosis
    Yuri Koh
    Clinical Cognitive Neuroscience Center, Neuroscience Institute, SNU MRC, Seoul, Republic of Korea
    Schizophr Res 126:36-42. 2011
    ..Because attention deficits have been noted in patients with schizophrenia, we examined alpha oscillations in schizophrenia and in the prodromal phase of psychosis...
  49. doi Processing of facial configuration in individuals at ultra-high risk for schizophrenia
    Hee Sun Kim
    Clinical Cognitive Neuroscience Center, Neuroscience Institute, SNU MRC, Seoul, Republic of Korea
    Schizophr Res 118:81-7. 2010
    ..However, little is known about whether these deficits in face recognition are present before the onset of schizophrenia...
  50. doi White matter alterations in male patients with obsessive-compulsive disorder
    Tae Hyon Ha
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea
    Neuroreport 20:735-9. 2009
    ..Our findings provide evidence that obsessive-compulsive disorder may be a heterogeneous disease with distinct white matter changes...
  51. ncbi An MRI study of structural variations in schizophrenia using deformation field morphometry
    Uicheul Yoon
    Department of Biomedical Engineering, Hanyang University, Sungdong P O Box 55, Seoul, 133 605, Korea
    Psychiatry Res 146:171-7. 2006
    ....
  52. ncbi Sex differences in the human corpus callosum: diffusion tensor imaging study
    Yong Wook Shin
    Neuroscience Institute, SNU MRC, Seoul, Korea
    Neuroreport 16:795-8. 2005
    ..We found increased T1 signal intensity and decreased fractional anisotropy in the female corpus callosum, as compared with that of the male. Despite the long-standing debates, the corpus callosum remains a region of sex differences...
  53. ncbi Altered asymmetry of the anterior cingulate cortex in subjects at genetic high risk for psychosis
    Hye Youn Park
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea
    Schizophr Res 150:512-8. 2013
    ..The relationships between morphological variations and executive function were also investigated...
  54. doi Neural correlate of impulsivity in subjects at ultra-high risk for psychosis
    Tae Young Lee
    Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea
    Prog Neuropsychopharmacol Biol Psychiatry 45:165-9. 2013
    ..The aim of the present study was to assess impulsivity in UHR subjects and to investigate the associated gray matter correlates...
  55. ncbi Left anterior subregion of orbitofrontal cortex volume reduction and impaired organizational strategies in obsessive-compulsive disorder
    Jung Seok Choi
    Department of Psychiatry, Seoul National University College of Medicine, 28 Yeongon dong, Chongno Gu, 110 744, Seoul, South Korea
    J Psychiatr Res 38:193-9. 2004
    ..These results suggest that left anterior subregion volume reduction of the OFC may be related to impaired organizational strategies in patients with OCD...
  56. doi Reduced volume in the anterior internal capsule but its maintained correlation with the frontal gray matter in subjects at ultra-high risk for psychosis
    Hyun Jung Han
    Department of Brain and Cognitive Sciences, World Class University Program, College of Natural Sciences, Seoul National University, Seoul, Republic of Korea
    Psychiatry Res 204:82-90. 2012
    ..An aberrant ALIC volume but its maintained correlation with the interconnecting frontal lobe was present prior to the onset of full psychosis, indicating the prodromal phase of psychosis...
  57. doi Neural correlates of altered response inhibition and dysfunctional connectivity at rest in obsessive-compulsive disorder
    Do Hyung Kang
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea
    Prog Neuropsychopharmacol Biol Psychiatry 40:340-6. 2013
    ..The present study investigated neural correlates associated with abnormal response inhibition in OCD and to examine how resting state functional connectivity relates to task-related activity...
  58. doi Increased white matter integrity in the corpus callosum in subjects with high genetic loading for schizophrenia
    Sung Nyun Kim
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea
    Prog Neuropsychopharmacol Biol Psychiatry 37:50-5. 2012
    ..This study aimed to investigate the effect of genetic predisposition on the white matter integrity of the CC, in subjects at genetically high risk for schizophrenia (GHR) and schizophrenia patients...
