Hyun Kyung Kim

Summary

Affiliation: Seoul National University
Country: Korea

Publications

  1. pmc Usefulness of circulating vascular endothelial growth factor and neutrophil elastase as diagnostic markers of disseminated intravascular coagulation in non-cancer patients
    Shin Young Joo
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    Korean J Hematol 45:23-8. 2010
  2. doi request reprint Significance of local international sensitivity index systems for monitoring warfarin and liver function
    Hwa Jeen Lee
    Dept of Laboratory Medicine, Seoul National University College of Medicine, 101 Daehak Ro, Jongno gu, Seoul 110 744, Korea
    Am J Clin Pathol 141:542-50. 2014
  3. doi request reprint Enhancement of anti-tumor activity by low-dose combination of the recombinant urokinase kringle domain and celecoxib in a glioma model
    Chung Kwon Kim
    Cancer Research Institute, The Catholic University of Korea, Seoul, Republic of Korea
    Cancer Lett 288:251-60. 2010
  4. doi request reprint Circulating hepatocyte growth factor as an independent prognostic factor of disseminated intravascular coagulation
    Soie Chung
    Department of Laboratory Medicine and Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Thromb Res 125:e285-93. 2010
  5. doi request reprint Aurintricarboxylic acid upregulates the thrombomodulin expression of endothelial cells and peripheral blood monocytes
    Hyun Kyung Kim
    Department of Laboratory Medicine, Republic of Korea
    Blood Coagul Fibrinolysis 19:489-94. 2008
  6. doi request reprint Contributions of procoagulants and anticoagulants to the international normalized ratio and thrombin generation assay in patients treated with warfarin: potential role of protein Z as a powerful determinant of coagulation assays
    Qute Choi
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    Thromb Res 132:e70-5. 2013
  7. pmc Coagulation proteins influencing global coagulation assays in cirrhosis: hypercoagulability in cirrhosis assessed by thrombomodulin-induced thrombin generation assay
    Nam Youngwon
    Department of Laboratory Medicine, Seoul National University College of Medicine, 101 Daehak Ro, Jongno gu, Seoul 110 744, Republic of Korea
    Biomed Res Int 2013:856754. 2013
  8. ncbi request reprint Inhibition of endothelial cell proliferation by the recombinant kringle domain of tissue-type plasminogen activator
    Hyun Kyung Kim
    Cancer Research Institute, Catholic Research Institutes of Medical Sciences, The Catholic University of Korea, 137 701, Seoul, Republic of Korea
    Biochem Biophys Res Commun 304:740-6. 2003
  9. doi request reprint Neutrophil and monocyte activation markers have prognostic impact in disseminated intravascular coagulation: in vitro effect of thrombin on monocyte CD163 shedding
    Soie Chung
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    Thromb Res 127:450-6. 2011
  10. ncbi request reprint Integrin alphavbeta3 is not significantly implicated in the anti-migratory effect of anti-angiogenic urokinase kringle domain
    Eunju O
    Cancer Research Institute and Department of Biomedical Science, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Oncol Rep 20:631-6. 2008

Collaborators

Detail Information

Publications65

  1. pmc Usefulness of circulating vascular endothelial growth factor and neutrophil elastase as diagnostic markers of disseminated intravascular coagulation in non-cancer patients
    Shin Young Joo
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    Korean J Hematol 45:23-8. 2010
    ..Hypercoagulable conditions such as DIC may induce the release of VEGF and neutrophil elastase from the platelets and neutrophils...
  2. doi request reprint Significance of local international sensitivity index systems for monitoring warfarin and liver function
    Hwa Jeen Lee
    Dept of Laboratory Medicine, Seoul National University College of Medicine, 101 Daehak Ro, Jongno gu, Seoul 110 744, Korea
    Am J Clin Pathol 141:542-50. 2014
    ..We investigated the performance of two commercial local calibrators for warfarin monitoring and determined the significance of liver-specific INR...
  3. doi request reprint Enhancement of anti-tumor activity by low-dose combination of the recombinant urokinase kringle domain and celecoxib in a glioma model
    Chung Kwon Kim
    Cancer Research Institute, The Catholic University of Korea, Seoul, Republic of Korea
    Cancer Lett 288:251-60. 2010
    ..Therefore, our data suggest that combined use at low doses of UK1 and celecoxib with different anti-angiogenic mechanisms provides a desirable strategy for anti-glioma therapy...
