Jun Soo Kwon

Summary

Affiliation: Seoul National University
Country: Korea

Publications

  1. pmc Impaired coupling of local and global functional feedbacks underlies abnormal synchronization and negative symptoms of schizophrenia
    Kyungchul Noh
    Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology KAIST, Daejeon, Republic of Korea
    BMC Syst Biol 7:30. 2013
  2. pmc Aberrant auditory processing in schizophrenia and in subjects at ultra-high-risk for psychosis
    Kyung Soon Shin
    Neuroscience Institute, Seoul National University Medical Research Center, Seoul, Korea
    Schizophr Bull 38:1258-67. 2012
  3. pmc Cortical thickness reduction in individuals at ultra-high-risk for psychosis
    Wi Hoon Jung
    Department of Psychiatry and Behavioral Sciences, Seoul National University College of Medicine, 101 Daehak no, Chongno Gu, Seoul, South Korea
    Schizophr Bull 37:839-49. 2011
  4. doi request reprint Proton magnetic resonance spectroscopy in subjects with high genetic risk of schizophrenia: investigation of anterior cingulate, dorsolateral prefrontal cortex and thalamus
    So Young Yoo
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea
    Schizophr Res 111:86-93. 2009
  5. doi request reprint The relationship between antipsychotic D2 occupancy and change in frontal metabolism and working memory : A dual [(11)C]raclopride and [(18) F]FDG imaging study with aripiprazole
    Euitae Kim
    Department of Psychiatry, Seoul National University College of Medicine, 28 Yeongon dong, Chongno Gu, Seoul, 110 744, South Korea
    Psychopharmacology (Berl) 227:221-9. 2013
  6. pmc Phase-specific brain change of spatial working memory processing in genetic and ultra-high risk groups of schizophrenia
    Jung Seok Choi
    Department of Psychiatry, Seoul National University College of Medicine, 101 Daehak no, Chongno Gu, Seoul 110 744, Korea
    Schizophr Bull 38:1189-99. 2012
  7. doi request reprint Taq1A polymorphism in the dopamine D2 receptor gene as a predictor of clinical response to aripiprazole
    Jun Soo Kwon
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea
    Eur Neuropsychopharmacol 18:897-907. 2008
  8. ncbi request reprint Cortical network dynamics during source memory retrieval: current density imaging with individual MRI
    Young Youn Kim
    BK21 Research Division of Human Life Sciences, Seoul National University College of Medicine, Seoul, Korea
    Hum Brain Mapp 30:78-91. 2009
  9. doi request reprint An MEG study of alpha modulation in patients with schizophrenia and in subjects at high risk of developing psychosis
    Yuri Koh
    Clinical Cognitive Neuroscience Center, Neuroscience Institute, SNU MRC, Seoul, Republic of Korea
    Schizophr Res 126:36-42. 2011
  10. doi request reprint Impairment of source memory in patients with obsessive-compulsive disorder: equivalent current dipole analysis
    Young Youn Kim
    BK21 Research Division of Human Life Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea
    Psychiatry Res 165:47-59. 2009

Collaborators

Detail Information

Publications116 found, 100 shown here

  1. pmc Impaired coupling of local and global functional feedbacks underlies abnormal synchronization and negative symptoms of schizophrenia
    Kyungchul Noh
    Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology KAIST, Daejeon, Republic of Korea
    BMC Syst Biol 7:30. 2013
    ..Abnormal synchronization of brain oscillations is found to be associated with various core symptoms of schizophrenia. However, the underlying mechanism of this association remains yet to be elucidated...
  2. pmc Aberrant auditory processing in schizophrenia and in subjects at ultra-high-risk for psychosis
    Kyung Soon Shin
    Neuroscience Institute, Seoul National University Medical Research Center, Seoul, Korea
    Schizophr Bull 38:1258-67. 2012
    ..Deficits in auditory sensory memory, on the other hand, may be similarly impaired in both groups...
  3. pmc Cortical thickness reduction in individuals at ultra-high-risk for psychosis
    Wi Hoon Jung
    Department of Psychiatry and Behavioral Sciences, Seoul National University College of Medicine, 101 Daehak no, Chongno Gu, Seoul, South Korea
    Schizophr Bull 37:839-49. 2011
    ..These structural abnormalities might reflect functional decline at the prodromal stage of schizophrenia, and there may be progressive thinning of GM cortex over time...
  4. doi request reprint Proton magnetic resonance spectroscopy in subjects with high genetic risk of schizophrenia: investigation of anterior cingulate, dorsolateral prefrontal cortex and thalamus
    So Young Yoo
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea
    Schizophr Res 111:86-93. 2009
    ....
  5. doi request reprint The relationship between antipsychotic D2 occupancy and change in frontal metabolism and working memory : A dual [(11)C]raclopride and [(18) F]FDG imaging study with aripiprazole
    Euitae Kim
    Department of Psychiatry, Seoul National University College of Medicine, 28 Yeongon dong, Chongno Gu, Seoul, 110 744, South Korea
    Psychopharmacology (Berl) 227:221-9. 2013
    ..This prompts the necessity of using an intermediate biomarker relating the drug effect on the brain to change in cognitive function...
  6. pmc Phase-specific brain change of spatial working memory processing in genetic and ultra-high risk groups of schizophrenia
    Jung Seok Choi
    Department of Psychiatry, Seoul National University College of Medicine, 101 Daehak no, Chongno Gu, Seoul 110 744, Korea
    Schizophr Bull 38:1189-99. 2012
    ..Our findings suggest that functional deficits associated with spatial WM processing emerge in the UHR before the onset of schizophrenia and compensatory neural processes exist in the GHR with genetic liability to schizophrenia...
