Daehee Kang

Summary

Affiliation: Seoul National University
Country: Korea

Publications

  1. ncbi request reprint Genetic variants in interleukin-2 and risk of lymphoma among children in Korea
    Nan Song
    Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology and College of Medicine, Seoul National University, Seoul, Korea
    Asian Pac J Cancer Prev 13:621-3. 2012
  2. pmc Innate immunity and non-Hodgkin's lymphoma (NHL) related genes in a nested case-control study for gastric cancer risk
    Sue K Park
    Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea
    PLoS ONE 7:e45274. 2012
  3. pmc Genetic polymorphisms of cytochrome P450 19 and 1B1, alcohol use, and breast cancer risk in Korean women
    K M Lee
    Department of Preventive Medicine, Seoul National University College of Medicine, Cancer Research Institute, Chongno Gu, Seoul, Korea
    Br J Cancer 88:675-8. 2003
  4. pmc DNA methylation in peripheral blood: a potential biomarker for cancer molecular epidemiology
    Lian Li
    Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea
    J Epidemiol 22:384-94. 2012
  5. pmc Asia Cohort Consortium: challenges for collaborative research
    Minkyo Song
    Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea
    J Epidemiol 22:287-90. 2012
  6. pmc A genome-wide association study identifies a breast cancer risk variant in ERBB4 at 2q34: results from the Seoul Breast Cancer Study
    Hyung Cheol Kim
    Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk Do, 363 951, Korea
    Breast Cancer Res 14:R56. 2012
  7. pmc Intrauterine environments and breast cancer risk: meta-analysis and systematic review
    Sue Kyung Park
    Department of Preventive Medicine, Seoul National University College of Medicine, Yeongeon Dong, Jongro Gu, Seoul 110 799, Seoul, Republic of Korea
    Breast Cancer Res 10:R8. 2008
  8. pmc Young age: an independent risk factor for disease-free survival in women with operable breast cancer
    Wonshik Han
    Department of Surgery, Seoul National University College of Medicine, Seoul 110 744, Korea
    BMC Cancer 4:82. 2004
  9. ncbi request reprint Design issues in cross-sectional biomarkers studies: urinary biomarkers of PAH exposure and oxidative stress
    Daehee Kang
    Department of Preventive Medicine, Seoul National University, College of Medicine, Institute of Environmental Medicine, SNUMRC, Seoul 110 799, South Korea
    Mutat Res 592:138-46. 2005
  10. ncbi request reprint Genetic polymorphisms and cancer susceptibility of breast cancer in Korean women
    Daehee Kang
    Department of Preventive Medicine, Seoul National University College of Medicine, Seoul 110 799, Korea
    J Biochem Mol Biol 36:28-34. 2003

Collaborators

Detail Information

Publications116 found, 100 shown here

  1. ncbi request reprint Genetic variants in interleukin-2 and risk of lymphoma among children in Korea
    Nan Song
    Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology and College of Medicine, Seoul National University, Seoul, Korea
    Asian Pac J Cancer Prev 13:621-3. 2012
    ..TT=3.43 (1.29-9.11), P(trend)=0.002, minP=0.005). These findings suggest that common genetic variants in IL2 might play a role in the pathogenesis of childhood lymphoma...
  2. pmc Innate immunity and non-Hodgkin's lymphoma (NHL) related genes in a nested case-control study for gastric cancer risk
    Sue K Park
    Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea
    PLoS ONE 7:e45274. 2012
    ..This nested case-control study was conducted to identify candidate genes for gastric cancer risk for future studies...
  3. pmc Genetic polymorphisms of cytochrome P450 19 and 1B1, alcohol use, and breast cancer risk in Korean women
    K M Lee
    Department of Preventive Medicine, Seoul National University College of Medicine, Cancer Research Institute, Chongno Gu, Seoul, Korea
    Br J Cancer 88:675-8. 2003
    ..5, 95% CI=1.1-2.2), especially in association with alcohol consumption (P for interaction=0.04), whereas the CYP1B1 Leu(432)Val polymorphism appears to play no role here...
  4. pmc DNA methylation in peripheral blood: a potential biomarker for cancer molecular epidemiology
    Lian Li
    Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea
    J Epidemiol 22:384-94. 2012
    ....
  5. pmc Asia Cohort Consortium: challenges for collaborative research
    Minkyo Song
    Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea
    J Epidemiol 22:287-90. 2012
    ..Many challenges remain, including data harmonization, resolution of ethical and legal issues, establishment of protocols for biologic samples and transfer agreements, and funding procurement...
  6. pmc A genome-wide association study identifies a breast cancer risk variant in ERBB4 at 2q34: results from the Seoul Breast Cancer Study
    Hyung Cheol Kim
    Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk Do, 363 951, Korea
    Breast Cancer Res 14:R56. 2012
    ..Furthermore, GWAS-identified loci were primarily identified in women of European descent...
  7. pmc Intrauterine environments and breast cancer risk: meta-analysis and systematic review
    Sue Kyung Park
    Department of Preventive Medicine, Seoul National University College of Medicine, Yeongeon Dong, Jongro Gu, Seoul 110 799, Seoul, Republic of Korea
    Breast Cancer Res 10:R8. 2008
    ..Despite ample biologic plausibility, epidemiologic studies to date have yielded conflicting results. We investigated the associations between perinatal factors and subsequent breast cancer risk through meta-analyses...
  8. pmc Young age: an independent risk factor for disease-free survival in women with operable breast cancer
    Wonshik Han
    Department of Surgery, Seoul National University College of Medicine, Seoul 110 744, Korea
    BMC Cancer 4:82. 2004
    ..The incidence of breast cancer in young women (age < 35) is low. The biology of the disease in this age group is poorly understood, and there are conflicting data regarding the prognosis for these women compared to older patients...