  59. doi Interaction between genetic variants of DLGAP3 and SLC1A1 affecting the risk of atypical antipsychotics-induced obsessive-compulsive symptoms
    Seunghyong Ryu
    Department of Psychiatry, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea
    Am J Med Genet B Neuropsychiatr Genet 156:949-59. 2011
    ..This study provides suggestive evidence that DLGAP3 and its interactive effect with SLC1A1 might be involved in susceptibility to developing OC symptoms in schizophrenia patients receiving AAP treatment...
  60. ncbi Cavum septum pellucidum in subjects at ultra-high risk for psychosis: compared with first-degree relatives of patients with schizophrenia and healthy volunteers
    Jung Seok Choi
    Department of Psychiatry, Seoul National University College of Medicine and Clinical Cognitive Neuroscience Center, SNU MRC, Seoul, Republic of Korea
    Prog Neuropsychopharmacol Biol Psychiatry 32:1326-30. 2008
    ..We examined whether CSP was present more frequently in subjects at ultra-high risk (UHR) for psychosis compared to first-degree relatives of patients with schizophrenia (genetic high risk, GHR) and healthy controls (HC)...
  61. doi Thalamus surface shape deformity in obsessive-compulsive disorder and schizophrenia
    Do Hyung Kang
    Department of Psychiatry, Seoul National University College of Medicine, Hanyang University, Seoul, Korea
    Neuroreport 19:609-13. 2008
    ..Different patterns of shape abnormality of specific thalamic nuclei may be related to the different phenomenology of OCD and schizophrenia...
  62. ncbi Asymmetry analysis of deformable hippocampal model using the principal component in schizophrenia
    Sun Hyung Kim
    Department of Biomedical Engineering, Hanyang University, Seoul, Korea
    Hum Brain Mapp 25:361-9. 2005
    ..The asymmetry in the schizophrenia group was statistically smaller than that in the control group through reduction of the left hemisphere hippocampus volume...
  63. doi Midsagittal structural differences and sexual dimorphism of the corpus callosum in obsessive-compulsive disorder
    Hye Yoon Park
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea
    Psychiatry Res 192:147-53. 2011
    ..Abnormal interhemispheric connectivity, including the parietotemporal and occipital areas, may affect the pathophysiology of OCD. Sexual dimorphism in the CC of OCD patients should be considered...
  64. ncbi MRI study of the cavum septum pellucidum in obsessive-compulsive disorder
    Myong Wuk Chon
    Department of Psychiatry, Seoul National University College of Medicine, Chongno Gu, Seoul, 110 744, Korea
    Eur Arch Psychiatry Clin Neurosci 260:337-43. 2010
    ..These results indicate that neurodevelopmental alterations in midline structures might contribute to the pathogenesis of OCD...
  65. ncbi Neuropsychological correlates of error negativity and positivity in schizophrenia patients
    Myung Sun Kim
    Department of Psychology, Sungshin Women s University, Seoul, Korea
    Psychiatry Clin Neurosci 60:303-11. 2006
    ..Reduced Ne amplitudes and augmented CRN amplitudes in patients with schizophrenia suggest the dysfunctional behavior-monitoring system in these patients. The functional significances of Ne and Pe are discussed...
  66. doi Association of genetic variations in DTNBP1 with cognitive function in schizophrenia patients and healthy subjects
    Ji Hyun Baek
    Department of Psychiatry, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Republic of Korea
    Am J Med Genet B Neuropsychiatr Genet 159:841-9. 2012
    ..The observed results suggest the involvement of DTNBP1 not only in the development of attention deficit of schizophrenia, but also in the inter-individual variability of this cognitive domain within the normal functional range...
  67. doi Symptom structure of antipsychotic-induced obsessive compulsive symptoms in schizophrenia patients
    Joo Hyun Kim
    Department of Psychiatry, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Republic of Korea
    Prog Neuropsychopharmacol Biol Psychiatry 39:75-9. 2012
    ..This study investigated the nature of symptoms and dimensions of SGA-induced OC symptoms in schizophrenia patients, which were then compared with those reported in pure OCD...
  68. pmc Predicting brain occupancy from plasma levels using PET: superiority of combining pharmacokinetics with pharmacodynamics while modeling the relationship
    Euitae Kim
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea
    J Cereb Blood Flow Metab 32:759-68. 2012
    ..1 to 12.1); while that derived from combined PK-PD modeling=8.63 ng/mL (95% CI=7.75 to 9.51)). This finding suggests that PK-PD modeling is required to obtain reliable prediction of brain occupancy by antipsychotics...
