Bong Kiun Kaang

Summary

Affiliation: Seoul National University
Country: Korea

Publications

  1. doi request reprint Optimization of AAV expression cassettes to improve packaging capacity and transgene expression in neurons
    Jun Hyeok Choi
    Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 151 747, Korea
    Mol Brain 7:17. 2014
  2. doi request reprint Synaptic protein degradation in memory reorganization
    Bong Kiun Kaang
    National Creative Research Initiative Center for Memory, Department of Biological Sciences, College of Natural Sciences, Seoul National University, 151 742 Seoul, South Korea
    Adv Exp Med Biol 970:221-40. 2012
  3. pmc Recent advances in basic neurosciences and brain disease: from synapses to behavior
    Guo Qiang Bi
    Department of Neurobiology, University of Pittsburgh, Pittsburgh, USA
    Mol Pain 2:38. 2006
  4. pmc Genetic alteration of anxiety and stress-like behavior in mice lacking CaMKIV
    Fanny W F Shum
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
    Mol Pain 1:22. 2005
  5. pmc Enhancement of presynaptic glutamate release and persistent inflammatory pain by increasing neuronal cAMP in the anterior cingulate cortex
    Long Jun Wu
    Department of Physiology, Faculty of Medicine, University of Toronto Centre for Study of Pain, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Mol Pain 4:40. 2008
  6. pmc Welcome to molecular brain
    Lin Mei
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Mol Brain 1:1. 2008
  7. pmc Two major gate-keepers in the self-renewal of neural stem cells: Erk1/2 and PLCgamma1 in FGFR signaling
    Jin A Lee
    Department of Biological Sciences, National Creative Research Initiative Center for Memory, College of Natural Sciences, Seoul National University, 599 Gwanak Ro, Gwanak Gu, Seoul 151 747, Korea
    Mol Brain 2:15. 2009
  8. pmc PKA-activated ApAF-ApC/EBP heterodimer is a key downstream effector of ApCREB and is necessary and sufficient for the consolidation of long-term facilitation
    Jin A Lee
    Institute of Molecular Biology and Genetics, Rio, Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 151 747, Korea
    J Cell Biol 174:827-38. 2006
  9. ncbi request reprint An Aplysia type 4 phosphodiesterase homolog localizes at the presynaptic terminals of Aplysia neuron and regulates synaptic facilitation
    Hyungju Park
    National Research Laboratory of Neurobiology, Institute of Molecular Biology and Genetics, School of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 151 742, Korea
    J Neurosci 25:9037-45. 2005
  10. ncbi request reprint Identification of nuclear/nucleolar localization signal in Aplysia learning associated protein of slug with a molecular mass of 18 kDa homologous protein
    Hyoung Kim
    National Research Laboratory, Institute of Molecular Biology and Genetics, School of Biological Sciences, College of Natural Sciences, Seoul National University, San 56 1 Silim dong Kwanak gu, Seoul 151 742, South Korea
    Neurosci Lett 343:134-8. 2003

Collaborators

Detail Information

Publications67

  1. doi request reprint Optimization of AAV expression cassettes to improve packaging capacity and transgene expression in neurons
    Jun Hyeok Choi
    Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 151 747, Korea
    Mol Brain 7:17. 2014
    ..This new expression cassette will allow us to package larger transgenes without compromising expression efficiency. ..
  2. doi request reprint Synaptic protein degradation in memory reorganization
    Bong Kiun Kaang
    National Creative Research Initiative Center for Memory, Department of Biological Sciences, College of Natural Sciences, Seoul National University, 151 742 Seoul, South Korea
    Adv Exp Med Biol 970:221-40. 2012
    ..We will introduce the role of the protein degradation-dependent destabilization process for memory reorganization and suggest a hypothetical model combining the recent findings...
  3. pmc Recent advances in basic neurosciences and brain disease: from synapses to behavior
    Guo Qiang Bi
    Department of Neurobiology, University of Pittsburgh, Pittsburgh, USA
    Mol Pain 2:38. 2006
    ..The second international meeting on Neurons and Brain Disease will be held in Toronto (August 29-31, 2007)...
