Research Topics
Genomes and Genes | V Narry KimSummaryAffiliation: Seoul National University Country: Korea Publications
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Publications
Genomics of microRNAV Narry Kim
Department of Biological Sciences and Research Center for Functional Cellulomics, Seoul National University, Seoul, 151 742, Korea
Trends Genet 22:165-73. 2006..In this article, we summarize the current status of miRNA gene mining and miRNA expression profiling. We also review up-to-date knowledge of miRNA gene structure and the biogenesis mechanism. Our focus is on animal miRNAs...- Small RNAs just got bigger: Piwi-interacting RNAs (piRNAs) in mammalian testesV Narry Kim
School of Biological Sciences and Institute of Molecular Biology and Genetics, Seoul National University, Korea
Genes Dev 20:1993-7. 2006..Although the biogenesis and function of these RNAs are yet to be determined, these findings may add new dimensions in small RNA biology and germline cell biology... - Processing of intronic microRNAsYoung Kook Kim
Department of Biological Sciences and Institute of Molecular Biology and Genetics, Seoul National University, Seoul, Korea
EMBO J 26:775-83. 2007..Our study provides a novel example of eukaryotic gene organization and RNA-processing control... - Sorting out small RNAsV Narry Kim
School of Biological Sciences and National Creative Research Initiatives Center, Seoul National University, Seoul, 151 742, Korea
Cell 133:25-6. 2008..Two papers in this issue (Mi et al., 2008; Montgomery et al., 2008) now reveal the importance of the 5' terminal nucleotide of the small RNA in the sorting process in Arabidopsis... - MicroRNA biogenesis: coordinated cropping and dicingV Narry Kim
Department of Biological Sciences and Institute of Molecular Biology and Genetics, Seoul National University, Seoul, 151 742, Korea
Nat Rev Mol Cell Biol 6:376-85. 2005..Among the most pressing questions regarding this unusual class of regulatory miRNA-encoding genes is how miRNAs are produced in cells and how the genes themselves are controlled by various regulatory networks... - Small RNAs: classification, biogenesis, and functionV Narry Kim
Department of Biological Sciences, Institute of Molecular Biology and Genetics, Seoul National University, Seoul 151 742, Korea
Mol Cells 19:1-15. 2005..In this review, I will summarize the current classification, biogenesis, action mechanism and function of these fascinating molecules... - Biogenesis of small RNAs in animalsV Narry Kim
School of Biological Sciences and Center for National Creative Research, Seoul National University, Seoul, 151 742, Korea
Nat Rev Mol Cell Biol 10:126-39. 2009..This Review summarizes our current knowledge of how these intriguing molecules are generated in animal cells... - MicroRNA precursors in motion: exportin-5 mediates their nuclear exportV Narry Kim
School of Biological Sciences and Institute of Molecular Biology and Genetics, Seoul National University, Korea
Trends Cell Biol 14:156-9. 2004..However, recent studies have shown that exportin-5 (Exp5), a Ran-dependent importin-beta-related transport receptor, mediates nuclear export of miRNA precursors (pre-miRNAs)... - RNA interference in functional genomics and medicineV Narry Kim
Institute of Molecular Biology and Genetics and School of Biological Science, Seoul National University, Seoul, Korea
J Korean Med Sci 18:309-18. 2003..The interesting biology as well as the remarkable technical value has been drawing widespread attention to this exciting new field... - Human UPF1 participates in small RNA-induced mRNA downregulationHua Jin
School of Biological Sciences, Seoul National University, Seoul 151 742, Republic of Korea
Mol Cell Biol 29:5789-99. 2009..Our data thus suggest that hUPF1 may participate in RNA silencing by facilitating the binding of the RNA-induced silencing complex to the target and by accelerating the decay of the mRNA... - Lin28 mediates the terminal uridylation of let-7 precursor MicroRNAInha Heo