  4. doi request reprint Circulating hepatocyte growth factor as an independent prognostic factor of disseminated intravascular coagulation
    Soie Chung
    Department of Laboratory Medicine and Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Thromb Res 125:e285-93. 2010
    ..We hypothesized that a hypercoagulable condition, such as disseminated intravascular coagulation (DIC), may increase circulating HGF through active cleavage by coagulation serine proteases...
  5. doi request reprint Aurintricarboxylic acid upregulates the thrombomodulin expression of endothelial cells and peripheral blood monocytes
    Hyun Kyung Kim
    Department of Laboratory Medicine, Republic of Korea
    Blood Coagul Fibrinolysis 19:489-94. 2008
    ..These findings provide, at least in part, a novel platelet-independent mechanism of ATA that may explain the demonstrated antithrombotic efficacy of ATA...
  6. doi request reprint Contributions of procoagulants and anticoagulants to the international normalized ratio and thrombin generation assay in patients treated with warfarin: potential role of protein Z as a powerful determinant of coagulation assays
    Qute Choi
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    Thromb Res 132:e70-5. 2013
    ..We analyzed the monitoring performance of the TGA and INR and investigated the impact of procoagulants (fibrinogen, factor (F)II, FVII, FIX, and FX) and anticoagulants (proteins C, S, and Z) on them...
  7. pmc Coagulation proteins influencing global coagulation assays in cirrhosis: hypercoagulability in cirrhosis assessed by thrombomodulin-induced thrombin generation assay
    Nam Youngwon
    Department of Laboratory Medicine, Seoul National University College of Medicine, 101 Daehak Ro, Jongno gu, Seoul 110 744, Republic of Korea
    Biomed Res Int 2013:856754. 2013
    ..We also investigated whether cirrhotic patients exhibit hypo- or hypercoagulability using the TGA...
  8. ncbi request reprint Inhibition of endothelial cell proliferation by the recombinant kringle domain of tissue-type plasminogen activator
    Hyun Kyung Kim
    Cancer Research Institute, Catholic Research Institutes of Medical Sciences, The Catholic University of Korea, 137 701, Seoul, Republic of Korea
    Biochem Biophys Res Commun 304:740-6. 2003
    ..These results suggest that the recombinant kringle domain of t-PA is a selective inhibitor of endothelial cell growth and identifies this molecule as a novel anti-angiogenic agent...
  9. doi request reprint Neutrophil and monocyte activation markers have prognostic impact in disseminated intravascular coagulation: in vitro effect of thrombin on monocyte CD163 shedding
    Soie Chung
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    Thromb Res 127:450-6. 2011
    ..NDW, a convenient parameter measured by an automated hematology analyzer, may be an independent prognostic parameter for DIC...
  10. ncbi request reprint Integrin alphavbeta3 is not significantly implicated in the anti-migratory effect of anti-angiogenic urokinase kringle domain
    Eunju O
    Cancer Research Institute and Department of Biomedical Science, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Oncol Rep 20:631-6. 2008
    ..These results suggest that UK1 interacts with integrin alphavbeta3, but its anti-migratory activity on endothelial cells is not significantly mediated by integrin alphavbeta3...
  11. doi request reprint Higher prognostic value of soluble fibrin complexes than D-dimer and fibrin degradation product for disseminated intravascular coagulation in patients with liver cirrhosis
    Seon Young Kim
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    Blood Coagul Fibrinolysis 24:150-6. 2013
    ..sFC is a powerful diagnostic and prognostic marker of DIC in patient with liver cirrhosis. The use of sFC is expected to enhance the diagnosis and prognosis of DIC, particularly in patients with liver cirrhosis...
  12. doi request reprint Protein Z efficiently depletes thrombin generation in disseminated intravascular coagulation with poor prognosis
    Nuri Lee
    aDepartment of Laboratory Medicine bCancer Research Institute cDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Blood Coagul Fibrinolysis 27:84-9. 2016
    ..The prolonged lag time and time-to-peak in both TGA and TGA-protein Z systems are expected to be used as independent prognostic factors of DIC. ..
