Tae You Kim

Summary

Affiliation: Seoul National University
Country: Korea

Publications

  1. ncbi Local tumor invasiveness is more predictive of survival than International Prognostic Index in stage I(E)/II(E) extranodal NK/T-cell lymphoma, nasal type
    Tae Min Kim
    Department of Internal Medicine, Seoul National University Hospital, Cancer Research Institute, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul, 110 744, Korea
    Blood 106:3785-90. 2005
  2. ncbi Histone deacetylase inhibitors for cancer therapy
    Tae You Kim
    National Research Laboratory for Cancer Epigenetics, Cancer Research Institute, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Epigenetics 1:14-23. 2006
  3. pmc Lapatinib, a dual EGFR and HER2 tyrosine kinase inhibitor, downregulates thymidylate synthase by inhibiting the nuclear translocation of EGFR and HER2
    Hwang Phill Kim
    Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
    PLoS ONE 4:e5933. 2009
  4. pmc Heterodimerization of glycosylated insulin-like growth factor-1 receptors and insulin receptors in cancer cells sensitive to anti-IGF1R antibody
    Jun Gyu Kim
    Cancer Research Institute, Seoul National University, Seoul, South Korea
    PLoS ONE 7:e33322. 2012
  5. pmc The beneficial effect of palliative resection in metastatic colorectal cancer
    J H Park
    Division of Medical Oncology, Department of Internal Medicine, Seoul National University Hospital, 101 Daehang ro, Jongno gu, Seoul 110 744, Republic of Korea
    Br J Cancer 108:1425-31. 2013
  6. pmc Correlation of HER2, p95HER2 and HER3 expression and treatment outcome of lapatinib plus capecitabine in her2-positive metastatic breast cancer
    Sae Won Han
    Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea
    PLoS ONE 7:e39943. 2012
  7. pmc Phase II study and biomarker analysis of cetuximab combined with modified FOLFOX6 in advanced gastric cancer
    S W Han
    Department of Internal Medicine, Seoul National University Hospital, Chongno Gu, Seoul, Korea
    Br J Cancer 100:298-304. 2009
  8. pmc Targeted sequencing of cancer-related genes in colorectal cancer using next-generation sequencing
    Sae Won Han
    Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea
    PLoS ONE 8:e64271. 2013
  9. pmc Biomarker analysis in stage III-IV (M0) gastric cancer patients who received curative surgery followed by adjuvant 5-fluorouracil and cisplatin chemotherapy: epidermal growth factor receptor (EGFR) associated with favourable survival
    J S Kim
    Department of Internal Medicine, Seoul National University Hospital, Republic of Korea
    Br J Cancer 100:732-8. 2009
  10. pmc Clinical outcomes of HER2-positive metastatic breast cancer patients with brain metastasis treated with lapatinib and capecitabine: an open-label expanded access study in Korea
    Jungsil Ro
    National Cancer Center Hospital and Research Institute, Goyang, Gyeonggi do 410 769, Republic of Korea
    BMC Cancer 12:322. 2012

Collaborators

Detail Information

Publications161 found, 100 shown here

  1. ncbi Local tumor invasiveness is more predictive of survival than International Prognostic Index in stage I(E)/II(E) extranodal NK/T-cell lymphoma, nasal type
    Tae Min Kim
    Department of Internal Medicine, Seoul National University Hospital, Cancer Research Institute, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul, 110 744, Korea
    Blood 106:3785-90. 2005
    ..LTI is the most important prognostic factor in predicting low probability of CR and reduced OS and DFS in nasal stage I(E)/II(E) NTCL...
  2. ncbi Histone deacetylase inhibitors for cancer therapy
    Tae You Kim
    National Research Laboratory for Cancer Epigenetics, Cancer Research Institute, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Epigenetics 1:14-23. 2006
    ..In this review, we discuss new insights into the molecular mechanism of HDACIs, their current status of clinical development, and possible future uses in cancer therapy...
  3. pmc Lapatinib, a dual EGFR and HER2 tyrosine kinase inhibitor, downregulates thymidylate synthase by inhibiting the nuclear translocation of EGFR and HER2
    Hwang Phill Kim
    Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
    PLoS ONE 4:e5933. 2009
    ..However, the molecular mechanism underlying the downregulation of TS has yet to be clearly elucidated...
  4. pmc Heterodimerization of glycosylated insulin-like growth factor-1 receptors and insulin receptors in cancer cells sensitive to anti-IGF1R antibody
    Jun Gyu Kim
    Cancer Research Institute, Seoul National University, Seoul, South Korea
    PLoS ONE 7:e33322. 2012
    ..However, recent clinical trials showed that anti-IGF1R antibody and chemotherapy are not effective for treating lung cancer...
  5. pmc The beneficial effect of palliative resection in metastatic colorectal cancer
    J H Park
    Division of Medical Oncology, Department of Internal Medicine, Seoul National University Hospital, 101 Daehang ro, Jongno gu, Seoul 110 744, Republic of Korea
    Br J Cancer 108:1425-31. 2013
    ..We aimed to determine the role of palliative resection in metastatic colorectal cancer (mCRC) and ascertain which patient populations would benefit most from this treatment...
  6. pmc Correlation of HER2, p95HER2 and HER3 expression and treatment outcome of lapatinib plus capecitabine in her2-positive metastatic breast cancer
    Sae Won Han
    Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea
    PLoS ONE 7:e39943. 2012
    ..We have investigated the correlation between quantitative measures of HER2, p95HER2, and HER3 and treatment outcomes using lapatinib and capecitabine...
