Seock Ah Im

Summary

Affiliation: Seoul National University
Country: Korea

Publications

  1. pmc Weekly paclitaxel and trastuzumab as a first-line therapy in patients with HER2-overexpressing metastatic breast cancer: magnitude of HER2/neu amplification as a predictive factor for efficacy
    Hye Suk Han
    Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea
    J Korean Med Sci 24:910-7. 2009
  2. pmc Reduced dose intensity FOLFOX-4 as first line palliative chemotherapy in elderly patients with advanced colorectal cancer
    Jee Hyun Kim
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    J Korean Med Sci 20:806-10. 2005
  3. pmc Efficacy of exemestane in korean patients with metastatic breast cancer after failure of nonsteroidal aromatase inhibitors
    June Koo Lee
    Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea
    J Breast Cancer 16:66-71. 2013
  4. pmc Body mass index is not associated with treatment outcomes of breast cancer patients receiving neoadjuvant chemotherapy: korean data
    Kyung Hun Lee
    Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea Cancer Research Institute, Seoul National University, Seoul, Korea
    J Breast Cancer 15:427-33. 2012
  5. doi request reprint RAD51C-deficient cancer cells are highly sensitive to the PARP inhibitor olaparib
    Ahrum Min
    Cancer Research Institute, Seoul National University, Seoul, Republic of Korea
    Mol Cancer Ther 12:865-77. 2013
  6. doi request reprint Clinicopathologic characteristics of patients with stage III/IV (M(0)) advanced gastric cancer, according to HER2 status assessed by immunohistochemistry and fluorescence in situ hybridization
    Seock Ah Im
    Department of Internal Medicine, Cancer Research Institute, Seoul, Republic of Korea
    Diagn Mol Pathol 20:94-100. 2011
  7. ncbi request reprint Potential prognostic significance of p185(HER2) overexpression with loss of PTEN expression in gastric carcinomas
    Seock Ah Im
    Section of Oncology Hematology, Department of Internal Medicine, Seoul National University, College of Medicine, 28 Yongondong Chongnogu, Seoul, 110 744, Korea
    Tumori 91:513-21. 2005
  8. pmc Clinicopathologic characteristics and treatment outcomes of hepatoid adenocarcinoma of the stomach, a rare but unique subtype of gastric cancer
    Sun Kyung Baek
    Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea
    BMC Gastroenterol 11:56. 2011
  9. pmc Prognostic significance of bcl-2 expression in stage III breast cancer patients who had received doxorubicin and cyclophosphamide followed by paclitaxel as adjuvant chemotherapy
    Kyung Hun Lee
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    BMC Cancer 7:63. 2007
  10. ncbi request reprint Epidermal growth factor receptor (EGFR) downstream molecules as response predictive markers for gefitinib (Iressa, ZD1839) in chemotherapy-resistant non-small cell lung cancer
    Sae Won Han
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Int J Cancer 113:109-15. 2005

Collaborators

Detail Information

Publications112 found, 100 shown here

  1. pmc Weekly paclitaxel and trastuzumab as a first-line therapy in patients with HER2-overexpressing metastatic breast cancer: magnitude of HER2/neu amplification as a predictive factor for efficacy
    Hye Suk Han
    Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea
    J Korean Med Sci 24:910-7. 2009
    ..Furthermore, the magnitude of HER2 amplification is an independent predictive factor of TTP...
  2. pmc Reduced dose intensity FOLFOX-4 as first line palliative chemotherapy in elderly patients with advanced colorectal cancer
    Jee Hyun Kim
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    J Korean Med Sci 20:806-10. 2005
    ..2%) and vomiting (1.0%). In conclusion, the mini-FOLFOX-4 regimen was found to be well tolerated with acceptable toxicity, and to provide a benefit for elderly patients with colorectal cancer...
  3. pmc Efficacy of exemestane in korean patients with metastatic breast cancer after failure of nonsteroidal aromatase inhibitors
    June Koo Lee
    Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea
    J Breast Cancer 16:66-71. 2013
    ..Exemestane has shown good efficacy and tolerability in postmenopausal women with hormone receptor-positive metastatic breast cancer. However, clinical outcomes in Korean patients have not yet been reported...
  4. pmc Body mass index is not associated with treatment outcomes of breast cancer patients receiving neoadjuvant chemotherapy: korean data
    Kyung Hun Lee
    Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea Cancer Research Institute, Seoul National University, Seoul, Korea
    J Breast Cancer 15:427-33. 2012
    ..The purpose of this study was to evaluate the predictive or prognostic value of obesity in breast cancer receiving neoadjuvant chemotherapy...
  5. doi request reprint RAD51C-deficient cancer cells are highly sensitive to the PARP inhibitor olaparib
    Ahrum Min
    Cancer Research Institute, Seoul National University, Seoul, Republic of Korea
    Mol Cancer Ther 12:865-77. 2013
    ..In summary, RAD51C-deficient cancer cells are highly sensitive to olaparib and offer preclinical proof-of-principle that RAD51C deficiency may be considered a biomarker for predicting the antitumor effects of olaparib...
  6. doi request reprint Clinicopathologic characteristics of patients with stage III/IV (M(0)) advanced gastric cancer, according to HER2 status assessed by immunohistochemistry and fluorescence in situ hybridization
    Seock Ah Im
    Department of Internal Medicine, Cancer Research Institute, Seoul, Republic of Korea
    Diagn Mol Pathol 20:94-100. 2011
    ..2% vs. 43.3%, respectively; P=0.086). These findings suggest that further investigations of adjuvant therapy with HER2-targeted therapy for advanced GC are warranted...