  9. ncbi request reprint Design issues in cross-sectional biomarkers studies: urinary biomarkers of PAH exposure and oxidative stress
    Daehee Kang
    Department of Preventive Medicine, Seoul National University, College of Medicine, Institute of Environmental Medicine, SNUMRC, Seoul 110 799, South Korea
    Mutat Res 592:138-46. 2005
    ....
  10. ncbi request reprint Genetic polymorphisms and cancer susceptibility of breast cancer in Korean women
    Daehee Kang
    Department of Preventive Medicine, Seoul National University College of Medicine, Seoul 110 799, Korea
    J Biochem Mol Biol 36:28-34. 2003
    ..e., TGF- beta, IGF-1, TNF- beta, IL-1B, IL-1RN, etc.). We also took into account the potential interaction between these and the known risk factors of breast cancer. The results of selected genes will be presented in this mini-review...
  11. ncbi request reprint Functional variant of manganese superoxide dismutase (SOD2 V16A) polymorphism is associated with prostate cancer risk in the prostate, lung, colorectal, and ovarian cancer study
    Daehee Kang
    Department of Preventive Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 799, Korea
    Cancer Epidemiol Biomarkers Prev 16:1581-6. 2007
    ..These results suggest that the Ala variant of SOD2 is associated with moderately increased risk of prostate cancer, particularly among men with lower intakes of dietary and supplemental vitamin E...
  12. ncbi request reprint Lack of association of transforming growth factor-beta1 polymorphisms and haplotypes with prostate cancer risk in the prostate, lung, colorectal, and ovarian trial
    Daehee Kang
    Department of Preventive Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 799, Korea
    Cancer Epidemiol Biomarkers Prev 16:1303-5. 2007
  13. ncbi request reprint Microsatellite polymorphisms in the epidermal growth factor receptor (EGFR) gene and the transforming growth factor-alpha (TGFA) gene and risk of oral cancer in Puerto Rico
    Daehee Kang
    Department of Preventive Medicine, Seoul National University College of Medicine, Cancer Research Institute, SNUCM, Seoul, Korea
    Pharmacogenet Genomics 15:343-7. 2005
    ....
  14. ncbi request reprint Multiple biomarkers study in painters in a shipyard in Korea
    Kyoung Ho Lee
    Department of Preventive Medicine, Institute of Environmental Medicine, Seoul National University College of Medicine, SNUMRC, 28 Yongon Dong, Chongno Gu, Seoul 110 799, South Korea
    Mutat Res 540:89-98. 2003
    ..These results suggest that painters in the shipyard were exposed to significant amounts of PAHs and possibly to other genotoxic aromatic compounds, and that urinary 1-OHPG may be a potential biomarker of PAH exposure in this population...
  15. pmc The role of TNF genetic variants and the interaction with cigarette smoking for gastric cancer risk: a nested case-control study
    Jae Jeong Yang
    Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea
    BMC Cancer 9:238. 2009
    ..The aim of this study was to investigate the role of TNF genetic variants and the combined effect between TNF gene and cigarette smoking in the development of gastric cancer in the Korean population...
  16. ncbi request reprint CASP8 polymorphisms, estrogen and progesterone receptor status, and breast cancer risk
    Sohee Han
    Department of Preventive Medicine, Seoul National University College of Medicine, Chongno Gu, Seoul, Korea
    Breast Cancer Res Treat 110:387-93. 2008
    ..This study was conducted to evaluate the potential role of CASP8 genetic polymorphisms in the etiology of breast cancer in a case-control study, Korea...
  17. ncbi request reprint Urinary PAH metabolites influenced by genetic polymorphisms of GSTM1 in male hospital incinerator workers
    Kyoung Ho Lee
    Department of Preventive Medicine, Seoul National University College of Medicine, Korea
    J Occup Health 45:168-71. 2003
    ..Our results suggest that the urinary 1-OHPG levels in hospital waste incinerator workers may be modified by the GSTM1 genotype, but these findings remain to be confirmed in future studies involving larger sample sizes...
  18. ncbi request reprint Genetic polymorphisms of TGF-beta1 & TNF-beta and breast cancer risk
    Kyoung Mu Lee
    Department of Preventive Medicine, Cancer Research Institute, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul, 110 799, Korea
    Breast Cancer Res Treat 90:149-55. 2005
    ..To evaluate the potential influences of TGF-beta1 T29C and TNF-beta A252G gene polymorphisms on breast cancer risk, a case-control study was conducted in Korea...
  19. ncbi request reprint Influence of polymorphism of GSTM1 gene on association between glycophorin a mutant frequency and urinary PAH metabolites in incineration workers
    Kyoung Ho Lee
    Institute of Environmental Medicine, Seoul National University MRC, and Cancer Research Institute, Seoul National University College of Medicine, Korea
    J Toxicol Environ Health A 65:355-63. 2002
    ..These results suggest that the association between urinary 1-OHPG and GPA mutation might be modulated by the GSTM1 genotype...
  20. ncbi request reprint Sources of polycyclic aromatic hydrocarbon exposure in non-occupationally exposed Koreans
    Mihi Yang
    Department of Preventive Medicine Cancer Research Institute, Seoul National University, Seoul, Korea
    Environ Mol Mutagen 42:250-7. 2003
    ..05). These epidemiological results suggest that the above factors that should be considered in preventing PAH exposure...
  21. doi request reprint Soybean product intake modifies the association between interleukin-10 genetic polymorphisms and gastric cancer risk
    Kwang Pil Ko
    Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea
    J Nutr 139:1008-12. 2009
    ..38 [1.40-8.13]) relative to the ATA haplotype. Our results suggest that the association between IL-10 genetic polymorphisms and gastric cancer risk was modified by soybean product intake...