  7. pmc Phase II study and biomarker analysis of cetuximab combined with modified FOLFOX6 in advanced gastric cancer
    S W Han
    Department of Internal Medicine, Seoul National University Hospital, Chongno Gu, Seoul, Korea
    Br J Cancer 100:298-304. 2009
    ..No patient exhibited EGFR amplification or K-ras mutations. Gastric cancer patients with EGFR expression and low ligand levels had better outcomes with cetuximab/mFOLFOX6 treatment...
  8. pmc Targeted sequencing of cancer-related genes in colorectal cancer using next-generation sequencing
    Sae Won Han
    Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea
    PLoS ONE 8:e64271. 2013
    ..Targeted sequencing platform using NGS technology is feasible for clinical use and provides comprehensive genetic alteration data...
  9. pmc Biomarker analysis in stage III-IV (M0) gastric cancer patients who received curative surgery followed by adjuvant 5-fluorouracil and cisplatin chemotherapy: epidermal growth factor receptor (EGFR) associated with favourable survival
    J S Kim
    Department of Internal Medicine, Seoul National University Hospital, Republic of Korea
    Br J Cancer 100:732-8. 2009
    ..475 (95% confidence interval, 0.282-0.791, P=0.005). Low EGFR expression might be a predictive marker for relapse in curative resected stage III-IV (M0) gastric cancer patients who received adjuvant FP chemotherapy...
  10. pmc Clinical outcomes of HER2-positive metastatic breast cancer patients with brain metastasis treated with lapatinib and capecitabine: an open-label expanded access study in Korea
    Jungsil Ro
    National Cancer Center Hospital and Research Institute, Goyang, Gyeonggi do 410 769, Republic of Korea
    BMC Cancer 12:322. 2012
    ..To evaluate efficacy in patients with brain metastasis (BM) on entry into the lapatinib expanded access program (LEAP)...
  11. pmc Identification of DNA methylation changes associated with human gastric cancer
    Jung Hoon Park
    Department of Biochemistry, College of Life Science and Technology, Yonsei University, Seoul, Korea
    BMC Med Genomics 4:82. 2011
    ..Epigenetic alteration of gene expression is a common event in human cancer. DNA methylation is a well-known epigenetic process, but verifying the exact nature of epigenetic changes associated with cancer remains difficult...
  12. pmc Clinicopathologic characteristics and treatment outcomes of hepatoid adenocarcinoma of the stomach, a rare but unique subtype of gastric cancer
    Sun Kyung Baek
    Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea
    BMC Gastroenterol 11:56. 2011
    ..In this study, we performed an evaluation of clinicopathologic characteristics, treatment outcome, and prognosis in patients with gastric HAC...
  13. pmc Diagnostic performance of contrast enhanced CT and 18F-FDG PET/CT in suspicious recurrence of biliary tract cancer after curative resection
    Yun Gyoo Lee
    Department of Internal Medicine, Seoul National University Hospital, and Cancer Research Institute, Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence, Seoul National University College of Medicine, Seoul, Republic of Korea
    BMC Cancer 11:188. 2011
    ..This study is to determine the clinical role of 18F-FDG PET/CT during post-operative surveillance of suspected recurrent BTC based on symptoms, laboratory findings and contrast-enhanced CT (ceCT) findings...
  14. pmc The role of PET/CT in detection of gastric cancer recurrence
    Sung Hoon Sim
    Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea
    BMC Cancer 9:73. 2009
    ..The purpose of this study is to evaluate the efficacy and usefulness of PET/CT for detecting recurrence of gastric cancer after curative resection...
  15. pmc Triple negativity and young age as prognostic factors in lymph node-negative invasive ductal carcinoma of 1 cm or less
    Ji Hyun Kwon
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea
    BMC Cancer 10:557. 2010
    ..Whether a systemic adjuvant treatment is needed is an area of controversy in patients with node-negative early breast cancer with tumor size of ≤1 cm, including T1mic...
  16. ncbi Paclitaxel/Platinum-based perioperative chemotherapy and surgery in stage IIIA non-small cell lung cancer
    In Sil Choi
    Department of Internal Medicine, Seoul National University College of Medicine, Chongno Gu, Seoul 110 744, Korea
    Jpn J Clin Oncol 35:6-12. 2005
    ..The objectives of the present study were to assess the efficacy and tolerability of perioperative paclitaxel/platinum-based chemotherapy and surgery in patients with stage IIIA clinical N2 (cN2) non-small cell lung cancer (NSCLC)...
  17. pmc Prognostic significance of bcl-2 expression in stage III breast cancer patients who had received doxorubicin and cyclophosphamide followed by paclitaxel as adjuvant chemotherapy
    Kyung Hun Lee
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    BMC Cancer 7:63. 2007
    ....
  18. ncbi Transcriptional silencing of the DLC-1 tumor suppressor gene by epigenetic mechanism in gastric cancer cells
    Tai Young Kim
    National Research Laboratory for Cancer Epigenetics, Cancer Research Institute, Seoul National University College of Medicine, Seoul 110 744, Korea
    Oncogene 22:3943-51. 2003
    ..Taken together, the results of our study suggest that the transcriptional silencing of DLC-1, by epigenetic mechanism, may be involved in gastric carcinogenesis...
  19. ncbi TGF-beta1-mediated activations of c-Src and Rac1 modulate levels of cyclins and p27(Kip1) CDK inhibitor in hepatoma cells replated on fibronectin
    Hwang Phill Kim
    National Research Laboratory for Cancer Epigenetics, Cancer Research Institute, Department of Tumor Biology, College of Medicine, Seoul National University, Seoul 110 799, South Korea
    Biochim Biophys Acta 1743:151-61. 2005
    ..Therefore, this study represents another mechanism to regulate cell cycle regulators when integrin signaling is collaborative with TGF-beta1 pathways...
