June Key Chung

Summary

Affiliation: Seoul National University
Country: Korea

Publications

  1. ncbi The effect of tumor size on F-18-labeled fluorodeoxyglucose and fluoroerythronitroimidazole uptake in a murine sarcoma model
    J K Chung
    Department of Nuclear Medicine, and Cancer Research Institute, Seoul National University College of Medicine, Chongno Gu, Korea
    Ann Nucl Med 13:303-8. 1999
  2. doi In vivo imaging of functional targeting of miR-221 in papillary thyroid carcinoma
    Hyun Joo Kim
    Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea
    J Nucl Med 49:1686-93. 2008
  3. pmc Analysis of serum levels of anti-Mullerian hormone, inhibin B, insulin-like growth factor-I, insulin-like growth factor binding protein-3, and follicle-stimulating hormone with respect to age and menopausal status
    Sun Young Shin
    Department of Nuclear Medicine, College of Medicine, Seoul National University, Seoul, Korea
    J Korean Med Sci 23:104-10. 2008
  4. doi Reporter gene imaging
    Hyewon Youn
    Department of Nuclear Medicine and Laboratory of Molecular Imaging and Therapy, Cancer Research Institute, Seoul National University College of Medicine, 101 Daehak Ro, Jongno gu, Seoul 110 744, Korea
    AJR Am J Roentgenol 201:W206-14. 2013
  5. ncbi Comparison of [18F]fluorodeoxyglucose uptake with glucose transporter-1 expression and proliferation rate in human glioma and non-small-cell lung cancer
    J K Chung
    Department of Nuclear Medicine, Seoul National University College of Medicine, Korea
    Nucl Med Commun 25:11-7. 2004
  6. ncbi Sodium iodide symporter: its role in nuclear medicine
    June Key Chung
    Department of Nuclear Medicine, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
    J Nucl Med 43:1188-200. 2002
  7. ncbi Usefulness of 99Tcm-MDP knee SPET for pre-arthroscopic evaluation of patients with internal derangements of the knee
    Y So
    Department of Nuclear Medicine, Seoul National University College of Medicine, Korea
    Nucl Med Commun 21:103-9. 2000
  8. ncbi Usefulness of 11C-methionine PET in the evaluation of brain lesions that are hypo- or isometabolic on 18F-FDG PET
    June Key Chung
    Department of Nuclear Medicine, Seoul National University Hospital, Korea
    Eur J Nucl Med Mol Imaging 29:176-82. 2002
  9. ncbi Visualization of endogenous p53-mediated transcription in vivo using sodium iodide symporter
    Kwang Il Kim
    Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea
    Clin Cancer Res 11:123-8. 2005
  10. doi Predictive value of FDG PET/CT for pathologic axillary node involvement after neoadjuvant chemotherapy
    Bhumsuk Keam
    Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul, 110 744, Korea
    Breast Cancer 20:167-73. 2013

Collaborators

Detail Information

Publications134 found, 100 shown here

  1. ncbi The effect of tumor size on F-18-labeled fluorodeoxyglucose and fluoroerythronitroimidazole uptake in a murine sarcoma model
    J K Chung
    Department of Nuclear Medicine, and Cancer Research Institute, Seoul National University College of Medicine, Chongno Gu, Korea
    Ann Nucl Med 13:303-8. 1999
    ..We concluded that increased tumor size is associated with decreased uptake of 18F-FDG and FETNIM, though this depends on the type of radiotracers and distribution of necrosis...
  2. doi In vivo imaging of functional targeting of miR-221 in papillary thyroid carcinoma
    Hyun Joo Kim
    Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea
    J Nucl Med 49:1686-93. 2008
    ..To evaluate the abundant gene regulation of miR-221 in papillary thyroid carcinoma (PTC), we performed microarray analysis and developed a Gaussia luciferase (Gluc) reporter system regulated by miR-221...
  3. pmc Analysis of serum levels of anti-Mullerian hormone, inhibin B, insulin-like growth factor-I, insulin-like growth factor binding protein-3, and follicle-stimulating hormone with respect to age and menopausal status
    Sun Young Shin
    Department of Nuclear Medicine, College of Medicine, Seoul National University, Seoul, Korea
    J Korean Med Sci 23:104-10. 2008
    ..In conclusion, the serum AMH level appears to be the best marker of the aging process in premenopausal women...