  7. ncbi request reprint Potential prognostic significance of p185(HER2) overexpression with loss of PTEN expression in gastric carcinomas
    Seock Ah Im
    Section of Oncology Hematology, Department of Internal Medicine, Seoul National University, College of Medicine, 28 Yongondong Chongnogu, Seoul, 110 744, Korea
    Tumori 91:513-21. 2005
    ..The authors investigated the correlation between clinicopathologic variables including survival and the overexpression of the p185(HER2) with loss of PTEN expression in gastric adenocarcinoma patients...
  8. pmc Clinicopathologic characteristics and treatment outcomes of hepatoid adenocarcinoma of the stomach, a rare but unique subtype of gastric cancer
    Sun Kyung Baek
    Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea
    BMC Gastroenterol 11:56. 2011
    ..In this study, we performed an evaluation of clinicopathologic characteristics, treatment outcome, and prognosis in patients with gastric HAC...
  9. pmc Prognostic significance of bcl-2 expression in stage III breast cancer patients who had received doxorubicin and cyclophosphamide followed by paclitaxel as adjuvant chemotherapy
    Kyung Hun Lee
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    BMC Cancer 7:63. 2007
    ....
  10. ncbi request reprint Epidermal growth factor receptor (EGFR) downstream molecules as response predictive markers for gefitinib (Iressa, ZD1839) in chemotherapy-resistant non-small cell lung cancer
    Sae Won Han
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Int J Cancer 113:109-15. 2005
    ..08-0.79, p = 0.018) and OS (HR 0.16, 95% CI 0.04-0.62, p = 0.008). These results support the assumption that gefitinib responsiveness might be predicted by activated EGFR downstream molecules such as p-Akt and p-Erk...
  11. doi request reprint Phase II study of biweekly S-1 and oxaliplatin combination chemotherapy in metastatic colorectal cancer and pharmacogenetic analysis
    Junshik Hong
    Department of Internal Medicine, Seoul National University Hospital, 101 Daehang ro, Jongno gu, Seoul, Korea
    Cancer Chemother Pharmacol 67:1323-31. 2011
    ..To evaluate the efficacy and safety of S-1 in combination with oxaliplatin in a biweekly schedule as first-line treatment in metastatic colorectal cancer and the association between genetic polymorphisms and treatment outcomes...
  12. ncbi request reprint Cytotoxic effects of pemetrexed in gastric cancer cells
    Jee Hyun Kim
    Department of Internal Medicine, Seoul National University College of Medicine, 28, Yongon Dong, Chongno Gu, Seoul
    Cancer Sci 96:365-71. 2005
    ..Drug sensitivity toward pemetrexed could not be predicted by the expressions of TS, RFC1, or FPGS and we suggest that it is determined by interactions between multiple genes...
  13. ncbi request reprint Optimization of patient selection for gefitinib in non-small cell lung cancer by combined analysis of epidermal growth factor receptor mutation, K-ras mutation, and Akt phosphorylation
    Sae Won Han
    Department of Internal Medicine and Pathology, Seoul National University Hospital, and Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Clin Cancer Res 12:2538-44. 2006
    ....
  14. doi request reprint Clinical course of neuroendocrine tumors with different origins (the pancreas, gastrointestinal tract, and lung)
    Su Jung Kim
    Division of Hematology and Medical Oncology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea
    Am J Clin Oncol 35:549-56. 2012
    ..Neuroendocrine tumor originates from several sites. This study was conducted to reveal the differences in clinical course of neuroendocrine tumors by the origin...
  15. ncbi request reprint Irinotecan combined with 5-fluorouracil and leucovorin third-line chemotherapy after failure of fluoropyrimidine, platinum, and taxane in gastric cancer: treatment outcomes and a prognostic model to predict survival
    Eun Joo Kang
    Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 300 Gumi dong, Bundang gu, Seongnam si, Gyeonggi Do, 463 707, Republic of Korea
    Gastric Cancer 16:581-9. 2013
    ....
  16. doi request reprint Predictive value of FDG PET/CT for pathologic axillary node involvement after neoadjuvant chemotherapy
    Bhumsuk Keam
    Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul, 110 744, Korea
    Breast Cancer 20:167-73. 2013
    ..The purpose of this study was to determine the usefulness of sequential FDG PET/CTs for prediction of axillary lymph node (ALN) status after neoadjuvant chemotherapy (NAC)...
  17. ncbi request reprint Phase II trial of low-dose paclitaxel and cisplatin in patients with advanced gastric cancer
    Keun Wook Lee
    Department of Internal Medicine, Seoul National University College of Medicine, Chongno Gu, Seoul 110 744, Republic of Korea
    Jpn J Clin Oncol 35:720-6. 2005
    ..This study was performed to evaluate the efficacy and toxicity of low-dose paclitaxel (145 mg/m(2)) plus cisplatin chemotherapy in metastatic or relapsed gastric cancer...
  18. ncbi request reprint A combination of HER-2 status and the St. Gallen classification provides useful information on prognosis in lymph node-negative breast carcinoma
    Jong Mu Sun
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Cancer 101:2516-22. 2004
    ..The authors investigated the clinical relevance of HER-2 overexpression when combined with the St. Gallen classification in lymph node-negative breast carcinoma...
  19. doi request reprint Antitumor activity of HM781-36B, a pan-HER tyrosine kinase inhibitor, in HER2-amplified breast cancer cells
    Hye Jin Kim
    Cancer Research Institute, Seoul, Korea
    Anticancer Drugs 23:288-97. 2012
    ....
  20. ncbi request reprint Clinical predictors versus epidermal growth factor receptor mutation in gefitinib-treated non-small-cell lung cancer patients
    Sae Won Han
    Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 744, Republic of Korea
    Lung Cancer 54:201-7. 2006
    ..Direct comparison between clinical predictors and EGFR mutation for their predictive power has not been reported...