  13. doi request reprint Decreased thrombomodulin mRNA expression on peripheral monocytes in disseminated intravascular coagulation patients relates to poor outcomes: the ex vivo effects of lipopolysaccharide and thrombin on monocyte thrombomodulin and CD14 mRNA
    Sung Kuk Hong
    Department of Laboratory Medicine and Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Thromb Res 132:392-7. 2013
    ..We used an ex vivo stimulation study to evaluate the association of the levels of monocyte-expressed thrombomodulin and CD14 messenger RNA (mRNA) with the severity and prognosis of disseminated intravascular coagulation...
  14. pmc Thrombomodulin phenotype of a distinct monocyte subtype is an independent prognostic marker for disseminated intravascular coagulation
    Sang Mee Hwang
    Department of Laboratory Medicine, Seoul National University College of Medicine, 101, Daehak ro Jongno gu, Seoul 110 744, Republic of Korea
    Crit Care 15:R113. 2011
    ..Therefore, we investigated the phenotypic difference in thrombomodulin and TF expression between different monocyte subtypes in coagulopathy severity and prognosis in patients suspected of having DIC...
  15. doi request reprint Influence of coagulation and anticoagulant factors on global coagulation assays in healthy adults
    Seon Young Kim
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    Am J Clin Pathol 139:370-9. 2013
    ..The synchronized plasma levels of vitamin K-dependent proteins with opposite functionalities may compensate a propensity to hyper- or hypocoagulability in a normal population...
  16. ncbi request reprint Lithium down-regulates the expression of CXCR4 in human neutrophils
    Hyun Kyung Kim
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
    J Trace Elem Med Biol 21:204-9. 2007
    ..Our studies support the concept that down-regulation of CXCR4 is one of the mechanisms by which causes neutrophilia...
  17. doi request reprint Evaluation of the TEST 1 erythrocyte sedimentation rate system and intra- and inter-laboratory quality control using new latex control materials
    Choong Hwan Cha
    Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea
    Clin Chem Lab Med 48:1043-8. 2010
    ..However, QC is essential for accuracy and precision. We evaluated the TEST 1 ESR system and performed QC procedures using newly developed latex control materials in three hospitals...
  18. ncbi request reprint Surface expression of neutrophil CXCR4 is down-modulated by bacterial endotoxin
    Hyun Kyung Kim
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    Int J Hematol 85:390-6. 2007
    ....
  19. doi request reprint Aurintricarboxylic acid inhibits the nuclear factor-κB-dependent expression of intercellular cell adhesion molecule-1 and endothelial cell selectin on activated human endothelial cells
    Ji Eun Kim
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
    Blood Coagul Fibrinolysis 22:132-9. 2011
    ....
  20. doi request reprint Clinical course of non-severe aplastic anemia in adults
    Ji Hyun Kwon
    Department of Internal Medicine, Seoul National University Hospital, College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul, 110 744, Republic of Korea
    Int J Hematol 91:770-5. 2010
    ..White blood cell and absolute neutrophil count at diagnosis and treatment responsiveness of thrombocytopenia were associated with disease progression. Careful monitoring and early management are needed for patients at risk...
  21. doi request reprint Correlation between plasma activity of ADAMTS-13 and coagulopathy, and prognosis in disseminated intravascular coagulation
    Jungwon Hyun
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
    Thromb Res 124:75-9. 2009
    ..We determined whether ADAMTS-13 activity showed a significant correlation with the activation status of the coagulation system and hospital mortality in DIC...
  22. pmc Utility of ELISA optical density values and clinical scores for the diagnosis of and thrombosis prediction in heparin-induced thrombocytopenia
    Seon Young Kim
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    Korean J Lab Med 31:1-8. 2011
    ..HIT diagnosis is challenging and depends on clinical presentation and laboratory tests. We investigated the usefulness of clinical scores and heparin/PF4 ELISA optical density (OD) as a diagnostic marker and thrombosis predictor in HIT...
  23. doi request reprint Prognostic values of the factor Xa-activated clotting time and endogenous thrombin potential in patients suspected of having disseminated intravascular coagulation
    Ji Weon Seo
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    Thromb Res 123:565-72. 2009
    ....
