Hyun Kyung Kim

Summary

Affiliation: Seoul National University
Country: Korea

Publications

  1. doi request reprint Significance of Local International Sensitivity Index Systems for Monitoring Warfarin and Liver function
    Hwa Jeen Lee
    Dept of Laboratory Medicine, Seoul National University College of Medicine, 101 Daehak Ro, Jongno gu, Seoul 110 744, Korea
    Am J Clin Pathol 141:542-50. 2014
  2. doi request reprint Influence of coagulation and anticoagulant factors on global coagulation assays in healthy adults
    Seon Young Kim
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    Am J Clin Pathol 139:370-9. 2013
  3. ncbi request reprint Lithium down-regulates the expression of CXCR4 in human neutrophils
    Hyun Kyung Kim
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
    J Trace Elem Med Biol 21:204-9. 2007
  4. ncbi request reprint Surface expression of neutrophil CXCR4 is down-modulated by bacterial endotoxin
    Hyun Kyung Kim
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    Int J Hematol 85:390-6. 2007
  5. doi request reprint Aurintricarboxylic acid upregulates the thrombomodulin expression of endothelial cells and peripheral blood monocytes
    Hyun Kyung Kim
    Department of Laboratory Medicine, Republic of Korea
    Blood Coagul Fibrinolysis 19:489-94. 2008
  6. ncbi request reprint Lipopolysaccharide down-regulates the thrombomodulin expression of peripheral blood monocytes: effect of serum on thrombomodulin expression in the THP-1 monocytic cell line
    Hyun Kyung Kim
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
    Blood Coagul Fibrinolysis 18:157-64. 2007
  7. doi request reprint Correlation between plasma activity of ADAMTS-13 and coagulopathy, and prognosis in disseminated intravascular coagulation
    Jungwon Hyun
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
    Thromb Res 124:75-9. 2009
  8. doi request reprint Neutrophil and monocyte activation markers have prognostic impact in disseminated intravascular coagulation: in vitro effect of thrombin on monocyte CD163 shedding
    Soie Chung
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    Thromb Res 127:450-6. 2011
  9. doi request reprint Circulating hepatocyte growth factor as an independent prognostic factor of disseminated intravascular coagulation
    Soie Chung
    Department of Laboratory Medicine and Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Thromb Res 125:e285-93. 2010
  10. doi request reprint Aurintricarboxylic acid inhibits the nuclear factor-κB-dependent expression of intercellular cell adhesion molecule-1 and endothelial cell selectin on activated human endothelial cells
    Ji Eun Kim
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
    Blood Coagul Fibrinolysis 22:132-9. 2011

Collaborators

  • Seonyang Park
  • Dong Soon Lee
  • Seon Young Kim
  • Yun Chul Hong
  • Jin Hee Kim
  • Cheng Hock Toh
  • Hee Jung Kang
  • Kyou Sup Han
  • Soie Chung
  • Qute Choi
  • Han Ik Cho
  • Sung Kuk Hong
  • Ji Weon Seo
  • Sang Mee Hwang
  • Ki Ho Hong
  • Jungwon Hyun
  • Hwa Jeen Lee
  • Hae Sook Lim
  • Nam Youngwon
  • Jong Cheol Jeong
  • Hyeon Jin Cho
  • Sung Soo Yoon
  • Miyoung Kim
  • Byoung Kook Kim
  • Cha Ja See
  • Shin Young Joo
  • Jae Seol Jung
  • Hye Ryun Lee
  • Hye Yeon Lee
  • Ji Won Ryu
  • Chul Woo Kim
  • Eun Hee Yeon
  • Yong Sung Shin
  • Kwon Wook Joo
  • Kyung Hun Lee
  • Inho Kim
  • Eun Kyung Ra
  • Dong Yeop Shin
  • Naeyu Kim
  • Jong Eun Lee
  • Myoung Hee Park
  • Ji Yeon Bae
  • Eun Kyung Park
  • Soo Hyun Ha
  • Min Gyu Lim