  4. doi Reporter gene imaging
    Hyewon Youn
    Department of Nuclear Medicine and Laboratory of Molecular Imaging and Therapy, Cancer Research Institute, Seoul National University College of Medicine, 101 Daehak Ro, Jongno gu, Seoul 110 744, Korea
    AJR Am J Roentgenol 201:W206-14. 2013
    ....
  5. ncbi Comparison of [18F]fluorodeoxyglucose uptake with glucose transporter-1 expression and proliferation rate in human glioma and non-small-cell lung cancer
    J K Chung
    Department of Nuclear Medicine, Seoul National University College of Medicine, Korea
    Nucl Med Commun 25:11-7. 2004
    ..In the case of glioma, FDG uptake also indicated increased cellular proliferation, which was not demonstrated in non-small-cell lung cancer...
  6. ncbi Sodium iodide symporter: its role in nuclear medicine
    June Key Chung
    Department of Nuclear Medicine, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
    J Nucl Med 43:1188-200. 2002
    ..The NIS has the potential to expand the role of nuclear medicine in the future, just as it has served as the base for the development of nuclear medicine in the past...
  7. ncbi Usefulness of 99Tcm-MDP knee SPET for pre-arthroscopic evaluation of patients with internal derangements of the knee
    Y So
    Department of Nuclear Medicine, Seoul National University College of Medicine, Korea
    Nucl Med Commun 21:103-9. 2000
    ..We conclude that knee SPET is very useful in the management of internal derangements of the knee, particularly in determining the need for arthroscopy by localizing lesion sites...
  8. ncbi Usefulness of 11C-methionine PET in the evaluation of brain lesions that are hypo- or isometabolic on 18F-FDG PET
    June Key Chung
    Department of Nuclear Medicine, Seoul National University Hospital, Korea
    Eur J Nucl Med Mol Imaging 29:176-82. 2002
    ..11C-methionine PET can provide additional information when used in combination with FDG PET in the evaluation of these patients...
  9. ncbi Visualization of endogenous p53-mediated transcription in vivo using sodium iodide symporter
    Kwang Il Kim
    Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea
    Clin Cancer Res 11:123-8. 2005
    ..To develop a gamma camera imaging method for the determination of endogenous gene expression, we evaluated the expression of endogenous p53 gene using human sodium iodide symporter (hNIS) gene as reporter...
  10. doi Predictive value of FDG PET/CT for pathologic axillary node involvement after neoadjuvant chemotherapy
    Bhumsuk Keam
    Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul, 110 744, Korea
    Breast Cancer 20:167-73. 2013
    ..The purpose of this study was to determine the usefulness of sequential FDG PET/CTs for prediction of axillary lymph node (ALN) status after neoadjuvant chemotherapy (NAC)...
  11. ncbi Feasibility of sodium/iodide symporter gene as a new imaging reporter gene: comparison with HSV1-tk
    Jae Hoon Shin
    Department of Nuclear Medicine, Cancer Research Institute, Seoul National University College of Medicine, Chongno Gu, Seoul, Korea
    Eur J Nucl Med Mol Imaging 31:425-32. 2004
    ..Scintigraphy using (131)I easily visualised CTN and CMN tumours. In conclusion, the NIS gene may be viewed as an imaging reporter gene with comparable performance to the HSV1-tk gene for monitoring target gene expression...
  12. ncbi Establishment of a human hepatocellular carcinoma cell line highly expressing sodium iodide symporter for radionuclide gene therapy
    Joo Hyun Kang
    Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea
    J Nucl Med 45:1571-6. 2004
    ..By targeting NIS expression in SK-Hep1, we could also investigate whether these cells concentrate 99mTc-pertechnetate and 188Re-perrhenate as well as 125I in vitro and in vivo...
  13. ncbi Development of a sodium/iodide symporter (NIS)-transgenic mouse for imaging of cardiomyocyte-specific reporter gene expression
    Joo Hyun Kang
    Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea
    J Nucl Med 46:479-83. 2005
    ..In this study, we developed a sodium/iodide symporter (NIS)-transgenic mouse in which NIS is constitutively expressed as an imaging reporter gene only in cardiomyocytes...