  20. pmc Reduced dose intensity FOLFOX-4 as first line palliative chemotherapy in elderly patients with advanced colorectal cancer
    Jee Hyun Kim
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    J Korean Med Sci 20:806-10. 2005
    ..2%) and vomiting (1.0%). In conclusion, the mini-FOLFOX-4 regimen was found to be well tolerated with acceptable toxicity, and to provide a benefit for elderly patients with colorectal cancer...
  21. doi Epidermal growth factor receptor intron 1 CA dinucleotide repeat polymorphism and survival of advanced gastric cancer patients treated with cetuximab plus modified FOLFOX6
    Sae Won Han
    Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea
    Cancer Sci 101:793-9. 2010
    ..These results suggest that the EGFR intron 1 CA repeat polymorphism could be a useful, predictive biomarker of cetuximab efficacy in AGC and merits further investigation in randomized studies...
  22. ncbi Antitumor activity of SK-7041, a novel histone deacetylase inhibitor, in human lung and breast cancer cells
    Keun Wook Lee
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Anticancer Res 26:3429-38. 2006
    ..In this study, the antitumor effects of SK-7041, one of those novel HDAC inhibitors, was evaluated on lung and breast cancer cell lines...
  23. ncbi Optimization of patient selection for gefitinib in non-small cell lung cancer by combined analysis of epidermal growth factor receptor mutation, K-ras mutation, and Akt phosphorylation
    Sae Won Han
    Department of Internal Medicine and Pathology, Seoul National University Hospital, and Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Clin Cancer Res 12:2538-44. 2006
    ....
  24. ncbi Cytotoxic effects of pemetrexed in gastric cancer cells
    Jee Hyun Kim
    Department of Internal Medicine, Seoul National University College of Medicine, 28, Yongon Dong, Chongno Gu, Seoul
    Cancer Sci 96:365-71. 2005
    ..Drug sensitivity toward pemetrexed could not be predicted by the expressions of TS, RFC1, or FPGS and we suggest that it is determined by interactions between multiple genes...
  25. ncbi Phase II trial of low-dose paclitaxel and cisplatin in patients with advanced gastric cancer
    Keun Wook Lee
    Department of Internal Medicine, Seoul National University College of Medicine, Chongno Gu, Seoul 110 744, Republic of Korea
    Jpn J Clin Oncol 35:720-6. 2005
    ..This study was performed to evaluate the efficacy and toxicity of low-dose paclitaxel (145 mg/m(2)) plus cisplatin chemotherapy in metastatic or relapsed gastric cancer...
  26. pmc TGF-beta1 (transforming growth factor-beta1)-mediated adhesion of gastric carcinoma cells involves a decrease in Ras/ERKs (extracellular-signal-regulated kinases) cascade activity dependent on c-Src activity
    Hwang Phill Kim
    Cancer Research Institute, Department of Tumor Biology, College of Medicine, Seoul National University, 28, Yongon Dong, Chongno Gu, Seoul 110 799, South Korea
    Biochem J 379:141-50. 2004
    ....
  27. ncbi Irinotecan combined with 5-fluorouracil and leucovorin third-line chemotherapy after failure of fluoropyrimidine, platinum, and taxane in gastric cancer: treatment outcomes and a prognostic model to predict survival
    Eun Joo Kang
    Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 300 Gumi dong, Bundang gu, Seongnam si, Gyeonggi Do, 463 707, Republic of Korea
    Gastric Cancer 16:581-9. 2013
    ....
  28. ncbi Epidermal growth factor receptor (EGFR) downstream molecules as response predictive markers for gefitinib (Iressa, ZD1839) in chemotherapy-resistant non-small cell lung cancer
    Sae Won Han
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Int J Cancer 113:109-15. 2005
    ..08-0.79, p = 0.018) and OS (HR 0.16, 95% CI 0.04-0.62, p = 0.008). These results support the assumption that gefitinib responsiveness might be predicted by activated EGFR downstream molecules such as p-Akt and p-Erk...
  29. doi Clinical course of neuroendocrine tumors with different origins (the pancreas, gastrointestinal tract, and lung)
    Su Jung Kim
    Division of Hematology and Medical Oncology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea
    Am J Clin Oncol 35:549-56. 2012
    ..Neuroendocrine tumor originates from several sites. This study was conducted to reveal the differences in clinical course of neuroendocrine tumors by the origin...
  30. doi Phase II study of biweekly S-1 and oxaliplatin combination chemotherapy in metastatic colorectal cancer and pharmacogenetic analysis
    Junshik Hong
    Department of Internal Medicine, Seoul National University Hospital, 101 Daehang ro, Jongno gu, Seoul, Korea
    Cancer Chemother Pharmacol 67:1323-31. 2011
    ..To evaluate the efficacy and safety of S-1 in combination with oxaliplatin in a biweekly schedule as first-line treatment in metastatic colorectal cancer and the association between genetic polymorphisms and treatment outcomes...
  31. doi Predictive value of FDG PET/CT for pathologic axillary node involvement after neoadjuvant chemotherapy
    Bhumsuk Keam
    Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul, 110 744, Korea
    Breast Cancer 20:167-73. 2013
    ..The purpose of this study was to determine the usefulness of sequential FDG PET/CTs for prediction of axillary lymph node (ALN) status after neoadjuvant chemotherapy (NAC)...
  32. ncbi A combination of HER-2 status and the St. Gallen classification provides useful information on prognosis in lymph node-negative breast carcinoma
    Jong Mu Sun
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Cancer 101:2516-22. 2004
    ..The authors investigated the clinical relevance of HER-2 overexpression when combined with the St. Gallen classification in lymph node-negative breast carcinoma...
  33. doi Antitumor activity of HM781-36B, a pan-HER tyrosine kinase inhibitor, in HER2-amplified breast cancer cells
    Hye Jin Kim
    Cancer Research Institute, Seoul, Korea
    Anticancer Drugs 23:288-97. 2012
    ....