  22. ncbi request reprint Soluble c-Met protein as a susceptible biomarker for gastric cancer risk: A nested case-control study within the Korean Multicenter Cancer Cohort
    Jae Jeong Yang
    Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea
    Int J Cancer 132:2148-56. 2013
    ..Our findings demonstrate the potential of the soluble form of c-Met protein as a novel biomarker for gastric cancer. The beneficial effects of a high soluble c-Met concentration in human plasma are strongly supported...
  23. ncbi request reprint Genetic polymorphisms of ataxia telangiectasia mutated and breast cancer risk
    Kyoung Mu Lee
    Department of Preventive Medicine, Cancer Research Institute, Seoul National University, College of Medicine, 28 Yongon dong Chongno gu, Seoul 110 799, Korea
    Cancer Epidemiol Biomarkers Prev 14:821-5. 2005
    ..01). Our results thus suggest that genetic polymorphisms of ATM play an important role in the development of breast cancer in Korean women...
  24. ncbi request reprint Genetic polymorphisms of interleukin-1 beta (IL-1B) and IL-1 receptor antagonist (IL-1RN) and breast cancer risk in Korean women
    Kyoung Mu Lee
    Cancer Research Institute, Institute of Environmental Medicine, SNUMRC, and Department of Preventive Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul, Korea
    Breast Cancer Res Treat 96:197-202. 2006
    ..To evaluate the potential role of genetic polymorphisms of interleukin-1 beta (IL-1B) and IL-1 receptor antagonist (IL-1RN) on breast cancer development, a hospital-based case-control study was conducted in Korea...
  25. ncbi request reprint Genetic polymorphism of XRCC3 Thr241Met and breast cancer risk: case-control study in Korean women and meta-analysis of 12 studies
    Sang Ah Lee
    Department of Preventive Medicine, Cancer Research Institute, Seoul National University College of Medicine, 28 Yongon dong Chongno gu, Seoul 110 799, South Korea
    Breast Cancer Res Treat 103:71-6. 2007
    ....
  26. ncbi request reprint Full sequencing analysis of estrogen receptor-alpha gene polymorphism and its association with breast cancer risk
    Wonshik Han
    Department of Surgery, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 744, Korea
    Anticancer Res 23:4703-7. 2003
    ..The estrogen receptor plays a critical role in breast cancer development and progression. So the genetic polymorphism of ER-alpha gene could affect cancer risk and phenotype...
  27. ncbi request reprint Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations
    Suk Kyun Yang
    Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    Gut 63:80-7. 2014
    ..Recent meta-analysis of the genome-wide association studies (GWAS) and Immunochip data identified 163 susceptibility loci to IBD in Caucasians, however there are limited studies in other populations...
  28. doi request reprint CYP1A1, GSTM1, and GSTT1 polymorphisms, smoking, and lung cancer risk in a pooled analysis among Asian populations
    Kyoung Mu Lee
    Department of Preventive Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 799, Korea
    Cancer Epidemiol Biomarkers Prev 17:1120-6. 2008
    ..However, further investigation is warranted considering the relatively small sample size when subgroup analyses were done and the lack of environmental exposure data other than smoking...
  29. doi request reprint Interaction effects between genes involved in the AKT signaling pathway and phytoestrogens in gastric carcinogenesis: a nested case-control study from the Korean Multi-Center Cancer Cohort
    Jae Jeong Yang
    Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea
    Mol Nutr Food Res 56:1617-26. 2012
    ..To investigate whether genes involved in AKT/nuclear factor kappa B signaling and/or gene-environment interactions between the genes and phytoestrogens may be susceptible factors for gastric cancer...
  30. pmc Genetic susceptibility on CagA-interacting molecules and gene-environment interaction with phytoestrogens: a putative risk factor for gastric cancer
    Jae Jeong Yang
    Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea
    PLoS ONE 7:e31020. 2012
    ....
  31. ncbi request reprint Estrogen receptor alpha gene polymorphisms and breast cancer risk
    Aesun Shin
    Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea
    Breast Cancer Res Treat 80:127-31. 2003
    ..3 (95% CI: 0.1-0.5) and 0.5 (95% CI: 0.3-0.9) for postmenopausal and premenopausal women, respectively. Our results therefore suggest that the ER alpha XbaI polymorphism modifies individual susceptibility to breast cancer in Korean women...
  32. ncbi request reprint Methylenetetrahydrofolate reductase polymorphism, diet, and breast cancer in Korean women
    Sang Ah Lee
    Department of Preventive Medicine, College of Medicine, Seoul National University 28 Yongon dong, Chongno Gu, Seoul 110 799, Korea
    Exp Mol Med 36:116-21. 2004
    ..Our findings suggest that MTHFR polymorphism did not influence individual susceptibility to breast cancer. However MTHFR (C667T) genotype and green vegetable intakes appeared to have the interactive effect in breast cancer development...
  33. ncbi request reprint A haplotype analysis of HER-2 gene polymorphisms: association with breast cancer risk, HER-2 protein expression in the tumor, and disease recurrence in Korea
    Wonshik Han
    Department of Surgery, Seoul National University College of Medicine, and DNA Link Inc, Seoul, Korea
    Clin Cancer Res 11:4775-8. 2005
    ..The purpose of this study was to investigate the association between common variants of HER-2 and breast cancer risk, HER-2 expression, and survival using a haplotype-based stepwise approach...
  34. pmc Alcohol consumption and mortality in the Korean Multi-Center Cancer Cohort Study
    En Joo Jung
    Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea
    J Prev Med Public Health 45:301-8. 2012
    ..To examine the association between alcohol consumption habit, types of beverages, alcohol consumption quantity, and overall and cancer-specific mortality among Korean adults...