  14. ncbi In vitro and in vivo properties of a human anaplastic thyroid carcinoma cell line transfected with the sodium iodide symporter gene
    Yong Jin Lee
    Department of Nuclear Medicine, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Thyroid 14:889-95. 2004
    ....
  15. doi Synthesis of 68Ga-labeled DOTA-nitroimidazole derivatives and their feasibilities as hypoxia imaging PET tracers
    Lathika Hoigebazar
    Department of Nuclear Medicine, Institute of Radiation Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
    Bioorg Med Chem 19:2176-81. 2011
    ..In an animal PET study, (68)Ga-4 showed higher standard uptake values (SUV) in tumors than (68)Ga-5 in mice xenografted with CT-26 mouse colon cancer cells...
  16. ncbi Consideration of serum glucose levels during malignant mediastinal lymph node detection in non-small-cell lung cancer by FDG-PET
    Won Woo Lee
    Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea
    J Surg Oncol 94:607-13. 2006
    ..Glucose and FDG compete for uptake by cancers. Here, we undertook to improve diagnostic accuracy of FDG-PET for determining mediastinal lymph node (LN) status in NSCLC by considering serum glucose level...
  17. ncbi In vitro and in vivo characteristics of a human colon cancer cell line, SNU-C5N, expressing sodium-iodide symporter
    Jung Jun Min
    Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea
    Nucl Med Biol 29:537-45. 2002
    ..In this study, NIS lipofection is efficient for triggering significant iodide uptake by a nonthyroidal tumor. However, for an increased therapeutic effect, the key issue is iodide retention in the target tissue...
  18. ncbi Noninvasive imaging for monitoring of viable cancer cells using a dual-imaging reporter gene
    Jae Hoon Shin
    Department of Nuclear Medicine, Seoul National University Hospital, Seoul 110 744, Korea
    J Nucl Med 45:2109-15. 2004
    ....
  19. ncbi In vivo monitoring of DNA vaccine gene expression using firefly luciferase as a naked DNA
    Yong Hyun Jeon
    Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea
    Vaccine 24:3057-62. 2006
    ..These findings suggest that optical imaging using Fluc could be useful for monitoring the location, intensity and duration of gene expression of naked DNA vaccines in living animals non-invasively and repetitively...
  20. ncbi An improved method of 18F peptide labeling: hydrazone formation with HYNIC-conjugated c(RGDyK)
    Yun Sang Lee
    Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul 110 744, Korea
    Nucl Med Biol 33:677-83. 2006
    ..We suggest that (18)F labeling via formation of hydrazone between HYNIC peptide and [(18)F]4 is a useful method for labeling c(RGDyK), which can be applied for imaging angiogenesis...
  21. ncbi Lipiodol solution of 188Re-HDD as a new therapeutic agent for transhepatic arterial embolization in liver cancer: preclinical study in a rabbit liver cancer model
    Jin Chul Paeng
    Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea
    J Nucl Med 44:2033-8. 2003
    ..In this study, we compared the tumor retention properties of (188)Re-HDD/lipiodol and (188)Re-TDD/lipiodol, using a rabbit liver cancer model, and performed dosimetry using the results...
  22. ncbi Voxel-based statistical analysis of cerebral glucose metabolism in the rat cortical deafness model by 3D reconstruction of brain from autoradiographic images
    Jae Sung Lee
    Department of Nuclear Medicine, Seoul National University College of Medicine, 28 Yungun Dong, Chongno Ku, Seoul, 110 799, Korea
    Eur J Nucl Med Mol Imaging 32:696-701. 2005
    ....
  23. doi Syntheses of 2-nitroimidazole derivatives conjugated with 1,4,7-triazacyclononane-N,N'-diacetic acid labeled with F-18 using an aluminum complex method for hypoxia imaging
    Lathika Hoigebazar
    Radiation Applied Life Sciences, Department of Nuclear Medicine, Institute of Radiation Medicine, Seoul National University College of Medicine, Seoul 110 744, Korea
    J Med Chem 55:3155-62. 2012
    ..In conclusion, (18)F-labeled NODA-nitroimidazole conjugates were developed and proved to be promising hypoxia PET agents...
  24. ncbi Role of magnetic resonance imaging and positron emission tomography/computed tomography in preoperative lymph node detection of uterine cervical cancer
    Hyun Hoon Chung
    Department of Obstetrics and Gynecology and Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea
    Am J Obstet Gynecol 203:156.e1-5. 2010
    ..The aim of this study was to compare magnetic resonance imaging (MRI) with positron emission tomography/computed tomography (PET/CT) in the preoperative detection of lymph node metastases in patients with uterine cervical cancer...
