V Narry Kim

Summary

Affiliation: Seoul National University
Country: Korea

Publications

  1. Kim Y, Kim B, Kim V. Re-evaluation of the roles of DROSHA, Export in 5, and DICER in microRNA biogenesis. Proc Natl Acad Sci U S A. 2016;113:E1881-9 pubmed publisher
    ..Thus, this study allows us to understand differential contributions of key biogenesis factors, and provides with valuable resources for miRNA research. ..
  2. Cho J, Yu N, Choi J, Sim S, Kang S, Kwak C, et al. Multiple repressive mechanisms in the hippocampus during memory formation. Science. 2015;350:82-7 pubmed publisher
    ..Collectively, this study unveils the yet-unappreciated importance of gene repression mechanisms for memory formation. ..
  3. Lee M, Kim B, Kim V. Emerging roles of RNA modification: m(6)A and U-tail. Cell. 2014;158:980-987 pubmed publisher
    ..This Minireview summarizes the molecular machineries and biological functions of methylation (N6-methyladenosine, m(6)A) and uridylation (U-tail). ..
  4. Kim B, Kim V. fCLIP-seq for transcriptomic footprinting of dsRNA-binding proteins: lessons from DROSHA. Methods. 2018;: pubmed publisher
    ..fCLIP-seq is a useful tool to obtain transcriptome-wide information on DROSHA activity and can be applied further to investigate other dsRNA-protein interactions. ..
  5. Lim J, Kim D, Lee Y, Ha M, Lee M, Yeo J, et al. Mixed tailing by TENT4A and TENT4B shields mRNA from rapid deadenylation. Science. 2018;361:701-704 pubmed publisher
    ..Thus, TENT4A and TENT4B produce a mixed tail that shields mRNA from rapid deadenylation. Our study unveils the role of mixed tailing and expands the complexity of posttranscriptional gene regulation. ..
  6. Yi H, Park J, Ha M, Lim J, Chang H, Kim V. PABP Cooperates with the CCR4-NOT Complex to Promote mRNA Deadenylation and Block Precocious Decay. Mol Cell. 2018;70:1081-1088.e5 pubmed publisher
    ..Concerted actions of CAF1 and CCR4 delineate the ?27 nt periodic PABPC footprints along shortening tail. Our study unveils distinct functions of deadenylases and PABPC, re-drawing the view on mRNA deadenylation and regulation. ..
  7. Kwon S, Nguyen T, Choi Y, Jo M, Hohng S, Kim V, et al. Structure of Human DROSHA. Cell. 2016;164:81-90 pubmed publisher
    ..Our study implicates the evolutionary origin of DROSHA and elucidates the molecular basis of Microprocessor assembly and primary microRNA processing. ..
  8. Chang H, Yeo J, Kim J, Kim H, Lim J, Lee M, et al. Terminal Uridylyltransferases Execute Programmed Clearance of Maternal Transcriptome in Vertebrate Embryos. Mol Cell. 2018;70:72-82.e7 pubmed publisher
    ..Our study demonstrates that uridylation plays a crucial role in timely mRNA degradation, thereby allowing the progression of early development. ..
  9. request reprint
    Kim V. MicroRNA precursors in motion: exportin-5 mediates their nuclear export. Trends Cell Biol. 2004;14:156-9 pubmed
    ..However, recent studies have shown that exportin-5 (Exp5), a Ran-dependent importin-beta-related transport receptor, mediates nuclear export of miRNA precursors (pre-miRNAs). ..

More Information

Publications18

  1. Son A, Park J, Kim V. PARN and TOE1 Constitute a 3' End Maturation Module for Nuclear Non-coding RNAs. Cell Rep. 2018;23:888-898 pubmed publisher
    ..Our findings extend the knowledge of nuclear ncRNA biogenesis, and they provide insights into the pathology of PARN/TOE1-associated genetic disorders whose therapeutic treatments are currently unavailable. ..
  2. Nguyen T, Jo M, Choi Y, Park J, Kwon S, Hohng S, et al. Functional Anatomy of the Human Microprocessor. Cell. 2015;161:1374-87 pubmed publisher
    ..These findings clarify controversies over the action mechanism of DROSHA and allow us to build a general model for pri-miRNA processing. ..
  3. Kim B, Jeong K, Kim V. Genome-wide Mapping of DROSHA Cleavage Sites on Primary MicroRNAs and Noncanonical Substrates. Mol Cell. 2017;66:258-269.e5 pubmed publisher
    ..We anticipate that fCLIP-seq could be a general tool for investigating interactions between dsRNA-binding proteins and structured RNAs. ..
  4. Kim V, Han J, Siomi M. Biogenesis of small RNAs in animals. Nat Rev Mol Cell Biol. 2009;10:126-39 pubmed publisher
    ..This Review summarizes our current knowledge of how these intriguing molecules are generated in animal cells. ..
  5. Lee M, Choi Y, Kim K, Jin H, Lim J, Nguyen T, et al. Adenylation of maternally inherited microRNAs by Wispy. Mol Cell. 2014;56:696-707 pubmed publisher
    ..Our work provides mechanistic insights into the regulation of maternal microRNAs and illustrates the importance of RNA tailing in development. ..
  6. Kim Y, Yeo J, Lee J, Cho J, Seo D, Kim J, et al. Deletion of human tarbp2 reveals cellular microRNA targets and cell-cycle function of TRBP. Cell Rep. 2014;9:1061-74 pubmed publisher
    ..By generating human TRBP KO cells, our study clarifies the role of TRBP and unveils negative feedback regulation of PKR through TRBP phosphorylation. ..
  7. Lim J, Ha M, Chang H, Kwon S, Simanshu D, Patel D, et al. Uridylation by TUT4 and TUT7 marks mRNA for degradation. Cell. 2014;159:1365-76 pubmed publisher
    ..Our study explains the mechanism underlying selective uridylation of deadenylated mRNAs and demonstrates a fundamental role of oligo-U-tail as a molecular mark for global mRNA decay. ..
  8. Park J, Yi H, Kim Y, Chang H, Kim V. Regulation of Poly(A) Tail and Translation during the Somatic Cell Cycle. Mol Cell. 2016;62:462-471 pubmed publisher
    ..Our quantitative and comprehensive data provide a revised view of translational control in the somatic cell cycle. ..
  9. Chang H, Lim J, Ha M, Kim V. TAIL-seq: genome-wide determination of poly(A) tail length and 3' end modifications. Mol Cell. 2014;53:1044-52 pubmed publisher
    ..TAIL-seq is a potent tool to dissect dynamic control of mRNA turnover and translational control, and to discover unforeseen features of RNA cleavage and tailing. ..