  35. ncbi request reprint Genetic polymorphism of glutathione S-transferase P1 and breast cancer risk
    Sook Un Kim
    Department of Preventive Medicine, Seoul National University College of Medicine, Cancer Research Institute, 28 Yongon Dong, Chongno Gu, Seoul, 110 799, Korea
    J Biochem Mol Biol 37:582-5. 2004
    ..5, 95 % CI = 0.27-0.93). Our findings suggest that the GSTP1 polymorphism influences individual susceptibility to breast cancer in the Korean women and this effect may be modified by alcohol consumption...
  36. ncbi request reprint Reproductive factors, glutathione S-transferase M1 and T1 genetic polymorphism and breast cancer risk
    Sue Kyung Park
    Department of Preventive Medicine, Konkuk University College of Medicine, Chungju, Korea
    Breast Cancer Res Treat 78:89-96. 2003
    ..01). Our findings suggest that genetic polymorphisms GSTM1/T1 could modify estrogen-related breast cancer risk...
  37. ncbi request reprint hOGG1 Ser326Cys polymorphism and breast cancer risk among Asian women
    Ji Yeob Choi
    Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea
    Breast Cancer Res Treat 79:59-62. 2003
    ..Our novel findings therefore suggest that hOGG1 Ser326Cys polymorphism is unlikely to play a modifying role in individual susceptibility to breast cancer among Asian women...
  38. ncbi request reprint Cytochrome P450 1A1 (CYP1A1) polymorphisms and breast cancer risk in Korean women
    Aesun Shin
    Department of Preventive Medicine, Seoul National University College of Medicine, Seoul 110 799, Korea
    Exp Mol Med 39:361-6. 2007
    ..18 (0.06-0.58)] or with a shorter lifetime exposure to estrogen [OR=0.23 (0.07-0.81)]. The results obtained suggest that the CYP1A1 MspI polymorphisms could affect susceptibility to breast cancer...
  39. pmc Genetic susceptibility factors on genes involved in the steroid hormone biosynthesis pathway and progesterone receptor for gastric cancer risk
    Lisa Y Cho
    Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea
    PLoS ONE 7:e47603. 2012
    ....
  40. pmc Intake of soy products and other foods and gastric cancer risk: a prospective study
    Kwang Pil Ko
    Department of Preventive Medicine, Gachon University, Incheon, Korea
    J Epidemiol 23:337-43. 2013
    ..Gastric cancer, the most common cancer in the world, is affected by some foods or food groups. We examined the relationship between dietary intake and stomach cancer risk in the Korean Multi-Center Cancer Cohort (KMCC)...
  41. ncbi request reprint Genetic polymorphisms of SULT1A1 and SULT1E1 and the risk and survival of breast cancer
    Ji Yeob Choi
    Department of Preventive Medicine, Cancer Research Institute, Seoul National University College of Medicine, 28 Yongon dong Chongno gu, Seoul 110 799, Korea
    Cancer Epidemiol Biomarkers Prev 14:1090-5. 2005
    ..2; 95% CI, 1.15-15.15). These findings suggest that genetic polymorphisms of SULT1E1 are associated with increased risk and a disease free survival of breast cancer in Korean women...
  42. ncbi request reprint Genetic polymorphisms of selected DNA repair genes, estrogen and progesterone receptor status, and breast cancer risk
    Kyoung Mu Lee
    Department of Preventive Medicine, Seoul National University College of Medicine, Chongno Gu, Seoul, Korea
    Clin Cancer Res 11:4620-6. 2005
    ..To evaluate the role of genetic polymorphisms of DNA repair genes in breast cancer, we conducted a hospital-based case-control study of Korean women...
  43. doi request reprint Common variation in genes related to immune response and risk of childhood leukemia
    Sohee Han
    Department of Preventive Medicine, Seoul National University College of Medicine, Seoul 110 799, Republic of Korea
    Hum Immunol 73:316-9. 2012
    ..30, 95% CI = 0.14-0.63, p(trend) = 0.002, min p = 0.004, FDR p = 0.17). Our findings suggest that genetic polymorphisms in immune response genes might play a role in childhood leukemia development with limited biologic evidence...
  44. pmc Polymorphisms in innate immunity genes and risk of childhood leukemia
    Sohee Han
    Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
    Hum Immunol 71:727-30. 2010
    ..Additional, larger studies are needed to identify the mechanism of these genes in childhood leukemia patients...
  45. ncbi request reprint Associations between breast cancer susceptibility gene polymorphisms and clinicopathological features
    Wonshik Han
    Departments of Surgery, Preventive Medicine, and Pathology, and Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Clin Cancer Res 10:124-30. 2004
    ..Experimental Design: We genotyped 664 Korean primary breast cancer patients for 17 single-nucleotide polymorphisms (SNPs) in nine genes, using a high-throughput SNP scoring method...
  46. pmc The association between the preoperative serum levels of lipocalin-2 and matrix metalloproteinase-9 (MMP-9) and prognosis of breast cancer
    Hyuna Sung
    Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea
    BMC Cancer 12:193. 2012
    ....
  47. pmc Common genetic polymorphisms of microRNA biogenesis pathway genes and breast cancer survival
    Hyuna Sung
    Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea
    BMC Cancer 12:195. 2012
    ..Although the role of microRNA's (miRNA's) biogenesis pathway genes in cancer development and progression has been well established, the association between genetic variants of this pathway genes and breast cancer survival is still unknown...