  7. doi request reprint Taq1A polymorphism in the dopamine D2 receptor gene as a predictor of clinical response to aripiprazole
    Jun Soo Kwon
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea
    Eur Neuropsychopharmacol 18:897-907. 2008
    ..The results suggest an association between the DRD2 Taq1A polymorphism status and the variation in the clinical response to aripiprazole...
  8. ncbi request reprint Cortical network dynamics during source memory retrieval: current density imaging with individual MRI
    Young Youn Kim
    BK21 Research Division of Human Life Sciences, Seoul National University College of Medicine, Seoul, Korea
    Hum Brain Mapp 30:78-91. 2009
    ..These results indicate that multiple neural systems may underlie the ability to recollect context...
  9. doi request reprint An MEG study of alpha modulation in patients with schizophrenia and in subjects at high risk of developing psychosis
    Yuri Koh
    Clinical Cognitive Neuroscience Center, Neuroscience Institute, SNU MRC, Seoul, Republic of Korea
    Schizophr Res 126:36-42. 2011
    ..Because attention deficits have been noted in patients with schizophrenia, we examined alpha oscillations in schizophrenia and in the prodromal phase of psychosis...
  10. doi request reprint Impairment of source memory in patients with obsessive-compulsive disorder: equivalent current dipole analysis
    Young Youn Kim
    BK21 Research Division of Human Life Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea
    Psychiatry Res 165:47-59. 2009
    ..These results indicate that OCD patients have preserved item memory about content, but impaired source memory about context...
  11. doi request reprint Longitudinal patterns of social functioning and conversion to psychosis in subjects at ultra-high risk
    Joon Hwan Jang
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea
    Aust N Z J Psychiatry 45:763-70. 2011
    ..The effect of pharmacotherapy on the course of social dysfunction was also examined...
  12. doi request reprint Pre-attentive auditory processing in ultra-high-risk for schizophrenia with magnetoencephalography
    Kyung Soon Shin
    Interdisciplinary Program in Cognitive Science, Seoul National University, Seoul, Korea
    Biol Psychiatry 65:1071-8. 2009
    ..Pre-attentive auditory deficits, which represent a core feature of schizophrenia, were investigated in individuals at UHR for schizophrenia...
  13. ncbi request reprint Cortical thinning in obsessive compulsive disorder
    Yong Wook Shin
    Clinical Cognitive Neuroscience Center, SNU MRC, Seoul, Korea
    Hum Brain Mapp 28:1128-35. 2007
    ..Most thinned regions were located in the left ventral cortex system, providing a new perspective that this ventral cortical system may be involved in the pathophysiology of OCD...
  14. ncbi request reprint Effect of cognitive training focusing on organizational strategies in patients with obsessive-compulsive disorder
    Hee Soo Park
    Department of Psychiatry, Seoul National University College of Medicine and Neuroscience Institute, SNU MRC, Korea
    Psychiatry Clin Neurosci 60:718-26. 2006
    ..Therefore, cognitive training, focusing on the improvement of organizational strategies, could be an effective treatment modality for patients with OCD...
  15. doi request reprint Long-term efficacy and safety of aripiprazole in patients with schizophrenia, schizophreniform disorder, or schizoaffective disorder: 26-week prospective study
    Jun Soo Kwon
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea
    Psychiatry Clin Neurosci 63:73-81. 2009
    ..The aim of the present study was therefore to investigate the long-term efficacy, safety and tolerability of aripiprazole in a large number of patients with schizophrenia, schizophreniform disorder, or schizoaffective disorder in Korea...
  16. doi request reprint Multi-level comparison of empathy in schizophrenia: an fMRI study of a cartoon task
    Seung Jae Lee
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, South Korea
    Psychiatry Res 181:121-9. 2010
    ....
  17. pmc The effect of meditation on brain structure: cortical thickness mapping and diffusion tensor imaging
    Do Hyung Kang
    Department of Psychiatry, Seoul National University College of Medicine, Seoul 110 744, Republic of Korea
    Soc Cogn Affect Neurosci 8:27-33. 2013
    ..Our findings suggest that long-term meditators have structural differences in both gray and white matter...
  18. doi request reprint Reduced prefrontal functional connectivity in the default mode network is related to greater psychopathology in subjects with high genetic loading for schizophrenia
    Joon Hwan Jang
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea
    Schizophr Res 127:58-65. 2011
    ..We sought to identify putative genetic vulnerability markers by examining whether aberrant DMN connectivity was present in GHR subjects with high genetic loading...
  19. doi request reprint Regional cortical thinning in subjects with high genetic loading for schizophrenia
    Min Soo Byun
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea
    Schizophr Res 141:197-203. 2012
    ..The effect of genetic loading on cortical thinning was also measured by comparing GHR subgroups according to the levels of genetic loading...
  20. doi request reprint Social cognition and neurocognition as predictors of conversion to psychosis in individuals at ultra-high risk
    Hee Sun Kim
    Clinical Cognitive Neuroscience Center, Neuroscience Institute, SNU MRC, Seoul, Republic of Korea
    Schizophr Res 130:170-5. 2011
    ..We examined longitudinally the social-cognitive and neurocognitive function of individuals at ultra-high risk for schizophrenia who developed psychosis later as predictive markers...
  21. doi request reprint Neuropsychological correlates of N400 anomalies in patients with schizophrenia: A preliminary report
    Kyung Soon Shin
    Interdisciplinary Program in Cognitive Science, Seoul National University, Seoul, Republic of Korea
    Neurosci Lett 448:226-30. 2008
    ..In addition, we concluded that the N400 amplitude is a candidate for an endophenotype marker of schizophrenia by revealing its relationship to neuropsychological deficits...