  21. doi request reprint Epidermal growth factor receptor intron 1 CA dinucleotide repeat polymorphism and survival of advanced gastric cancer patients treated with cetuximab plus modified FOLFOX6
    Sae Won Han
    Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea
    Cancer Sci 101:793-9. 2010
    ..These results suggest that the EGFR intron 1 CA repeat polymorphism could be a useful, predictive biomarker of cetuximab efficacy in AGC and merits further investigation in randomized studies...
  22. doi request reprint Serum epidermal growth factor is associated with prognosis and hormone receptor status in patients with HER2-positive metastatic breast cancer treated with first-line trastuzumab plus taxane chemotherapy
    Ji Won Kim
    Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehak Ro, Jongno gu, Seoul, 110 744, Korea
    Cancer Chemother Pharmacol 72:1023-9. 2013
    ..In this study, we investigated the clinical and pathologic implications of serum EGF levels in patients with HER2-positive metastatic breast cancer (MBC)...
  23. ncbi request reprint Epidermal growth factor receptor mutations and response to chemotherapy in patients with non-small-cell lung cancer
    Kyung Hun Lee
    Department of Internal Medicine, Seoul National University College of Medicine, Chongno Gu, Seoul, 110 744, South Korea
    Jpn J Clin Oncol 36:344-50. 2006
    ..We retrospectively analyzed the associations between response to chemotherapy and molecular markers associated with gefitinib responsiveness including EGFR mutations...
  24. doi request reprint Antitumor activity of saracatinib (AZD0530), a c-Src/Abl kinase inhibitor, alone or in combination with chemotherapeutic agents in gastric cancer
    Hyun Jin Nam
    Cancer Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea
    Mol Cancer Ther 12:16-26. 2013
    ..These data indicate that the inhibition of Src kinase activity by saracatinib alone or in combination with other agents can be a strategy to target gastric cancer...
  25. doi request reprint Adjuvant chemoradiotherapy after curative resection for extrahepatic bile duct cancer: a long-term single center experience
    Kyubo Kim
    Departments of Radiation Oncology, Seoul National University College of Medicine, Republic of Korea
    Am J Clin Oncol 35:136-40. 2012
    ..To analyze the outcome of adjuvant chemoradiotherapy for patients with extrahepatic bile duct (EHBD) cancer, and to identify the prognostic factors for these patients...
  26. doi request reprint Increasing nodal ratio is a poor prognostic factor for survival in stage III-IV (M0) gastric cancer patients who received curative surgery followed by adjuvant chemotherapy: a retrospective study
    Jin Soo Kim
    Department of Internal Medicine, Seoul National University Hospital, 28 Yongon Dong, Chongno Gu, Seoul 110 744, Republic of Korea
    Jpn J Clin Oncol 41:245-52. 2011
    ..The aim of this study is to evaluate the efficacy of adjuvant chemotherapy with 5-fluorouracil and cisplatin in gastric cancer patients and to assess prognostic factors affecting relapse and survival...
  27. ncbi request reprint ABCB1, FCGR2A, and FCGR3A polymorphisms in patients with HER2-positive metastatic breast cancer who were treated with first-line taxane plus trastuzumab chemotherapy
    Ji Won Kim
    Department of Internal Medicine, Seoul National University College of Medicine, Korea
    Oncology 83:218-27. 2012
    ..The aim of this study was to elucidate clinical implications of ABCB1, FCGR2A, and FCGR3A polymorphisms in patients with HER2-positive metastatic breast cancer (MBC) after taxane plus trastuzumab (TH) chemotherapy...
  28. doi request reprint The lack of CD34 expression in gastrointestinal stromal tumors is related to cystic degeneration following imatinib use
    Youngil Koh
    Department of Internal Medicine, Seoul National University Hospital, Cancer Research Institute, Seoul National University College of Medicine, 101 Daehangro, Chongno Gu, Seoul 110 744, Republic of Korea
    Jpn J Clin Oncol 42:1020-7. 2012
    ..We also investigated the clinical applicability of Choi's criteria to Korean gastrointestinal stromal tumor patients undergoing imatinib therapy...
  29. doi request reprint HER2/CEP17 ratio and HER2 immunohistochemistry predict clinical outcome after first-line trastuzumab plus taxane chemotherapy in patients with HER2 fluorescence in situ hybridization-positive metastatic breast cancer
    Ji Won Kim
    Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehak Ro, Jongno gu, Seoul, 110 744, Korea
    Cancer Chemother Pharmacol 72:109-15. 2013
    ....
  30. doi request reprint The relationship between response to previous systemic treatment and the efficacy of subsequent pemetrexed therapy in advanced non-small cell lung cancer
    Jong Mu Sun
    Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea
    Lung Cancer 68:427-32. 2010
    ..We sought to identify the relationship between response to previous systemic treatment and the efficacy of subsequent pemetrexed therapy in advanced non-small cell lung cancer (NSCLC)...
  31. doi request reprint Is duodenal invasion a relevant prognosticator in patients undergoing adjuvant chemoradiotherapy for distal common bile duct cancer?
    Kyubo Kim
    Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Republic of Korea
    Int J Radiat Oncol Biol Phys 77:1186-90. 2010
    ..To analyze the outcome of adjuvant chemoradiotherapy for patients with distal common bile duct (CBD) cancer who underwent curative surgery, and to identify the prognostic factors for these patients...
  32. doi request reprint Clinical outcomes of sorafenib treatment in patients with metastatic hepatocellular carcinoma who had been previously treated with fluoropyrimidine plus platinum-based chemotherapy
    Ji Won Kim
    Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea
    Am J Clin Oncol 34:125-9. 2011
    ..The objectives of this analysis were to investigate efficacy and safety of sorafenib in these patients and to elucidate risk factors associated with clinical outcomes...