National Creative Research Center and School of Biological Sciences, Seoul National University, Seoul 151 742, Korea
Mol Cell 32:276-84. 2008..The Lin28-mediated downregulation of let-7 may play a key role in development, stem cell programming, and tumorigenesis... - Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complexJinju Han
School of Biological Sciences and Research Center for Functional Cellulomics, Seoul National University, Seoul
Cell 125:887-901. 2006..Our current study thus facilitates the prediction of novel microRNAs and will assist in the rational design of small hairpin RNAs for RNA interference... - Posttranscriptional crossregulation between Drosha and DGCR8Jinju Han
School of Biological Sciences and National Creative Research Center, Seoul National University, Seoul 151 742, Korea
Cell 136:75-84. 2009..Our study reveals a previously unsuspected function of Microprocessor in mRNA stability control... - miR-29 miRNAs activate p53 by targeting p85 alpha and CDC42Seong Yeon Park
National Creative Research Center and School of Biological Sciences, Seoul National University, 599 Gwanangno, Gwanak Gu, Seoul 151 742, South Korea
Nat Struct Mol Biol 16:23-9. 2009..Our findings provide new insights into the role of miRNAs in the p53 pathway... - The Drosha-DGCR8 complex in primary microRNA processingJinju Han
School of Biological Sciences and Institute of Molecular Biology and Genetics, Seoul National University, Seoul, 151 742, Korea
Genes Dev 18:3016-27. 2004..Based on these results, we propose a model for the action mechanism of class II RNase III proteins... - Characterization of DGCR8/Pasha, the essential cofactor for Drosha in primary miRNA processingKyu-Hyeon Yeom
Department of Biological Sciences and Research Center for Functional Cellulomics, Seoul National University, Seoul 151-742, Korea
Nucleic Acids Res 34:4622-9. 2006..Our study thus provides further insights into the mechanism of action of the Drosha-DGCR8 complex in pri-miRNA processing... - MicroRNA genes are transcribed by RNA polymerase IIYoontae Lee
Institute of Molecular Biology and Genetics and School of Biological Science, Seoul National University, Seoul, Korea
EMBO J 23:4051-60. 2004..These data indicate that pol II is the main, if not the only, RNA polymerase for miRNA gene transcription. Our study offers a basis for understanding the structure and regulation of miRNA genes... - The nuclear RNase III Drosha initiates microRNA processingYoontae Lee
Institute of Molecular Biology and Genetics and School of Biological Sciences, Seoul National University, Seoul 151 742, Korea
Nature 425:415-9. 2003..Thus, the two RNase III proteins, Drosha and Dicer, may collaborate in the stepwise processing of miRNAs, and have key roles in miRNA-mediated gene regulation in processes such as development and differentiation... - The role of PACT in the RNA silencing pathwayYoontae Lee
Department of Biological Sciences and Research Center for Functional Cellulomics, Seoul National University, Seoul, Korea
EMBO J 25:522-32. 2006..Our study indicates that, unlike other RNase III type proteins, human Dicer may employ two different dsRBD-containing proteins that facilitate RISC assembly... - Dicer recognizes the 5' end of RNA for efficient and accurate processingJong Eun Park
School of Biological Sciences, Seoul National University, Seoul 151 742, Korea
Nature 475:201-5. 2011..Thus, 5'-end recognition by Dicer is important for precise and effective biogenesis of miRNAs. Insights from this study should also afford practical benefits to the design of small hairpin RNAs... - Modifications of small RNAs and their associated proteinsYoung Kook Kim
Center for National Creative Research, Seoul National University, Korea
Cell 143:703-9. 2010..Some of the modifications are under the influence of cellular signaling, thus contributing to the dynamic regulation of RNA silencing... - Mono-Uridylation of Pre-MicroRNA as a Key Step in the Biogenesis of Group II let-7 MicroRNAsInha Heo
Institute for Basic Science, Seoul National University, Seoul 151 742, Korea School of Biological Sciences, Seoul National University, Seoul 151 742, Korea
