Jun Soo Kwon

..The limitations of traditional imaging techniques and recent developments to overcome them will also be discussed...

..The aim of the present study was therefore to investigate the long-term efficacy, safety and tolerability of aripiprazole in a large number of patients with schizophrenia, schizophreniform disorder, or schizoaffective disorder in Korea...

..The effects of the weight management program were also assessed with regard to safety and quality of life...

..Also, further considering the hippocampal neural connections specific to its surface topography, these surface deformities may reflect developmental alterations in these patients with regard to the neural circuitry involving hippocampus...

..The results suggest an association between the DRD2 Taq1A polymorphism status and the variation in the clinical response to aripiprazole...

..The authors used proton magnetic resonance spectroscopic imaging ((1)H-MRSI) to investigate regional N-acetylaspartate level abnormalities and changes after 12 weeks of pharmacotherapy with citalopram in drug-naive OCD patients...

..These findings contribute towards integrating micro and macrostructural abnormalities and syndromes of schizophrenia...

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..These results indicate that OCD patients have preserved item memory about content, but impaired source memory about context...

..The effect of pharmacotherapy on the course of social dysfunction was also examined...

..Pre-attentive auditory deficits, which represent a core feature of schizophrenia, were investigated in individuals at UHR for schizophrenia...

..These structural abnormalities might reflect functional decline at the prodromal stage of schizophrenia, and there may be progressive thinning of GM cortex over time...

..These results indicate that multiple neural systems may underlie the ability to recollect context...

..We investigated the metabolic response of glucose in the brain to aripiprazole in relation to the DRD2 Taq1A polymorphism...

..In addition, NoGo-N2 seems to result in more accurate response inhibition measurements in patients with OCD than does NoGo-P3...

..We sought to identify putative genetic vulnerability markers by examining whether aberrant DMN connectivity was present in GHR subjects with high genetic loading...

..Therefore, cognitive training, focusing on the improvement of organizational strategies, could be an effective treatment modality for patients with OCD...

..We examined longitudinally the social-cognitive and neurocognitive function of individuals at ultra-high risk for schizophrenia who developed psychosis later as predictive markers...

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..Most thinned regions were located in the left ventral cortex system, providing a new perspective that this ventral cortical system may be involved in the pathophysiology of OCD...

..These emotion-specific activations suggest that each emotion uses a separate network to integrate bimodal information and shares a common network for cross-modal integration...

..The effect of genetic loading on cortical thinning was also measured by comparing GHR subgroups according to the levels of genetic loading...

..However, few studies on the clinical and neurocognitive implications of OCS in individuals at ultra-high risk for psychosis (UHR) have been conducted...

..In addition, we concluded that the N400 amplitude is a candidate for an endophenotype marker of schizophrenia by revealing its relationship to neuropsychological deficits...

..We used functional magnetic resonance imaging (fMRI) to investigate neural activity associated with the perception of biological motion in OCD patients...

..The neurophysiological mechanisms underlying P300 abnormalities observed in schizophrenic and OCD patients are discussed...

..Pathological gambling (PG) is a severe and persistent pattern of problem gambling that has been aligned with obsessive-compulsive disorder (OCD). However, no study has compared the neurocognitive profiles of individuals with PG and OCD...

..However, little is known about the relationship between perceptual processing and structural deficits in ultra-high-risk for psychosis...

..This is the first evidence that meditation produces different effects on plasma catecholamines according to BDNF or COMT polymorphisms...

..Our findings provide evidence that obsessive-compulsive disorder may be a heterogeneous disease with distinct white matter changes...

..Because attention deficits have been noted in patients with schizophrenia, we examined alpha oscillations in schizophrenia and in the prodromal phase of psychosis...

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..All of these results suggest that schizophrenic patients have recognition memory impairment, the cause of which may range from early encoding, and memory search to late retrieval...

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..We found increased T1 signal intensity and decreased fractional anisotropy in the female corpus callosum, as compared with that of the male. Despite the long-standing debates, the corpus callosum remains a region of sex differences...

