Jae Sung Ko

Summary

Affiliation: Seoul National University
Country: Korea

Publications

  1. ncbi request reprint [The intestinal microbiota and human disease]
    Jae Sung Ko
    Department of Pediatrics, Seoul National University Children s Hospital, 101 Daehak Ro, Jongno gu, Seoul 110 744, Korea
    Korean J Gastroenterol 62:85-91. 2013
  2. ncbi request reprint Clinical and histological features of nonalcoholic fatty liver disease in children
    Jae Sung Ko
    Department of Pediatrics, Seoul National University College of Medicine, Jongrogu, Seoul 110 744, Korea
    Dig Dis Sci 54:2225-30. 2009
  3. ncbi request reprint [Nonalcoholic fatty liver disease]
    Jae Sung Ko
    Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea
    Korean J Gastroenterol 56:6-14. 2010
  4. ncbi request reprint A mutation analysis of the AGL gene in Korean patients with glycogen storage disease type III
    Jae Sung Ko
    Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea
    J Hum Genet 59:42-5. 2014
  5. ncbi request reprint Interleukin-10 receptor mutations in children with neonatal-onset Crohn's disease and intractable ulcerating enterocolitis
    Jung Ok Shim
    Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Seoul National University College of Medicine, Seoul, Korea
    Eur J Gastroenterol Hepatol 25:1235-40. 2013
  6. pmc Noninvasive parameters and hepatic fibrosis scores in children with nonalcoholic fatty liver disease
    Hye Ran Yang
    Department of Pediatrics, Seoul National University College of Medicine, Seoul, South Korea
    World J Gastroenterol 18:1525-30. 2012
  7. doi request reprint cagA, vacA, and iceA genotypes of Helicobacter pylori in Korean children
    Jae Sung Ko
    Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea
    Pediatr Int 50:628-31. 2008
  8. doi request reprint Clinical features of congenital portosystemic shunt in children
    Myung Jin Kim
    Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea
    Eur J Pediatr 171:395-400. 2012
  9. ncbi request reprint Correlations of plasma citrulline levels with clinical and endoscopic score and blood markers according to small bowel involvement in pediatric Crohn disease
    Eun Hye Lee
    Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Seoul National University College of Medicine, Seoul, Korea
    J Pediatr Gastroenterol Nutr 57:570-5. 2013
  10. pmc Living donor liver transplantation for an infant with osteogenesis imperfecta and intrahepatic cholestasis: report of a case
    Youngrok Choi
    Department of Surgery, Seoul National University College of Medicine, Seoul, Korea
    J Korean Med Sci 29:441-4. 2014

