V Narry Kim

Summary

Affiliation: Seoul National University
Country: Korea

Publications

  1. ncbi request reprint Genomics of microRNA
    V Narry Kim
    Department of Biological Sciences and Research Center for Functional Cellulomics, Seoul National University, Seoul, 151 742, Korea
    Trends Genet 22:165-73. 2006
  2. ncbi request reprint Small RNAs just got bigger: Piwi-interacting RNAs (piRNAs) in mammalian testes
    V Narry Kim
    School of Biological Sciences and Institute of Molecular Biology and Genetics, Seoul National University, Korea
    Genes Dev 20:1993-7. 2006
  3. pmc Processing of intronic microRNAs
    Young Kook Kim
    Department of Biological Sciences and Institute of Molecular Biology and Genetics, Seoul National University, Seoul, Korea
    EMBO J 26:775-83. 2007
  4. pmc Functional links between clustered microRNAs: suppression of cell-cycle inhibitors by microRNA clusters in gastric cancer
    Young Kook Kim
    Department of Biological Sciences, Seoul National University, Seoul, Korea
    Nucleic Acids Res 37:1672-81. 2009
  5. pmc Characterization of DGCR8/Pasha, the essential cofactor for Drosha in primary miRNA processing
    Kyu Hyeon Yeom
    Department of Biological Sciences and Research Center for Functional Cellulomics, Seoul National University, Seoul 151 742, Korea
    Nucleic Acids Res 34:4622-9. 2006
  6. doi request reprint Biogenesis of small RNAs in animals
    V Narry Kim
    School of Biological Sciences and Center for National Creative Research, Seoul National University, Seoul, 151 742, Korea
    Nat Rev Mol Cell Biol 10:126-39. 2009
  7. ncbi request reprint MicroRNA biogenesis: coordinated cropping and dicing
    V Narry Kim
    Department of Biological Sciences and Institute of Molecular Biology and Genetics, Seoul National University, Seoul, 151 742, Korea
    Nat Rev Mol Cell Biol 6:376-85. 2005
  8. ncbi request reprint Small RNAs: classification, biogenesis, and function
    V Narry Kim
    Department of Biological Sciences, Institute of Molecular Biology and Genetics, Seoul National University, Seoul 151 742, Korea
    Mol Cells 19:1-15. 2005
  9. pmc RNA interference in functional genomics and medicine
    V Narry Kim
    Institute of Molecular Biology and Genetics and School of Biological Science, Seoul National University, Seoul, Korea
    J Korean Med Sci 18:309-18. 2003
  10. doi request reprint Sorting out small RNAs
    V Narry Kim
    School of Biological Sciences and National Creative Research Initiatives Center, Seoul National University, Seoul, 151 742, Korea
    Cell 133:25-6. 2008

Collaborators

Detail Information

Publications46

  1. ncbi request reprint Genomics of microRNA
    V Narry Kim
    Department of Biological Sciences and Research Center for Functional Cellulomics, Seoul National University, Seoul, 151 742, Korea
    Trends Genet 22:165-73. 2006
    ..In this article, we summarize the current status of miRNA gene mining and miRNA expression profiling. We also review up-to-date knowledge of miRNA gene structure and the biogenesis mechanism. Our focus is on animal miRNAs...
  2. ncbi request reprint Small RNAs just got bigger: Piwi-interacting RNAs (piRNAs) in mammalian testes
    V Narry Kim
    School of Biological Sciences and Institute of Molecular Biology and Genetics, Seoul National University, Korea
    Genes Dev 20:1993-7. 2006
    ..Although the biogenesis and function of these RNAs are yet to be determined, these findings may add new dimensions in small RNA biology and germline cell biology...
  3. pmc Processing of intronic microRNAs
    Young Kook Kim
    Department of Biological Sciences and Institute of Molecular Biology and Genetics, Seoul National University, Seoul, Korea
    EMBO J 26:775-83. 2007
    ..Our study provides a novel example of eukaryotic gene organization and RNA-processing control...
  4. pmc Functional links between clustered microRNAs: suppression of cell-cycle inhibitors by microRNA clusters in gastric cancer
    Young Kook Kim
    Department of Biological Sciences, Seoul National University, Seoul, Korea
    Nucleic Acids Res 37:1672-81. 2009
    ..Our study demonstrates the functional associations between clustered miRNAs and further implicates that effective cancer treatment may require a combinatorial approach to target multiple oncogenic miRNA clusters...