Cell 151:521-32. 2012..Our study reveals functional duality of uridylation and introduces TUT7/4/2 as components of the miRNA biogenesis pathway... - Conserved MicroRNA miR-8/miR-200 and its target USH/FOG2 control growth by regulating PI3KSeogang Hyun
School of Biological Sciences and National Creative Research Center, Seoul National University, Seoul, 151 742, Korea
Cell 139:1096-108. 2009..Our study identifies two novel regulators of insulin signaling, miR-8/miR-200 and USH/FOG2, and suggests their roles in adolescent growth, aging, and cancer... - Single-molecule approach to immunoprecipitated protein complexes: insights into miRNA uridylationKyu Hyeon Yeom
School of Biological Sciences and Creative Research Center, Seoul National University, Seoul 151 742, Korea Kavli Institute of NanoScience and Department of BioNanoScience, Delft University of Technology, Lorentzweg 1, Delft 2628 CJ, The Netherlands
EMBO Rep 12:690-6. 2011..Our new technique, SIMPlex (single-molecule approach to immunoprecipitated protein complexes), provides a universal tool to analyse complex proteins at the single-molecule level... - TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylationInha Heo
Creative Research Center and School of Biological Sciences, Seoul National University, Seoul, Korea
Cell 138:696-708. 2009..This study uncovers the role of TUT4 and Lin28 as specific suppressors of miRNA biogenesis, which has implications for stem cell research and cancer biology... - Regulation of ApC/EBP mRNA by the Aplysia AU-rich element-binding protein, ApELAV, and its effects on 5-hydroxytryptamine-induced long-term facilitationSe-Jeong Yim
National Research Laboratory, Institute of Molecular Biology and Genetics, School of Biological Sciences, College of Natural Sciences, Seoul National University, San 56-1 Silim-dong, Gwanak-gu, Seoul 151-747, Korea
J Neurochem 98:420-9. 2006.... - LIN28A Is a Suppressor of ER-Associated Translation in Embryonic Stem CellsJun Cho
Institute for Basic Science, Seoul National University, Seoul 151 742, Korea School of Biological Sciences, Seoul National University, Seoul 151 742, Korea
Cell 151:765-77. 2012..Our study suggests a selective regulatory mechanism for ER-associated translation and reveals an unexpected role of LIN28A as a global suppressor of genes in the secretory pathway... - Conserved microRNA miR-8 controls body size in response to steroid signaling in DrosophilaHua Jin
School of Biological Sciences, Seoul National University, Seoul 151 742, Korea
Genes Dev 26:1427-32. 2012..Consistently, perturbation of USH impedes ecdysone's effect on body growth. Thus, miR-8 acts as a molecular rheostat that tunes organismal growth in response to a developmental maturation signal... - Functional links between clustered microRNAs: suppression of cell-cycle inhibitors by microRNA clusters in gastric cancerYoung Kook Kim
Department of Biological Sciences, Seoul National University, Seoul, Korea
Nucleic Acids Res 37:1672-81. 2009..Our study demonstrates the functional associations between clustered miRNAs and further implicates that effective cancer treatment may require a combinatorial approach to target multiple oncogenic miRNA clusters... - In vitro and in vivo assays for the activity of Drosha complexYoontae Lee
School of Biological Sciences, Seoul National University, Seoul, Korea
Methods Enzymol 427:89-106. 2007..Here we describe the methods for the analysis of pri-miRNA processing that is mediated by Drosha and its cofactor, DiGeorge Syndrome Critical Region Gene 8 (DGCR8)... - Cell adhesion-dependent control of microRNA decayYoung Kook Kim
School of Biological Sciences, Seoul National University, Seoul 151 742, Korea
Mol Cell 43:1005-14. 2011..Induced destruction of persistent regulatory molecules such as miRNAs may increase cellular plasticity and facilitate cellular remodeling in response to the changes in cell adhesion... - Structural and functional insights into Dom34, a key component of no-go mRNA decayHyung Ho Lee