  22. doi request reprint Clinical and neurocognitive profiles of subjects at high risk for psychosis with and without obsessive-compulsive symptoms
    Ji Won Hur
    Department of Brain and Cognitive Sciences World Class University Program, College of Natural Sciences, Seoul National University, Seoul, Republic of Korea
    Aust N Z J Psychiatry 46:161-9. 2012
    ..However, few studies on the clinical and neurocognitive implications of OCS in individuals at ultra-high risk for psychosis (UHR) have been conducted...
  23. doi request reprint BOLD response during visual perception of biological motion in obsessive-compulsive disorder : an fMRI study using the dynamic point-light animation paradigm
    Wi Hoon Jung
    Interdisciplinary Program in Brain Science and in Cognitive Science, Seoul National University, Seoul, Korea
    Eur Arch Psychiatry Clin Neurosci 259:46-54. 2009
    ..We used functional magnetic resonance imaging (fMRI) to investigate neural activity associated with the perception of biological motion in OCD patients...
  24. ncbi request reprint Electrophysiological correlates of behavioral response inhibition in patients with obsessive-compulsive disorder
    Myung Sun Kim
    Department of Psychology, Sungshin Women s University, Seoul, Korea
    Depress Anxiety 24:22-31. 2007
    ..In addition, NoGo-N2 seems to result in more accurate response inhibition measurements in patients with OCD than does NoGo-P3...
  25. ncbi request reprint Shape deformity of the corpus striatum in obsessive-compulsive disorder
    Jung Seok Choi
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea
    Psychiatry Res 155:257-64. 2007
    ....
  26. doi request reprint Taq1A polymorphism in the dopamine D2 receptor gene predicts brain metabolic response to aripiprazole in healthy male volunteers
    Euitae Kim
    Department of Psychiatry, Seoul National University College of Medicine, and Department of Clinical Pharmacology and Clinical Trial Center, Seoul National University Hospital, Seoul, Korea
    Pharmacogenet Genomics 18:91-7. 2008
    ..We investigated the metabolic response of glucose in the brain to aripiprazole in relation to the DRD2 Taq1A polymorphism...
  27. doi request reprint Neuromagnetic auditory response and its relation to cortical thickness in ultra-high-risk for psychosis
    Kyung Soon Shin
    Clinical Cognitive Neuroscience Center, Neuroscience Institute, SNU MRC, Seoul, Republic of Korea
    Schizophr Res 140:93-8. 2012
    ..However, little is known about the relationship between perceptual processing and structural deficits in ultra-high-risk for psychosis...
  28. ncbi request reprint Increased water diffusivity in the frontal and temporal cortices of schizophrenic patients
    Yong Wook Shin
    Clinical Cognitive Neuroscience Center, SNU MRC, Seoul, Republic of Korea
    Neuroimage 30:1285-91. 2006
    ..These findings contribute towards integrating micro and macrostructural abnormalities and syndromes of schizophrenia...
  29. doi request reprint Influence of brain-derived neurotrophic factor and catechol O-methyl transferase polymorphisms on effects of meditation on plasma catecholamines and stress
    Ye Ha Jung
    Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea
    Stress 15:97-104. 2012
    ..This is the first evidence that meditation produces different effects on plasma catecholamines according to BDNF or COMT polymorphisms...
  30. doi request reprint Do organizational strategies mediate nonverbal memory impairment in drug-naïve patients with obsessive-compulsive disorder?
    Na Young Shin
    Interdisciplinary Cognitive Science Program, Seoul National University, Seoul, Korea
    Neuropsychology 24:527-33. 2010
    ..The present study aimed to examine nonverbal memory and organizational skill functions in psychotropic-naïve patients with OCD...
  31. pmc Reduced cortical folding of the anterior cingulate cortex in obsessive-compulsive disorder
    GeumSook Shim
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea
    J Psychiatry Neurosci 34:443-9. 2009
    ..We hypothesized that patients with OCD would show reduced cortical folding of the ACC compared with controls...
  32. doi request reprint Thalamus surface shape deformity in obsessive-compulsive disorder and schizophrenia
    Do Hyung Kang
    Department of Psychiatry, Seoul National University College of Medicine, Hanyang University, Seoul, Korea
    Neuroreport 19:609-13. 2008
    ..Different patterns of shape abnormality of specific thalamic nuclei may be related to the different phenomenology of OCD and schizophrenia...
  33. ncbi request reprint Left anterior subregion of orbitofrontal cortex volume reduction and impaired organizational strategies in obsessive-compulsive disorder
    Jung Seok Choi
    Department of Psychiatry, Seoul National University College of Medicine, 28 Yeongon dong, Chongno Gu, 110 744, Seoul, South Korea
    J Psychiatr Res 38:193-9. 2004
    ..These results suggest that left anterior subregion volume reduction of the OFC may be related to impaired organizational strategies in patients with OCD...
  34. ncbi request reprint Neuropsychological correlates of P300 abnormalities in patients with schizophrenia and obsessive-compulsive disorder
    Myung Sun Kim
    Department of Psychiatry, Seoul National University College of Medicine and Clinical Research Institute, Seoul National University Hospital, Seoul, South Korea
    Psychiatry Res 123:109-23. 2003
    ..The neurophysiological mechanisms underlying P300 abnormalities observed in schizophrenic and OCD patients are discussed...