  4. pmc Genetic alteration of anxiety and stress-like behavior in mice lacking CaMKIV
    Fanny W F Shum
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
    Mol Pain 1:22. 2005
    ..In addition, CaMKIV(-/-) mice displayed a lack of stress-induced analgesia following restraint or cold swim stress. Our results demonstrate a key role for CaMKIV in anxiety and stress-related behavior...
  5. pmc Enhancement of presynaptic glutamate release and persistent inflammatory pain by increasing neuronal cAMP in the anterior cingulate cortex
    Long Jun Wu
    Department of Physiology, Faculty of Medicine, University of Toronto Centre for Study of Pain, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Mol Pain 4:40. 2008
    ..The present study provides the first evidence linking enhanced presynaptic glutamate release in the ACC to behavioral sensitization caused by peripheral inflammation...
  6. pmc Welcome to molecular brain
    Lin Mei
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Mol Brain 1:1. 2008
    ..It will be a premier platform for neuroscientists to exchange their ideas with researchers from around the world to help improve our understanding of the molecular mechanisms of the brain and mind...
  7. pmc Two major gate-keepers in the self-renewal of neural stem cells: Erk1/2 and PLCgamma1 in FGFR signaling
    Jin A Lee
    Department of Biological Sciences, National Creative Research Initiative Center for Memory, College of Natural Sciences, Seoul National University, 599 Gwanak Ro, Gwanak Gu, Seoul 151 747, Korea
    Mol Brain 2:15. 2009
    ..These novel findings provide insights into basic neural stem cell biology and clinical applications of potential stem-cell-based therapy...
  8. pmc PKA-activated ApAF-ApC/EBP heterodimer is a key downstream effector of ApCREB and is necessary and sufficient for the consolidation of long-term facilitation
    Jin A Lee
    Institute of Molecular Biology and Genetics, Rio, Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 151 747, Korea
    J Cell Biol 174:827-38. 2006
    ..Collectively, these results suggest that PKA-activated ApAF-ApC/EBP heterodimer is a core downstream effector of ApCREB in the consolidation of LTF...
  9. ncbi request reprint An Aplysia type 4 phosphodiesterase homolog localizes at the presynaptic terminals of Aplysia neuron and regulates synaptic facilitation
    Hyungju Park
    National Research Laboratory of Neurobiology, Institute of Molecular Biology and Genetics, School of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 151 742, Korea
    J Neurosci 25:9037-45. 2005
    ..Together, we suggest that PDE4s localized in the synapses play a critical role in regulating the optimum cAMP level required for normal synaptic plasticity...
  10. ncbi request reprint Identification of nuclear/nucleolar localization signal in Aplysia learning associated protein of slug with a molecular mass of 18 kDa homologous protein
    Hyoung Kim
    National Research Laboratory, Institute of Molecular Biology and Genetics, School of Biological Sciences, College of Natural Sciences, Seoul National University, San 56 1 Silim dong Kwanak gu, Seoul 151 742, South Korea
    Neurosci Lett 343:134-8. 2003
    ..Analysis of deletion mutants of ApLLP-EGFP showed that the N-terminal and the C-terminal nucleolar and nucleus localization signal sequences are important for localization to the nucleus and the nucleoli...
  11. ncbi request reprint Regulation of ApC/EBP mRNA by the Aplysia AU-rich element-binding protein, ApELAV, and its effects on 5-hydroxytryptamine-induced long-term facilitation
    Se Jeong Yim
    National Research Laboratory, Institute of Molecular Biology and Genetics, School of Biological Sciences, College of Natural Sciences, Seoul National University, San 56 1 Silim dong, Gwanak Gu, Seoul 151 747, Korea
    J Neurochem 98:420-9. 2006
    ....
  12. ncbi request reprint A nucleolar protein ApLLP induces ApC/EBP expression required for long-term synaptic facilitation in aplysia neurons
    Hyoung Kim
    National Research Laboratory, Institute of Molecular Biology and Genetics, School of Biological Sciences, College of Natural Sciences, Seoul National University, San 56 1 Silim dong Kwanak gu, Seoul 151 742, Korea
    Neuron 49:707-18. 2006
    ..These results suggest that ApLLP is an activity-dependent transcriptional activator that switches short-term facilitation to long-term facilitation...