  69. ncbi Association of the glutamate transporter gene SLC1A1 with atypical antipsychotics-induced obsessive-compulsive symptoms
    Jun Soo Kwon
    Department of Neuropsychiatry, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea
    Arch Gen Psychiatry 66:1233-41. 2009
    ..The glutamate transporter gene SLC1A1, which was recently reported to be associated with obsessive-compulsive disorder (OCD), is a promising candidate gene for susceptibility to AAP-induced OC symptoms...
  70. ncbi Equivalent current dipole of word repetition effects in patients with obsessive-compulsive disorder
    Young Youn Kim
    Institute for Neuroscience, Seoul National University College of Medicine, Seoul, Korea
    Brain Topogr 18:201-12. 2006
    ..These results suggest that OCD patients suffer from the encoding deficits in word processing, particularly in the left hemisphere...
  71. ncbi Persistent cognitive dysfunction in patients with obsessive-compulsive disorder: a naturalistic study
    Kyu Sik Roh
    Neuroscience Institute, SNU MRC, and Department of Psychiatry, Seoul National University, Seoul, Korea
    Psychiatry Clin Neurosci 59:539-45. 2005
    ..The findings in this study suggested that impaired performance on cognitive domains, such as visuospatial memory and verbal fluency may underline the pathology of OCD...
  72. doi Functional connectivity in fronto-subcortical circuitry during the resting state in obsessive-compulsive disorder
    Joon Hwan Jang
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea
    Neurosci Lett 474:158-62. 2010
    ..These data provide evidence for fronto-subcortical dysfunction in OCD. Results from this study also support the notion that OCD is a heterogeneous disorder mediated by distinct circuits...
  73. ncbi Structural abnormalities of the right inferior colliculus in schizophrenia
    Do Hyung Kang
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea
    Psychiatry Res 164:160-5. 2008
    ..The reduced IC volume suggests that a structural abnormality of the IC in patients with schizophrenia may be involved in the auditory cognitive dysfunction of schizophrenia...
  74. ncbi Neural correlates of cognitive inflexibility during task-switching in obsessive-compulsive disorder
    Bon Mi Gu
    Interdisciplinary Program in Brain Science, Seoul National University College of Medicine, Korea
    Brain 131:155-64. 2008
    ..The results suggest that impaired task-switching ability in OCD patients might be associated with an imbalance in brain activation between dorsal and ventral frontal-striatal circuits...
  75. doi Nonverbal memory and organizational dysfunctions are related with distinct symptom dimensions in obsessive-compulsive disorder
    Joon Hwan Jang
    Department of Psychiatry, Seoul National University College of Medicine, Chongno Gu, Seoul, Republic of Korea
    Psychiatry Res 180:93-8. 2010
    ..They also suggest the possibility that nonverbal memory dysfunction and organizational impairment are mediated by distinct obsessive-compulsive dimensions...
  76. doi Differences between bipolar I and bipolar II disorders in clinical features, comorbidity, and family history
    Ji Hyun Baek
    Department of Psychiatry, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Republic of Korea
    J Affect Disord 131:59-67. 2011
    ....
  77. ncbi LORETA imaging of P300 in schizophrenia with individual MRI and 128-channel EEG
    Ji Soo Pae
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, 110 744, Korea
    Neuroimage 20:1552-60. 2003
    ..In conclusion, the reduced and increased areas of current density in schizophrenic patients suggest that the medial temporal and frontal areas contribute to the pathophysiology of schizophrenia, the frontotemporal circuitry abnormality...
  78. doi Clinical efficacy of individual cognitive therapy in reducing psychiatric symptoms in people at ultra-high risk for psychosis
    Kyung Ran Kim
    Department of Psychiatry, Section of Affect and Neuroscience, Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul
    Early Interv Psychiatry 5:174-8. 2011
    ..The aim of this study was to assess the feasibility and efficacy of cognitive therapy in reducing psychiatric symptoms in UHR people in Korea...