  24. doi request reprint Clinical significance of the mixing test in laboratory diagnoses of lupus anticoagulant: the fate of the mixing test in integrated lupus anticoagulant test systems
    Sung Kuk Hong
    Department of Laboratory Medicine bCancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Blood Coagul Fibrinolysis 23:739-44. 2012
    ..The updated two-step procedure without the mixing test is relevant for lupus anticoagulant detection in the context of thrombotic risk estimation...
  25. doi request reprint Quantity of clonal cells detected by conventional cytogenetic analysis correlates with bone marrow blasts and survival in myelodysplastic syndromes
    Miyoung Kim
    Department of Laboratory Medicine, Seoul National University College of Medicine, Jongno gu, Seoul, South Korea
    Leuk Res 36:163-8. 2012
    ..7% vs. 23.1%, p=0.017). Multivariate analysis showed that a high quantity of clonal cells in CCA analysis is an independent prognostic factor for overall survival in MDS (p=0.012)...
  26. ncbi request reprint Lipopolysaccharide down-regulates the thrombomodulin expression of peripheral blood monocytes: effect of serum on thrombomodulin expression in the THP-1 monocytic cell line
    Hyun Kyung Kim
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
    Blood Coagul Fibrinolysis 18:157-64. 2007
    ..Regulation of the THP-1 thrombomodulin expression by lipopolysaccharide depends on the presence of serum...
  27. doi request reprint Plasma haemostatic potential of haemodialysis patients assessed by thrombin generation assay: hypercoagulability in patients with vascular access thrombosis
    Jong Cheol Jeong
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Thromb Res 132:604-9. 2013
    ..We investigated the global haemostatic potential assessed by TGA in ESRD patients on haemodialysis and patients who developed vascular access thrombosis...
  28. doi request reprint Local anesthetics inhibit tissue factor expression in activated monocytes via inhibition of tissue factor mRNA synthesis
    Ji Eun Kim
    Department of Laboratory Medicine and Cancer Research Institute, Seoul National University College of Medicine, Jongnogu, Seoul, Korea
    Clin Appl Thromb Hemost 17:E4-9. 2011
    ....
  29. doi request reprint Serum des-R prothrombin activation peptide fragment 2: a novel prognostic marker for disseminated intravascular coagulation
    Soie Chung
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    Thromb Res 131:547-53. 2013
    ..Because the collection of blood plasma samples is a fastidious procedure, the serum sample method may be preferred for measurement of coagulation markers when feasible...
  30. doi request reprint The Rho kinase inhibitor fasudil augments the number of functional endothelial progenitor cells in ex vivo cultures
    Eunju O
    Cancer Research Institute and Department of Medical Lifescience, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
    Int J Mol Med 28:357-63. 2011
    ..Therefore, these data suggest that the ROCK inhibitor fasudil can provide a beneficial effect in the treatment of ischemic diseases by increasing EPC numbers...
  31. doi request reprint Prognosis of secondary acute myeloid leukemia is affected by the type of the preceding hematologic disorders and the presence of trisomy 8
    Youngil Koh
    Department of Internal Medicine, College of Medicine, Seoul National University, Seoul, Republic of Korea
    Jpn J Clin Oncol 40:1037-45. 2010
    ..We also intended to find prognostic factors in secondary acute myeloid leukemia overall...
  32. doi request reprint Accuracy of platelet counting by automated hematologic analyzers in acute leukemia and disseminated intravascular coagulation: potential effects of platelet activation
    Seon Young Kim
    Dept of Laboratory Medicine, Seoul National University College of Medicine, 101, Daehang no Jongno gu, Seoul 110 744, Republic of Korea
    Am J Clin Pathol 134:634-47. 2010
    ..The inaccuracy of automated platelet counts increased the risk for misdiagnosis of DIC. More attention needs to be given to the accuracy of platelet counts, especially in clinical conditions with florid platelet activation...
  33. doi request reprint [Usefulness of silica clotting time for detection of lupus anticoagulants]
    Hye Ryun Lee
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    Korean J Lab Med 29:497-504. 2009
    ..Also, we analyzed differences in the thrombotic features and the characteristics of antiphospholipid antibodies between dRVVT and SCT...