  33. doi request reprint Distant metastasis risk stratification for patients undergoing curative resection followed by adjuvant chemoradiation for extrahepatic bile duct cancer
    Kyubo Kim
    Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Republic of Korea
    Int J Radiat Oncol Biol Phys 84:81-7. 2012
    ..To analyze the prognostic factors predicting distant metastasis in patients undergoing adjuvant chemoradiation for extrahepatic bile duct (EHBD) cancer...
  34. ncbi request reprint Antitumor activity of SK-7041, a novel histone deacetylase inhibitor, in human lung and breast cancer cells
    Keun Wook Lee
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Anticancer Res 26:3429-38. 2006
    ..In this study, the antitumor effects of SK-7041, one of those novel HDAC inhibitors, was evaluated on lung and breast cancer cell lines...
  35. doi request reprint Irinotecan combined with 5-fluorouracil and leucovorin as second-line chemotherapy for metastatic or relapsed gastric cancer
    Myung Deok Seo
    Department of Internal Medicine, Cheju National University Hospital, Jeju, Republic of Korea
    Jpn J Clin Oncol 38:589-95. 2008
    ..Factors to select patients who may benefit from salvage chemotherapy was also analysed...
  36. ncbi request reprint Methylation and microsatellite status and recurrence following adjuvant FOLFOX in colorectal cancer
    Sae Won Han
    Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea
    Int J Cancer 132:2209-16. 2013
    ..006). In conclusion, concurrent methylation of NEUROG1 and CDKN2A (p16) is associated with recurrence following adjuvant FOLFOX in Stages II/III colorectal cancer...
  37. doi request reprint Role of adjuvant chemoradiotherapy for duodenal cancer: a single center experience
    Kyubo Kim
    Departments of Radiation Oncology, Seoul National University College of Medicine, Seoul, Republic of Korea
    Am J Clin Oncol 35:533-6. 2012
    ..To compare the treatment outcome of surgery alone with that of surgery followed by adjuvant chemoradiotherapy (CRT) for duodenal cancer...
  38. pmc Prognostic value of p53 and bcl-2 expression in patients treated with breast conservative therapy
    Kyubo Kim
    Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Korea
    J Korean Med Sci 25:235-9. 2010
    ..A bcl-2(-)/ER(-) phenotype and p53 expression are useful molecular markers predicting loco-regional relapse-free and distant metastasis-free survival, respectively, in patients treated with breast conserving surgery and radiotherapy...
  39. ncbi request reprint Docetaxel plus epirubicin as first-line chemotherapy in MBC (KCSG 01-10-05): phase II trial and the predictive values of circulating HER2 extracellular domain and vascular endothelial growth factor
    Seock Ah Im
    Breast Cancer Subcommittee, Korean Cancer Study Group, Seoul, Korea
    Oncol Rep 14:481-7. 2005
    ..We concluded that the docetaxel and epirubicin combination is an effective first-line treatment in MBC patients and that elevated serum HER2 ECD levels, but not circulating VEGF levels, predict a poor outcome...
  40. ncbi request reprint Trastuzumab inhibits the growth of human gastric cancer cell lines with HER2 amplification synergistically with cisplatin
    Sun Young Kim
    Department of Internal Medicine, Seoul National University College of Medicine, Chongro Gu, Seoul 110 799, Korea
    Int J Oncol 32:89-95. 2008
    ..These results suggest that trastuzumab combined with chemotherapeutic agents can be active against gastric cancer with HER2 amplification...
  41. doi request reprint A phase II study of bevacizumab, oxaliplatin, and capecitabine in patients with previously untreated metastatic colorectal cancer: a prospective, multicenter trial of the Korean Cancer Study Group
    Yong Sang Hong
    Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul Department of Internal Medicine, Yonsei Cancer Center, Division of Medical Oncology, Yonsei University College of Medicine, Seoul Department of Internal Medicine, Division of Hematology and Medical Oncology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul Department of Internal Medicine, Samsung Medical Center, Division of Hematology Oncology, Sungkyunkwan University School of Medicine, Seoul Center for Colorectal Cancer, National Cancer Center, Research Institute and Hospital, Goyang Department of Internal Medicine, Division of Hematology and Medical Oncology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea
    Am J Clin Oncol 37:19-23. 2014
    ..We have investigated the efficacy and safety of bevacizumab plus capecitabine and oxaliplatin as first-line chemotherapy for Korean patients with mCRC...
  42. doi request reprint Clinical usefulness of AJCC response criteria for neoadjuvant chemotherapy in breast cancer
    Bhumsuk Keam
    Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea
    Ann Surg Oncol 20:2242-9. 2013
    ..The purpose of this study was to evaluate the clinical usefulness of AJCC response criteria...
  43. pmc Modified FOLFOX-6 chemotherapy in advanced gastric cancer: Results of phase II study and comprehensive analysis of polymorphisms as a predictive and prognostic marker
    Bhumsuk Keam
    Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea
    BMC Cancer 8:148. 2008
    ..We also analyzed the predictive or prognostic value of germline polymorphisms of candidate genes associated with 5-FU and oxaliplatin...
  44. doi request reprint RAD001 shows activity against gastric cancer cells and overcomes 5-FU resistance by downregulating thymidylate synthase
    Kyung Hun Lee
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
    Cancer Lett 299:22-8. 2010
    ..In conclusion, RAD001 showed growth inhibitory activity against gastric cancer cells and acted synergistically with cytotoxic agents such as 5-FU by downregulating TS...
  45. doi request reprint OPB-31121, a novel small molecular inhibitor, disrupts the JAK2/STAT3 pathway and exhibits an antitumor activity in gastric cancer cells
    Mi Jung Kim
    Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea
    Cancer Lett 335:145-52. 2013
    ..Taken together, our study suggests that STAT3 inhibition with OPB-31121 can be tested in patients with gastric cancer...