  25. ncbi Reversing the silencing of reporter sodium/iodide symporter transgene for stem cell tracking
    Yun Hui Kim
    Program in Neuroscience, Seoul National University College of Natural Science, Seoul 110 744, Korea
    J Nucl Med 46:305-11. 2005
    ..Referring to the knowledge about epigenetic modulation, we succeeded in reversing the silencing of sodium/sodide symporter (hNIS) transgenes transfected into human neural stem (HB1.F3) cells...
  26. ncbi Effect of all-trans retinoic acid on sodium/iodide symporter expression, radioiodine uptake and gene expression profiles in a human anaplastic thyroid carcinoma cell line
    Hwanjeong Jeong
    Department of Nuclear Medicine, College of Medicine, Wonkwang University, Iksan, Jellabuk do 570 711, South Korea
    Nucl Med Biol 33:875-82. 2006
    ..Therefore, tRA treatment and NIS gene transfection are potential tools for the diagnosis and treatment of thyroid cancer...
  27. doi Human sodium/iodide symporter-mediated radioiodine gene therapy enhances the killing activities of CTLs in a mouse tumor model
    Yong Hyun Jeon
    Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea
    Mol Cancer Ther 9:126-33. 2010
    ..01). Our findings suggest that hNIS radioiodine gene therapy can generate tumor-associated immunity in tumor microenvironments and enhance the killing activities of CTLs...
  28. ncbi Immune response to firefly luciferase as a naked DNA
    Yong Hyun Jeon
    Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea
    Cancer Biol Ther 6:781-6. 2007
    ..We suggest that immune response to the Fluc gene is cautionary in preclinical or clinical trials involving the Fluc gene, and that the immunologic potential of firefly luciferase as a naked DNA may be useful in cancer immunotherapy...
  29. ncbi Differential features of metabolic abnormalities between medial and lateral temporal lobe epilepsy: quantitative analysis of (18)F-FDG PET using SPM
    Yu Kyeong Kim
    Department of Nuclear Medicine, Seoul National University, College of Medicine, Seoul, Korea
    J Nucl Med 44:1006-12. 2003
    ..We tried to find the differential features in metabolic abnormalities between medial and lateral TLE groups using quantitative analysis including statistical parametric mapping (SPM)...
  30. ncbi Doxorubicin enhances the expression of transgene under control of the CMV promoter in anaplastic thyroid carcinoma cells
    Kwang Il Kim
    Department of Nuclear Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Jongno gu, Seoul 110 744, Korea
    J Nucl Med 48:1553-61. 2007
    ..We investigated the effect of doxorubicin on transgene expression and evaluated the mechanism of enhanced transgene expression by doxorubicin in transfected human anaplastic thyroid cancer cells (ARO cells)...
  31. ncbi Human sodium iodide symporter gene adjunctive radiotherapy to enhance the preventive effect of hMUC1 DNA vaccine
    Yong Hyun Jeon
    Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea
    Int J Cancer 121:1593-9. 2007
    ..This study shows that the weak preventive effects of cancer DNA vaccine can be overcome by radioiodine gene therapy utilizing sodium iodide symporter...
  32. ncbi The clinical impact of 18F-FDG PET in papillary thyroid carcinoma with a negative 131I whole body scan: a single-center study of 108 patients
    Mi Yeon Choi
    Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea
    Ann Nucl Med 20:547-52. 2006
    ..To assess whether FDG PET could localize the recurrent or metastatic lesions in papillary thyroid cancer patients with negative radioiodine scan...
  33. ncbi 11C-methionine PET as a prognostic marker in patients with glioma: comparison with 18F-FDG PET
    Sungeun Kim
    Department of Nuclear Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul, 110 744, Korea
    Eur J Nucl Med Mol Imaging 32:52-9. 2005
    ..The purpose of this study was to compare the prognostic value of 11C-methionine (MET) and 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) in glioma patients...
  34. ncbi 99mTc-neolactosylated human serum albumin for imaging the hepatic asialoglycoprotein receptor
    Jae Min Jeong
    Department of Nuclear Medicine, Seoul National University College of Medicine, Korea
    Bioconjug Chem 15:850-5. 2004
    ....