..The present study aimed to examine nonverbal memory and organizational skill functions in psychotropic-naïve patients with OCD...

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..We hypothesized that patients with OCD would show reduced cortical folding of the ACC compared with controls...

..Further studies to explore regional FD changes in mental disorders and clinical implications of the FD including diagnostic value should be performed in the future...

..However, little is known about whether these deficits in face recognition are present before the onset of schizophrenia...

..The present study investigated neural correlates associated with abnormal response inhibition in OCD and to examine how resting state functional connectivity relates to task-related activity...

..This study aimed to investigate the effect of genetic predisposition on the white matter integrity of the CC, in subjects at genetically high risk for schizophrenia (GHR) and schizophrenia patients...

..This study provides suggestive evidence that DLGAP3 and its interactive effect with SLC1A1 might be involved in susceptibility to developing OC symptoms in schizophrenia patients receiving AAP treatment...

..We examined whether CSP was present more frequently in subjects at ultra-high risk (UHR) for psychosis compared to first-degree relatives of patients with schizophrenia (genetic high risk, GHR) and healthy controls (HC)...

..Abnormal interhemispheric connectivity, including the parietotemporal and occipital areas, may affect the pathophysiology of OCD. Sexual dimorphism in the CC of OCD patients should be considered...

..The asymmetry in the schizophrenia group was statistically smaller than that in the control group through reduction of the left hemisphere hippocampus volume...

..Different patterns of shape abnormality of specific thalamic nuclei may be related to the different phenomenology of OCD and schizophrenia...

..These results indicate that neurodevelopmental alterations in midline structures might contribute to the pathogenesis of OCD...

..The observed results suggest the involvement of DTNBP1 not only in the development of attention deficit of schizophrenia, but also in the inter-individual variability of this cognitive domain within the normal functional range...

..This study investigated the nature of symptoms and dimensions of SGA-induced OC symptoms in schizophrenia patients, which were then compared with those reported in pure OCD...

..1 to 12.1); while that derived from combined PK-PD modeling=8.63 ng/mL (95% CI=7.75 to 9.51)). This finding suggests that PK-PD modeling is required to obtain reliable prediction of brain occupancy by antipsychotics...

..The glutamate transporter gene SLC1A1, which was recently reported to be associated with obsessive-compulsive disorder (OCD), is a promising candidate gene for susceptibility to AAP-induced OC symptoms...

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..They also suggest the possibility that nonverbal memory dysfunction and organizational impairment are mediated by distinct obsessive-compulsive dimensions...

..These data provide evidence for fronto-subcortical dysfunction in OCD. Results from this study also support the notion that OCD is a heterogeneous disorder mediated by distinct circuits...

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..The aim of this study was to assess the feasibility and efficacy of cognitive therapy in reducing psychiatric symptoms in UHR people in Korea...

..The results suggest that impaired task-switching ability in OCD patients might be associated with an imbalance in brain activation between dorsal and ventral frontal-striatal circuits...

..These results suggest that OCD patients suffer from the encoding deficits in word processing, particularly in the left hemisphere...

..Our results demonstrate a need for further evaluation of the CYP2D6 genotypic effect on the pharmacodynamics of aripiprazole...

..Although a deficit in social cognition is regarded as an early indicator of schizophrenia, few studies have investigated social cognition in ultra-high-risk (UHR) individuals...

..In conclusion, the reduced and increased areas of current density in schizophrenic patients suggest that the medial temporal and frontal areas contribute to the pathophysiology of schizophrenia, the frontotemporal circuitry abnormality...

..The reduced IC volume suggests that a structural abnormality of the IC in patients with schizophrenia may be involved in the auditory cognitive dysfunction of schizophrenia...

..The findings in this study suggested that impaired performance on cognitive domains, such as visuospatial memory and verbal fluency may underline the pathology of OCD...