Collaborators

Detail Information

Publications31

  1. ncbi request reprint [The intestinal microbiota and human disease]
    Jae Sung Ko
    Department of Pediatrics, Seoul National University Children s Hospital, 101 Daehak Ro, Jongno gu, Seoul 110 744, Korea
    Korean J Gastroenterol 62:85-91. 2013
    ..Therapeutic options for the diseases linked to imbalance in the microbiota include modifying the gut microbiota through diet, probiotics, and fecal transplants...
  2. ncbi request reprint Clinical and histological features of nonalcoholic fatty liver disease in children
    Jae Sung Ko
    Department of Pediatrics, Seoul National University College of Medicine, Jongrogu, Seoul 110 744, Korea
    Dig Dis Sci 54:2225-30. 2009
    ..Nonalcoholic fatty liver disease (NAFLD) is becoming more frequently diagnosed as the prevalence of obesity in children increases rapidly...
  3. ncbi request reprint [Nonalcoholic fatty liver disease]
    Jae Sung Ko
    Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea
    Korean J Gastroenterol 56:6-14. 2010
    ..Pediatric NASH often displays a histologic pattern distinct from that found in adults. Lifestyle modification through diet and exercise should be attempted in patients diagnosed with NAFLD...
  4. ncbi request reprint A mutation analysis of the AGL gene in Korean patients with glycogen storage disease type III
    Jae Sung Ko
    Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea
    J Hum Genet 59:42-5. 2014
    ..R285X, c.1735+1G>T and p.L1139P accounted for 56% of all alleles, while the remaining mutations are heterogeneous. These three mutations can be common in Korea, and further larger studies are needed to confirm our findings. ..
  5. ncbi request reprint Interleukin-10 receptor mutations in children with neonatal-onset Crohn's disease and intractable ulcerating enterocolitis
    Jung Ok Shim
    Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Seoul National University College of Medicine, Seoul, Korea
    Eur J Gastroenterol Hepatol 25:1235-40. 2013
    ..Mutations, c.[272A>G];[301C>T] (p.[Y91C];[R101W]), were found in IL-10RA. This report confirms the genetic defect of IL-10RA in neonatal-onset IBD including 'intractable ulcerating enterocolitis in infancy'. ..
  6. pmc Noninvasive parameters and hepatic fibrosis scores in children with nonalcoholic fatty liver disease
    Hye Ran Yang
    Department of Pediatrics, Seoul National University College of Medicine, Seoul, South Korea
    World J Gastroenterol 18:1525-30. 2012
    ..To evaluate the noninvasive parameters and hepatic fibrosis scores in obese children with nonalcoholic fatty liver disease (NAFLD)...
  7. doi request reprint cagA, vacA, and iceA genotypes of Helicobacter pylori in Korean children
    Jae Sung Ko
    Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea
    Pediatr Int 50:628-31. 2008
    ..The aims of the present study were to study the distribution of cagA, vacA, and iceA genotypes in children with H. pylori gastritis and to examine the association of genotypes with severity of gastritis...
  8. doi request reprint Clinical features of congenital portosystemic shunt in children
    Myung Jin Kim
    Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea
    Eur J Pediatr 171:395-400. 2012
    ..Spontaneous closure occurred in four infants with intrahepatic shunts including patent ductus venosus. The shunts were closed using transcatheter embolizations in four patients with intrahepatic shunts...
  9. ncbi request reprint Correlations of plasma citrulline levels with clinical and endoscopic score and blood markers according to small bowel involvement in pediatric Crohn disease
    Eun Hye Lee
    Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Seoul National University College of Medicine, Seoul, Korea
    J Pediatr Gastroenterol Nutr 57:570-5. 2013
    ..This study was performed to determine whether plasma citrulline levels correlate with the disease activity in pediatric patients with Crohn disease (CD)...
  10. pmc Living donor liver transplantation for an infant with osteogenesis imperfecta and intrahepatic cholestasis: report of a case
    Youngrok Choi
    Department of Surgery, Seoul National University College of Medicine, Seoul, Korea
    J Korean Med Sci 29:441-4. 2014
    ..He was discharged without surgical complications. Therefore, LT should be considered for patients with end stage liver disease and OI under organic multidisciplinary cooperation. ..
  11. pmc Novel CFTR mutations in a Korean infant with cystic fibrosis and pancreatic insufficiency
    Young June Choe
    Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea
    J Korean Med Sci 25:163-5. 2010
    ..This is the first report of a Korean patient with CF demonstrating pancreatic insufficiency. CF should therefore be considered in the differential diagnosis of infants with steatorrhea and failure to thrive...
  12. ncbi request reprint Does the diagnostic accuracy of the 13C-urea breath test vary with age even after the application of urea hydrolysis rate?
    Hye Ran Yang
    Department of Pediatrics, Seoul National University College of Medicine, Seoul, South Korea
    Helicobacter 13:239-44. 2008
    ..In this study, we evaluated whether age affects the diagnostic accuracy of the (13)C-UBT even after the application of urea hydrolysis rate (UHR) in children...
  13. doi request reprint Congenital chloride diarrhea in Korean children: novel mutations and genetic characteristics
    Jeana Hong
    Division of Pediatric Gastroenterology, Hepatology and Nutrition, Seoul National University Children s Hospital, 101 Daehak Ro, Jongno gu, Seoul 110 169, South Korea
    Eur J Pediatr 172:545-50. 2013
    ..Ser134Asn in exon 5). One previously identified mutation was also found (p.Pro131Leu in exon 5). The most common mutation was c.2063-1G>T, which was found in at least one allele of all patients...
  14. pmc Heterogeneous spectrum of CFTR gene mutations in Korean patients with cystic fibrosis
    Haiyoung Jung
    Department of Laboratory Medicine and Genetics, Samsung Medical Center and Sungkyunkwan University School of Medicine, Seoul, Korea
    Korean J Lab Med 31:219-24. 2011
    ..In Koreans, however, there are very few cases of genetically confirmed CF thus far, and the spectrum of mutations seems quite different from that observed in Caucasians...
  15. doi request reprint Aberrant CpG island hypermethylation in pediatric gastric mucosa in association with Helicobacter pylori infection
    So Hyun Shin
    Laboratory of Epigenetics, Cancer Research Institute, Seoul National University College of Medicine, Korea
    Arch Pathol Lab Med 135:759-65. 2011
    ..Thus, aberrant CpG island hypermethylation in gastric epithelial cells likely occurs early in life, although there are no existing data supporting this notion...
  16. ncbi request reprint Serum ferritin and Helicobacter pylori infection in children: a sero-epidemiologic study in Korea
    Jeong Kee Seo
    Department of Pediatrics, Seoul National University College of Medicine, Clinical Research Institute, Seoul National University Hospital, Korea
    J Gastroenterol Hepatol 17:754-7. 2002
    ..pylori infection. The aim of the present study was to investigate the association between H. pylori infection and iron status in healthy Korean children...
  17. pmc Long-term outcomes of endoscopic variceal ligation to prevent rebleeding in children with esophageal varices
    Ki Soo Kang
    Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea Department of Pediatrics, Jeju national University School of Medicine, Jeju, Korea
    J Korean Med Sci 28:1657-60. 2013
    ..EVL is a safe and highly effective method for the long-term prophylaxis of variceal rebleeding in children with portal hypertension. ..
  18. pmc Genetically confirmed Wilson disease in a 9-month old boy with elevations of aminotransferases
    Joo Whee Kim
    Joo Whee Kim, Jeong Kee Seo, Jae Sung Ko, Ju Young Chang, Hye Ran Yang, Department of Pediatrics, Seoul National University Children s Hospital, Jongro Gu, Seoul 110 744, South Korea
    World J Hepatol 5:156-9. 2013
    ..We report a case of a 9-mo old boy with WD who presented as chronic hepatitis. Genetic analysis showed compound heterozygotes of p.G1186S and c.4006delA...
  19. pmc Long term outcomes of pediatric liver transplantation according to age
    Jeik Byun
    Department of Surgery, Seoul National University College of Medicine, Seoul, Korea
    J Korean Med Sci 29:320-7. 2014
    ..212). The survival outcome of pediatric LT is excellent and similar regardless of age. LTs in infancy are not riskier than those of children. ..
  20. doi request reprint Orthopaedic manifestations of arthrogryposis-renal dysfunction-cholestasis syndrome
    Woo Young Jang
    Department of Orthopaedic Surgery, Seoul National University Children s Hospital, Seoul, South Korea
    J Pediatr Orthop 31:107-12. 2011
    ..It is inherited as an autosomal-recessive trait, associated with germ-line mutations in the VPS33B gene. In this study, the authors reviewed the orthopaedic manifestations of ARC syndrome...