  48. ncbi request reprint N-acetyltransferase (NAT1, NAT2) and glutathione S-transferase (GSTM1, GSTT1) polymorphisms in breast cancer
    Kyoung Mu Lee
    Department of Preventive Medicine, Seoul National University College of Medicine, Cancer Research Institute, 28 Yongon Dong, Chongno Gu, Seoul 110 799, South Korea
    Cancer Lett 196:179-86. 2003
    ..1, 95% CI=1.0-9.1). These results suggest that genetic polymorphisms of NAT1 and NAT2 have no independent effect on breast cancer risk, but they modulate breast cancer risk in the presence of GSTM1 and GSTT1 null genotypes...
  49. doi request reprint Combined genetic effect of CDK7 and ESR1 polymorphisms on breast cancer
    Sujee Jeon
    Department of Cancer Biology, Seoul National University College of Medicine, 28 Yongon Dong, Jongno gu, Seoul 110 799, Korea
    Breast Cancer Res Treat 121:737-42. 2010
    ..7; 95% CI, 1.1-2.5; P for trend, <0.01). In conclusion, our findings suggest that the combined genotypes of CDK7 and ESR1 are associated with breast cancer risk among Korean women...
  50. ncbi request reprint GSTM1 and TNF-alpha gene polymorphisms and relations between blood lead and inflammatory markers in a non-occupational population
    Jin Hee Kim
    Department of Preventive Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 799, Republic of Korea
    Mutat Res 629:32-9. 2007
    ..1) genotype. These results suggest that blood lead affects the inflammatory response and that GSTM1 and TNF-alpha gene polymorphisms are genetic factors associated with lead-induced inflammatory response...
  51. ncbi request reprint [Cigarette smoking and gastric cancer risk in a community-based cohort study in Korea]
    Yeonju Kim
    Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea
    J Prev Med Public Health 40:467-74. 2007
    ..The objective of this study is to evaluate the relationship between cigarette smoking and gastric cancer risk in a Korean population...
  52. pmc Prognosis of breast cancer is associated with one-carbon metabolism related nutrients among Korean women
    Yunhee Lee
    Department of Biomedical Sciences, Seoul National University, Seoul, Republic of Korea
    Nutr J 11:59. 2012
    ..This aim of this study was to investigate the associations of dietary intake of vitamin B2, vitamin B6 and folate before diagnosis on the prognosis of breast cancer...
  53. ncbi request reprint Genetic polymorphisms of GSTM1, p21, p53 and HPV infection with cervical cancer in Korean women
    Sang Ah Lee
    Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea
    Gynecol Oncol 93:14-8. 2004
    ..The multiplicative interaction of GSTM1 and GSTT1 genotype with p21, p53 polymorphism, and HPV genotype was also investigated...
  54. doi request reprint Combined effects of antioxidant vitamin and NOS3 genetic polymorphisms on breast cancer risk in women
    Sang Ah Lee
    Department of Preventive Medicine, Kangwon National University, Kangwon Do, Republic of Korea
    Clin Nutr 31:93-8. 2012
    ..It is becoming increasingly clear that there is wide heterogeneity in genetic predisposition to breast cancer and that breast cancer risk is determined by interactive effect between genetic and environmental factors...
  55. doi request reprint Genome-wide association study of childhood acute lymphoblastic leukemia in Korea
    Sohee Han
    Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
    Leuk Res 34:1271-4. 2010
    ..2). Our genome-wide association study in Korea children identified a few genetic variations as potential susceptibility markers for ALL, warranting further replication studies among various ethnic groups...
  56. ncbi request reprint Interactive effect of genetic polymorphism of glutathione S-transferase M1 and smoking on squamous cell lung cancer risk in Korea
    Kyoung Mu Lee
    Department of Preventive Medicine and Institute of Environmental Medicine, Seoul National University College of Medicine, Cancer Research Institute, Seoul 110 799, Korea
    Oncol Rep 16:1035-9. 2006
    ..04). These results suggest that the GSTM1 null genotype is associated with squamous cell lung cancer and modifies the effect of smoking on squamous cell lung cancer development in Korean males...
  57. pmc A prospective cohort study on the relationship of sleep duration with all-cause and disease-specific mortality in the Korean Multi-center Cancer Cohort study
    Yohwan Yeo
    Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea
    J Prev Med Public Health 46:271-81. 2013
    ..This study was designed to determine the relationship of sleep duration with mortality as a parameter for long-term health in a large prospective cohort study in Korea...
  58. pmc Association of selected medical conditions with breast cancer risk in Korea
    Sun Jae Jung
    Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
    J Prev Med Public Health 46:346-52. 2013
    ..To estimate the effect of medical conditions in the population of Korea on breast cancer risk in a case-control study...
  59. doi request reprint Association between chronological change of reproductive factors and breast cancer risk defined by hormone receptor status: results from the Seoul Breast Cancer Study
    Seokang Chung
    Department of Biomedical Sciences, Seoul National University Graduate School, 103 Daehakro, Jongno gu, Seoul 110 799, Korea
    Breast Cancer Res Treat 140:557-65. 2013
    ..Our results suggest that the associations of age at menarche, parity, age at FFTP, and duration of EEBF with breast cancer risk were different based on the hormone receptor status and birth year groups in Korea. ..
  60. doi request reprint Preoperative serum levels of matrix metalloproteinase-2 (MMP-2) and survival of breast cancer among Korean women
    Nan Song
    Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Cancer Epidemiol Biomarkers Prev 21:1371-80. 2012
    ..We evaluated whether preoperative serum levels of MMP-2 work as a prognostic biomarker in breast cancer prognosis...
  61. doi request reprint Common genetic polymorphisms of microRNA biogenesis pathway genes and risk of breast cancer: a case-control study in Korea
    Hyuna Sung
    Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea
    Breast Cancer Res Treat 130:939-51. 2011
    ..04). Our results suggest that genetic variants in miRNA biogenesis pathway genes may be associated with breast cancer risk, and the modifiable effects might be different according to the menopausal status and hormone receptor status...