  35. doi Development of a ¹⁷⁷Lu-labeled RGD derivative for targeting angiogenesis
    Chang Hwan Ju
    Department of Nuclear Medicine, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Cancer Biother Radiopharm 25:687-91. 2010
    ..29) and tumor-to-muscle (2.06 ± 0.40) ratios were observed. This study shows that ¹⁷⁷Lu-NOTA-SCN-c(RGDyK) is a potential therapeutic agent for angiogenic tumors, but special care is required to prevent kidney toxicity...
  36. doi Synthesis and characterization of nitroimidazole derivatives for 68Ga-labeling and testing in tumor xenografted mice
    Lathika Hoigebazar
    Department of Nuclear Medicine, Radiation Applied Life Sciences, Institute of Radiation Medicine, Seoul National University College of Medicine, 101 Daehangno, Jongno gu, Seoul 110 744, Korea
    J Med Chem 53:6378-85. 2010
    ..Also, (68)Ga-NOTA-NI showed higher tumor uptake than (68)Ga-NOTA-SCN-NI in an animal PET study. In conclusion, we successfully developed (68)Ga labeled NI derivatives for hypoxic tissue imaging...
  37. ncbi Noninvasive in vivo monitoring of neuronal differentiation using reporter driven by a neuronal promoter
    Do Won Hwang
    Programs in Neuroscience, Seoul National University, Seoul, South Korea
    Eur J Nucl Med Mol Imaging 35:135-45. 2008
    ..We imaged neuronal differentiation in vivo using dual reporters (sodium iodide symporter [NIS] and luciferase) coupled to a neuron-specific enolase (NSE) promoter...
  38. ncbi Preparation of 18F-human serum albumin: a simple and efficient protein labeling method with 18F using a hydrazone-formation method
    Young Soo Chang
    Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea
    Bioconjug Chem 16:1329-33. 2005
    ..We concluded that 18F-HSA was successfully labeled using a novel method which involves hydrazone formation between [18F]FBA and HYNIC-HSA. This method can be applied to the 18F-labeling of other proteins or peptides...
  39. ncbi Development of a dual membrane protein reporter system using sodium iodide symporter and mutant dopamine D2 receptor transgenes
    Do Won Hwang
    Programs in Neuroscience, Seoul National University, Seoul, Korea
    J Nucl Med 48:588-95. 2007
    ..Human sodium iodide symporter (hNIS) and mutant dopamine D(2) receptor (D(2)R) transgenes were chosen considering their complementarity...
  40. ncbi Preparation of (188) Re-labeled paper for treating skin cancer
    Jae Min Jeong
    Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, South Korea
    Appl Radiat Isot 58:551-5. 2003
    ..Tumors disappeared 7 days after irradiation in all the groups irradiated by 50 or 100 Gy. The (188) Re-labeled paper provided a convenient, economical, effective, and non-invasive method of treating skin cancer...
  41. doi 18F-FDG PET in the assessment of tumor grade and prediction of tumor recurrence in intracranial meningioma
    Jeong Won Lee
    Department of Nuclear Medicine, Seoul National University College of Medicine, 28 Yeongeon dong, Jongno gu, Seoul, 110 744, Korea
    Eur J Nucl Med Mol Imaging 36:1574-82. 2009
    ..The purpose of this study was to investigate the role of (18)F-fluorodeoxyglucose (FDG) PET in detecting high-grade meningioma and predicting the recurrence in patients with meningioma after surgical resection...
  42. ncbi MIDGE/hNIS vaccination generates antigen-associated CD8+IFN-gamma+ T cells and enhances protective antitumor immunity
    Yun Choi
    Department of Pathology, Seoul National University College of Medicine, Seoul, Korea
    Int J Cancer 120:1942-50. 2007
    ..Overall, hNIS has a potential use as an antigen for immunization approaches, and vaccination with MIDGE/hNIS vectors is an effective means of generating hNIS-associated immune responses in mice...
  43. doi Visualization of hypoxia-inducible factor-1 transcriptional activation in C6 glioma using luciferase and sodium iodide symporter genes
    Chan Joo Yeom
    Department of Nuclear Medicine, Tumor Immunity Medical Research Center, Laboratory of Molecular Imaging and Therapy of Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
    J Nucl Med 49:1489-97. 2008
    ..We assessed whether the human sodium iodide symporter (NIS) reporter systems can be used to visualize transcriptional activation of HIF-1 in C6 glioma...