  34. doi request reprint Poor prognosis of hypocoagulability assessed by thrombin generation assay in disseminated intravascular coagulation
    Kyunghoon Lee
    aDepartment of Laboratory Medicine bCancer Research Institute cDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea Kyunghoon Lee and Ji Eun Kim contributed equally to this work
    Blood Coagul Fibrinolysis 25:241-7. 2014
    ..ETP and peak thrombin well reflect DIC severity. Hypocoagulability manifesting as prolonged lag time and time to peak is expected to be an independent prognostic marker in DIC. ..
  35. ncbi request reprint The kringle domain of tissue-type plasminogen activator inhibits extracellular matrix-induced adhesion and migration of endothelial cells
    Byung Hun Lee
    Cancer Research Institute and Department of Biomedical Science, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Biosci Biotechnol Biochem 72:2303-8. 2008
    ..Hence the results suggest that disturbance of extracellular matrix-induced adhesion, signaling, and migration of endothelial cells is involved in the anti-angiogenic activity of TK1-2...
  36. doi request reprint Increased copy number of the interleukin-6 receptor gene is associated with adverse survival in multiple myeloma patients treated with autologous stem cell transplantation
    Seon Young Kim
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, South Korea
    Biol Blood Marrow Transplant 17:810-20. 2011
    ..These findings suggest the potential role of IL-6R in myeloma cell growth and therapeutic implications of the IL-6R blocker in the future...
  37. doi request reprint Vitamin E inhibition on platelet procoagulant activity: involvement of aminophospholipid translocase activity
    Ji Eun Kim
    Department of Laboratory Medicine and Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Thromb Res 127:435-42. 2011
    ..Although vitamin E has been investigated for its anti-aggregating effect on platelets, its effect on platelet procoagulant activity has not been reported...
  38. doi request reprint Prognostic value of immature platelet fraction and plasma thrombopoietin in disseminated intravascular coagulation
    Ki Ho Hong
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    Blood Coagul Fibrinolysis 20:409-14. 2009
    ..These results suggest that IPF and TPO are new potential candidates to detect the severity of DIC and to predict DIC mortality...
  39. doi request reprint Quantitative comparison of CDKN2B methylation in pediatric and adult myelodysplastic syndromes
    Miyoung Kim
    Department of Laboratory Medicine, Hallym University Sacred Heart Hospital, Anyang, Korea
    Acta Haematol 130:115-21. 2013
    ..Transcriptional repression of tumor suppressor genes is determined by the quantity of promoter hypermethylation. We analyzed the methylation quantity of CDKN2B in pediatric myelodysplastic syndromes (MDS)...
  40. ncbi request reprint Neutrophil CD64 expression is associated with severity and prognosis of disseminated intravascular coagulation
    Sang Hoon Song
    Department of Laboratory Medicine, Seoul National University, College of Medicine, Seoul, Korea
    Thromb Res 121:499-507. 2008
    ..We investigated the relationship between neutrophil activation and DIC severity and determined the prognostic value of neutrophil activation markers in patients with DIC...
  41. doi request reprint Synergistic thrombotic risk of antibodies against phosphatidylserine and prothrombin and β-2-glycoprotein I
    Hyungsuk Kim
    1Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    Clin Appl Thromb Hemost 20:442-7. 2014
    ..Coagulation and anticoagulation systems are good targets of antiphospholipid antibodies. We assessed the contribution of the antiphospholipid antibodies to the thrombotic risk...
  42. doi request reprint Aurintricarboxylic acid inhibits endothelial activation, complement activation, and von Willebrand factor secretion in vitro and attenuates hyperacute rejection in an ex vivo model of pig-to-human pulmonary xenotransplantation
    Hyun Kyung Kim
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    Xenotransplantation 15:246-56. 2008
    ..We also assessed its role in hyperacute xenograft rejection using a porcine ex vivo lung perfusion model...
  43. doi request reprint Molecular identification of a TPR-FGFR1 fusion transcript in an adult with myeloproliferative neoplasm, T-lymphoblastic lymphoma, and a t(1;8)(q25;p11.2)
    Seon Young Kim
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
    Cancer Genet 207:258-62. 2014
    ..Sequence analysis revealed a fusion transcript with exon 22 of the TPR gene joined to exon 13 of the FGFR1 gene, which is a novel breakpoint for the TPR gene in the TPR-FGFR1 rearrangement...