  34. doi Is duodenal invasion a relevant prognosticator in patients undergoing adjuvant chemoradiotherapy for distal common bile duct cancer?
    Kyubo Kim
    Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Republic of Korea
    Int J Radiat Oncol Biol Phys 77:1186-90. 2010
    ..To analyze the outcome of adjuvant chemoradiotherapy for patients with distal common bile duct (CBD) cancer who underwent curative surgery, and to identify the prognostic factors for these patients...
  35. ncbi Clinical predictors versus epidermal growth factor receptor mutation in gefitinib-treated non-small-cell lung cancer patients
    Sae Won Han
    Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 744, Republic of Korea
    Lung Cancer 54:201-7. 2006
    ..Direct comparison between clinical predictors and EGFR mutation for their predictive power has not been reported...
  36. doi Antitumor activity of saracatinib (AZD0530), a c-Src/Abl kinase inhibitor, alone or in combination with chemotherapeutic agents in gastric cancer
    Hyun Jin Nam
    Cancer Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea
    Mol Cancer Ther 12:16-26. 2013
    ..These data indicate that the inhibition of Src kinase activity by saracatinib alone or in combination with other agents can be a strategy to target gastric cancer...
  37. ncbi Smad2 mediates Erk1/2 activation by TGF-beta1 in suspended, but not in adherent, gastric carcinoma cells
    Mi Sook Lee
    National Research Laboratory for Cancer Epigenetics, Cancer Research Institute, Department of Tumor Biology, College of Medicine, Seoul National University, Seoul 110 799, Korea
    Int J Oncol 24:1229-34. 2004
    ....
  38. doi Adjuvant chemoradiotherapy after curative resection for extrahepatic bile duct cancer: a long-term single center experience
    Kyubo Kim
    Departments of Radiation Oncology, Seoul National University College of Medicine, Republic of Korea
    Am J Clin Oncol 35:136-40. 2012
    ..To analyze the outcome of adjuvant chemoradiotherapy for patients with extrahepatic bile duct (EHBD) cancer, and to identify the prognostic factors for these patients...
  39. doi Serum epidermal growth factor is associated with prognosis and hormone receptor status in patients with HER2-positive metastatic breast cancer treated with first-line trastuzumab plus taxane chemotherapy
    Ji Won Kim
    Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehak Ro, Jongno gu, Seoul, 110 744, Korea
    Cancer Chemother Pharmacol 72:1023-9. 2013
    ..In this study, we investigated the clinical and pathologic implications of serum EGF levels in patients with HER2-positive metastatic breast cancer (MBC)...
  40. ncbi Gastric epithelial reactive oxygen species prevent normoxic degradation of hypoxia-inducible factor-1alpha in gastric cancer cells
    Jung Hyun Park
    Department of Tumor Biology, Seoul National University College of Medicine, Seoul 110 799, Korea
    Clin Cancer Res 9:433-40. 2003
    ..pylori-stimulated, lead to the constant expression of HIF-1alpha protein under normoxia...
  41. ncbi Potential advantages of DNA methyltransferase 1 (DNMT1)-targeted inhibition for cancer therapy
    Yeonjoo Jung
    National Research Laboratory for Cancer Epigenetics, Cancer Research Institute, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul, 110 799, South Korea
    J Mol Med (Berl) 85:1137-48. 2007
    ..These results provide a rationale for the development of a DNMT1-targeted strategy as an effective epigenetic cancer therapy...
  42. ncbi Epidermal growth factor receptor mutations and response to chemotherapy in patients with non-small-cell lung cancer
    Kyung Hun Lee
    Department of Internal Medicine, Seoul National University College of Medicine, Chongno Gu, Seoul, 110 744, South Korea
    Jpn J Clin Oncol 36:344-50. 2006
    ..We retrospectively analyzed the associations between response to chemotherapy and molecular markers associated with gefitinib responsiveness including EGFR mutations...
  43. ncbi Methylation and microsatellite status and recurrence following adjuvant FOLFOX in colorectal cancer
    Sae Won Han
    Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea
    Int J Cancer 132:2209-16. 2013
    ..006). In conclusion, concurrent methylation of NEUROG1 and CDKN2A (p16) is associated with recurrence following adjuvant FOLFOX in Stages II/III colorectal cancer...
  44. ncbi ABCB1, FCGR2A, and FCGR3A polymorphisms in patients with HER2-positive metastatic breast cancer who were treated with first-line taxane plus trastuzumab chemotherapy
    Ji Won Kim
    Department of Internal Medicine, Seoul National University College of Medicine, Korea
    Oncology 83:218-27. 2012
    ..The aim of this study was to elucidate clinical implications of ABCB1, FCGR2A, and FCGR3A polymorphisms in patients with HER2-positive metastatic breast cancer (MBC) after taxane plus trastuzumab (TH) chemotherapy...
  45. ncbi Docetaxel plus epirubicin as first-line chemotherapy in MBC (KCSG 01-10-05): phase II trial and the predictive values of circulating HER2 extracellular domain and vascular endothelial growth factor
    Seock Ah Im
    Breast Cancer Subcommittee, Korean Cancer Study Group, Seoul, Korea
    Oncol Rep 14:481-7. 2005
    ..We concluded that the docetaxel and epirubicin combination is an effective first-line treatment in MBC patients and that elevated serum HER2 ECD levels, but not circulating VEGF levels, predict a poor outcome...