  5. pmc Characterization of DGCR8/Pasha, the essential cofactor for Drosha in primary miRNA processing
    Kyu Hyeon Yeom
    Department of Biological Sciences and Research Center for Functional Cellulomics, Seoul National University, Seoul 151 742, Korea
    Nucleic Acids Res 34:4622-9. 2006
    ..Our study thus provides further insights into the mechanism of action of the Drosha-DGCR8 complex in pri-miRNA processing...
  6. doi request reprint Biogenesis of small RNAs in animals
    V Narry Kim
    School of Biological Sciences and Center for National Creative Research, Seoul National University, Seoul, 151 742, Korea
    Nat Rev Mol Cell Biol 10:126-39. 2009
    ..This Review summarizes our current knowledge of how these intriguing molecules are generated in animal cells...
  7. ncbi request reprint MicroRNA biogenesis: coordinated cropping and dicing
    V Narry Kim
    Department of Biological Sciences and Institute of Molecular Biology and Genetics, Seoul National University, Seoul, 151 742, Korea
    Nat Rev Mol Cell Biol 6:376-85. 2005
    ..Among the most pressing questions regarding this unusual class of regulatory miRNA-encoding genes is how miRNAs are produced in cells and how the genes themselves are controlled by various regulatory networks...
  8. ncbi request reprint Small RNAs: classification, biogenesis, and function
    V Narry Kim
    Department of Biological Sciences, Institute of Molecular Biology and Genetics, Seoul National University, Seoul 151 742, Korea
    Mol Cells 19:1-15. 2005
    ..In this review, I will summarize the current classification, biogenesis, action mechanism and function of these fascinating molecules...
  9. pmc RNA interference in functional genomics and medicine
    V Narry Kim
    Institute of Molecular Biology and Genetics and School of Biological Science, Seoul National University, Seoul, Korea
    J Korean Med Sci 18:309-18. 2003
    ..The interesting biology as well as the remarkable technical value has been drawing widespread attention to this exciting new field...
  10. doi request reprint Sorting out small RNAs
    V Narry Kim
    School of Biological Sciences and National Creative Research Initiatives Center, Seoul National University, Seoul, 151 742, Korea
    Cell 133:25-6. 2008
    ..Two papers in this issue (Mi et al., 2008; Montgomery et al., 2008) now reveal the importance of the 5' terminal nucleotide of the small RNA in the sorting process in Arabidopsis...
  11. ncbi request reprint MicroRNA precursors in motion: exportin-5 mediates their nuclear export
    V Narry Kim
    School of Biological Sciences and Institute of Molecular Biology and Genetics, Seoul National University, Korea
    Trends Cell Biol 14:156-9. 2004
    ..However, recent studies have shown that exportin-5 (Exp5), a Ran-dependent importin-beta-related transport receptor, mediates nuclear export of miRNA precursors (pre-miRNAs)...
  12. pmc Human UPF1 participates in small RNA-induced mRNA downregulation
    Hua Jin
    School of Biological Sciences, Seoul National University, Seoul 151 742, Republic of Korea
    Mol Cell Biol 29:5789-99. 2009
    ..Our data thus suggest that hUPF1 may participate in RNA silencing by facilitating the binding of the RNA-induced silencing complex to the target and by accelerating the decay of the mRNA...
  13. ncbi request reprint Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex
    Jinju Han
    School of Biological Sciences and Research Center for Functional Cellulomics, Seoul National University, Seoul
    Cell 125:887-901. 2006
    ..Our current study thus facilitates the prediction of novel microRNAs and will assist in the rational design of small hairpin RNAs for RNA interference...
  14. doi request reprint Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA
    Inha Heo
    National Creative Research Center and School of Biological Sciences, Seoul National University, Seoul 151 742, Korea
    Mol Cell 32:276-84. 2008
    ..The Lin28-mediated downregulation of let-7 may play a key role in development, stem cell programming, and tumorigenesis...
  15. pmc The role of PACT in the RNA silencing pathway
    Yoontae Lee
    Department of Biological Sciences and Research Center for Functional Cellulomics, Seoul National University, Seoul, Korea
    EMBO J 25:522-32. 2006
    ..Our study indicates that, unlike other RNase III type proteins, human Dicer may employ two different dsRBD-containing proteins that facilitate RISC assembly...