  62. pmc Association of paternal age at birth and the risk of breast cancer in offspring: a case control study
    Ji Yeob Choi
    Department of Preventive Medicine, Seoul National University College of Medicine, 28 Yongon dong Chongno gu, Seoul 110 799 Korea
    BMC Cancer 5:143. 2005
    ..To evaluate the association between paternal and maternal age at birth with the risk of breast cancer in female offspring, a case-control study was conducted in Korea...
  63. doi request reprint Polycyclic aromatic hydrocarbon (1-OHPG and 2-naphthol) and oxidative stress (malondialdehyde) biomarkers in urine among Korean adults and children
    Hyung Suk Yoon
    Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
    Int J Hyg Environ Health 215:458-64. 2012
    ..94 vs. 0.86 ng/mL; p=0.02). Our results indicate that both region and season can significantly influence the levels of PAH exposure and oxidative stress biomarkers...
  64. ncbi request reprint Role of alcohol and genetic polymorphisms of CYP2E1 and ALDH2 in breast cancer development
    Ji Yeob Choi
    Department of Preventive Medicine, General Surgery and Cancer Research Institute, Seoul National University College of Medicine, 27 Yongon Dong, Chongno Gu, Seoul 110 799, Korea
    Pharmacogenetics 13:67-72. 2003
    ..We examined the potential association between alcohol consumption and genetic polymorphisms in the alcohol metabolizing enzymes, CYP2E1 and ALDH2, in individual susceptibility to breast cancer in a Korean study population...
  65. ncbi request reprint Dose-dependent protective effect of breast-feeding against breast cancer among ever-lactated women in Korea
    Yeonju Kim
    Departments of Preventive Medicine, Seoul National University College of Medicine, Yongon dong Chongno gu, Seoul, Republic of Korea
    Eur J Cancer Prev 16:124-9. 2007
    ..006). This study confirms that lactation has an apparent dose-dependent protective effect against breast cancer in Korean women...
  66. doi request reprint Candidate gene approach evaluates association between innate immunity genes and breast cancer risk in Korean women
    Ji Young Lee
    Department of Preventive Medicine, Seoul National University College of Medicine, 103 Daehak Ro, Jongno gu, Seoul 110 799, Korea
    Carcinogenesis 30:1528-31. 2009
    ..This study was conducted to investigate the role of common variation in innate immunity-related genes as susceptibility factors to breast cancer risk in Korean women...
  67. pmc Paternal smoking, genetic polymorphisms in CYP1A1 and childhood leukemia risk
    Kyoung Mu Lee
    Department of Preventive Medicine, Cancer Research Institute, Seoul National University College of Medicine, 28 Yongon dong Chongno gu, Seoul, Republic of Korea
    Leuk Res 33:250-8. 2009
    ..12, 1.04-1.21) were significantly associated with childhood leukemia risk. Our results suggest that paternal smoking is a risk factor for childhood leukemia and the effect may be modified by CYP1A1 genotype...
  68. ncbi request reprint CYP2E1 and NQO1 genotypes, smoking and bladder cancer
    Ji Yeob Choi
    Department of Preventive Medicine, Seoul National University College of Medicine, Korea
    Pharmacogenetics 13:349-55. 2003
    ..We conducted a hospital based case-control study to evaluate the potential association between genetic polymorphisms of CYP2E1 (C1019T in the 5' flanking region) and NQO1 (C609T in exon 6) and bladder cancer risk in Asian population...
  69. doi request reprint Expression of vascular endothelial growth factor and hypoxia inducible factor-1alpha in cervical neoplasia
    Jae Hong No
    Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea
    Ann N Y Acad Sci 1171:105-10. 2009
    ..In addition, the weak correlation between VEGF and HIF-1alpha expressions suggests that regulatory mechanisms other than HIF-1alpha may be involved in the expression of VEGF during cervical carcinogenesis...
  70. ncbi request reprint Multiplex genotyping of 1107 SNPs from 232 candidate genes identified an association between IL1A polymorphism and breast cancer risk
    Wonshik Han
    Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Oncol Rep 23:763-9. 2010
    ..88, 95% confidence interval (CI)=1.58-5.27 for heterozygote and OR=8.17, 95% CI=2.23-29.99 for rare homozygote]. In summary, we identified a common genetic variant in IL1A strongly associated with breast cancer risk...
  71. ncbi request reprint Obesity and genetic polymorphism of ERCC2 and ERCC4 as modifiers of risk of breast cancer
    Sang Ah Lee
    Department of Preventive Medicine, Seoul National University College of Medicine, Seoul 110 749, Korea
    Exp Mol Med 37:86-90. 2005
    ..Our finding suggests that the combined effect of ERCC2 Asp(312)Asn and ERCC4 Ser(835)Ser genotypes might be associated with breast cancer risk in Korean women...
  72. ncbi request reprint Effect of genetic polymorphisms of MnSOD and MPO on the relationship between PAH exposure and oxidative DNA damage
    So Yeon Park
    Department of Preventive Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 799, South Korea
    Mutat Res 593:108-15. 2006
    ..012). We suggest that the oxidative injury caused by PAH exposure is modulated by genetic polymorphisms such as MnSOD and MPO...
  73. doi request reprint Isoflavones from phytoestrogens and gastric cancer risk: a nested case-control study within the Korean Multicenter Cancer Cohort
    Kwang Pil Ko
    Department of Preventive Medicine, Seoul National University College of Medicine, 103 Daehangno, Chongno Gu, Seoul 110 799, Korea
    Cancer Epidemiol Biomarkers Prev 19:1292-300. 2010
    ..To examine the association between soybean products and gastric cancer risk, we measured phytoestrogen biological markers in a nested case-control study...