  13. pmc Role of Aplysia cell adhesion molecules during 5-HT-induced long-term functional and structural changes
    Jin Hee Han
    National Research Laboratory of Neurobiology, Institute of Molecular Biology and Genetics, School of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 151 742, Korea
    Learn Mem 11:421-35. 2004
    ..Thus, our data suggest that TM-apCAM may act as a suppressor of both synaptic-strength enhancement in pre-existing synapses and of new synaptic varicosity formation in the nonsynaptic region, via different mechanisms...
  14. ncbi request reprint Synaptic facilitation by ectopic octopamine and 5-HT receptors in Aplysia
    Deok Jin Chang
    National Research Laboratory of Neurobiology, Institute of Molecular Biology and Genetics, School of Biological Sciences, College of Natural Sciences, Seoul National University, San 56 1 Silim dong Kwanak gu, Seoul 151 742, South Korea
    Brain Res Bull 60:73-9. 2003
    ..These results imply that the role of cAMP in synaptic facilitation is reduced as the synapse becomes depressed due to repeated activity...
  15. ncbi request reprint Aggregate formation and the impairment of long-term synaptic facilitation by ectopic expression of mutant huntingtin in Aplysia neurons
    Jin A Lee
    National Research Laboratory, Institute of Molecular Biology and Genetics, School of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, Korea
    J Neurochem 85:160-9. 2003
    ..This study demonstrates the stability of polyQ-based aggregates and their specific effects on long-term synaptic plasticity...
  16. pmc A cellular model of memory reconsolidation involves reactivation-induced destabilization and restabilization at the sensorimotor synapse in Aplysia
    Sue Hyun Lee
    Department of Biological Sciences, National Creative Research Initiative Center for Memory, College of Natural Sciences, Seoul National University, Seoul 151 747, Korea
    Proc Natl Acad Sci U S A 109:14200-5. 2012
    ....
  17. doi request reprint Learning-related synaptic growth mediated by internalization of Aplysia cell adhesion molecule is controlled by membrane phosphatidylinositol 4,5-bisphosphate synthetic pathway
    Seung Hee Lee
    National Creative Research Initiative Center for Memory, Department of Biological Sciences, College of Natural Sciences, Seoul National University, Gwanak Gu, Seoul 151 747, Korea
    J Neurosci 32:16296-305. 2012
    ....
  18. pmc Cofilin expression induces cofilin-actin rod formation and disrupts synaptic structure and function in Aplysia synapses
    Dong Hyuk Jang
    National Research Laboratory of Neurobiology, Institute of Molecular Biology and Genetics, School of Biological Sciences, College of Natural Sciences, Seoul National University, San 56 1 Silim dong Kwanak gu, Seoul 151 742, Korea
    Proc Natl Acad Sci U S A 102:16072-7. 2005
    ..These findings suggest that the formation of cofilin-actin rod-like structures can lead to neurodegeneration, and this might be a mechanism of rundown of neuronal and synaptic function without cell death in neurodegenerative diseases...
  19. doi request reprint Synaptic protein degradation underlies destabilization of retrieved fear memory
    Sue Hyun Lee
    National Creative Research Initiative Center for Memory, Department of Biological Sciences, College of Natural Sciences, Seoul National University, San 56 1 Silim dong, Gwanak Gu, Seoul 151 747, Korea
    Science 319:1253-6. 2008
    ..It also provides strong evidence for the existence of reorganization processes whereby preexisting memory is disrupted by protein degradation, and updated memory is reconsolidated by protein synthesis...
  20. ncbi request reprint Plasticity of metabotropic glutamate receptor-dependent long-term depression in the anterior cingulate cortex after amputation
    SukJae Joshua Kang
    Department of Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul 151 746, Korea
    J Neurosci 32:11318-29. 2012
    ..Our results provide in vitro evidence of the spatiotemporal properties of ACC LTD in adult mice. We demonstrate that tail amputation causes LTD impairment within the ACC circuit and that this can be rescued by activation of mGluR1...