  16. pmc The Drosha-DGCR8 complex in primary microRNA processing
    Jinju Han
    School of Biological Sciences and Institute of Molecular Biology and Genetics, Seoul National University, Seoul, 151 742, Korea
    Genes Dev 18:3016-27. 2004
    ..Based on these results, we propose a model for the action mechanism of class II RNase III proteins...
  17. doi request reprint Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs
    Inha Heo
    Institute for Basic Science, Seoul National University, Seoul 151 742, Korea
    Cell 151:521-32. 2012
    ..Our study reveals functional duality of uridylation and introduces TUT7/4/2 as components of the miRNA biogenesis pathway...
  18. pmc Posttranscriptional crossregulation between Drosha and DGCR8
    Jinju Han
    School of Biological Sciences and National Creative Research Center, Seoul National University, Seoul 151 742, Korea
    Cell 136:75-84. 2009
    ..Our study reveals a previously unsuspected function of Microprocessor in mRNA stability control...
  19. doi request reprint miR-29 miRNAs activate p53 by targeting p85 alpha and CDC42
    Seong Yeon Park
    National Creative Research Center and School of Biological Sciences, Seoul National University, 599 Gwanangno, Gwanak Gu, Seoul 151 742, South Korea
    Nat Struct Mol Biol 16:23-9. 2009
    ..Our findings provide new insights into the role of miRNAs in the p53 pathway...
  20. pmc MicroRNA genes are transcribed by RNA polymerase II
    Yoontae Lee
    Institute of Molecular Biology and Genetics and School of Biological Science, Seoul National University, Seoul, Korea
    EMBO J 23:4051-60. 2004
    ..These data indicate that pol II is the main, if not the only, RNA polymerase for miRNA gene transcription. Our study offers a basis for understanding the structure and regulation of miRNA genes...
  21. ncbi request reprint TAIL-seq: genome-wide determination of poly(A) tail length and 3' end modifications
    Hyeshik Chang
    Center for RNA Research, Institute for Basic Science, Seoul 151 742, Korea School of Biological Sciences, Seoul National University, Seoul 151 742, Korea
    Mol Cell 53:1044-52. 2014
    ..TAIL-seq is a potent tool to dissect dynamic control of mRNA turnover and translational control, and to discover unforeseen features of RNA cleavage and tailing. ..
  22. ncbi request reprint The nuclear RNase III Drosha initiates microRNA processing
    Yoontae Lee
    Institute of Molecular Biology and Genetics and School of Biological Sciences, Seoul National University, Seoul 151 742, Korea
    Nature 425:415-9. 2003
    ..Thus, the two RNase III proteins, Drosha and Dicer, may collaborate in the stepwise processing of miRNAs, and have key roles in miRNA-mediated gene regulation in processes such as development and differentiation...
  23. doi request reprint Dicer recognizes the 5' end of RNA for efficient and accurate processing
    Jong Eun Park
    School of Biological Sciences, Seoul National University, Seoul 151 742, Korea
    Nature 475:201-5. 2011
    ..Thus, 5'-end recognition by Dicer is important for precise and effective biogenesis of miRNAs. Insights from this study should also afford practical benefits to the design of small hairpin RNAs...
  24. doi request reprint Modifications of small RNAs and their associated proteins
    Young Kook Kim
    Center for National Creative Research, Seoul National University, Korea
    Cell 143:703-9. 2010
    ..Some of the modifications are under the influence of cellular signaling, thus contributing to the dynamic regulation of RNA silencing...
  25. doi request reprint LIN28A is a suppressor of ER-associated translation in embryonic stem cells
    Jun Cho
    Institute for Basic Science, Seoul National University, Seoul 151 742, Korea
    Cell 151:765-77. 2012
    ..Our study suggests a selective regulatory mechanism for ER-associated translation and reveals an unexpected role of LIN28A as a global suppressor of genes in the secretory pathway...
  26. pmc Single-molecule approach to immunoprecipitated protein complexes: insights into miRNA uridylation
    Kyu Hyeon Yeom
    School of Biological Sciences and Creative Research Center, Seoul National University, Seoul 151 742, Korea Kavli Institute of NanoScience and Department of BioNanoScience, Delft University of Technology, Lorentzweg 1, Delft 2628 CJ, The Netherlands
    EMBO Rep 12:690-6. 2011
    ..Our new technique, SIMPlex (single-molecule approach to immunoprecipitated protein complexes), provides a universal tool to analyse complex proteins at the single-molecule level...