  74. ncbi request reprint XRCC1 genetic polymorphism and breast cancer risk
    Sook Un Kim
    Department of Preventive Medicine, Konkuk University College of Medicine, Chungju, Korea
    Pharmacogenetics 12:335-8. 2002
  75. ncbi request reprint Polymorphism in the nuclear factor kappa-B binding promoter region of cyclooxygenase-2 is associated with an increased risk of bladder cancer
    Sokbom Kang
    Department of Obstetrics and Gynecology, Seoul National University Hospital, Seoul, 110 744, South Korea
    Cancer Lett 217:11-6. 2005
    ..Further research is needed to investigate the functional implications of the polymorphisms of the COX-2 promoter gene in human cancer...
  76. pmc Common genetic variants in the microRNA biogenesis pathway are not associated with breast cancer risk in Asian women
    Hyuna Sung
    Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea
    Cancer Epidemiol Biomarkers Prev 21:1385-7. 2012
    ..Although the role of miRNA in cancer development and progression has been well established, the association between genetic variants in miRNA biogenesis pathway genes and breast cancer risk has been yet unclear...
  77. doi request reprint Association between CASP7 and CASP14 genetic polymorphisms and the risk of childhood leukemia
    Chulbum Park
    Department of Biomedical Sciences, Graduate School of Seoul National University, Seoul, Republic of Korea
    Hum Immunol 73:736-9. 2012
    ..013, FDR = 0.042) and CASP14 (rs8110862, P(trend)<0.001, minP = 0.002, FDR = 0.027). This study suggests that genetic polymorphisms in apoptosis and cell cycle related genes might play a role in childhood leukemia development...
  78. ncbi request reprint Determinants of urinary 1-hydroxypyrene glucuronide in South Korean children
    Kyoung Ho Lee
    Biomedical Research Group, Hanyang Brain Korea 21, Hanyang University, Seoul, Republic of Korea
    Int Arch Occup Environ Health 82:961-8. 2009
    ..This study was conducted to investigate the dominant sources of the urinary pyrene metabolite, 1-hydroxypyrene glucuronide (1-OHPG), in South Korean children...
  79. doi request reprint SNP-SNP interactions between DNA repair genes were associated with breast cancer risk in a Korean population
    Wonshik Han
    Department of Surgery and Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea
    Cancer 118:594-602. 2012
    ..A case-control study was conducted by evaluating genes involved in DNA repair to identify polymorphisms associated with BC...
  80. doi request reprint [Cigarette smoking and mortality in the Korean Multi-center Cancer Cohort (KMCC) study]
    Eun Ha Lee
    Department of Preventive Medicine, Seoul National University College of Medicine, Korea
    J Prev Med Public Health 43:151-8. 2010
    ..The aim of this study was to evaluate the association between cigarette smoking and total mortality, cancer mortality and other disease mortalities in Korean adults...
  81. pmc Interaction of body mass index and diabetes as modifiers of cardiovascular mortality in a cohort study
    Seung Hyun Ma
    Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea
    J Prev Med Public Health 45:394-401. 2012
    ..The objective of this study is to determine whether an interaction exists between body mass index (BMI) and diabetes, which can modify the risk of death by cardiovascular disease (CVD)...
  82. doi request reprint Estrogen and progesterone receptor status affect genome-wide DNA methylation profile in breast cancer
    Lian Li
    Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea
    Hum Mol Genet 19:4273-7. 2010
    ..05). In the first genome-wide DNA methylation profiling according to the receptor status of breast cancer, we found that ER/PR status affects the DNA methylation state of FAM124B, ST6GALNAC1, NAV1 and PER1 in breast cancer...
  83. ncbi request reprint Rare variant of hypoxia-inducible factor-1alpha (HIF-1A) and breast cancer risk in Korean women
    Ji Young Lee
    Department of Preventive Medicine, Seoul National University College of Medicine, Jongnoo Gu, Seoul, South Korea
    Clin Chim Acta 389:167-70. 2008
    ..Tumors exhibiting extensive hypoxia are more aggressive than tumors oxygenized better...
  84. ncbi request reprint Prevalence and risk factors of distal radius and calcaneus bone mineral density in Korean population
    Aesun Shin
    Department of Preventive Medicine, Seoul National University College of Medicine, 28 Yongon dong Chongno gu, 110 799, Korea
    Osteoporos Int 15:639-44. 2004
    ..9, 95% ci = 1.36-6.31)...
  85. ncbi request reprint Lifestyle, genetic susceptibility and future trends of breast cancer in Korea
    Keun Young Yoo
    Department of Preventive Medicine, Seoul National University College of Medicine, 410 769, Korea
    Asian Pac J Cancer Prev 7:679-82. 2006
    ..Future predictions point to a 2- to 3-fold increase in incidence by 2020. Here, we briefly introduce health education programs and breast cancer campaigns, in the broad context of the Korean National Cancer Control Program...
  86. ncbi request reprint Genomic epidemiology cohorts in Korea: present and the future
    Keun Young Yoo
    Department of Preventive Medicine, Seoul National University College of Medicine, Seoul 110 799, Korea
    Asian Pac J Cancer Prev 6:238-43. 2005
    ..A new genomic cohort has been launched since 2001 in Korea, for which the target number of subjects is 250,000 men and women over the next 5 years. This article describes the goals and the designs of each of the above-mentioned cohorts...