  21. doi request reprint Impedance-pH monitoring and conventional pH monitoring are complementary methods to detect association between gastroesophageal reflux and apnea-related symptoms in preterm infants and neonates
    Myung Seok Shin
    Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea
    J Matern Fetal Neonatal Med 25:2406-10. 2012
    ....
  22. doi request reprint Pediatric liver transplantation for fibropolycystic liver disease
    Jae Sung Ko
    Department of Pediatrics Surgery, Seoul National University College of Medicine, Seoul, South Korea
    Pediatr Transplant 16:195-200. 2012
    ..91 mg/dL at the last follow-up (p = 0.01). LT is an excellent option for children with complications from fibropolycystic liver disease. Renal function should be monitored cautiously after LT in the patients with ARPKD...
  23. doi request reprint Germline mutation analysis of STK11 gene using direct sequencing and multiplex ligation-dependent probe amplification assay in Korean children with Peutz-Jeghers syndrome
    Hye Ran Yang
    Department of Pediatrics, Seoul National University Collegeof Medicine, Seoul, Korea
    Dig Dis Sci 55:3458-65. 2010
    ..In the future, these results may be useful for the genetic diagnosis of Peutz-Jeghers syndrome in Korean children...
  24. pmc Tufting Enteropathy with EpCAM Mutations in Two Siblings
    Jae Sung Ko
    Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea
    Gut Liver 4:407-10. 2010
    ..491+1G>A) and 2) a novel nonsense mutation in exon 3 (c.316A>T, Lys106X). Analysis of EpCAM will be useful for genetic counseling and prenatal diagnosis of tufting enteropathy...
  25. ncbi request reprint Lactobacillus plantarum inhibits epithelial barrier dysfunction and interleukin-8 secretion induced by tumor necrosis factor-alpha
    Jae Sung Ko
    Department of Pediatrics, Seoul National University College of Medicine, 28 Yongon Dong, Chongro Gu, Seoul 110 744, Korea
    World J Gastroenterol 13:1962-5. 2007
    ..To determine whether Lactobacillus plantarum can modify the deleterious effects of tumor necrosis factor-alpha (TNF-alpha) on intestinal epithelial cells...
  26. pmc A novel DHCR7 mutation in a Smith-Lemli-Opitz syndrome infant presenting with neonatal cholestasis
    Jae Sung Ko
    Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea
    J Korean Med Sci 25:159-62. 2010
    ..Although rare in Korea, SLOS should be considered in the differential diagnosis of neonatal cholestasis, especially in patients with multiple congenital anomalies and low serum cholesterol levels...
  27. pmc Clinical application of liver MR imaging in Wilson's disease
    Jung Eun Cheon
    Department of Radiology, Seoul National University College of Medicine, and the Institute of Radiation Medicine, SNUMRC, Seoul, Korea
    Korean J Radiol 11:665-72. 2010
    ..To determine whether there is a correlation between liver MR findings and the clinical manifestations and severity of liver dysfunction in patients with Wilson's disease...
  28. ncbi request reprint cag pathogenicity island of Helicobacter pylori in Korean children
    Jae Sung Ko
    Department of Pediatrics, Seoul National University College of Medicine, Chongno Gu, Seoul, Korea
    Helicobacter 7:232-6. 2002
    ..The aim of this study was to investigate the status of cag pathogenicity island genes and gastric histology in Korean children with H. pylori gastritis...
  29. pmc Neonatal intrahepatic cholestasis caused by citrin deficiency in Korean infants
    Jae Sung Ko
    Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea
    J Korean Med Sci 22:952-6. 2007
    ..With nutritional manipulation, liver functions were normalized and catch-up growth was achieved. NICCD should be considered in the differential diagnosis of cholestatic jaundice in Korean infants...
  30. ncbi request reprint Histopathology and expression of Ki-67 and cyclooxygenase-2 in childhood Helicobacter pylori gastritis
    Kyung Mo Kim
    Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    J Gastroenterol 39:231-7. 2004
    ..pylori-infected children, including histopathologic features, cell proliferation-associated Ki-67 antigen expression, and cyclooxygenase (COX)-2 expression...
  31. doi request reprint Late hepatic complications after Fontan operation; non-invasive markers of hepatic fibrosis and risk factors
    Jae Suk Baek
    Department of Pediatrics, Seoul National University Children s Hospital, Jongno gu, Seoul 110 744, South Korea
    Heart 96:1750-5. 2010
    ..To identify the prevalence, clinical characteristics, risk factors of hepatic complications after a Fontan operation...