  44. ncbi Clinical impact of integrated PET/CT on the management of suspected cervical cancer recurrence
    Hyun Hoon Chung
    Department of Obstetrics and Gynecology, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 744, South Korea
    Gynecol Oncol 104:529-34. 2007
    ..To assess the value and clinical impact of integrated PET/CT using (18)F-FDG in the diagnosis and management of women with suspected cervical cancer recurrence...
  45. ncbi Role of [18F]FDG PET/CT in the assessment of suspected recurrent ovarian cancer: correlation with clinical or histological findings
    Hyun Hoon Chung
    Department of Obstetrics and Gynecology, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul, 110 744, South Korea
    Eur J Nucl Med Mol Imaging 34:480-6. 2007
    ....
  46. ncbi Consideration of perfusion reserve in viability assessment by myocardial Tl-201 rest-redistribution SPECT: a quantitative study with dual-isotope SPECT
    Jin Chul Paeng
    Department of Nuclear Medicine, Seoul National University College of Medicine, Yongun dong, Seoul, Korea
    J Nucl Cardiol 9:68-74. 2002
    ....
  47. ncbi Probabilistic map of blood flow distribution in the brain from the internal carotid artery
    Jae Sung Lee
    Department of Nuclear Medicine, Seoul National University, College of Medicine, Seoul 110 744, Korea
    Neuroimage 23:1422-31. 2004
    ..The probabilistic maps developed in this study illustrate the perfusion distribution and extent of vascular territory for ICA and would be useful for objective evaluations of perfusion status in cerebrovascular disease...
  48. ncbi Novel one-pot one-step synthesis of 2'-[(18)F]fluoroflumazenil (FFMZ) for benzodiazepine receptor imaging
    Young Hyun Yoon
    Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, South Korea
    Nucl Med Biol 30:521-7. 2003
    ..Specific binding of [(18)F]FFMZ to central benzodiazepine receptor of rats was demonstrated by phosphoimaging...
  49. ncbi Dosimetry in leakage of (188)Re-DTPA during intracoronary balloon brachytherapy
    Jin Chul Paeng
    Department of Nuclear Medicine, Seoul National University College of Medicine, Jongno gu, Seoul, Korea
    Eur J Nucl Med Mol Imaging 30:1263-5. 2003
    ..The radiation exposures to other vital organs were also within the tolerated ranges. We conclude that (188)Re-DTPA has better clinical feasibility and safety for intracoronary balloon brachytherapy than (188)Re-perrhenate...
  50. ncbi Development of 99mTc-neomannosyl human serum albumin (99mTc-MSA) as a novel receptor binding agent for sentinel lymph node imaging
    Jae Min Jeong
    Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, South Korea
    Nucl Med Commun 25:1211-7. 2004
    ..In order to simplify the synthesis and labelling procedure and to improve the biological properties, we developed a novel mannose receptor-binding agent, 99mTc-neomannosyl human serum albumin (99mTc-MSA), for SLN imaging...
  51. doi Development of a bifunctional chelating agent containing isothiocyanate residue for one step F-18 labeling of peptides and application for RGD labeling
    Dinesh Shetty
    Department of Nuclear Medicine, Department of Radiation Applied Life Science and Institute of Radiation Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
    Bioorg Med Chem 20:5941-7. 2012
    ..In general, successful application of synthesized ligand for labeling of RGD peptide could facilitate the possibility of using this ligand for labeling peptides containing an amino functional group...
  52. ncbi In vivo scintigraphic imaging of antitumor effects by combined radioiodine therapy and human sodium iodide symporter gene immunotherapy
    Yun Choi
    Departments of Pathology, Tumor Biology, and Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea
    Mol Imaging 9:141-52. 2010
    ..These findings provide a novel and effective means of treating cancer...
  53. doi Wild-type p53 enhances the cytotoxic effect of radionuclide gene therapy using sodium iodide symporter in a murine anaplastic thyroid cancer model
    Yong Jin Lee
    Department of Nuclear Medicine, Seoul National University College of Medicine, 28 Yungun Dong, Chongno Gu, Seoul, 110 744, Korea
    Eur J Nucl Med Mol Imaging 37:235-41. 2010
    ..To evaluate the role of p53 in radionuclide gene therapy, we investigated the cytotoxic effect of (131)I and (188)Re following cotransfection of the sodium iodide symporter (NIS) and wild-type p53 (wt-p53) genes into cancer cells...