  35. ncbi request reprint Functional disconnection between the prefrontal and parietal cortices during working memory processing in schizophrenia: a[15(O)]H2O PET study
    Jae Jin Kim
    Department of Psychiatry and Nuclear Medicine, College of Medicine, Seoul National University Hospital, 28 Yongun dong, Chongno Gu, Seoul, Korea 110 744
    Am J Psychiatry 160:919-23. 2003
    ..The purpose of this study was to use direct neuroimaging to address whether interregional correlation in the prefrontal-parietal circuits is impaired in schizophrenia...
  36. pmc Population pharmacokinetic modelling of aripiprazole and its active metabolite, dehydroaripiprazole, in psychiatric patients
    Jung Ryul Kim
    Department of Pharmacology, Seoul National University College of Medicine, Seoul, Korea
    Br J Clin Pharmacol 66:802-10. 2008
    ....
  37. doi request reprint Integration of cross-modal emotional information in the human brain: an fMRI study
    Ji Young Park
    Interdisciplinary Program in Cognitive Science, Seoul National University, Seoul, Republic of Korea
    Cortex 46:161-9. 2010
    ..These emotion-specific activations suggest that each emotion uses a separate network to integrate bimodal information and shares a common network for cross-modal integration...
  38. doi request reprint Processing of facial configuration in individuals at ultra-high risk for schizophrenia
    Hee Sun Kim
    Clinical Cognitive Neuroscience Center, Neuroscience Institute, SNU MRC, Seoul, Republic of Korea
    Schizophr Res 118:81-7. 2010
    ..However, little is known about whether these deficits in face recognition are present before the onset of schizophrenia...
  39. doi request reprint Reduced volume in the anterior internal capsule but its maintained correlation with the frontal gray matter in subjects at ultra-high risk for psychosis
    Hyun Jung Han
    Department of Brain and Cognitive Sciences, World Class University Program, College of Natural Sciences, Seoul National University, Seoul, Republic of Korea
    Psychiatry Res 204:82-90. 2012
    ..An aberrant ALIC volume but its maintained correlation with the interconnecting frontal lobe was present prior to the onset of full psychosis, indicating the prodromal phase of psychosis...
  40. doi request reprint Neural correlates of altered response inhibition and dysfunctional connectivity at rest in obsessive-compulsive disorder
    Do Hyung Kang
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea
    Prog Neuropsychopharmacol Biol Psychiatry 40:340-6. 2013
    ..The present study investigated neural correlates associated with abnormal response inhibition in OCD and to examine how resting state functional connectivity relates to task-related activity...
  41. doi request reprint White matter neuroplastic changes in long-term trained players of the game of "Baduk" (GO): a voxel-based diffusion-tensor imaging study
    Boreom Lee
    Clinical Cognitive Neuroscience Center, Neuroscience Institute, Seoul National University Medical Research Center, Seoul, Republic of Korea
    Neuroimage 52:9-19. 2010
    ....
  42. doi request reprint Cavum septum pellucidum in subjects at ultra-high risk for psychosis: compared with first-degree relatives of patients with schizophrenia and healthy volunteers
    Jung Seok Choi
    Department of Psychiatry, Seoul National University College of Medicine and Clinical Cognitive Neuroscience Center, SNU MRC, Seoul, Republic of Korea
    Prog Neuropsychopharmacol Biol Psychiatry 32:1326-30. 2008
    ..We examined whether CSP was present more frequently in subjects at ultra-high risk (UHR) for psychosis compared to first-degree relatives of patients with schizophrenia (genetic high risk, GHR) and healthy controls (HC)...
  43. doi request reprint Interaction between genetic variants of DLGAP3 and SLC1A1 affecting the risk of atypical antipsychotics-induced obsessive-compulsive symptoms
    Seunghyong Ryu
    Department of Psychiatry, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea
    Am J Med Genet B Neuropsychiatr Genet 156:949-59. 2011
    ..This study provides suggestive evidence that DLGAP3 and its interactive effect with SLC1A1 might be involved in susceptibility to developing OC symptoms in schizophrenia patients receiving AAP treatment...
  44. doi request reprint Increased white matter integrity in the corpus callosum in subjects with high genetic loading for schizophrenia
    Sung Nyun Kim
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea
    Prog Neuropsychopharmacol Biol Psychiatry 37:50-5. 2012
    ..This study aimed to investigate the effect of genetic predisposition on the white matter integrity of the CC, in subjects at genetically high risk for schizophrenia (GHR) and schizophrenia patients...
  45. doi request reprint White matter alterations in male patients with obsessive-compulsive disorder
    Tae Hyon Ha
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea
    Neuroreport 20:735-9. 2009
    ..Our findings provide evidence that obsessive-compulsive disorder may be a heterogeneous disease with distinct white matter changes...
  46. ncbi request reprint Neural correlates of cognitive inflexibility during task-switching in obsessive-compulsive disorder
    Bon Mi Gu
    Interdisciplinary Program in Brain Science, Seoul National University College of Medicine, Korea
    Brain 131:155-64. 2008
    ..The results suggest that impaired task-switching ability in OCD patients might be associated with an imbalance in brain activation between dorsal and ventral frontal-striatal circuits...
  47. ncbi request reprint Fractal dimension of cerebral cortical surface in schizophrenia and obsessive-compulsive disorder
    Tae Hyon Ha
    Department of Psychiatry, Seoul National University College of Medicine and Hospital, 28 Yongon Dong, Chongno Gu, Seoul 110 744, Korea
    Neurosci Lett 384:172-6. 2005
    ..Further studies to explore regional FD changes in mental disorders and clinical implications of the FD including diagnostic value should be performed in the future...