  21. ncbi request reprint Overexpression and RNA interference of Ap-cyclic AMP-response element binding protein-2, a repressor of long-term facilitation, in Aplysia kurodai sensory-to-motor synapses
    Jin A Lee
    National Research Laboratory, Institute of Molecular Biology and Genetics, School of Biological Sciences, College of Natural Sciences, Seoul National University, South Korea
    Neurosci Lett 337:9-12. 2003
    ..These results suggest that ApCREB2 is a functional repressor of long-term facilitation in Aplysia sensory-to-motor synapses...
  22. pmc Using an aplysia two-hybrid system to examine the interactions between transcription factors involved in long-term facilitation in the nervous system of aplysia
    Jung Hwan Choi
    National Research Laboratory, Institute of Molecular Biology and Genetics, School of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 151 742, Korea
    Learn Mem 10:40-3. 2003
    ..Therefore, our study shows that formerly described interactions between the proteins actually occur in the Aplysia neurons and that interactions between these transcription factors are specific...
  23. ncbi request reprint Impairment of a parabolic bursting rhythm by the ectopic expression of a small conductance Ca2+-activated K+ channel in Aplysia neuron R15
    Yong Lee
    National Research Laboratory of Neurobiology, Institute of Molecular Biology and Genetics, School of Biological Sciences, College of Natural Sciences, Seoul National University, San 56 1 Silim dong Kwanak gu, Seoul 151 742, South Korea
    Neurosci Lett 349:53-7. 2003
    ..Thus, our results suggest that ectopic SK(Ca) channels play an important role in regulating the firing pattern and the shape of the action potential...
  24. doi request reprint N termini of apPDE4 isoforms are responsible for targeting the isoforms to different cellular membranes
    Deok Jin Jang
    National Creative Research Initiative Center for Memory, Department of Biological Sciences, College of Natural Sciences, Seoul National University, Gwanak Gu, Seoul, Korea
    Learn Mem 17:469-79. 2010
    ..Thus, these results suggest that apPDE4s can participate in the regulation of cAMP signaling through specific subcellular localization by means of lipid binding activities...
  25. pmc AU-rich element-binding protein negatively regulates CCAAT enhancer-binding protein mRNA stability during long-term synaptic plasticity in Aplysia
    Yong Seok Lee
    National Creative Research Initiative Center for Memory, Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, Korea
    Proc Natl Acad Sci U S A 109:15520-5. 2012
    ..These results provide evidence for a critical role of the posttranscriptional modification of ApC/EBP mRNA during the consolidation of synaptic plasticity...
  26. ncbi request reprint Nuclear translocation of CAM-associated protein activates transcription for long-term facilitation in Aplysia
    Seung Hee Lee
    Department of Biological Sciences, Institute of Molecular Biology and Genetics, Rio, College of Natural Sciences, Seoul National University, San 56 1 Silim dong Gwanak gu, Seoul 151 747, Korea
    Cell 129:801-12. 2007
    ..Combined, our data suggest that CAMAP is a retrograde signaling component that translocates from activated synapses to the nucleus during synapse-specific LTF...
  27. ncbi request reprint Suppression of long-term facilitation by Rab3-effector protein interaction
    Jin Hee Han
    National Research Laboratory of Neurobiology, Institute of Molecular Biology and Genetics, School of Biological Sciences, College of Natural Sciences, Seoul National University, San 56 1 Silim dong Kwanak gu, Seoul 151 742, South Korea
    Brain Res Mol Brain Res 139:13-22. 2005
    ..In conclusion, our data suggest that apRab3 may act as a negative clamp of LTF through the interaction with effector protein(s), possibly Rim...
  28. doi request reprint PI3Kγ is required for NMDA receptor-dependent long-term depression and behavioral flexibility
    Jae Ick Kim
    National Creative Research Initiative Center for Memory, Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, Korea
    Nat Neurosci 14:1447-54. 2011
    ..Thus, individual isoforms of PI3Ks may have distinct roles in different types of synaptic plasticity and may therefore influence various kinds of behavior...
  29. ncbi request reprint Thiol oxidation-mediated cell death in Aplysia cultured sensory neurons
    Deok Jin Chang
    National Research Laboratory, Institute of Molecular Biology and Genetics, School of Biological Sciences, College of Natural Sciences, Seoul National University, San 56 1 Silim dong Kwanak gu, Seoul 151 742, South Korea
    Brain Res 1007:71-7. 2004
    ....