  79. ncbi Deficit of theory of mind in individuals at ultra-high-risk for schizophrenia
    Yu Sun Chung
    Clinical Cognitive Neuroscience Center, Neuroscience Institute, SNU MRC, 28 Yongon Dong, Chongno Gu, Seoul, Republic of Korea
    Schizophr Res 99:111-8. 2008
    ..Although a deficit in social cognition is regarded as an early indicator of schizophrenia, few studies have investigated social cognition in ultra-high-risk (UHR) individuals...
  80. doi Potential vulnerability markers within the affective domain in subjects at genetic and clinical high risk for schizophrenia
    Seung Jae Lee
    Department of Neuropsychiatry, Seoul National University College of Medicine, Seoul, Korea
    Psychopathology 41:236-44. 2008
    ....
  81. ncbi Pharmacotherapy and clinical characteristics of ultra-high-risk for psychosis according to conversion status: a naturalistic observational study
    Euitae Kim
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea
    Early Interv Psychiatry 6:30-7. 2012
    ..To explore the differences in pharmacotherapy and clinical characteristics of individuals at ultra-high-risk (UHR) for psychosis according to the conversion status, we analyzed the data for UHR patients seen at the Seoul Youth Clinic...
  82. ncbi Fractal dimension in human cortical surface: multiple regression analysis with cortical thickness, sulcal depth, and folding area
    Kiho Im
    Department of Biomedical Engineering, Hanyang University, Seoul, Korea
    Hum Brain Mapp 27:994-1003. 2006
    ..Our findings may indicate the structural characteristics that are revealed in the cerebral cortex when the FD in human brain is increased, and provide important information about brain development...
  83. ncbi Analysis of the hemispheric asymmetry using fractal dimension of a skeletonized cerebral surface
    Jong Min Lee
    Department of Biomedical Engineering, Hanyang University, Seoul, Korea
    IEEE Trans Biomed Eng 51:1494-8. 2004
    ..None of the intracranial gray matter or white matter volumes showed any significant asymmetric changes. It could be said that the FD of the skeletonized cerebral surface is a novel measure of cerebral asymmetry...
  84. ncbi Volumetric investigation of the frontal-subcortical circuitry in patients with obsessive-compulsive disorder
    Do Hyung Kang
    Department of Psychiatry, BK 21 Human Life Science, Seoul National University College of Medicine, Seoul, Korea
    J Neuropsychiatry Clin Neurosci 16:342-9. 2004
    ..These findings suggest that a structural abnormality of this brain region is implicated in the pathophysiology of OCD...
  85. pmc Voxel-based morphometry study of gray matter abnormalities in obsessive-compulsive disorder
    So Young Yoo
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea
    J Korean Med Sci 23:24-30. 2008
    ..These findings indicate that the frontal-subcortical circuitry is dysfunctional in OCD, and suggest that the parietal cortex may play a role in the pathophysiology of this disease...
  86. pmc Altered resting-state connectivity in subjects at ultra-high risk for psychosis: an fMRI study
    GeumSook Shim
    Department of Psychiatry, Seoul National University College of Medicine, Chongno Gu, Seoul, 110 744, Korea
    Behav Brain Funct 6:58. 2010
    ..Thus, the neural substrates within the default mode network (DMN) have the potential to mediate self-referential and social cognitive information processing in UHR subjects...
  87. doi Prospective outcome of early intervention for individuals at ultra-high-risk for psychosis
    GeumSook Shim
    Department of Psychiatry, Seoul National University, College of Medicine, Clinical Cognitive Neuroscience Center, Neuroscience Institute, SNU MRC, Chongno Gu, Seoul, Korea
    Early Interv Psychiatry 2:277-84. 2008
    ....
  88. doi Volumetric differences in the pituitary between drug-naïve and medicated male patients with obsessive-compulsive disorder
    Myung Hun Jung
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea
    Prog Neuropsychopharmacol Biol Psychiatry 33:605-9. 2009
    ..We examined pituitary volume in drug-naïve and medicated male patients with obsessive-compulsive disorder (OCD)...
  89. ncbi Morphometric alterations of anterior superior temporal cortex in obsessive-compulsive disorder
    Jung Seok Choi
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea
    Depress Anxiety 23:290-6. 2006
    ....