Department of Chemistry, College of Natural Sciences, Seoul National University, Seoul 151 747, Korea
Mol Cell 27:938-50. 2007..We also demonstrate that domain 1 of Dom34 has an endoribonuclease activity against defined RNA substrates containing a stem loop, which supports a direct catalytic role of yeast Dom34 in no-go mRNA decay... - Regulating the regulators: posttranslational modifications of RNA silencing factorsInha Heo
School of Biological Sciences and National Creative Research Initiatives Center, Seoul National University, Seoul 151 742, Korea
Cell 139:28-31. 2009..Recent papers, including one in this issue of Cell (Paroo et al., 2009), now reveal the posttranslational modifications that take part in the regulation of the core RNA silencing factors, Ago, Piwi, and TRBP... - Control of splicing efficiency by the mouse histone H2a element in a murine leukemia virus-based retroviral vectorJun Tae Lee
Institute of Molecular Biology and Genetics, Seoul National University, Seoul, South Korea
Mol Ther 15:167-72. 2007..Our data suggested that the mH2aE could be used for the fine-tuning of the splicing process, thus improving the level of gene expression and viral titer in the context of retroviral vectors... - MicroRNA maturation: stepwise processing and subcellular localizationYoontae Lee
Institute of Molecular Biology and Genetics and School of Biological Science, Seoul National University, Seoul 151-742, Korea
EMBO J 21:4663-70. 2002..Our study suggests that the regulation of miRNA expression may occur at multiple levels, including the two processing steps and the nuclear export step. These data will provide a framework for further studies on miRNA biogenesis... - The co-regulation mechanism of transcription factors in the human gene regulatory networkJunil Kim
Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology KAIST, 291 Daehak ro, Yuseong Gu, Daejeon 305 701, Department of Mathematics, University of Seoul, Seoul 130 743 and School of Biological Sciences and National Creative Research Center, Seoul National University, Seoul 151 742, Republic of Korea
Nucleic Acids Res 40:8849-61. 2012.... - Human cytomegalovirus microRNA miR-US4-1 inhibits CD8(+) T cell responses by targeting the aminopeptidase ERAP1Sungchul Kim
National Creative Research Initiative Center for Antigen Presentation, Department of Biological Sciences, Seoul National University, Seoul, Republic of Korea
Nat Immunol 12:984-91. 2011..Our findings identify a previously unknown viral miRNA-based CTL-evasion mechanism that targets a key step in the MHC class I antigen-processing pathway... - Human microRNA prediction through a probabilistic co-learning model of sequence and structureJin-Wu Nam
Graduate Program in Bioinformatics, Seoul National University Seoul 151-744, Korea
Nucleic Acids Res 33:3570-81. 2005..Our study suggests that the miRNA gene family may be more abundant than previously anticipated, and confer highly extensive regulatory networks on eukaryotic cells... - Crystal structure of human DGCR8 coreSun Young Sohn
National Creative Research Center for Structural Biology and Department of Life Science, Pohang University of Science and Technology, Hyo ja dong, San31, Pohang, Kyungbook 790 784, South Korea
Nat Struct Mol Biol 14:847-53. 2007..This structure, together with fluorescent resonance energy transfer and mutational analyses, suggests that the DGCR8 core recognizes pri-miRNA in two possible orientations. We propose a model for DGCR8's recognition of pri-miRNA... - Human embryonic stem cells express a unique set of microRNAsMi Ra Suh
Cell and Gene Therapy Research Institute, Pochon CHA University College of Medicine, Seoul 135 081, South Korea
Dev Biol 270:488-98. 2004..The newly identified hES-specific miRNAs may also serve as molecular markers for the early embryonic stage and for undifferentiated hES cells... - Preparation and analysis of DroshaYoontae Lee
School of Biological Science, Seoul National University, South Korea
Methods Mol Biol 309:17-28. 2005