  48. ncbi request reprint An MRI study of structural variations in schizophrenia using deformation field morphometry
    Uicheul Yoon
    Department of Biomedical Engineering, Hanyang University, Sungdong P O Box 55, Seoul, 133 605, Korea
    Psychiatry Res 146:171-7. 2006
    ....
  49. doi request reprint Potential vulnerability markers within the affective domain in subjects at genetic and clinical high risk for schizophrenia
    Seung Jae Lee
    Department of Neuropsychiatry, Seoul National University College of Medicine, Seoul, Korea
    Psychopathology 41:236-44. 2008
    ....
  50. ncbi request reprint A proton MRSI study of brain N-acetylaspartate level after 12 weeks of citalopram treatment in drug-naive patients with obsessive-compulsive disorder
    Joon Hwan Jang
    Department of Psychiatry, Seoul National University College of Medicine, 28 Yeongon dong, Chongno Gu, Seoul, Korea
    Am J Psychiatry 163:1202-7. 2006
    ..The authors used proton magnetic resonance spectroscopic imaging ((1)H-MRSI) to investigate regional N-acetylaspartate level abnormalities and changes after 12 weeks of pharmacotherapy with citalopram in drug-naive OCD patients...
  51. doi request reprint Differences between bipolar I and bipolar II disorders in clinical features, comorbidity, and family history
    Ji Hyun Baek
    Department of Psychiatry, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Republic of Korea
    J Affect Disord 131:59-67. 2011
    ....
  52. pmc Altered resting-state connectivity in subjects at ultra-high risk for psychosis: an fMRI study
    GeumSook Shim
    Department of Psychiatry, Seoul National University College of Medicine, Chongno Gu, Seoul, 110 744, Korea
    Behav Brain Funct 6:58. 2010
    ..Thus, the neural substrates within the default mode network (DMN) have the potential to mediate self-referential and social cognitive information processing in UHR subjects...
  53. doi request reprint Midsagittal structural differences and sexual dimorphism of the corpus callosum in obsessive-compulsive disorder
    Hye Yoon Park
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea
    Psychiatry Res 192:147-53. 2011
    ..Abnormal interhemispheric connectivity, including the parietotemporal and occipital areas, may affect the pathophysiology of OCD. Sexual dimorphism in the CC of OCD patients should be considered...
  54. pmc Predicting brain occupancy from plasma levels using PET: superiority of combining pharmacokinetics with pharmacodynamics while modeling the relationship
    Euitae Kim
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea
    J Cereb Blood Flow Metab 32:759-68. 2012
    ..1 to 12.1); while that derived from combined PK-PD modeling=8.63 ng/mL (95% CI=7.75 to 9.51)). This finding suggests that PK-PD modeling is required to obtain reliable prediction of brain occupancy by antipsychotics...
  55. ncbi request reprint Sex differences in the human corpus callosum: diffusion tensor imaging study
    Yong Wook Shin
    Neuroscience Institute, SNU MRC, Seoul, Korea
    Neuroreport 16:795-8. 2005
    ..We found increased T1 signal intensity and decreased fractional anisotropy in the female corpus callosum, as compared with that of the male. Despite the long-standing debates, the corpus callosum remains a region of sex differences...
  56. doi request reprint Clinical efficacy of individual cognitive therapy in reducing psychiatric symptoms in people at ultra-high risk for psychosis
    Kyung Ran Kim
    Department of Psychiatry, Section of Affect and Neuroscience, Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul
    Early Interv Psychiatry 5:174-8. 2011
    ..The aim of this study was to assess the feasibility and efficacy of cognitive therapy in reducing psychiatric symptoms in UHR people in Korea...
  57. doi request reprint Volumetric differences in the pituitary between drug-naïve and medicated male patients with obsessive-compulsive disorder
    Myung Hun Jung
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea
    Prog Neuropsychopharmacol Biol Psychiatry 33:605-9. 2009
    ..We examined pituitary volume in drug-naïve and medicated male patients with obsessive-compulsive disorder (OCD)...
  58. doi request reprint Functional connectivity in fronto-subcortical circuitry during the resting state in obsessive-compulsive disorder
    Joon Hwan Jang
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea
    Neurosci Lett 474:158-62. 2010
    ..These data provide evidence for fronto-subcortical dysfunction in OCD. Results from this study also support the notion that OCD is a heterogeneous disorder mediated by distinct circuits...
  59. doi request reprint Association of the glutamate transporter gene SLC1A1 with atypical antipsychotics-induced obsessive-compulsive symptoms
    Jun Soo Kwon
    Department of Neuropsychiatry, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea
    Arch Gen Psychiatry 66:1233-41. 2009
    ..The glutamate transporter gene SLC1A1, which was recently reported to be associated with obsessive-compulsive disorder (OCD), is a promising candidate gene for susceptibility to AAP-induced OC symptoms...
  60. ncbi request reprint Impairment of recognition memory in schizophrenia: event-related potential study using a continuous recognition task
    Myung Sun Kim
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea
    Psychiatry Clin Neurosci 58:465-72. 2004
    ..All of these results suggest that schizophrenic patients have recognition memory impairment, the cause of which may range from early encoding, and memory search to late retrieval...
  61. ncbi request reprint Deficit of theory of mind in individuals at ultra-high-risk for schizophrenia
    Yu Sun Chung
    Clinical Cognitive Neuroscience Center, Neuroscience Institute, SNU MRC, 28 Yongon Dong, Chongno Gu, Seoul, Republic of Korea
    Schizophr Res 99:111-8. 2008
    ..Although a deficit in social cognition is regarded as an early indicator of schizophrenia, few studies have investigated social cognition in ultra-high-risk (UHR) individuals...