  46. ncbi Cyclooxygenase-2 inhibits novel ginseng metabolite-mediated apoptosis
    Hyung Woo Yim
    National Research Laboratory for Cancer Epigenetics, Cancer Research Institute and Department of Internal Medicine, Seoul National University College of Medicine, Chongno, Seoul, Republic of Korea
    Cancer Res 65:1952-60. 2005
    ..In conclusion, IH-901 induced both G1 arrest and apoptosis, and this apoptosis could be inhibited by COX-2 induction...
  47. pmc CD24 expression predicts distant metastasis in extrahepatic bile duct cancer
    Kyubo Kim
    Department of Radiation Oncology, Seoul National University College of Medicine, Seoul 110 744, South Korea
    World J Gastroenterol 19:1438-43. 2013
    ..To evaluate the prognostic significance of CD24 expression in patients undergoing adjuvant chemoradiotherapy for extrahepatic bile duct (EHBD) cancer...
  48. doi The relationship between response to previous systemic treatment and the efficacy of subsequent pemetrexed therapy in advanced non-small cell lung cancer
    Jong Mu Sun
    Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea
    Lung Cancer 68:427-32. 2010
    ..We sought to identify the relationship between response to previous systemic treatment and the efficacy of subsequent pemetrexed therapy in advanced non-small cell lung cancer (NSCLC)...
  49. doi The lack of CD34 expression in gastrointestinal stromal tumors is related to cystic degeneration following imatinib use
    Youngil Koh
    Department of Internal Medicine, Seoul National University Hospital, Cancer Research Institute, Seoul National University College of Medicine, 101 Daehangro, Chongno Gu, Seoul 110 744, Republic of Korea
    Jpn J Clin Oncol 42:1020-7. 2012
    ..We also investigated the clinical applicability of Choi's criteria to Korean gastrointestinal stromal tumor patients undergoing imatinib therapy...
  50. doi Increasing nodal ratio is a poor prognostic factor for survival in stage III-IV (M0) gastric cancer patients who received curative surgery followed by adjuvant chemotherapy: a retrospective study
    Jin Soo Kim
    Department of Internal Medicine, Seoul National University Hospital, 28 Yongon Dong, Chongno Gu, Seoul 110 744, Republic of Korea
    Jpn J Clin Oncol 41:245-52. 2011
    ..The aim of this study is to evaluate the efficacy of adjuvant chemotherapy with 5-fluorouracil and cisplatin in gastric cancer patients and to assess prognostic factors affecting relapse and survival...
  51. ncbi Histone deacetylase inhibitor enhances 5-fluorouracil cytotoxicity by down-regulating thymidylate synthase in human cancer cells
    Ju Hee Lee
    Natonal Research Laboratory, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 744, Korea
    Mol Cancer Ther 5:3085-95. 2006
    ..We conclude that a combinatorial approach using histone deacetylase inhibitors may be useful at overcoming 5-FU resistance...
  52. doi HER2/CEP17 ratio and HER2 immunohistochemistry predict clinical outcome after first-line trastuzumab plus taxane chemotherapy in patients with HER2 fluorescence in situ hybridization-positive metastatic breast cancer
    Ji Won Kim
    Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehak Ro, Jongno gu, Seoul, 110 744, Korea
    Cancer Chemother Pharmacol 72:109-15. 2013
    ....
  53. doi Concurrent versus sequential administration of CMF chemotherapy and radiotherapy after breast-conserving surgery in early breast cancer
    Kyubo Kim
    Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Republic of Korea
    Tumori 97:280-5. 2011
    ..To compare the outcome of concurrent versus sequential administration of cyclophosphamide, methotrexate, and 5-fluorouracil (CMF) chemotherapy and radiotherapy after breast-conserving surgery in early breast cancer...
  54. doi Clinical outcomes of sorafenib treatment in patients with metastatic hepatocellular carcinoma who had been previously treated with fluoropyrimidine plus platinum-based chemotherapy
    Ji Won Kim
    Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea
    Am J Clin Oncol 34:125-9. 2011
    ..The objectives of this analysis were to investigate efficacy and safety of sorafenib in these patients and to elucidate risk factors associated with clinical outcomes...
  55. doi Distant metastasis risk stratification for patients undergoing curative resection followed by adjuvant chemoradiation for extrahepatic bile duct cancer
    Kyubo Kim
    Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Republic of Korea
    Int J Radiat Oncol Biol Phys 84:81-7. 2012
    ..To analyze the prognostic factors predicting distant metastasis in patients undergoing adjuvant chemoradiation for extrahepatic bile duct (EHBD) cancer...
  56. doi Sunitinib synergizes the antitumor effect of cisplatin via modulation of ERCC1 expression in models of gastric cancer
    Young Kwang Yoon
    Cancer Research Institute, Seoul National University, Seoul 110 799, South Korea
    Cancer Lett 321:128-36. 2012
    ..The effect was verified via SNU484 xenograft model. Our data support the rationale of clinical trial using sunitinib in combination of cisplatin in gastric cancer...
  57. doi Combined lapatinib and cetuximab enhance cytotoxicity against gefitinib-resistant lung cancer cells
    Hwang Phill Kim
    Cancer Research Institute, Seoul National University College of Medicine, Chongno Gu, Seoul, Korea
    Mol Cancer Ther 7:607-15. 2008
    ....
  58. ncbi Cell adhesion status-dependent histone acetylation is regulated through intracellular contractility-related signaling activities
    Yong Bae Kim
    Cancer Research Institute, Department of Tumor Biology, College of Medicine, Seoul National University, 28, Yeongeon Dong, Jongno gu, Seoul 110 799, Korea
    J Biol Chem 280:28357-64. 2005
    ....
  59. ncbi Efficacy of platinum-based chemotherapy after cranial radiation in patients with brain metastasis from non-small cell lung cancer
    Dae Young Kim
    Department of Internal Medicine, Seoul National University Hospital, Cancer Research Institute, Seoul National University College of Medicine, 28 Yongon Dong, Chongro Gu, Seoul 110 744, Korea
    Oncol Rep 14:207-11. 2005
    ....