  87. ncbi request reprint Polymorphisms in the estrogen receptor-alpha gene and breast cancer risk
    Hee Joon Kang
    Department of Surgery, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 744, South Korea
    Cancer Lett 178:175-80. 2002
    ..04) and ER expression (P for trend=0.06) and negatively associated with p53 expression (P for trend=0.02)...
  88. doi request reprint Identification and application of biomarkers in molecular and genomic epidemiologic research
    Kyoung Mu Lee
    Clinical Research Institute, Seoul National University Hospital, Seoul, Korea
    J Prev Med Public Health 42:349-55. 2009
    ..The spectrum of genomic approaches currently used to identify and apply biomarkers and strategies to validate genomic biomarkers will also be discussed...
  89. doi request reprint Age curves of bone mineral density at the distal radius and calcaneus in Koreans
    Jin Young Min
    Department of Epidemiology, School of Public Health, Institute of Health and Environment, Seoul National University, Seoul, Republic of Korea
    J Bone Miner Metab 28:94-100. 2010
    ..09 g/cm(2) in males. Peak ages were the thirties for females and the twenties for males. These results could facilitate international or interracial comparisons and be used as reference data to screen for osteoporosis in Koreans...
  90. doi request reprint Breast cancer prevention based on gene-environment interaction
    Minkyo Song
    Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea
    Mol Carcinog 50:280-90. 2011
    ..The accumulating evidences of the gene-environment interactions provide a better understanding of the breast cancer development and enable us to adopt individualized preventive strategies for personalized health care...
  91. pmc Oncogenic CagA promotes gastric cancer risk via activating ERK signaling pathways: a nested case-control study
    Jae Jeong Yang
    Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea
    PLoS ONE 6:e21155. 2011
    ..This study aimed to evaluate whether genes involved in ERK downstream signaling pathways activated by CagA are susceptible genetic markers for gastric cancer...
  92. doi request reprint Common genetic variants associated with breast cancer in Korean women and differential susceptibility according to intrinsic subtype
    Wonshik Han
    Cancer Research Institute, Department of Surgery, Seoul National University College of Medicine, Seoul, Korea
    Cancer Epidemiol Biomarkers Prev 20:793-8. 2011
    ....
  93. ncbi request reprint Influence of GSTM1 genotype on association between aromatic DNA adducts and urinary PAH metabolites in incineration workers
    Jeongmi Lee
    Department of Preventive Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, 110 799, Seoul, South Korea
    Mutat Res 514:213-21. 2002
    ..These results remain to be confirmed in future larger studies...
  94. ncbi request reprint Effect of diet and Helicobacter pylori infection to the risk of early gastric cancer
    Sang Ah Lee
    Department of Food and Nutrition, Seoul National University, Shillim Dong, Kwanak gu, Korea
    J Epidemiol 13:162-8. 2003
    ..The association of dietary habits and Helicobacter pylori infection with early gastric cancer is still unclear...
  95. pmc Epidemiology of breast cancer in Korea: occurrence, high-risk groups, and prevention
    Keun Young Yoo
    Department of Preventive Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 799, Korea
    J Korean Med Sci 17:1-6. 2002
    ..Strategies aimed at controlling breast cancer that include the screening guidelines and the identification of individual predispositions may give us further insights into both the etiology and the prevention of breast cancer...
  96. ncbi request reprint Current researches on breast cancer epidemiology in Korea
    Keun Young Yoo
    Department of Preventive Medicine, Seoul National University College of Medicine, 28 Yongon dong Chongno gu, Seoul 110 799, Korea
    Breast Cancer 10:289-93. 2003
    ..that predispose individuals to breast cancer by gene-environment or gene-gene interactions may possibly give further insight into both the etiology and the prevention of this malignancy...
  97. pmc Cancer incidence among paraquat exposed applicators in the agricultural health study: prospective cohort study
    Sue K Park
    Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
    Int J Occup Environ Health 15:274-81. 2009
    ..1). There was some suggestion of a possible link between paraquat exposure and NHL risk in humans, but the inconsistency in exposure level trend suggests that this could be a chance finding...
  98. ncbi request reprint Rising prostate cancer rates in South Korea
    Sue Kyung Park
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland, USA
    Prostate 66:1285-91. 2006
    ..Prostate cancer incidence and mortality rates in South Korea are relatively low, but rising steadily...
  99. pmc Breast cancer and urinary biomarkers of polycyclic aromatic hydrocarbon and oxidative stress in the Shanghai Women's Health Study
    Kyoung Ho Lee
    Department of Preventive Medicine, Seoul National University College of Medicine, Institute of Environmental Medicine, SNUMRC, Seoul, Korea
    Cancer Epidemiol Biomarkers Prev 19:877-83. 2010
    ..This nested case-control study provides no evidence of association between PAH exposure and oxidative stress and risk of breast cancer in Shanghai women...
  100. ncbi request reprint Effect of short-term fasting on urinary excretion of primary lipid peroxidation products and on markers of oxidative DNA damage in healthy women
    Kyoung Ho Lee
    Department of Preventive Medicine, Seoul National University College of Medicine, Institute for Environmental Medicine, SNUMRC, Seoul 110 799, Korea
    Carcinogenesis 27:1398-403. 2006
    ..51, n = 27, P = 0.02). Our results demonstrate that the short-term fasting reduces lipid peroxidation products but does not affect oxidative stress-induced DNA damage...
  101. doi request reprint A pilot study on the association between job stress and repeated measures of immunological biomarkers in female nurses
    Kyoung Mu Lee
    Department of Preventive Medicine, Seoul National University College of Medicine, 28 Yongon dong Chongno gu, Seoul 110 799, Korea
    Int Arch Occup Environ Health 83:779-89. 2010
    ..To evaluate the immunosuppressive effects of job stress in female nurses, an 8-month longitudinal study was conducted at a major university hospital...