  62. doi request reprint Nonverbal memory and organizational dysfunctions are related with distinct symptom dimensions in obsessive-compulsive disorder
    Joon Hwan Jang
    Department of Psychiatry, Seoul National University College of Medicine, Chongno Gu, Seoul, Republic of Korea
    Psychiatry Res 180:93-8. 2010
    ..They also suggest the possibility that nonverbal memory dysfunction and organizational impairment are mediated by distinct obsessive-compulsive dimensions...
  63. pmc Voxel-based morphometry study of gray matter abnormalities in obsessive-compulsive disorder
    So Young Yoo
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea
    J Korean Med Sci 23:24-30. 2008
    ..These findings indicate that the frontal-subcortical circuitry is dysfunctional in OCD, and suggest that the parietal cortex may play a role in the pathophysiology of this disease...
  64. pmc Regional brain atrophy and functional disconnection in Broca's area in individuals at ultra-high risk for psychosis and schizophrenia
    Wi Hoon Jung
    Clinical Cognitive Neuroscience Center, Neuroscience Institute, Seoul National University Medical Research Center, Seoul, South Korea
    PLoS ONE 7:e51975. 2012
    ..Thus, it is important to understand how the structural volume and functional connectivity in this area changes at rest according to the course of the illness...
  65. doi request reprint Symptom structure of antipsychotic-induced obsessive compulsive symptoms in schizophrenia patients
    Joo Hyun Kim
    Department of Psychiatry, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Republic of Korea
    Prog Neuropsychopharmacol Biol Psychiatry 39:75-9. 2012
    ..This study investigated the nature of symptoms and dimensions of SGA-induced OC symptoms in schizophrenia patients, which were then compared with those reported in pure OCD...
  66. pmc Altered brain activity during reward anticipation in pathological gambling and obsessive-compulsive disorder
    Jung Seok Choi
    Department of Psychiatry, Seoul National University College of Medicine, Korea
    PLoS ONE 7:e45938. 2012
    ..However, no neuroimaging studies to date have examined reward circuitry during the anticipation phase of reward in PG compared with in OCD while considering repetitive gambling and compulsion as addictive behaviors...
  67. doi request reprint Reduced fronto-callosal fiber integrity in unmedicated OCD patients: a diffusion tractography study
    Jungsu S Oh
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea
    Hum Brain Mapp 33:2441-52. 2012
    ..Using a more quantitative method in terms of functional and regional specificity than previous studies, we report abnormalities in interhemispheric connectivity of both dorsal and ventral networks in the pathophysiology of OCD...
  68. doi request reprint The effects of mind-body training on stress reduction, positive affect, and plasma catecholamines
    Ye Ha Jung
    Clinical Cognitive Neuroscience Center, Neuroscience Institute, SNU MRC, Seoul, Republic of Korea
    Neurosci Lett 479:138-42. 2010
    ..Thus, mind-body training may influence stress, positive affect and the sympathetic nervous system including DA activity...
  69. ncbi request reprint Neuropsychological correlates of error negativity and positivity in schizophrenia patients
    Myung Sun Kim
    Department of Psychology, Sungshin Women s University, Seoul, Korea
    Psychiatry Clin Neurosci 60:303-11. 2006
    ..Reduced Ne amplitudes and augmented CRN amplitudes in patients with schizophrenia suggest the dysfunctional behavior-monitoring system in these patients. The functional significances of Ne and Pe are discussed...
  70. ncbi request reprint Analysis of the hemispheric asymmetry using fractal dimension of a skeletonized cerebral surface
    Jong Min Lee
    Department of Biomedical Engineering, Hanyang University, Seoul, Korea
    IEEE Trans Biomed Eng 51:1494-8. 2004
    ..None of the intracranial gray matter or white matter volumes showed any significant asymmetric changes. It could be said that the FD of the skeletonized cerebral surface is a novel measure of cerebral asymmetry...
  71. ncbi request reprint N-methyl-D-aspartate receptor in working memory impairments in schizophrenia: event-related potential study of late stage of working memory process
    Kyung Heup Ahn
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea
    Prog Neuropsychopharmacol Biol Psychiatry 27:993-9. 2003
    ..021). In conclusion, NMDA receptor antagonist administration elicited WM deficit both in behavioral and electrophysiological level. Electrophysiological component reflecting later stage of WM was impaired by NMDA antagonist...
  72. ncbi request reprint Activity of left inferior frontal gyrus related to word repetition effects: LORETA imaging with 128-channel EEG and individual MRI
    Young Youn Kim
    Institute for Neuroscience, Seoul National University College of Medicine, Seoul, Korea
    Neuroimage 29:712-20. 2006
    ..This is the first study to investigate the generators of word repetition effects using voxel-by-voxel statistical mapping of the current density with individual MRI and high-density EEG...
  73. ncbi request reprint Volumetric investigation of the frontal-subcortical circuitry in patients with obsessive-compulsive disorder
    Do Hyung Kang
    Department of Psychiatry, BK 21 Human Life Science, Seoul National University College of Medicine, Seoul, Korea
    J Neuropsychiatry Clin Neurosci 16:342-9. 2004
    ..These findings suggest that a structural abnormality of this brain region is implicated in the pathophysiology of OCD...
  74. doi request reprint Prospective outcome of early intervention for individuals at ultra-high-risk for psychosis
    GeumSook Shim
    Department of Psychiatry, Seoul National University, College of Medicine, Clinical Cognitive Neuroscience Center, Neuroscience Institute, SNU MRC, Chongno Gu, Seoul, Korea
    Early Interv Psychiatry 2:277-84. 2008
    ....