  30. ncbi request reprint Elevated RalA activity in the hippocampus of PI3Kγ knock-out mice lacking NMDAR-dependent long-term depression
    Su Eon Sim
    Department of Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul 151 747, Korea
    BMB Rep 46:103-6. 2013
    ..We propose that PI3Kγ regulates the activity of RalA, which is one of the molecular mechanisms inducing NMDAR dependent LTD...
  31. doi request reprint State-dependent disruption of short-term facilitation due to overexpression of the apPDE4 supershort form in Aplysia
    Deok Jin Jang
    National Creative Research Initiative Center for Memory, College of Natural Sciences, Seoul National University, Seoul, Korea
    Mol Cells 31:175-80. 2011
    ..These results show that the supershort form plays an important role in 5-HT-induced synaptic plasticity and disrupts it mainly by impairing cAMP signaling in Aplysia...
  32. ncbi request reprint The GIT family of proteins forms multimers and associates with the presynaptic cytomatrix protein Piccolo
    Seho Kim
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
    J Biol Chem 278:6291-300. 2003
    ..These results suggest that, through their multimerization and interaction with Piccolo, the GIT family proteins are involved in the organization of the CAZ...
  33. doi request reprint Differential evolutionary rates of neuronal transcriptome in Aplysia kurodai and Aplysia californica as a tool for gene mining
    Sun Lim Choi
    National Creative Research Initiative Center for Memory and Institute of Molecular Biology and Genetics, Department of Biological Sciences, College of Natural Sciences, Seoul National University, Bldg 504, Rm 202, 599 Gwanangno, Gwanak Gu, Seoul 151 747, Korea
    J Neurogenet 24:75-82. 2010
    ....
  34. doi request reprint Synaptic protein degradation as a mechanism in memory reorganization
    Bong Kiun Kaang
    From the National Creative Research Initiative Center for Memory, Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, Korea kaang snu ac kr
    Neuroscientist 15:430-5. 2009
    ..Here, the authors review this finding and focus on the labile state that is critical for the reorganization of memory triggered after memory retrieval...
  35. doi request reprint Presynaptic structure of Aplysia single live neuron by atomic force and confocal laser scanning microscope
    Aee Young Park
    Molecular Electronics and NanoStructures Laboratory, School of Chemistry, NS60, Seoul National University, Seoul 151 747, Republic of Korea
    J Phys Chem B 117:4779-88. 2013
    ..Our combined AFM-CLSM system is successfully adapted for measuring learning-related structural changes and the movement of synaptic molecules in the single live neuron through interaction force and fluorescence imaging...
  36. pmc Transcriptome analysis and identification of regulators for long-term plasticity in Aplysia kurodai
    Yong Seok Lee
    National Creative Research Initiative, Center for Memory and Institute of Molecular Biology and Genetics, Department of Biological Sciences, College of Natural Sciences, Seoul National University, San 56 1 Silim dong, Gwanak Gu, Seoul 151 747, Korea
    Proc Natl Acad Sci U S A 105:18602-7. 2008
    ..Among these, we further demonstrated that the Ap-eIF3e plays a key role in 5-HT-induced long-term facilitation (LTF) as a positive regulator...
  37. ncbi request reprint Assessment of the effects of virus-mediated limited Oct4 overexpression on the structure of the hippocampus and behavior in mice
    Su Eon Sim
    Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul 151 747, Korea
    BMB Rep 44:793-8. 2011
    ..This first trial for pluripotency induction in vivo, despite negative results, provides implications and information for future studies on in vivo cellular reprogramming...
  38. ncbi request reprint Beta-amyloid peptide binding protein does not couple to G protein in a heterologous Xenopus expression system
    Yong Lee
    National Research Laboratory of Neurobiology, School of Biological Sciences, Seoul National University, Seoul, Korea
    J Neurosci Res 73:255-9. 2003
    ..Our results suggest that BBP is not directly coupled to G alpha(i/o), G alpha(s), or G alpha(q) proteins and that BBP may need a component other than APP to exert its toxic effect in concert with A beta...