  60. doi RAD001 shows activity against gastric cancer cells and overcomes 5-FU resistance by downregulating thymidylate synthase
    Kyung Hun Lee
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
    Cancer Lett 299:22-8. 2010
    ..In conclusion, RAD001 showed growth inhibitory activity against gastric cancer cells and acted synergistically with cytotoxic agents such as 5-FU by downregulating TS...
  61. doi Role of adjuvant chemoradiotherapy for duodenal cancer: a single center experience
    Kyubo Kim
    Departments of Radiation Oncology, Seoul National University College of Medicine, Seoul, Republic of Korea
    Am J Clin Oncol 35:533-6. 2012
    ..To compare the treatment outcome of surgery alone with that of surgery followed by adjuvant chemoradiotherapy (CRT) for duodenal cancer...
  62. pmc Modified FOLFOX-6 chemotherapy in advanced gastric cancer: Results of phase II study and comprehensive analysis of polymorphisms as a predictive and prognostic marker
    Bhumsuk Keam
    Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea
    BMC Cancer 8:148. 2008
    ..We also analyzed the predictive or prognostic value of germline polymorphisms of candidate genes associated with 5-FU and oxaliplatin...
  63. ncbi DNA methyltransferase 3-like affects promoter methylation of thymine DNA glycosylase independently of DNMT1 and DNMT3B in cancer cells
    Heesun Kim
    Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Int J Oncol 36:1563-72. 2010
    ..This study is the first to show that DNMT3L exerts a major effect on the transcriptional regulation of a specific target gene, such as TDG, despite the absence of enzymatic activity...
  64. pmc Weekly paclitaxel and trastuzumab as a first-line therapy in patients with HER2-overexpressing metastatic breast cancer: magnitude of HER2/neu amplification as a predictive factor for efficacy
    Hye Suk Han
    Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea
    J Korean Med Sci 24:910-7. 2009
    ..Furthermore, the magnitude of HER2 amplification is an independent predictive factor of TTP...
  65. pmc Prognostic value of p53 and bcl-2 expression in patients treated with breast conservative therapy
    Kyubo Kim
    Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Korea
    J Korean Med Sci 25:235-9. 2010
    ..A bcl-2(-)/ER(-) phenotype and p53 expression are useful molecular markers predicting loco-regional relapse-free and distant metastasis-free survival, respectively, in patients treated with breast conserving surgery and radiotherapy...
  66. ncbi Trastuzumab inhibits the growth of human gastric cancer cell lines with HER2 amplification synergistically with cisplatin
    Sun Young Kim
    Department of Internal Medicine, Seoul National University College of Medicine, Chongro Gu, Seoul 110 799, Korea
    Int J Oncol 32:89-95. 2008
    ..These results suggest that trastuzumab combined with chemotherapeutic agents can be active against gastric cancer with HER2 amplification...
  67. doi High serum TGF-α predicts poor response to lapatinib and capecitabine in HER2-positive breast cancer
    Jiyoung Rhee
    Department of Internal Medicine, Seoul National University Hospital, 101 Daehang ro, Jongno gu, Seoul, Korea
    Breast Cancer Res Treat 125:107-14. 2011
    ..These data suggest that TGF-α plays a role in resistance to lapatinib and capecitabine therapy among HER2-positive breast cancer...
  68. doi Clinical usefulness of AJCC response criteria for neoadjuvant chemotherapy in breast cancer
    Bhumsuk Keam
    Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea
    Ann Surg Oncol 20:2242-9. 2013
    ..The purpose of this study was to evaluate the clinical usefulness of AJCC response criteria...
  69. ncbi Inhibitors of histone deacetylases induce tumor-selective cytotoxicity through modulating Aurora-A kinase
    Jung Hyun Park
    National Research Laboratory for Cancer Epigenetics, Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea
    J Mol Med (Berl) 86:117-28. 2008
    ..Overall, these provide a novel molecular basis of tumor selectivity of HDI. LAQ824 and SK-7068 might be more effective HDIs in cancer cells with Aurora-A overexpression...
  70. ncbi A multi-center, late phase II clinical trial of Genexol (paclitaxel) and cisplatin for patients with advanced gastric cancer
    Sook Ryun Park
    Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 744, Korea
    Oncol Rep 12:1059-64. 2004
    ..In conclusion, the combination of Genexol and cisplatin was found to be an active and relatively well-tolerated regimen for the treatment of advanced gastric carcinoma...
  71. doi OPB-31121, a novel small molecular inhibitor, disrupts the JAK2/STAT3 pathway and exhibits an antitumor activity in gastric cancer cells
    Mi Jung Kim
    Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea
    Cancer Lett 335:145-52. 2013
    ..Taken together, our study suggests that STAT3 inhibition with OPB-31121 can be tested in patients with gastric cancer...
  72. doi Prognostic significance of tumour location after adjuvant chemoradiotherapy for periampullary adenocarcinoma
    Kyubo Kim
    Department of Radiation Oncology, Seoul National University College of Medicine, 101 Daehak Ro, Jongno gu, Seoul 110 744, Republic of Korea
    Clin Transl Oncol 14:391-5. 2012
    ..To analyse the outcome of adjuvant chemoradiotherapy for periampullary adenocarcinoma and the impact of tumour location as a prognosticator...
  73. ncbi The prognostic significance of HER2 positivity for advanced gastric cancer patients undergoing first-line modified FOLFOX-6 regimen
    Jin Won Kim
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University, Seoul, Korea
    Anticancer Res 32:1547-53. 2012
    ..We aimed to clarify the prognostic significance of HER2 positivity in advanced gastric cancer...