  46. doi request reprint Sunitinib synergizes the antitumor effect of cisplatin via modulation of ERCC1 expression in models of gastric cancer
    Young Kwang Yoon
    Cancer Research Institute, Seoul National University, Seoul 110 799, South Korea
    Cancer Lett 321:128-36. 2012
    ..The effect was verified via SNU484 xenograft model. Our data support the rationale of clinical trial using sunitinib in combination of cisplatin in gastric cancer...
  47. doi request reprint Prognostic significance of tumour location after adjuvant chemoradiotherapy for periampullary adenocarcinoma
    Kyubo Kim
    Department of Radiation Oncology, Seoul National University College of Medicine, 101 Daehak Ro, Jongno gu, Seoul 110 744, Republic of Korea
    Clin Transl Oncol 14:391-5. 2012
    ..To analyse the outcome of adjuvant chemoradiotherapy for periampullary adenocarcinoma and the impact of tumour location as a prognosticator...
  48. ncbi request reprint The prognostic significance of HER2 positivity for advanced gastric cancer patients undergoing first-line modified FOLFOX-6 regimen
    Jin Won Kim
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University, Seoul, Korea
    Anticancer Res 32:1547-53. 2012
    ..We aimed to clarify the prognostic significance of HER2 positivity in advanced gastric cancer...
  49. doi request reprint Concurrent versus sequential administration of CMF chemotherapy and radiotherapy after breast-conserving surgery in early breast cancer
    Kyubo Kim
    Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Republic of Korea
    Tumori 97:280-5. 2011
    ..To compare the outcome of concurrent versus sequential administration of cyclophosphamide, methotrexate, and 5-fluorouracil (CMF) chemotherapy and radiotherapy after breast-conserving surgery in early breast cancer...
  50. ncbi request reprint Intron 1 CA dinucleotide repeat polymorphism and mutations of epidermal growth factor receptor and gefitinib responsiveness in non-small-cell lung cancer
    Sae Won Han
    Department of Internal Medicine, Seoul National University Hospital and Cancer Research Institute, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 744, Korea
    Pharmacogenet Genomics 17:313-9. 2007
    ..Therefore, CA repeat polymorphism in intron 1 was analyzed for its association with gefitinib responsiveness together with epidermal growth factor receptor mutation in Korean patients...
  51. doi request reprint Clinical significance of axillary nodal ratio in stage II/III breast cancer treated with neoadjuvant chemotherapy
    Bhumsuk Keam
    Department of Internal Medicine, Seoul National University College of Medicine, Chongno Gu, Seoul, Republic of Korea
    Breast Cancer Res Treat 116:153-60. 2009
    ..The purpose of this study was to identify the clinical significance of the involved nodal ratios in patients with stage II/III breast cancer treated with neoadjuvant chemotherapy...
  52. ncbi request reprint DNA methyltransferase 3-like affects promoter methylation of thymine DNA glycosylase independently of DNMT1 and DNMT3B in cancer cells
    Heesun Kim
    Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Int J Oncol 36:1563-72. 2010
    ..This study is the first to show that DNMT3L exerts a major effect on the transcriptional regulation of a specific target gene, such as TDG, despite the absence of enzymatic activity...
  53. ncbi request reprint Predictive and prognostic impact of epidermal growth factor receptor mutation in non-small-cell lung cancer patients treated with gefitinib
    Sae Won Han
    Department of Internal Medicine, Seoul National University Hospital, Seoul, 110 744 Korea
    J Clin Oncol 23:2493-501. 2005
    ..This study was undertaken to investigate the effects of epidermal growth factor receptor (EGFR) mutation and its downstream signaling on response and survival in non-small-cell lung cancer (NSCLC) patients treated with gefitinib...
  54. doi request reprint Prognostic factors affecting the outcome of salvage radiotherapy for isolated locoregional recurrence after mastectomy
    Kyubo Kim
    Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Korea
    Am J Clin Oncol 33:23-7. 2010
    ..To evaluate the prognostic factors affecting the outcome of salvage radiotherapy for isolated locoregional recurrence after mastectomy...
  55. doi request reprint Combination of EGFR and MEK1/2 inhibitor shows synergistic effects by suppressing EGFR/HER3-dependent AKT activation in human gastric cancer cells
    Young Kwang Yoon
    Cancer Research Institute, Seoul National University College of Medicine, Korea
    Mol Cancer Ther 8:2526-36. 2009
    ..Our results provide the basis for a rational combination strategy against human EGFR WT gastric cancers, predicated on the understanding of cross-talk between the MEK and EGFR pathways...
  56. doi request reprint Differing effects of adjuvant chemotherapy according to BRCA1 nuclear expression in gastric cancer
    Jin Won Kim
    Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehang ro, Jongno gu, Seoul 110 744, Republic of Korea
    Cancer Chemother Pharmacol 71:1435-43. 2013
    ..We aimed to investigate the role of BRCA1 nuclear expression in sporadic gastric cancer; currently, the role remains unknown...
  57. ncbi request reprint High fluorodeoxyglucose uptake on positron emission tomography in patients with advanced non-small cell lung cancer on platinum-based combination chemotherapy
    Kyung Hun Lee
    Department of Internal Medicine and Nuclear Medicine, Seoul National University Hospital, Korea
    Clin Cancer Res 12:4232-6. 2006
    ....
  58. doi request reprint Breast cancer molecular phenotype and the use of HER2-targeted agents influence the accuracy of breast MRI after neoadjuvant chemotherapy
    Hyeong Gon Moon
    Department of Surgery, Seoul National University College of Medicine, Seoul National University Hospital, South Korea
    Ann Surg 257:133-7. 2013
    ....
  59. ncbi request reprint ERCC1 expression by immunohistochemistry and EGFR mutations in resected non-small cell lung cancer
    Kyung Hun Lee
    Department of Internal Medicine, Seoul National University Hospital, Republic of Korea
    Lung Cancer 60:401-7. 2008
    ..30% in ERCC1-negative tumors, P=0.014). In conclusion, ERCC1 expression was identified as a positive prognostic marker in resected NSCLC. In addition, EGFR mutations were more frequently found in ERCC1-negative tumors...