  39. pmc Long-term potentiation of synaptic transmission in the adult mouse insular cortex: multielectrode array recordings
    Ming Gang Liu
    Department of Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul, Korea
    J Neurophysiol 110:505-21. 2013
    ..Our results provide the first in vitro report of long-term multichannel recordings of L-LTP in the IC in adult mice and suggest its potential important roles in insula-related memory and chronic pain. ..
  40. pmc Neuronal RNA granule contains ApCPEB1, a novel cytoplasmic polyadenylation element binding protein, in Aplysia sensory neuron
    Yeon Su Chae
    National Creative Research Initiative Center for Memory and Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, Korea
    Exp Mol Med 42:30-7. 2010
    ..We propose that ApCPEB1 granule might modulate translation, as other RNA granules do, and furthermore, influence memory...
  41. ncbi request reprint The effect of brain-derived neurotrophic factor on neuritogenesis and synaptic plasticity in Aplysia neurons and the hippocampal cell line HiB5
    Seung Hee Lee
    National Research Laboratory of Neurobiology, Institute of Molecular Biology and Genetics, School of Biological Sciences, Seoul National University, Seoul 151 742, Korea
    Mol Cells 15:233-9. 2003
    ..In contrast, BDNF in combination with platelet-derived growth factor (PDGF) increases the length of the neurites and the number of spine-like structures in cells of HiB5...
  42. ncbi request reprint Hydrogen peroxide modulates K+ ion currents in cultured Aplysia sensory neurons
    Deok Jin Chang
    National Research Laboratory of Neurobiology, Institute of Molecular Biology and Genetics, School of Biological Sciences, College of Natural Sciences, Seoul National University, San 56 1 Silim dong Kwanak gu, South Korea
    Brain Res 970:159-68. 2003
    ....
  43. ncbi request reprint Regulation of neuritogenesis and synaptic transmission by msec7-1, a guanine nucleotide exchange factor, in cultured Aplysia neurons
    Minjung Huh
    National Research Laboratory of Neurobiology, Institute of Molecular Biology and Genetics, School of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, Korea
    J Neurochem 85:282-5. 2003
    ..Our results demonstrate that msec7-1 regulates neuritogenesis and synaptic transmission...
  44. ncbi request reprint Overexpression of calbindin-D28K in hippocampal progenitor cells increases neuronal differentiation and neurite outgrowth
    Ju Hee Kim
    Department of Biochemistry and Molecular Biology, Hanyang University College of Medicine, Seoul, Korea
    FASEB J 20:109-11. 2006
    ..Together, these findings establish the novel calbindin-regulated function of CaMKII and NeuroD in control of neuronal differentiation and neurite outgrowth...
  45. pmc DNA methylation-mediated control of learning and memory
    Nam Kyung Yu
    National Creative Research Initiative Center for Memory, Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, Korea
    Mol Brain 4:5. 2011
    ..We will overview the current understanding of the mechanism of modifying the methyl code on DNA and its impact on learning and memory...
  46. pmc N-type voltage gated calcium channels mediate excitatory synaptic transmission in the anterior cingulate cortex of adult mice
    SukJae Joshua Kang
    Department of Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul 151 746, South Korea
    Mol Pain 9:58. 2013
    ..Our results provide strong evidence that N-type VGCCs mediate fast synaptic transmission in the ACC. ..
  47. pmc Null effect of antidepressants on the astrocytes-mediated proliferation of hippocampal progenitor cells in vitro
    Hyoung Gon Ko
    National Creative Research Initiative Center for Memory and Institute of Molecular Biology and Genetics, Department of Biological Sciences, College of Natural Sciences, Seoul National University, Gwanak Gu, Seoul, Korea
    Mol Pain 3:16. 2007
    ..It has been recently reported that astroglia induce the neurogenesis of the hippocampal neural progenitor cells (NPCs). Therefore, we hypothesized that antidepressants may act on astrocytes, and this in turn induces neurogenesis of NPCs...
  48. doi request reprint Long-term depression of synaptic transmission in the adult mouse insular cortex in vitro
    Ming Gang Liu
    Department of Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul, Korea Department of Physiology, Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, Ontario, M5S 1A8, Canada
    Eur J Neurosci 38:3128-45. 2013
    ..Our studies have characterised the basic mechanisms of LTD in the IC at the network level, and suggest that two different forms of LTD may co-exist in the same population of IC synapses. ..