  27. doi request reprint Conserved MicroRNA miR-8/miR-200 and its target USH/FOG2 control growth by regulating PI3K
    Seogang Hyun
    School of Biological Sciences and National Creative Research Center, Seoul National University, Seoul, 151 742, Korea
    Cell 139:1096-108. 2009
    ..Our study identifies two novel regulators of insulin signaling, miR-8/miR-200 and USH/FOG2, and suggests their roles in adolescent growth, aging, and cancer...
  28. ncbi request reprint PKR is activated by cellular dsRNAs during mitosis and acts as a mitotic regulator
    Yoosik Kim
    Center for RNA Research, Institute for Basic Science, Seoul 151 742, Korea School of Biological Sciences, Seoul National University, Seoul 151 742, Korea
    Genes Dev 28:1310-22. 2014
    ..Our study unveils a novel function of PKR and endogenous dsRNAs as signaling molecules during the mitosis of uninfected cells. ..
  29. doi request reprint TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation
    Inha Heo
    Creative Research Center and School of Biological Sciences, Seoul National University, Seoul, Korea
    Cell 138:696-708. 2009
    ..This study uncovers the role of TUT4 and Lin28 as specific suppressors of miRNA biogenesis, which has implications for stem cell research and cancer biology...
  30. ncbi request reprint Regulation of ApC/EBP mRNA by the Aplysia AU-rich element-binding protein, ApELAV, and its effects on 5-hydroxytryptamine-induced long-term facilitation
    Se Jeong Yim
    National Research Laboratory, Institute of Molecular Biology and Genetics, School of Biological Sciences, College of Natural Sciences, Seoul National University, San 56 1 Silim dong, Gwanak Gu, Seoul 151 747, Korea
    J Neurochem 98:420-9. 2006
    ....
  31. doi request reprint TALEN-based knockout library for human microRNAs
    Young Kook Kim
    1 Center for RNA Research, Institute for Basic Science, Seoul, Korea 2 School of Biological Sciences, Seoul National University, Seoul, Korea 3
    Nat Struct Mol Biol 20:1458-64. 2013
    ..Our study illustrates the potency of TALEN technology and provides useful resources for miRNA research. ..
  32. pmc MicroRNA maturation: stepwise processing and subcellular localization
    Yoontae Lee
    Institute of Molecular Biology and Genetics and School of Biological Science, Seoul National University, Seoul 151 742, Korea
    EMBO J 21:4663-70. 2002
    ..Our study suggests that the regulation of miRNA expression may occur at multiple levels, including the two processing steps and the nuclear export step. These data will provide a framework for further studies on miRNA biogenesis...
  33. pmc Conserved microRNA miR-8 controls body size in response to steroid signaling in Drosophila
    Hua Jin
    School of Biological Sciences, Seoul National University, Seoul 151 742, Korea
    Genes Dev 26:1427-32. 2012
    ..Consistently, perturbation of USH impedes ecdysone's effect on body growth. Thus, miR-8 acts as a molecular rheostat that tunes organismal growth in response to a developmental maturation signal...
  34. doi request reprint Cell adhesion-dependent control of microRNA decay
    Young Kook Kim
    School of Biological Sciences, Seoul National University, Seoul 151 742, Korea
    Mol Cell 43:1005-14. 2011
    ..Induced destruction of persistent regulatory molecules such as miRNAs may increase cellular plasticity and facilitate cellular remodeling in response to the changes in cell adhesion...
  35. ncbi request reprint In vitro and in vivo assays for the activity of Drosha complex
    Yoontae Lee
    School of Biological Sciences, Seoul National University, Seoul, Korea
    Methods Enzymol 427:89-106. 2007
    ..Here we describe the methods for the analysis of pri-miRNA processing that is mediated by Drosha and its cofactor, DiGeorge Syndrome Critical Region Gene 8 (DGCR8)...
  36. ncbi request reprint MeCP2 caught moonlighting as a suppressor of MicroRNA processing
    Jae Sung Woo
    Center for RNA Research, Institute for Basic Science, Seoul 151 742, Korea School of Biological Sciences, Seoul National University, Seoul 151 742, Korea
    Dev Cell 28:477-8. 2014
    ..MeCP2 phosphorylation induces a direct interaction with DGCR8, leading to reduced microRNA processing and retardation of dendritic growth. ..