  44. doi request reprint Prominent protein Z-induced thrombin inhibition in cirrhosis: a new functional assay for hypercoagulability assessment
    Seon Young Kim
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    J Gastroenterol Hepatol 30:784-93. 2015
    ..We assessed functional status of PZ system in 158 patients with liver cirrhosis and 59 healthy controls...
  45. doi request reprint Impact of vitamin D receptor gene polymorphisms on clinical outcomes of HLA-matched sibling hematopoietic stem cell transplantation
    Hyeon Jin Cho
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Clin Transplant 26:476-83. 2012
    ..This study suggests that the genotype and haplotype of VDR in recipient might be associated with clinical outcome of sibling HLA-matched HSCT...
  46. doi request reprint Erythrocyte sedimentation rate measurements by TEST 1 better reflect inflammation than do those by the Westergren method in patients with malignancy, autoimmune disease, or infection
    Choong Hwan Cha
    Department of Laboratory Medicine, University of Ulsan College of Medicine and Gangneung Asan Hospital, Gangneung, Korea
    Am J Clin Pathol 131:189-94. 2009
    ..These findings indicate that ESR measurements by TEST 1 reflect inflammation better than do those by the Westergren method in patients with malignancy, autoimmune disease, or infection...
  47. ncbi request reprint [Clinical usefulness of plasma interleukin-6 and interleukin-10 in disseminated intravascular coagulation]
    Ji Weon Seo
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    Korean J Lab Med 27:83-8. 2007
    ..Inflammatory cytokines can activate the coagulation system. This study investigated the diagnostic and prognostic usefulness of the plasma level of interleukin-6 (IL-6) and interleukin-10 (IL-10) for predicting DIC...
  48. pmc Changes in plasma levels of natural anticoagulants in disseminated intravascular coagulation: high prognostic value of antithrombin and protein C in patients with underlying sepsis or severe infection
    Qute Choi
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    Ann Lab Med 34:85-91. 2014
    ..Herein, the diagnostic value of 4 natural anticoagulants was assessed, and the prognostic value of antithrombin and protein C were validated in a large population...
  49. ncbi request reprint Utility of the fibrinogen/C-reactive protein ratio for the diagnosis of disseminated intravascular coagulation
    Hyun Kyung Kim
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    Acta Haematol 117:34-9. 2007
    ..The results of our study suggest that replacement of fibrinogen by the fibrinogen/CRP ratio for calculating the DIC score may lead to enhance diagnostic and prognostic power for DIC...
  50. pmc Influence of blood lipids on global coagulation test results
    Jung Ah Kim
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    Ann Lab Med 35:15-21. 2015
    ..We investigated whether blood lipids influence the results of global coagulation tests, including prothrombin time (PT), activated partial thromboplastin time (aPTT), and thrombin generation assay (TGA)...
  51. pmc Acute lymphoblastic leukemia in elderly patients: a single institution's experience
    Dong Yeop Shin
    Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea
    Korean J Intern Med 26:328-39. 2011
    ..We investigated the clinical characteristics and prognosis of elderly patients with acute lymphoblastic leukemia (ALL)...
  52. doi request reprint Presence of antiheparin/platelet factor 4 immunoglobulin g is associated with poor prognosis in patients with suspected disseminated intravascular coagulation
    Jae Hyeon Park
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    Clin Appl Thromb Hemost 21:66-71. 2015
    ..The presence of antiheparin/PF4 IgG in old age or low antithrombin level patients with DIC with old age or low antithrombin level suggests a poor prognosis. ..
  53. doi request reprint Differential expression of leukocyte receptors in disseminated intravascular coagulation: prognostic value of low protein C receptor expression
    Ji Yeon Sung
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    Thromb Res 134:1130-4. 2014
    ..We investigated whether the expressions of 3 leukocyte receptors (PROCR, TLR4, L-selectin) was related to clinical outcomes in patients suggestive of having DIC...
  54. doi request reprint Diagnostic and prognostic significance of neutrophil gelatinase-associated lipocalin in disseminated intravascular coagulation
    Ji Won In
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
    Clin Chim Acta 430:145-9. 2014
    ..We investigated the diagnostic performance of the plasma NGAL level in predicting acute kidney injury (AKI) in patients with DIC and determined the prognostic value of NGAL...