  60. ncbi request reprint Local tumor invasiveness is more predictive of survival than International Prognostic Index in stage I(E)/II(E) extranodal NK/T-cell lymphoma, nasal type
    Tae Min Kim
    Department of Internal Medicine, Seoul National University Hospital, Cancer Research Institute, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul, 110 744, Korea
    Blood 106:3785-90. 2005
    ..LTI is the most important prognostic factor in predicting low probability of CR and reduced OS and DFS in nasal stage I(E)/II(E) NTCL...
  61. ncbi request reprint A multi-center, late phase II clinical trial of Genexol (paclitaxel) and cisplatin for patients with advanced gastric cancer
    Sook Ryun Park
    Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 744, Korea
    Oncol Rep 12:1059-64. 2004
    ..In conclusion, the combination of Genexol and cisplatin was found to be an active and relatively well-tolerated regimen for the treatment of advanced gastric carcinoma...
  62. doi request reprint The irreversible pan-HER inhibitor PF00299804 alone or combined with gemcitabine has an antitumor effect in biliary tract cancer cell lines
    Hyun Jin Nam
    Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea
    Invest New Drugs 30:2148-60. 2012
    ..Our results support the need for further study of PF00299804 alone or combined with gemcitabine for the treatment of BTC...
  63. doi request reprint Expression of class III beta-tubulin correlates with unfavorable survival outcome in patients with resected non-small cell lung cancer
    Youngil Koh
    Departments of Internal Medicine and daggerPathology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea
    J Thorac Oncol 5:320-5. 2010
    ..We analyzed the significance of class III beta-tubulin (TUBB3) expression in curatively resected non-small cell lung cancer as a prognostic marker along with previously reported excision repair cross complementation group 1 (ERCC1)...
  64. doi request reprint Discordant human epidermal growth factor receptor 2 and hormone receptor status in primary and metastatic breast cancer and response to trastuzumab
    Hye Jung Chang
    Department of Internal Medicine, Seoul National University Hospital, 28 Yongon Dong, Chongno Gu, Seoul 110 744, South Korea
    Jpn J Clin Oncol 41:593-9. 2011
    ..Recent studies have shown that the human epidermal growth factor receptor 2 status of a metastatic site may differ from that of the primary site. This difference may influence patient prognosis and response to therapy...
  65. pmc Ki-67 can be used for further classification of triple negative breast cancer into two subtypes with different response and prognosis
    Bhumsuk Keam
    Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehang ro, Jongno gu, Seoul, 110 744, Korea
    Breast Cancer Res 13:R22. 2011
    ..The purpose of this study was to identify the predictive or prognostic value of Ki-67 among patients with TNBC treated with neoadjuvant chemotherapy, and the role of Ki-67 in further classification of TNBC...
  66. doi request reprint Phase II trial of preoperative paclitaxel, gemcitabine, and trastuzumab combination therapy in HER2 positive stage II/III breast cancer: the Korean Cancer Study Group BR 07-01
    Seock Ah Im
    Department of Internal Medicine, Seoul National University Hospital, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Breast Cancer Res Treat 132:589-600. 2012
    ..7% distant metastasis-free survival rates. Remarkable pCR rate was obtained with non-anthracycline-based PGH therapy for HER2-positive stage II/III breast cancer. Adverse events were mild with few incidences of febrile neutropenia...
  67. doi request reprint Nomogram prediction of survival and recurrence in patients with extrahepatic bile duct cancer undergoing curative resection followed by adjuvant chemoradiation therapy
    Changhoon Song
    Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Republic of Korea
    Int J Radiat Oncol Biol Phys 87:499-504. 2013
    ..To develop nomograms for predicting the overall survival (OS) and relapse-free survival (RFS) in patients with extrahepatic bile duct cancer undergoing adjuvant chemoradiation therapy after curative resection...
  68. pmc Early metabolic response using FDG PET/CT and molecular phenotypes of breast cancer treated with neoadjuvant chemotherapy
    Bhumsuk Keam
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    BMC Cancer 11:452. 2011
    ....
  69. ncbi request reprint Prognostic factors for recurrent breast cancer patients with an isolated, limited number of lung metastases and implications for pulmonary metastasectomy
    Ho Young Yhim
    Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea
    Cancer 116:2890-901. 2010
    ..The aim of this study was to evaluate the clinical treatment outcomes of recurrent breast cancer with a limited number of isolated lung metastases, and to evaluate the role of pulmonary metastasectomy...
  70. doi request reprint Combined lapatinib and cetuximab enhance cytotoxicity against gefitinib-resistant lung cancer cells
    Hwang Phill Kim
    Cancer Research Institute, Seoul National University College of Medicine, Chongno Gu, Seoul, Korea
    Mol Cancer Ther 7:607-15. 2008
    ....
  71. doi request reprint High serum TGF-α predicts poor response to lapatinib and capecitabine in HER2-positive breast cancer
    Jiyoung Rhee
    Department of Internal Medicine, Seoul National University Hospital, 101 Daehang ro, Jongno gu, Seoul, Korea
    Breast Cancer Res Treat 125:107-14. 2011
    ..These data suggest that TGF-α plays a role in resistance to lapatinib and capecitabine therapy among HER2-positive breast cancer...
  72. pmc Lapatinib, a dual EGFR and HER2 tyrosine kinase inhibitor, downregulates thymidylate synthase by inhibiting the nuclear translocation of EGFR and HER2
    Hwang Phill Kim
    Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
    PLoS ONE 4:e5933. 2009
    ..However, the molecular mechanism underlying the downregulation of TS has yet to be clearly elucidated...