  75. doi request reprint MRI study of the cavum septum pellucidum in obsessive-compulsive disorder
    Myong Wuk Chon
    Department of Psychiatry, Seoul National University College of Medicine, Chongno Gu, Seoul, 110 744, Korea
    Eur Arch Psychiatry Clin Neurosci 260:337-43. 2010
    ..These results indicate that neurodevelopmental alterations in midline structures might contribute to the pathogenesis of OCD...
  76. doi request reprint Structural abnormalities of the right inferior colliculus in schizophrenia
    Do Hyung Kang
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea
    Psychiatry Res 164:160-5. 2008
    ..The reduced IC volume suggests that a structural abnormality of the IC in patients with schizophrenia may be involved in the auditory cognitive dysfunction of schizophrenia...
  77. doi request reprint Association of genetic variations in DTNBP1 with cognitive function in schizophrenia patients and healthy subjects
    Ji Hyun Baek
    Department of Psychiatry, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Republic of Korea
    Am J Med Genet B Neuropsychiatr Genet 159:841-9. 2012
    ..The observed results suggest the involvement of DTNBP1 not only in the development of attention deficit of schizophrenia, but also in the inter-individual variability of this cognitive domain within the normal functional range...
  78. ncbi request reprint Morphometric alterations of anterior superior temporal cortex in obsessive-compulsive disorder
    Jung Seok Choi
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea
    Depress Anxiety 23:290-6. 2006
    ....
  79. ncbi request reprint Equivalent current dipole of word repetition effects in patients with obsessive-compulsive disorder
    Young Youn Kim
    Institute for Neuroscience, Seoul National University College of Medicine, Seoul, Korea
    Brain Topogr 18:201-12. 2006
    ..These results suggest that OCD patients suffer from the encoding deficits in word processing, particularly in the left hemisphere...
  80. ncbi request reprint Gray matter abnormalities in paranoid schizophrenia and their clinical correlations
    Tae Hyon Ha
    Department of Psychiatry, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul, South Korea
    Psychiatry Res 132:251-60. 2004
    ..These results suggest the important roles of the paralimbic structures in the pathophysiology of schizophrenia and the involvement of the perceptual and monitoring systems in the mechanism of insight...
  81. doi request reprint The use of healthy volunteers instead of patients to inform drug dosing studies: a [¹¹C]raclopride PET study
    Euitae Kim
    Department of Psychiatry, Seoul National University College of Medicine, 28 Yeongon dong, Chongno Gu, Seoul 110 744, South Korea
    Psychopharmacology (Berl) 217:515-23. 2011
    ....
  82. pmc Altered brain activation in ventral frontal-striatal regions following a 16-week pharmacotherapy in unmedicated obsessive-compulsive disorder
    Ji Yeon Han
    Interdisciplinary Program in Neuroscience, Seoul National University, Seoul, Korea
    J Korean Med Sci 26:665-74. 2011
    ..It is suggested that altered brain activation in ventral frontal-striatal regions in OCD patients is associated with their cognitive flexibility and changes in these regions may underlie the pathophysiology of OCD...
  83. ncbi request reprint Fractal dimension in human cortical surface: multiple regression analysis with cortical thickness, sulcal depth, and folding area
    Kiho Im
    Department of Biomedical Engineering, Hanyang University, Seoul, Korea
    Hum Brain Mapp 27:994-1003. 2006
    ..Our findings may indicate the structural characteristics that are revealed in the cerebral cortex when the FD in human brain is increased, and provide important information about brain development...
  84. doi request reprint Social functioning deficits in young people at risk for schizophrenia
    GeumSook Shim
    Department of Neuropsychiatry, Seoul National University, College of Medicine, Seoul, Korea
    Aust N Z J Psychiatry 42:678-85. 2008
    ..The aim of the present study was to test the hypothesis that social impairment is simultaneously a state and trait marker of risk for schizophrenia and schizophrenia-related disorder...
  85. ncbi request reprint Persistent cognitive dysfunction in patients with obsessive-compulsive disorder: a naturalistic study
    Kyu Sik Roh
    Neuroscience Institute, SNU MRC, and Department of Psychiatry, Seoul National University, Seoul, Korea
    Psychiatry Clin Neurosci 59:539-45. 2005
    ..The findings in this study suggested that impaired performance on cognitive domains, such as visuospatial memory and verbal fluency may underline the pathology of OCD...
  86. ncbi request reprint Asymmetry analysis of deformable hippocampal model using the principal component in schizophrenia
    Sun Hyung Kim
    Department of Biomedical Engineering, Hanyang University, Seoul, Korea
    Hum Brain Mapp 25:361-9. 2005
    ..The asymmetry in the schizophrenia group was statistically smaller than that in the control group through reduction of the left hemisphere hippocampus volume...
  87. doi request reprint Diagnostic stability of first-episode psychosis and predictors of diagnostic shift from non-affective psychosis to bipolar disorder: a retrospective evaluation after recurrence
    Ji Sun Kim
    Department of Psychiatry, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    Psychiatry Res 188:29-33. 2011
    ..Special consideration on a diagnostic shift to bipolar disorder is required in patients exhibiting the predictive factors identified in the current study...
  88. pmc Calculating occupancy when one does not have baseline: a comparison of different options
    Euitae Kim
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea
    J Cereb Blood Flow Metab 31:1760-7. 2011
    ..The I(max) method can be applied for receptor occupancy study, and bring more reliability and accuracy to the occupancy study in patients with schizophrenia...