Detail Information

Publications33

  1. doi request reprint Significance of Local International Sensitivity Index Systems for Monitoring Warfarin and Liver function
    Hwa Jeen Lee
    Dept of Laboratory Medicine, Seoul National University College of Medicine, 101 Daehak Ro, Jongno gu, Seoul 110 744, Korea
    Am J Clin Pathol 141:542-50. 2014
    ..The alternative ISI calibration using liver-specific calibration plasma is expected to reduce INR variability for the evaluation of liver function. ..
  2. doi request reprint Influence of coagulation and anticoagulant factors on global coagulation assays in healthy adults
    Seon Young Kim
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    Am J Clin Pathol 139:370-9. 2013
    ..The synchronized plasma levels of vitamin K-dependent proteins with opposite functionalities may compensate a propensity to hyper- or hypocoagulability in a normal population...
  3. ncbi request reprint Lithium down-regulates the expression of CXCR4 in human neutrophils
    Hyun Kyung Kim
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
    J Trace Elem Med Biol 21:204-9. 2007
    ..Our studies support the concept that down-regulation of CXCR4 is one of the mechanisms by which causes neutrophilia...
  4. ncbi request reprint Surface expression of neutrophil CXCR4 is down-modulated by bacterial endotoxin
    Hyun Kyung Kim
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    Int J Hematol 85:390-6. 2007
    ....
  5. doi request reprint Aurintricarboxylic acid upregulates the thrombomodulin expression of endothelial cells and peripheral blood monocytes
    Hyun Kyung Kim
    Department of Laboratory Medicine, Republic of Korea
    Blood Coagul Fibrinolysis 19:489-94. 2008
    ..These findings provide, at least in part, a novel platelet-independent mechanism of ATA that may explain the demonstrated antithrombotic efficacy of ATA...
  6. ncbi request reprint Lipopolysaccharide down-regulates the thrombomodulin expression of peripheral blood monocytes: effect of serum on thrombomodulin expression in the THP-1 monocytic cell line
    Hyun Kyung Kim
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
    Blood Coagul Fibrinolysis 18:157-64. 2007
    ..Regulation of the THP-1 thrombomodulin expression by lipopolysaccharide depends on the presence of serum...
  7. doi request reprint Correlation between plasma activity of ADAMTS-13 and coagulopathy, and prognosis in disseminated intravascular coagulation
    Jungwon Hyun
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
    Thromb Res 124:75-9. 2009
    ..We determined whether ADAMTS-13 activity showed a significant correlation with the activation status of the coagulation system and hospital mortality in DIC...
  8. doi request reprint Neutrophil and monocyte activation markers have prognostic impact in disseminated intravascular coagulation: in vitro effect of thrombin on monocyte CD163 shedding
    Soie Chung
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    Thromb Res 127:450-6. 2011
    ..NDW, a convenient parameter measured by an automated hematology analyzer, may be an independent prognostic parameter for DIC...
  9. doi request reprint Circulating hepatocyte growth factor as an independent prognostic factor of disseminated intravascular coagulation
    Soie Chung
    Department of Laboratory Medicine and Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Thromb Res 125:e285-93. 2010
    ..We hypothesized that a hypercoagulable condition, such as disseminated intravascular coagulation (DIC), may increase circulating HGF through active cleavage by coagulation serine proteases...
  10. doi request reprint Aurintricarboxylic acid inhibits the nuclear factor-κB-dependent expression of intercellular cell adhesion molecule-1 and endothelial cell selectin on activated human endothelial cells
    Ji Eun Kim
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
    Blood Coagul Fibrinolysis 22:132-9. 2011
    ....
  11. pmc Utility of ELISA optical density values and clinical scores for the diagnosis of and thrombosis prediction in heparin-induced thrombocytopenia
    Seon Young Kim
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    Korean J Lab Med 31:1-8. 2011
    ..HIT diagnosis is challenging and depends on clinical presentation and laboratory tests. We investigated the usefulness of clinical scores and heparin/PF4 ELISA optical density (OD) as a diagnostic marker and thrombosis predictor in HIT...
  12. doi request reprint Contributions of procoagulants and anticoagulants to the international normalized ratio and thrombin generation assay in patients treated with warfarin: potential role of protein Z as a powerful determinant of coagulation assays
    Qute Choi
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    Thromb Res 132:e70-5. 2013