  73. doi request reprint Gene silencing of EREG mediated by DNA methylation and histone modification in human gastric cancers
    Jiyeon Yun
    Cancer Research Institute, Seoul National University College of Medicine, South Korea
    Lab Invest 92:1033-44. 2012
    ..Taken together, the results of our study showed for the first time that EREG is epigenetically silenced in gastric cancer cells by aberrant DNA methylation and histone modification...
  74. doi request reprint Evaluation of the antitumor effects and mechanisms of PF00299804, a pan-HER inhibitor, alone or in combination with chemotherapy or targeted agents in gastric cancer
    Hyun Jin Nam
    Cancer Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Jongno gu, Seoul, 110 744, Korea
    Mol Cancer Ther 11:439-51. 2012
    ....
  75. doi request reprint Clinical outcome of central nervous system metastases from breast cancer: differences in survival depending on systemic treatment
    Hee Jun Kim
    Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 744, Korea
    J Neurooncol 106:303-13. 2012
    ..Our results suggest that appropriate palliative systemic therapy after WBRT or GKS, and adequate palliative treatment via combined modalities are helpful for breast cancer patients, even after the detection of CNS metastases...
  76. pmc Biological characteristics and treatment outcomes of metastatic or recurrent neuroendocrine tumors: tumor grade and metastatic site are important for treatment strategy
    Su Jung Kim
    Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea
    BMC Cancer 10:448. 2010
    ..Studies about the biology, treatment pattern, and treatment outcome of metastatic/recurrent neuroendocrine tumor (NET) have been few...
  77. ncbi request reprint Potential advantages of DNA methyltransferase 1 (DNMT1)-targeted inhibition for cancer therapy
    Yeonjoo Jung
    National Research Laboratory for Cancer Epigenetics, Cancer Research Institute, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul, 110 799, South Korea
    J Mol Med (Berl) 85:1137-48. 2007
    ..These results provide a rationale for the development of a DNMT1-targeted strategy as an effective epigenetic cancer therapy...
  78. doi request reprint Aggressiveness of cancer-care near the end-of-life in Korea
    Bhumsuk Keam
    Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 744, Republic of Korea
    Jpn J Clin Oncol 38:381-6. 2008
    ..The aim of this study was to examine the appropriateness of chemotherapy and care in Korean cancer patients near the end-of-life...
  79. doi request reprint Efficacy of infusional 5-fluorouracil, doxorubicin, and mitomycin-C (iFAM) in the treatment of patients with gemcitabine-pretreated pancreatic cancer and analysis of prognostic factors in a salvage setting
    Kyu Hyoung Lim
    Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul, 110 744, Korea
    Cancer Chemother Pharmacol 68:1017-26. 2011
    ....
  80. doi request reprint Antitumor activity of HM781-36B, an irreversible Pan-HER inhibitor, alone or in combination with cytotoxic chemotherapeutic agents in gastric cancer
    Hyun Jin Nam
    Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea
    Cancer Lett 302:155-65. 2011
    ..Therefore, HM781-36B may be useful for the treatment of HER2 amplified gastric cancer alone or in combination with chemotherapeutic agents...
  81. doi request reprint Pharmacogenetic analysis of adjuvant FOLFOX for Korean patients with colon cancer
    Kyung Hun Lee
    Department of Internal Medicine, Seoul National University Hospital, 28 Yongon Dong, 110 744 Chongno gu, Seoul, Korea
    Cancer Chemother Pharmacol 71:843-51. 2013
    ..Ethnic diversity of genetic polymorphism can result in individual differences in the efficacy and toxicity of cancer chemotherapy...
  82. doi request reprint Estrogen receptor status confers a distinct pattern of response to neoadjuvant chemotherapy: implications for optimal durations of therapy: distinct patterns of response according to ER expression
    Hyeong Gon Moon
    Department of Surgery and Cancer Research Institute, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 744, Korea
    Breast Cancer Res Treat 134:1133-40. 2012
    ..Our observation generates the hypothesis that the optimal duration of NST can be tailored to the molecular phenotypes of tumors...
  83. doi request reprint Down-regulation of P-cadherin with PF-03732010 inhibits cell migration and tumor growth in gastric cancer
    Jinah Park
    Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea
    Invest New Drugs 30:1404-12. 2012
    ..This demonstrates the potential for P-cadherin to be used as a target for treatment of gastric cancer...
  84. pmc Prognostic impact of clinicopathologic parameters in stage II/III breast cancer treated with neoadjuvant docetaxel and doxorubicin chemotherapy: paradoxical features of the triple negative breast cancer
    Bhumsuk Keam
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    BMC Cancer 7:203. 2007
    ..The purpose of this study was to identify the clinical significance of potential predictive and prognostic factors in breast cancer patients treated by neoadjuvant chemotherapy...
  85. doi request reprint Down-regulation of mitogen-inducible gene 6, a negative regulator of EGFR, enhances resistance to MEK inhibition in KRAS mutant cancer cells
    Young Kwang Yoon
    Cancer Research Institute, Seoul National University College of Medicine, South Korea
    Cancer Lett 316:77-84. 2012
    ..Our study provides a mechanism of differential response to MEK inhibition in KRAS mutant cancer...
  86. doi request reprint Age <40Years is an independent prognostic factor predicting inferior overall survival in patients treated with breast conservative therapy
    Kyubo Kim
    Departments of Radiation Oncology Surgery Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Breast J 17:75-8. 2011
    ..There was also a trend for inferior DMFS and OS in younger patients. Age at diagnosis should be considered for individualized patient management...
  87. ncbi request reprint Zinc-fingers and homeoboxes 1 (ZHX1) binds DNA methyltransferase (DNMT) 3B to enhance DNMT3B-mediated transcriptional repression
    Sung Hak Kim
    National Research Laboratory for Cancer Epigenetics, Cancer Research Institute, Seoul, Republic of Korea
    Biochem Biophys Res Commun 355:318-23. 2007
    ..These results showed for the first the direct linkage between DNMT and zinc-fingers homeoboxes protein, leading to enhanced gene silencing by DNMT3B...