  37. doi request reprint Regulating the regulators: posttranslational modifications of RNA silencing factors
    Inha Heo
    School of Biological Sciences and National Creative Research Initiatives Center, Seoul National University, Seoul 151 742, Korea
    Cell 139:28-31. 2009
    ..Recent papers, including one in this issue of Cell (Paroo et al., 2009), now reveal the posttranslational modifications that take part in the regulation of the core RNA silencing factors, Ago, Piwi, and TRBP...
  38. ncbi request reprint Structural and functional insights into Dom34, a key component of no-go mRNA decay
    Hyung Ho Lee
    Department of Chemistry, College of Natural Sciences, Seoul National University, Seoul 151 747, Korea
    Mol Cell 27:938-50. 2007
    ..We also demonstrate that domain 1 of Dom34 has an endoribonuclease activity against defined RNA substrates containing a stem loop, which supports a direct catalytic role of yeast Dom34 in no-go mRNA decay...
  39. doi request reprint The RNA-binding protein repertoire of embryonic stem cells
    S Chul Kwon
    1 Center for RNA Research, Institute for Basic Science IBS, Seoul, Korea 2 School of Biological Sciences, Seoul National University, Seoul, Korea
    Nat Struct Mol Biol 20:1122-30. 2013
    ..Our study confirms and expands the atlas of RBPs, providing a useful resource for the study of the RNA-RBP network in stem cells. ..
  40. ncbi request reprint Control of splicing efficiency by the mouse histone H2a element in a murine leukemia virus-based retroviral vector
    Jun Tae Lee
    Institute of Molecular Biology and Genetics, Seoul National University, Seoul, South Korea
    Mol Ther 15:167-72. 2007
    ..Our data suggested that the mH2aE could be used for the fine-tuning of the splicing process, thus improving the level of gene expression and viral titer in the context of retroviral vectors...
  41. pmc The co-regulation mechanism of transcription factors in the human gene regulatory network
    Junil Kim
    Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, 291 Daehak ro, Yuseong Gu, Daejeon 305 701, Republic of Korea
    Nucleic Acids Res 40:8849-61. 2012
    ....
  42. pmc Human cytomegalovirus microRNA miR-US4-1 inhibits CD8(+) T cell responses by targeting the aminopeptidase ERAP1
    Sungchul Kim
    National Creative Research Initiative Center for Antigen Presentation, Department of Biological Sciences, Seoul National University, Seoul, Republic of Korea
    Nat Immunol 12:984-91. 2011
    ..Our findings identify a previously unknown viral miRNA-based CTL-evasion mechanism that targets a key step in the MHC class I antigen-processing pathway...
  43. pmc Human microRNA prediction through a probabilistic co-learning model of sequence and structure
    Jin Wu Nam
    Graduate Program in Bioinformatics, Seoul National University Seoul 151 744, Korea
    Nucleic Acids Res 33:3570-81. 2005
    ..Our study suggests that the miRNA gene family may be more abundant than previously anticipated, and confer highly extensive regulatory networks on eukaryotic cells...
  44. ncbi request reprint Crystal structure of human DGCR8 core
    Sun Young Sohn
    National Creative Research Center for Structural Biology and Department of Life Science, Pohang University of Science and Technology, Hyo ja dong, San31, Pohang, Kyungbook 790 784, South Korea
    Nat Struct Mol Biol 14:847-53. 2007
    ..This structure, together with fluorescent resonance energy transfer and mutational analyses, suggests that the DGCR8 core recognizes pri-miRNA in two possible orientations. We propose a model for DGCR8's recognition of pri-miRNA...
  45. ncbi request reprint Human embryonic stem cells express a unique set of microRNAs
    Mi Ra Suh
    Cell and Gene Therapy Research Institute, Pochon CHA University College of Medicine, Seoul 135 081, South Korea
    Dev Biol 270:488-98. 2004
    ..The newly identified hES-specific miRNAs may also serve as molecular markers for the early embryonic stage and for undifferentiated hES cells...
  46. ncbi request reprint Preparation and analysis of Drosha
    Yoontae Lee
    School of Biological Science, Seoul National University, South Korea
    Methods Mol Biol 309:17-28. 2005