  49. doi request reprint Functional roles of neurotransmitters and neuromodulators in the dorsal striatum
    Jeehaeh Do
    Department of Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul 151 747, Korea
    Learn Mem 20:21-8. 2012
    ..Here, we review the cellular connections and modulation of striatal microcircuits and propose that modulating the excitatory and inhibitory balance in synaptic transmission of the dorsal striatum is important for regulating locomotion...
  50. doi request reprint Detection of TrkB receptors distributed in cultured hippocampal neurons through bioconjugation between highly luminescent (quantum dot-neutravidin) and (biotinylated anti-TrkB antibody) on neurons by combined atomic force microscope and confocal laser sca
    Ji Won Park
    Molecular Electronics and NanoStructures Laboratory, School of Chemistry, NS60, National Creative Research Initiative Center for Memory, Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 151 747, Republic of Korea
    Bioconjug Chem 21:597-603. 2010
    ..Furthermore, this technique can be applied for real-time fluorescence imaging or long-term study of live neurons...
  51. pmc AMPA receptor exchange underlies transient memory destabilization on retrieval
    Ingie Hong
    School of Biological Sciences, Seoul National University, Seoul 151 747, Korea
    Proc Natl Acad Sci U S A 110:8218-23. 2013
    ..Taken together, our results reveal unexpected physiological roles of CI-AMPARs and CP-AMPARs in transforming a consolidated memory into an unstable memory and subsequently guiding reconsolidation...
  52. pmc Mind bomb-1 is an essential modulator of long-term memory and synaptic plasticity via the Notch signaling pathway
    Ki Jun Yoon
    Department of Biological Sciences, College of Natural Sciences, Seoul National University, San 56 1 Silim dong Gwanak gu, Seoul 151 747, South Korea
    Mol Brain 5:40. 2012
    ..Therefore, genetic ablation of Mib1 in mature neuron would give valuable insight to understand the cell-to-cell interaction between neurons via Notch signaling for their proper function...
  53. pmc Genetic enhancement of behavioral itch responses in mice lacking phosphoinositide 3-kinase-γ (PI3Kγ)
    Bolam Lee
    Department of Brain and Cognitive Sciences, Seoul National University, Seoul 151 747, Korea
    Mol Pain 7:96. 2011
    ..Our findings indicate that PI3Kγ selectively contributes to behavioral itching induced by histamine and PAR-2 agonist, but not chloroquine agonist...
  54. pmc Protein synthesis and degradation are required for the incorporation of modified information into the pre-existing object-location memory
    Jun Hyeok Choi
    National Creative Research Initiative Center for Memory, Department of Biological Sciences, College of Natural Sciences, Seoul National University, 151 742 Seoul, Korea
    Mol Brain 3:1. 2010
    ..These results indicate that protein synthesis and degradation play key roles in memory modification...
  55. pmc Transcriptional regulation of long-term memory in the marine snail Aplysia
    Yong Seok Lee
    National Creative Research Initiative Center for Memory, Department of Biological Sciences, Seoul National University, Korea
    Mol Brain 1:3. 2008
    ..In this review, we examine the roles of these transcription factors during consolidation of LTF induced by different stimulation paradigms...
  56. pmc Effect of intensity of unconditional stimulus on reconsolidation of contextual fear memory
    Chuljung Kwak
    National Creative Research Initiative Center for Memory, Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 151 747, Korea
    Korean J Physiol Pharmacol 16:293-6. 2012
    ..This suggests that a US of strong intensity can inhibit reconsolidation of contextual fear memory...
  57. ncbi request reprint Pyrexia is a new thermal transient receptor potential channel endowing tolerance to high temperatures in Drosophila melanogaster
    Youngseok Lee
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 373 1 Guseong dong, Yuseong Gu, Daejeon 305 701, Korea
    Nat Genet 37:305-10. 2005
    ..From these findings, we propose that the primary in vivo role of Pyx is to protect flies from high-temperature stress...
  58. pmc Shank mutant mice as an animal model of autism
    Juyoun Yoo
    Department of Biological Sciences, Seoul National University, Gwanangno 599, Gwanak Gu, Seoul 151 747, South Korea
    Philos Trans R Soc Lond B Biol Sci 369:20130143. 2014
    ..Here, we analyse studies that relate Shank to autism and discuss what light this sheds on the possible causes of autism. ..