    ..We analyzed the monitoring performance of the TGA and INR and investigated the impact of procoagulants (fibrinogen, factor (F)II, FVII, FIX, and FX) and anticoagulants (proteins C, S, and Z) on them...
  13. pmc Thrombomodulin phenotype of a distinct monocyte subtype is an independent prognostic marker for disseminated intravascular coagulation
    Sang Mee Hwang
    Department of Laboratory Medicine, Seoul National University College of Medicine, 101, Daehak ro Jongno gu, Seoul 110 744, Republic of Korea
    Crit Care 15:R113. 2011
    ..Therefore, we investigated the phenotypic difference in thrombomodulin and TF expression between different monocyte subtypes in coagulopathy severity and prognosis in patients suspected of having DIC...
  14. doi request reprint Higher prognostic value of soluble fibrin complexes than D-dimer and fibrin degradation product for disseminated intravascular coagulation in patients with liver cirrhosis
    Seon Young Kim
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    Blood Coagul Fibrinolysis 24:150-6. 2013
    ..sFC is a powerful diagnostic and prognostic marker of DIC in patient with liver cirrhosis. The use of sFC is expected to enhance the diagnosis and prognosis of DIC, particularly in patients with liver cirrhosis...
  15. doi request reprint Local anesthetics inhibit tissue factor expression in activated monocytes via inhibition of tissue factor mRNA synthesis
    Ji Eun Kim
    Department of Laboratory Medicine and Cancer Research Institute, Seoul National University College of Medicine, Jongnogu, Seoul, Korea
    Clin Appl Thromb Hemost 17:E4-9. 2011
    ....
  16. ncbi request reprint Plasma level of stromal derived factor-1 (SDF-1) is increased in disseminated intravascular coagulation patients who have poor outcomes: in vitro effect of SDF-1 on coagulopathy
    Hyun Kyung Kim
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
    Thromb Res 120:559-66. 2007
    ..These findings suggest that plasma SDF-1 might be closely associated with hypercoagulability though its action as a platelet activator...
  17. doi request reprint Increased copy number of the interleukin-6 receptor gene is associated with adverse survival in multiple myeloma patients treated with autologous stem cell transplantation
    Seon Young Kim
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, South Korea
    Biol Blood Marrow Transplant 17:810-20. 2011
    ..These findings suggest the potential role of IL-6R in myeloma cell growth and therapeutic implications of the IL-6R blocker in the future...
  18. doi request reprint Accuracy of platelet counting by automated hematologic analyzers in acute leukemia and disseminated intravascular coagulation: potential effects of platelet activation
    Seon Young Kim
    Dept of Laboratory Medicine, Seoul National University College of Medicine, 101, Daehang no Jongno gu, Seoul 110 744, Republic of Korea
    Am J Clin Pathol 134:634-47. 2010
    ..The inaccuracy of automated platelet counts increased the risk for misdiagnosis of DIC. More attention needs to be given to the accuracy of platelet counts, especially in clinical conditions with florid platelet activation...
  19. doi request reprint Quantity of clonal cells detected by conventional cytogenetic analysis correlates with bone marrow blasts and survival in myelodysplastic syndromes
    Miyoung Kim
    Department of Laboratory Medicine, Seoul National University College of Medicine, Jongno gu, Seoul, South Korea
    Leuk Res 36:163-8. 2012
    ..7% vs. 23.1%, p=0.017). Multivariate analysis showed that a high quantity of clonal cells in CCA analysis is an independent prognostic factor for overall survival in MDS (p=0.012)...
  20. doi request reprint Prognostic value of immature platelet fraction and plasma thrombopoietin in disseminated intravascular coagulation
    Ki Ho Hong
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    Blood Coagul Fibrinolysis 20:409-14. 2009
    ..These results suggest that IPF and TPO are new potential candidates to detect the severity of DIC and to predict DIC mortality...
  21. doi request reprint [Usefulness of silica clotting time for detection of lupus anticoagulants]
    Hye Ryun Lee
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    Korean J Lab Med 29:497-504. 2009
    ..Also, we analyzed differences in the thrombotic features and the characteristics of antiphospholipid antibodies between dRVVT and SCT...
  22. ncbi request reprint [Clinical usefulness of plasma interleukin-6 and interleukin-10 in disseminated intravascular coagulation]
    Ji Weon Seo
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    Korean J Lab Med 27:83-8. 2007
    ..Inflammatory cytokines can activate the coagulation system. This study investigated the diagnostic and prognostic usefulness of the plasma level of interleukin-6 (IL-6) and interleukin-10 (IL-10) for predicting DIC...