  74. ncbi Intron 1 CA dinucleotide repeat polymorphism and mutations of epidermal growth factor receptor and gefitinib responsiveness in non-small-cell lung cancer
    Sae Won Han
    Department of Internal Medicine, Seoul National University Hospital and Cancer Research Institute, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 744, Korea
    Pharmacogenet Genomics 17:313-9. 2007
    ..Therefore, CA repeat polymorphism in intron 1 was analyzed for its association with gefitinib responsiveness together with epidermal growth factor receptor mutation in Korean patients...
  75. ncbi Prognostic factors for recurrent breast cancer patients with an isolated, limited number of lung metastases and implications for pulmonary metastasectomy
    Ho Young Yhim
    Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea
    Cancer 116:2890-901. 2010
    ..The aim of this study was to evaluate the clinical treatment outcomes of recurrent breast cancer with a limited number of isolated lung metastases, and to evaluate the role of pulmonary metastasectomy...
  76. ncbi Comparison of intrathecal chemotherapy for leptomeningeal carcinomatosis of a solid tumor: methotrexate alone versus methotrexate in combination with cytosine arabinoside and hydrocortisone
    Dae Young Kim
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Jpn J Clin Oncol 33:608-12. 2003
    ..To compare the efficacy of intrathecal methotrexate single therapy with three-drug combination therapy in patients with leptomeningeal carcinomatosis...
  77. doi The irreversible pan-HER inhibitor PF00299804 alone or combined with gemcitabine has an antitumor effect in biliary tract cancer cell lines
    Hyun Jin Nam
    Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea
    Invest New Drugs 30:2148-60. 2012
    ..Our results support the need for further study of PF00299804 alone or combined with gemcitabine for the treatment of BTC...
  78. doi Gene silencing of EREG mediated by DNA methylation and histone modification in human gastric cancers
    Jiyeon Yun
    Cancer Research Institute, Seoul National University College of Medicine, South Korea
    Lab Invest 92:1033-44. 2012
    ..Taken together, the results of our study showed for the first time that EREG is epigenetically silenced in gastric cancer cells by aberrant DNA methylation and histone modification...
  79. pmc Ki-67 can be used for further classification of triple negative breast cancer into two subtypes with different response and prognosis
    Bhumsuk Keam
    Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehang ro, Jongno gu, Seoul, 110 744, Korea
    Breast Cancer Res 13:R22. 2011
    ..The purpose of this study was to identify the predictive or prognostic value of Ki-67 among patients with TNBC treated with neoadjuvant chemotherapy, and the role of Ki-67 in further classification of TNBC...
  80. doi Prognostic factors affecting the outcome of salvage radiotherapy for isolated locoregional recurrence after mastectomy
    Kyubo Kim
    Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Korea
    Am J Clin Oncol 33:23-7. 2010
    ..To evaluate the prognostic factors affecting the outcome of salvage radiotherapy for isolated locoregional recurrence after mastectomy...
  81. ncbi DLC-1, a GTPase-activating protein for Rho, is associated with cell proliferation, morphology, and migration in human hepatocellular carcinoma
    Tai Young Kim
    National Research Laboratory for Cancer Epigenetics, Cancer Research Institute, Seoul National University College of Medicine, Seoul 110 744, Republic of Korea
    Biochem Biophys Res Commun 355:72-7. 2007
    ..These observations suggest that DLC-1 plays important roles in signal transduction pathway regulating cell proliferation, cell morphology, and cell migration by affecting Rho family GTPases and focal adhesion proteins...
  82. doi Combination of EGFR and MEK1/2 inhibitor shows synergistic effects by suppressing EGFR/HER3-dependent AKT activation in human gastric cancer cells
    Young Kwang Yoon
    Cancer Research Institute, Seoul National University College of Medicine, Korea
    Mol Cancer Ther 8:2526-36. 2009
    ..Our results provide the basis for a rational combination strategy against human EGFR WT gastric cancers, predicated on the understanding of cross-talk between the MEK and EGFR pathways...
  83. doi Discordant human epidermal growth factor receptor 2 and hormone receptor status in primary and metastatic breast cancer and response to trastuzumab
    Hye Jung Chang
    Department of Internal Medicine, Seoul National University Hospital, 28 Yongon Dong, Chongno Gu, Seoul 110 744, South Korea
    Jpn J Clin Oncol 41:593-9. 2011
    ..Recent studies have shown that the human epidermal growth factor receptor 2 status of a metastatic site may differ from that of the primary site. This difference may influence patient prognosis and response to therapy...
  84. doi Efficacy of infusional 5-fluorouracil, doxorubicin, and mitomycin-C (iFAM) in the treatment of patients with gemcitabine-pretreated pancreatic cancer and analysis of prognostic factors in a salvage setting
    Kyu Hyoung Lim
    Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul, 110 744, Korea
    Cancer Chemother Pharmacol 68:1017-26. 2011
    ....
  85. doi Differing effects of adjuvant chemotherapy according to BRCA1 nuclear expression in gastric cancer
    Jin Won Kim
    Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehang ro, Jongno gu, Seoul 110 744, Republic of Korea
    Cancer Chemother Pharmacol 71:1435-43. 2013
    ..We aimed to investigate the role of BRCA1 nuclear expression in sporadic gastric cancer; currently, the role remains unknown...
  86. doi Pharmacogenetic analysis of adjuvant FOLFOX for Korean patients with colon cancer
    Kyung Hun Lee
    Department of Internal Medicine, Seoul National University Hospital, 28 Yongon Dong, 110 744 Chongno gu, Seoul, Korea
    Cancer Chemother Pharmacol 71:843-51. 2013
    ..Ethnic diversity of genetic polymorphism can result in individual differences in the efficacy and toxicity of cancer chemotherapy...