  55. doi request reprint Circulating levels of DNA-histone complex and dsDNA are independent prognostic factors of disseminated intravascular coagulation
    Ji Eun Kim
    Department of Laboratory Medicine and Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea Cancer Research Institute, Seoul National University College of Medicine, 103 Daehak Ro, Jongno gu, Seoul 110 799, Korea Electronic address
    Thromb Res 135:1064-9. 2015
    ..Therefore, we investigated circulating levels of NET in DIC and analyzed their potential values to assess coagulation severity and predict clinical outcome...
  56. doi request reprint Beneficial effect of a nitric oxide donor in an ex vivo model of pig-to-human pulmonary xenotransplantation
    Hee Sue Park
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    Xenotransplantation 22:391-8. 2015
    ....
  57. ncbi request reprint Plasma level of stromal derived factor-1 (SDF-1) is increased in disseminated intravascular coagulation patients who have poor outcomes: in vitro effect of SDF-1 on coagulopathy
    Hyun Kyung Kim
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
    Thromb Res 120:559-66. 2007
    ..These findings suggest that plasma SDF-1 might be closely associated with hypercoagulability though its action as a platelet activator...
  58. doi request reprint Priming Wharton's jelly-derived mesenchymal stromal/stem cells with ROCK inhibitor improves recovery in an intracerebral hemorrhage model
    Hyun Sun Lee
    Cancer Research Institute and Department of Medical Life Sciences, College of Medicine, The Catholic University of Korea, Seoul, 137 701, Korea
    J Cell Biochem 116:310-9. 2015
    ..Therefore, this work suggests that priming WJ-MSCs with fasudil is a possible application for enhanced cell therapy in stroke, with additional beneficial effect of up-regulation of GDNF...
  59. doi request reprint Assessment of heavy metal exposure via the intake of oriental medicines in Korea
    Hyun Kyung Kim
    Risk Assessment Division, National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, Korea
    J Toxicol Environ Health A 72:1336-42. 2009
    ..This is the first study to evaluate exposure and risk of heavy metal intoxication through intake of oriental medicines in Korea. Despite the uncertainties and limits of the data, these results simulate realistic exposure levels...
  60. doi request reprint Contact and fumigant toxicity of Armoracia rusticana essential oil, allyl isothiocyanate and related compounds to Dermatophagoides farinae
    Yeon Kyeong Yun
    Entomology Major, Department of Agricultural Biotechnology, Seoul National University, Seoul, Republic of Korea
    Pest Manag Sci 68:788-94. 2012
    ..Results were compared with those of two conventional acaricides, benzyl benzoate and dibutyl phthalate...
  61. doi request reprint Maternal and fetal exposure to bisphenol A in Korea
    Young Joo Lee
    Human Exposure Assessment Team, National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, Republic of Korea
    Reprod Toxicol 25:413-9. 2008
    ..86 microg/L in umbilical cords. Serum BPA levels in most pregnant women were higher than in corresponding fetal umbilical cords and a positive correlation was found between in maternal and fetal BPA concentrations (p<0.05)...
  62. doi request reprint Effects of an anti-transforming growth factor-β agent (pirfenidone) on strabismus surgery in rabbits
    Kyoung In Jung
    Department of Ophthalmology and Visual Science, Seoul St Mary s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Curr Eye Res 37:770-6. 2012
    ..To evaluate the usefulness of an anti-transforming growth factor-β (TGF-β) agent, pirfenidone (PFD) on postoperative inflammation and fibrosis following strabismus surgery in rabbits...
  63. ncbi request reprint Prevalence of beta2-glycoprotein I antibody in patients with liver cirrhosis: relationship with beta2-glycoprotein I plasma levels and thrombosis
    Kyung Soon Song
    Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea
    Clin Appl Thromb Hemost 10:183-6. 2004
    ..Anti-beta2-GPI antibodies were positive in 11 (15.9%) patients. However, there were no differences in beta2-GPI levels, platelet counts, and thrombosis between positive and negative groups for anti-beta2-GPI antibodies...
  64. doi request reprint High coagulation factor levels and low protein C levels contribute to enhanced thrombin generation in patients with diabetes who do not have macrovascular complications
    Hyun Kyung Kim
    Department of Laboratory Medicine and Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
    J Diabetes Complications 28:365-9. 2014
    ..We used this thrombin generation assay to investigate global hemostatic potential in patients with diabetes who did not have macrovascular complications...