..To explore the differences in pharmacotherapy and clinical characteristics of individuals at ultra-high-risk (UHR) for psychosis according to the conversion status, we analyzed the data for UHR patients seen at the Seoul Youth Clinic...

..Reduced Ne amplitudes and augmented CRN amplitudes in patients with schizophrenia suggest the dysfunctional behavior-monitoring system in these patients. The functional significances of Ne and Pe are discussed...

..We examined pituitary volume in drug-naïve and medicated male patients with obsessive-compulsive disorder (OCD)...

..Our findings may indicate the structural characteristics that are revealed in the cerebral cortex when the FD in human brain is increased, and provide important information about brain development...

..Thus, the neural substrates within the default mode network (DMN) have the potential to mediate self-referential and social cognitive information processing in UHR subjects...

..None of the intracranial gray matter or white matter volumes showed any significant asymmetric changes. It could be said that the FD of the skeletonized cerebral surface is a novel measure of cerebral asymmetry...

..These findings indicate that the frontal-subcortical circuitry is dysfunctional in OCD, and suggest that the parietal cortex may play a role in the pathophysiology of this disease...

..These findings suggest that a structural abnormality of this brain region is implicated in the pathophysiology of OCD...

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..This is the first study to investigate the generators of word repetition effects using voxel-by-voxel statistical mapping of the current density with individual MRI and high-density EEG...

..These results suggest the important roles of the paralimbic structures in the pathophysiology of schizophrenia and the involvement of the perceptual and monitoring systems in the mechanism of insight...

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..Here, a Korean version of SIPS is presented, and its reliability, validity, and factor structures are examined using a representative Korean sample...

..The aim of the present study was to test the hypothesis that social impairment is simultaneously a state and trait marker of risk for schizophrenia and schizophrenia-related disorder...

..This neural underpinning might be called the neural correlates for visual concept formation...

..The primary aim of this study was to examine the efficacy and feasibility of a weight control program for overweight and obese patients with schizophrenia or schizoaffective disorder using a large sample across various clinical settings...

..The results did not support the recent finding of higher twinning incidence in industrialized regions...

..The majority of patients was successfully switched from other antipsychotics without serious symptom exacerbation or adverse events over a course of 12 weeks...

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..Thus, these findings suggest that a volumetric abnormality of the caudal anterior cingulate gyrus in schizophrenia may be related to positive symptoms and possibly involved in the pathophysiology of schizophrenia...

..Internal phonological processing seems to play a predominant role in working memory processing for the native language with a high proficiency, whereas visual higher order control does so for the second language with a low proficiency...

..504). CONCLUSION: This study suggests that OCD with SPT could be distinguished as a distinct subtype of OCD, based on observations of gray matter volume...

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..These relationships provide indirect evidence of the possibility that the main pathology of OCD is located in the left hyperfrontality and that the right hyperfrontality of OCD occurs by a compensatory mechanism...

..This implies that a dysfunction of the visuo-cerebellar circuit in patients with schizophrenia increases according to age...

..The neuropsychological profile of the OCD patients found in the present study is consistent with current theories proposing that the frontal-striatal system is the possible pathophysiological mechanism underlying the development of OCD...

..Our findings suggest that different patterns of prodromal symptoms between male and female begin before the onset of the psychosis. Further prospective studies should be needed...

..021). In conclusion, NMDA receptor antagonist administration elicited WM deficit both in behavioral and electrophysiological level. Electrophysiological component reflecting later stage of WM was impaired by NMDA antagonist...

..Our findings provide evidence for differential processing of emotional faces as a function of race...

..Bilateral inward deformities in the anterior and posterior hippocampus and a unilateral outward deformity in the right anterior hippocampus were observed, respectively...

..CONCLUSIONS: The findings suggest prefrontal-parietal functional disconnection, particularly prefrontal dissociation and abnormal prefrontal-parietal interaction, during working memory processing in schizophrenia...

..In addition, pathologic WM changes in this region may be an important step in the development of auditory hallucinations in schizophrenia...