  90. ncbi Activity of left inferior frontal gyrus related to word repetition effects: LORETA imaging with 128-channel EEG and individual MRI
    Young Youn Kim
    Institute for Neuroscience, Seoul National University College of Medicine, Seoul, Korea
    Neuroimage 29:712-20. 2006
    ..This is the first study to investigate the generators of word repetition effects using voxel-by-voxel statistical mapping of the current density with individual MRI and high-density EEG...
  91. ncbi Gray matter abnormalities in paranoid schizophrenia and their clinical correlations
    Tae Hyon Ha
    Department of Psychiatry, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul, South Korea
    Psychiatry Res 132:251-60. 2004
    ..These results suggest the important roles of the paralimbic structures in the pathophysiology of schizophrenia and the involvement of the perceptual and monitoring systems in the mechanism of insight...
  92. ncbi Objects and their icons in the brain: the neural correlates of visual concept formation
    Yong Wook Shin
    Department of Psychiatry, Seoul National University Hospital, Seoul, Republic of Korea
    Neurosci Lett 436:300-4. 2008
    ..This neural underpinning might be called the neural correlates for visual concept formation...
  93. pmc The reliability and validity of the korean version of the structured interview for prodromal syndrome
    Myung Hun Jung
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea
    Psychiatry Investig 7:257-63. 2010
    ..Here, a Korean version of SIPS is presented, and its reliability, validity, and factor structures are examined using a representative Korean sample...
  94. ncbi Optimized individual mismatch negativity source localization using a realistic head model and the Talairach coordinate system
    Kyoo Seob Ha
    Department of Psychiatry, Seoul National University College of Medicine, Chongno Gu, Seoul, South Korea
    Brain Topogr 15:233-8. 2003
    ....
  95. doi Social functioning deficits in young people at risk for schizophrenia
    GeumSook Shim
    Department of Neuropsychiatry, Seoul National University, College of Medicine, Seoul, Korea
    Aust N Z J Psychiatry 42:678-85. 2008
    ..The aim of the present study was to test the hypothesis that social impairment is simultaneously a state and trait marker of risk for schizophrenia and schizophrenia-related disorder...
  96. ncbi A naturalistic multicenter trial of a 12-week weight management program for overweight and obese patients with schizophrenia or schizoaffective disorder
    Seung Jae Lee
    Department of Psychiatry, Seoul National University Hospital and Neuroscience Institute, Seoul, South Korea
    J Clin Psychiatry 69:555-62. 2008
    ..The primary aim of this study was to examine the efficacy and feasibility of a weight control program for overweight and obese patients with schizophrenia or schizoaffective disorder using a large sample across various clinical settings...
  97. doi A 12-week, naturalistic switch study of the efficacy and tolerability of aripiprazole in stable outpatients with schizophrenia or schizoaffective disorder
    Chang Yoon Kim
    Department of Psychiatry, University of Ulsan College of Medicine, Asan Medical Center, Seoul 138 736, Korea
    Int Clin Psychopharmacol 24:181-8. 2009
    ..The majority of patients was successfully switched from other antipsychotics without serious symptom exacerbation or adverse events over a course of 12 weeks...
  98. ncbi Brain single photon emission computed tomography findings in depressive pseudodementia patients
    Maeng Je Cho
    Department of Neuropsychiatry, Clinical Research Institute, Seoul National University College of Medicine and Hospital, 28 Yongon Dong, Chongno Gu, Seoul, 110 744 South Korea
    J Affect Disord 69:159-66. 2002
    ....
  99. ncbi Changes in twinning rates in South Korea: 1981-2002
    Yoon Mi Hur
    Seoul National University, College of Medicine, Seoul, South Korea
    Twin Res Hum Genet 8:76-9. 2005
    ..The results did not support the recent finding of higher twinning incidence in industrialized regions...
  100. ncbi Altered hemispheric asymmetry and positive symptoms in schizophrenia: equivalent current dipole of auditory mismatch negativity
    Tak Youn
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, South Korea
    Schizophr Res 59:253-60. 2003
    ....
  101. ncbi Dissociation of working memory processing associated with native and second languages: PET investigation
    Jae Jin Kim
    Human Life Sciences, Seoul National University College of Medicine, Seoul 110 744, Korea
    Neuroimage 15:879-91. 2002
    ..Internal phonological processing seems to play a predominant role in working memory processing for the native language with a high proficiency, whereas visual higher order control does so for the second language with a low proficiency...