  59. pmc NMDA receptor-dependent long-term potentiation comprises a family of temporally overlapping forms of synaptic plasticity that are induced by different patterns of stimulation
    Pojeong Park
    Department of Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul 151 746, South Korea
    Philos Trans R Soc Lond B Biol Sci 369:20130131. 2014
    ....
  60. doi request reprint Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function
    Hyejung Won
    Department of Biological Sciences, KAIST, Daejeon 305 701, Korea
    Nature 486:261-5. 2012
    ..These results suggest that reduced NMDAR function may contribute to the development of ASD-like phenotypes in Shank2(-/-) mice, and mGluR modulation of NMDARs offers a potential strategy to treat ASD...
  61. pmc Effect of ablated hippocampal neurogenesis on the formation and extinction of contextual fear memory
    Hyoung Gon Ko
    National Creative Research Initiative Center for Memory, Department of Biological Sciences, College of Natural Sciences, Seoul National University, San 56 1 Silim dong, Gwanak Gu, Seoul, 151 747, Korea
    Mol Brain 2:1. 2009
    ..These results suggest that although adult newborn neurons contribute to contextual fear memory, they may not be involved in the extinction or erasure of hippocampus-dependent contextual fear memory...
  62. ncbi request reprint In vivo quantitative analysis of PKA subunit interaction and cAMP level by dual color fluorescence cross correlation spectroscopy
    Hyungju Park
    Neurobiology Laboratory, Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 151 747, Korea
    Mol Cells 26:87-92. 2008
    ..Our study demonstrates that in vivo FCCS measurements and their quantitative analysis permit one not only to directly quantify protein-protein interactions but also to estimate changes in the intracellular cAMP concentration...
  63. pmc Social Isolation Selectively Increases Anxiety in Mice without Affecting Depression-like Behavior
    Chuljung Kwak
    National Creative Research Initiative Center for Memory, Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 151 747, Korea
    Korean J Physiol Pharmacol 13:357-60. 2009
    ..These results suggest that environmental variables may have a prominent impact on experimental animals' emotional behaviors and possibly their psychological states, leading to bias in the behavioral data produced from experiments...
  64. pmc Reviewer acknowledgement
    Tim Bliss
    Department of Biological Sciences, Seoul National University, Seoul, Korea
    Mol Brain 6:7. 2013
    ..CONTRIBUTING REVIEWERS: The editors of Molecular Brain would like to thank all our reviewers who have contributed to the journal in Volume 5 (2012)...
  65. pmc Identification of a serotonin receptor coupled to adenylyl cyclase involved in learning-related heterosynaptic facilitation in Aplysia
    Yong Seok Lee
    Department of Biological Sciences, National Creative Research Initiative Center for Memory and Institute of Molecular Biology and Genetics, College of Natural Sciences, Seoul National University, Gwanak Gu, Seoul 151 747, Korea
    Proc Natl Acad Sci U S A 106:14634-9. 2009
    ..These data implicate 5-HT(apAC1) as a major modulator of learning related synaptic facilitation in the direct sensory to motor neuron pathway of the gill withdrawal reflex...
  66. pmc Protein Degradation during Reconsolidation as a Mechanism for Memory Reorganization
    Bong Kiun Kaang
    National Creative Research Initiative Center for Memory, Department of Biological Sciences, College of Natural Sciences, Seoul National University Seoul, South Korea
    Front Behav Neurosci 5:2. 2011
    ..Using protein degradation inhibition as a method to block reconsolidation, recent researches suggest that reconsolidation, especially the protein degradation-dependent destabilization process is necessary for memory reorganization...
  67. ncbi request reprint The role of lipid binding for the targeting of synaptic proteins into synaptic vesicles
    Deok Jin Jang
    National Creative Research Initiative Center for Memory, Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 151 747, Korea
    BMB Rep 42:1-5. 2009
    ..In addition, numerous SV proteins can be palmitoylated. Palmitoylation is thought to be another synaptic targeting signal. Here, we briefly describe the relationship between lipid binding and SV targeting. [BMB reports 2009; 42(1): 1-5]...