  23. doi request reprint Changes in plasma levels of natural anticoagulants in disseminated intravascular coagulation: high prognostic value of antithrombin and protein C in patients with underlying sepsis or severe infection
    Qute Choi
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    Ann Lab Med 34:85-91. 2014
    ..Herein, the diagnostic value of 4 natural anticoagulants was assessed, and the prognostic value of antithrombin and protein C were validated in a large population...
  24. doi request reprint Decreased thrombomodulin mRNA expression on peripheral monocytes in disseminated intravascular coagulation patients relates to poor outcomes: the ex vivo effects of lipopolysaccharide and thrombin on monocyte thrombomodulin and CD14 mRNA
    Sung Kuk Hong
    Department of Laboratory Medicine and Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Thromb Res 132:392-7. 2013
    ..We used an ex vivo stimulation study to evaluate the association of the levels of monocyte-expressed thrombomodulin and CD14 messenger RNA (mRNA) with the severity and prognosis of disseminated intravascular coagulation...
  25. doi request reprint Vitamin E inhibition on platelet procoagulant activity: involvement of aminophospholipid translocase activity
    Ji Eun Kim
    Department of Laboratory Medicine and Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Thromb Res 127:435-42. 2011
    ..Although vitamin E has been investigated for its anti-aggregating effect on platelets, its effect on platelet procoagulant activity has not been reported...
  26. doi request reprint Clinical significance of the mixing test in laboratory diagnoses of lupus anticoagulant: the fate of the mixing test in integrated lupus anticoagulant test systems
    Sung Kuk Hong
    Department of Laboratory Medicine bCancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Blood Coagul Fibrinolysis 23:739-44. 2012
    ..The updated two-step procedure without the mixing test is relevant for lupus anticoagulant detection in the context of thrombotic risk estimation...
  27. pmc Coagulation proteins influencing global coagulation assays in cirrhosis: hypercoagulability in cirrhosis assessed by thrombomodulin-induced thrombin generation assay
    Nam Youngwon
    Department of Laboratory Medicine, Seoul National University College of Medicine, 101 Daehak Ro, Jongno gu, Seoul 110 744, Republic of Korea
    Biomed Res Int 2013:856754. 2013
    ..We also investigated whether cirrhotic patients exhibit hypo- or hypercoagulability using the TGA...
  28. doi request reprint Plasma haemostatic potential of haemodialysis patients assessed by thrombin generation assay: hypercoagulability in patients with vascular access thrombosis
    Jong Cheol Jeong
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Thromb Res 132:604-9. 2013
    ..We investigated the global haemostatic potential assessed by TGA in ESRD patients on haemodialysis and patients who developed vascular access thrombosis...
  29. doi request reprint Serum des-R prothrombin activation peptide fragment 2: a novel prognostic marker for disseminated intravascular coagulation
    Soie Chung
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    Thromb Res 131:547-53. 2013
    ..Because the collection of blood plasma samples is a fastidious procedure, the serum sample method may be preferred for measurement of coagulation markers when feasible...
  30. doi request reprint Aurintricarboxylic acid inhibits endothelial activation, complement activation, and von Willebrand factor secretion in vitro and attenuates hyperacute rejection in an ex vivo model of pig-to-human pulmonary xenotransplantation
    Hyun Kyung Kim
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    Xenotransplantation 15:246-56. 2008
    ..We also assessed its role in hyperacute xenograft rejection using a porcine ex vivo lung perfusion model...
  31. pmc Usefulness of circulating vascular endothelial growth factor and neutrophil elastase as diagnostic markers of disseminated intravascular coagulation in non-cancer patients
    Shin Young Joo
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    Korean J Hematol 45:23-8. 2010
    ..Hypercoagulable conditions such as DIC may induce the release of VEGF and neutrophil elastase from the platelets and neutrophils...
  32. doi request reprint Prognostic values of the factor Xa-activated clotting time and endogenous thrombin potential in patients suspected of having disseminated intravascular coagulation
    Ji Weon Seo
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    Thromb Res 123:565-72. 2009
    ....
  33. doi request reprint Impact of vitamin D receptor gene polymorphisms on clinical outcomes of HLA-matched sibling hematopoietic stem cell transplantation
    Hyeon Jin Cho
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Clin Transplant 26:476-83. 2012
    ..This study suggests that the genotype and haplotype of VDR in recipient might be associated with clinical outcome of sibling HLA-matched HSCT...