  87. doi Down-regulation of mitogen-inducible gene 6, a negative regulator of EGFR, enhances resistance to MEK inhibition in KRAS mutant cancer cells
    Young Kwang Yoon
    Cancer Research Institute, Seoul National University College of Medicine, South Korea
    Cancer Lett 316:77-84. 2012
    ..Our study provides a mechanism of differential response to MEK inhibition in KRAS mutant cancer...
  88. doi Down-regulation of P-cadherin with PF-03732010 inhibits cell migration and tumor growth in gastric cancer
    Jinah Park
    Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea
    Invest New Drugs 30:1404-12. 2012
    ..This demonstrates the potential for P-cadherin to be used as a target for treatment of gastric cancer...
  89. doi Evaluation of the antitumor effects and mechanisms of PF00299804, a pan-HER inhibitor, alone or in combination with chemotherapy or targeted agents in gastric cancer
    Hyun Jin Nam
    Cancer Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Jongno gu, Seoul, 110 744, Korea
    Mol Cancer Ther 11:439-51. 2012
    ....
  90. doi Clinical outcome of central nervous system metastases from breast cancer: differences in survival depending on systemic treatment
    Hee Jun Kim
    Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 744, Korea
    J Neurooncol 106:303-13. 2012
    ..Our results suggest that appropriate palliative systemic therapy after WBRT or GKS, and adequate palliative treatment via combined modalities are helpful for breast cancer patients, even after the detection of CNS metastases...
  91. doi Aggressiveness of cancer-care near the end-of-life in Korea
    Bhumsuk Keam
    Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 744, Republic of Korea
    Jpn J Clin Oncol 38:381-6. 2008
    ..The aim of this study was to examine the appropriateness of chemotherapy and care in Korean cancer patients near the end-of-life...
  92. doi Antitumor activity of HM781-36B, an irreversible Pan-HER inhibitor, alone or in combination with cytotoxic chemotherapeutic agents in gastric cancer
    Hyun Jin Nam
    Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea
    Cancer Lett 302:155-65. 2011
    ..Therefore, HM781-36B may be useful for the treatment of HER2 amplified gastric cancer alone or in combination with chemotherapeutic agents...
  93. pmc Transforming growth factor-beta 1 induces apoptosis through Fas ligand-independent activation of the Fas death pathway in human gastric SNU-620 carcinoma cells
    Sang Gyun Kim
    National Research Laboratory for Cancer Epigenetics, Cancer Research Institute, Seoul National University College of Medicine, Seoul 110 744, Korea
    Mol Biol Cell 15:420-34. 2004
    ....
  94. ncbi Predictive and prognostic impact of epidermal growth factor receptor mutation in non-small-cell lung cancer patients treated with gefitinib
    Sae Won Han
    Department of Internal Medicine, Seoul National University Hospital, Seoul, 110 744 Korea
    J Clin Oncol 23:2493-501. 2005
    ..This study was undertaken to investigate the effects of epidermal growth factor receptor (EGFR) mutation and its downstream signaling on response and survival in non-small-cell lung cancer (NSCLC) patients treated with gefitinib...
  95. doi Inhibition of histone deacetylase 10 induces thioredoxin-interacting protein and causes accumulation of reactive oxygen species in SNU-620 human gastric cancer cells
    Ju Hee Lee
    Cancer Research Institute, College of Medicine, Seoul National University, Seoul 110 799, Korea
    Mol Cells 30:107-12. 2010
    ..How TXNIP is preferentially regulated by HDAC10 needs further investigation...
  96. pmc Biological characteristics and treatment outcomes of metastatic or recurrent neuroendocrine tumors: tumor grade and metastatic site are important for treatment strategy
    Su Jung Kim
    Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea
    BMC Cancer 10:448. 2010
    ..Studies about the biology, treatment pattern, and treatment outcome of metastatic/recurrent neuroendocrine tumor (NET) have been few...
  97. pmc Gemcitabine-based versus fluoropyrimidine-based chemotherapy with or without platinum in unresectable biliary tract cancer: a retrospective study
    Mi Jung Kim
    Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea
    BMC Cancer 8:374. 2008
    ..Fluoropyrimidine or gemcitabine, with or without platinum, are most frequently used. We conducted this study to clarify the efficacy of palliative chemotherapy in BTC...
  98. pmc Prognostic impact of clinicopathologic parameters in stage II/III breast cancer treated with neoadjuvant docetaxel and doxorubicin chemotherapy: paradoxical features of the triple negative breast cancer
    Bhumsuk Keam
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    BMC Cancer 7:203. 2007
    ..The purpose of this study was to identify the clinical significance of potential predictive and prognostic factors in breast cancer patients treated by neoadjuvant chemotherapy...
  99. pmc Early metabolic response using FDG PET/CT and molecular phenotypes of breast cancer treated with neoadjuvant chemotherapy
    Bhumsuk Keam
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    BMC Cancer 11:452. 2011
    ....
  100. doi Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are effective for leptomeningeal metastasis from non-small cell lung cancer patients with sensitive EGFR mutation or other predictive factors of good response for EGFR TKI
    Hyeon Gyu Yi
    Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea
    Lung Cancer 65:80-4. 2009
    ..Two patients showed responses to higher than standard dose of gefitinib. The median overall survival was not reached. In conclusion, EGFR TKIs are effective in the treatment of LM from NSCLC when patients were selected properly...
  101. doi The growth inhibitory effect of lapatinib, a dual inhibitor of EGFR and HER2 tyrosine kinase, in gastric cancer cell lines
    Jin Won Kim
    Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 744, Republic of Korea
    Cancer Lett 272:296-306. 2008
    ..These results provide a rationale for the future clinical trials of lapatinib combined with cytotoxic drugs in the treatment of HER2-positive gastric cancer...