  88. doi request reprint The growth inhibitory effect of lapatinib, a dual inhibitor of EGFR and HER2 tyrosine kinase, in gastric cancer cell lines
    Jin Won Kim
    Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 744, Republic of Korea
    Cancer Lett 272:296-306. 2008
    ..These results provide a rationale for the future clinical trials of lapatinib combined with cytotoxic drugs in the treatment of HER2-positive gastric cancer...
  89. doi request reprint Antitumor activity of NVP-AUY922, a novel heat shock protein 90 inhibitor, in human gastric cancer cells is mediated through proteasomal degradation of client proteins
    Kyung Hun Lee
    Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea
    Cancer Sci 102:1388-95. 2011
    ....
  90. pmc The role of PET/CT in detection of gastric cancer recurrence
    Sung Hoon Sim
    Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea
    BMC Cancer 9:73. 2009
    ..The purpose of this study is to evaluate the efficacy and usefulness of PET/CT for detecting recurrence of gastric cancer after curative resection...
  91. ncbi request reprint VEGF expression is related to good response and long progression-free survival in gastrointestinal stromal tumor patients treated with Sunitinib
    Youngil Koh
    Department of Internal Medicine, Seoul National University Hospital, Korea
    Diagn Mol Pathol 20:143-7. 2011
    ..However, the genotype did not affect either response rate or the PFS of sunitinib. In conclusion, expressions of VEGF, PDGFR, and CD34 may have predictive value in sunitinib treatments...
  92. doi request reprint Comparison of diffusion-weighted MR imaging and FDG PET/CT to predict pathological complete response to neoadjuvant chemotherapy in patients with breast cancer
    Sang Hee Park
    Department of Radiology, Seoul National University Hospital, 28 Yongon Dong, Chongno Gu, Seoul 110 744, South Korea
    Eur Radiol 22:18-25. 2012
    ..To compare the use of diffusion-weighted MR imaging (DWI) and (18)F-FDG PET/CT to predict pathological complete response (pCR) in breast cancer patients receiving neoadjuvant chemotherapy...
  93. pmc Gemcitabine-based versus fluoropyrimidine-based chemotherapy with or without platinum in unresectable biliary tract cancer: a retrospective study
    Mi Jung Kim
    Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea
    BMC Cancer 8:374. 2008
    ..Fluoropyrimidine or gemcitabine, with or without platinum, are most frequently used. We conducted this study to clarify the efficacy of palliative chemotherapy in BTC...
  94. pmc Heterodimerization of glycosylated insulin-like growth factor-1 receptors and insulin receptors in cancer cells sensitive to anti-IGF1R antibody
    Jun Gyu Kim
    Cancer Research Institute, Seoul National University, Seoul, South Korea
    PLoS ONE 7:e33322. 2012
    ..However, recent clinical trials showed that anti-IGF1R antibody and chemotherapy are not effective for treating lung cancer...
  95. doi request reprint Metaplastic breast carcinoma: clinicopathologic features and prognostic value of triple negativity
    Kyu Hyoung Lim
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Jpn J Clin Oncol 40:112-8. 2010
    ..The aim of this study was to compare the clinical features and prognosis between triple-negative metaplastic carcinoma (TNMC) and non-triple-negative metaplastic carcinoma (NTNMC)...
  96. doi request reprint Prognostic implication of (18)F FDG-PET in patients with extrahepatic metastatic hepatocellular carcinoma undergoing systemic treatment, a retrospective cohort study
    Dong Yeop Shin
    Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, 101 Daehagro, Chongno Gu, Seoul 110 744, Korea
    Cancer Chemother Pharmacol 68:165-75. 2011
    ..We conducted this study to investigate the clinical implication of SUVmax on (18)F FDG-PET as a prognostic factor in patients with HCC, especially in the metastatic setting...
  97. doi request reprint Clinicopathologic features and clinical outcomes of gastric cancer that initially presents with disseminated intravascular coagulation: a retrospective study
    Jiyoung Rhee
    Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea
    J Gastroenterol Hepatol 25:1537-42. 2010
    ..We evaluated the clinicopathologic features and clinical outcomes of this population...
  98. doi request reprint Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are effective for leptomeningeal metastasis from non-small cell lung cancer patients with sensitive EGFR mutation or other predictive factors of good response for EGFR TKI
    Hyeon Gyu Yi
    Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea
    Lung Cancer 65:80-4. 2009
    ..Two patients showed responses to higher than standard dose of gefitinib. The median overall survival was not reached. In conclusion, EGFR TKIs are effective in the treatment of LM from NSCLC when patients were selected properly...
  99. pmc The clinicopathologic characteristics and prognostic significance of triple-negativity in node-negative breast cancer
    Jiyoung Rhee
    Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea
    BMC Cancer 8:307. 2008
    ..We investigated the clinicopathologic characteristics and prognostic indicators of lymph node-negative TN breast cancer...
  100. pmc Adjuvant concurrent chemoradiation therapy (CCRT) alone versus CCRT followed by adjuvant chemotherapy: which is better in patients with radically resected extrahepatic biliary tract cancer?: a non-randomized, single center study
    Kyu Hyoung Lim
    Departments of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea
    BMC Cancer 9:345. 2009
    ....
  101. ncbi request reprint Nomogram predicting clinical outcomes in breast cancer patients treated with neoadjuvant chemotherapy
    Bhumsuk Keam
    Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul, 110 744, Korea
    J Cancer Res Clin Oncol 137:1301-8. 2011
    ..The aim of this study was to combine clinical pathologic variables that are associated with pathologic completer response (pCR) and relapse-free survival (RFS) after neoadjuvant chemotherapy into prediction nomograms...