  89. doi request reprint Pharmacotherapy and clinical characteristics of ultra-high-risk for psychosis according to conversion status: a naturalistic observational study
    Euitae Kim
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea
    Early Interv Psychiatry 6:30-7. 2012
    ..To explore the differences in pharmacotherapy and clinical characteristics of individuals at ultra-high-risk (UHR) for psychosis according to the conversion status, we analyzed the data for UHR patients seen at the Seoul Youth Clinic...
  90. ncbi request reprint LORETA imaging of P300 in schizophrenia with individual MRI and 128-channel EEG
    Ji Soo Pae
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, 110 744, Korea
    Neuroimage 20:1552-60. 2003
    ..In conclusion, the reduced and increased areas of current density in schizophrenic patients suggest that the medial temporal and frontal areas contribute to the pathophysiology of schizophrenia, the frontotemporal circuitry abnormality...
  91. ncbi request reprint Neuropsychological profiles of patients with obsessive-compulsive disorder: early onset versus late onset
    Seon Hee Hwang
    Clinical Research Center, Seoul National University Hospital, Seoul, South Korea
    J Int Neuropsychol Soc 13:30-7. 2007
    ..These results suggest that different neurophysiological mechanisms are in play in early and late-onset OCD patients, and age of onset can serve as a potential marker for the subtyping of OCD...
  92. ncbi request reprint Hippocampal shape deformity analysis in obsessive-compulsive disorder
    Soon Beom Hong
    Department of Psychiatry, Seoul National University College of Medicine, SNUMRC, 28 Yongon Dong, Chongno Gu, 110 744 Seoul, Korea
    Eur Arch Psychiatry Clin Neurosci 257:185-90. 2007
    ..Also, further considering the hippocampal neural connections specific to its surface topography, these surface deformities may reflect developmental alterations in these patients with regard to the neural circuitry involving hippocampus...
  93. pmc Gender difference in the prodromal symptoms of first-episode schizophrenia
    Jung Seok Choi
    Department of Psychiatry, SMG SNU Boramae Medical Center, Seoul, Korea
    J Korean Med Sci 24:1083-8. 2009
    ..Our findings suggest that different patterns of prodromal symptoms between male and female begin before the onset of the psychosis. Further prospective studies should be needed...
  94. ncbi request reprint Decreased caudal anterior cingulate gyrus volume and positive symptoms in schizophrenia
    Jung Seok Choi
    Department of Psychiatry, Seoul National University College of Medicine, 28 Yeongon dong, Chongno Gu, Seoul 110 744, Republic of Korea
    Psychiatry Res 139:239-47. 2005
    ..Thus, these findings suggest that a volumetric abnormality of the caudal anterior cingulate gyrus in schizophrenia may be related to positive symptoms and possibly involved in the pathophysiology of schizophrenia...
  95. pmc The reliability and validity of the korean version of the structured interview for prodromal syndrome
    Myung Hun Jung
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea
    Psychiatry Investig 7:257-63. 2010
    ..Here, a Korean version of SIPS is presented, and its reliability, validity, and factor structures are examined using a representative Korean sample...
  96. ncbi request reprint Impact of coexistent schizotypal personality traits on frontal lobe function in obsessive-compulsive disorder
    Na Young Shin
    Interdisciplinary Cognitive Science Program, Seoul National University, Seoul, South Korea
    Prog Neuropsychopharmacol Biol Psychiatry 32:472-8. 2008
    ....
  97. doi request reprint Increased default mode network connectivity associated with meditation
    Joon Hwan Jang
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea
    Neurosci Lett 487:358-62. 2011
    ..These results suggest that the long-term practice of meditation may be associated with functional changes in regions related to internalized attention even when meditation is not being practiced...
  98. doi request reprint Coping strategies and their relationship to psychopathologies in people at ultra high-risk for psychosis and with schizophrenia
    Su Young Lee
    Department of Psychiatry, Yonsei University College of Medicine, Seoul, South Korea
    J Nerv Ment Dis 199:106-10. 2011
    ..These findings suggest that maladaptive coping strategies might have already emerged in the (putative) prodromal stage and could influence symptom severities...
  99. doi request reprint Dysfunctional role of parietal lobe during self-face recognition in schizophrenia
    Je Yeon Yun
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea Institute of Human Behavioral Medicine, SNU MRC, Seoul, Republic of Korea
    Schizophr Res 152:81-8. 2014
    ..The present study examined the effective neural network connectivity underlying self-face recognition in patients with schizophrenia (SZ) using [(15)O]H2O Positron Emission Tomography (PET) and Structural Equation Modeling...
  100. ncbi request reprint A naturalistic multicenter trial of a 12-week weight management program for overweight and obese patients with schizophrenia or schizoaffective disorder
    Seung Jae Lee
    Department of Psychiatry, Seoul National University Hospital and Neuroscience Institute, Seoul, South Korea
    J Clin Psychiatry 69:555-62. 2008
    ..The primary aim of this study was to examine the efficacy and feasibility of a weight control program for overweight and obese patients with schizophrenia or schizoaffective disorder using a large sample across various clinical settings...
  101. ncbi request reprint Weight management program for treatment-emergent weight gain in olanzapine-treated patients with schizophrenia or schizoaffective disorder: A 12-week randomized controlled clinical trial
    Jun Soo Kwon
    Department of Psychiatry, Seoul National University College of Medicine, Chongno Gu, Seoul, Korea
    J Clin Psychiatry 67:547-53. 2006
    ..The effects of the weight management program were also assessed with regard to safety and quality of life...