  54. ncbi 18F-FDG PET/CT in mediastinal lymph node staging of non-small-cell lung cancer in a tuberculosis-endemic country: consideration of lymph node calcification and distribution pattern to improve specificity
    Jeong Won Lee
    Department of Nuclear Medicine, College of Medicine, Seoul National University, Seoul, Korea
    Eur J Nucl Med Mol Imaging 36:1794-802. 2009
    ..The aim of the study was to assess the accuracy of (18)F-fluorodeoxyglucose (FDG) PET/CT in mediastinal lymph node staging of patients with non-small-cell lung cancer (NSCLC) in a region with a high prevalence of granulomatous disease...
  55. doi Development of 68Ga-labeled mannosylated human serum albumin (MSA) as a lymph node imaging agent for positron emission tomography
    Jae Yeon Choi
    Department of Nuclear Medicine, Institute of Radiation Medicine, Seoul National University College of Medicine, Seoul, South Korea
    Nucl Med Biol 38:371-9. 2011
    ..Here, we describe the development of a novel positron-emitting SLN imaging agent labeled with (68)Ga...
  56. ncbi In vivo bioluminescence visualization of antitumor effects by human MUC1 vaccination
    Yong Hyun Jeon
    Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea
    Mol Imaging 6:297-303. 2007
    ..We conclude that optical bioluminescent imaging offers a useful means of monitoring the antitumor effects of cancer DNA immunization in living animals...
  57. ncbi [18F]FDG PET as a substitute for second-look laparotomy in patients with advanced ovarian carcinoma
    Sungeun Kim
    Department of Nuclear Medicine, Seoul National University Hospital, Chongno Gu, Seoul, Korea
    Eur J Nucl Med Mol Imaging 31:196-201. 2004
    ..6 +/- 12.1 months (P = 0.12). In conclusion, FDG PET has a similar prognostic value to SLL, and can substitute for SLL in the follow-up of patients who have had ovarian carcinoma, especially when there is a high risk for recurrence...
  58. ncbi Characterization of surgically transposed ovaries in integrated PET/CT scan in patients with cervical cancer
    Hyun Hoon Chung
    Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, South Korea
    Acta Obstet Gynecol Scand 86:88-93. 2007
    ..The purpose of this study was to determine the ovarian findings on integrated positron emission tomography/computed tomography scans during follow-up in cervical cancer patients with ovarian transposition...
  59. ncbi Identification of angiogenesis in primary breast carcinoma according to the image analysis
    Sung Won Kim
    Department of Surgery, College of Medicine, Seoul National University, Chongno Gu, Korea
    Breast Cancer Res Treat 74:121-9. 2002
    ..Tc-99m MIBI scintimammography needs further study to use it as an image analysis for angiogenesis...
  60. ncbi Correlation between serum CEA level and metabolic volume as determined by FDG PET in postoperative patients with recurrent colorectal cancer
    Mi Yeon Choi
    Department of Nuclear Medicine, Seoul National University, College of Medicine, Seoul, Korea
    Ann Nucl Med 19:123-9. 2005
    ..Tumor volume determined by FDG PET can be used as an effective marker of tumor burden in postoperative patients with colorectal carcinoma...
  61. ncbi FDG uptake, glucose transporter type 1, and Ki-67 expressions in non-small-cell lung cancer: correlations and prognostic values
    Xuan Canh Nguyen
    Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
    Eur J Radiol 62:214-9. 2007
    ..Here, we compared the prognostic significances of FDG uptake, and of Glut-1 and Ki-67 expressions in patients with NSCLC...
  62. ncbi Usefulness of whole-body (18)F-FDG PET in patients with suspected metastatic brain tumors
    Hwan Jeong Jeong
    Department of Nuclear Medicine, Seoul National University College of Medicine, Korea
    J Nucl Med 43:1432-7. 2002
    ....
  63. ncbi Diagnostic performance of 18F-FDG PET and ictal 99mTc-HMPAO SPET in pediatric temporal lobe epilepsy: quantitative analysis by statistical parametric mapping, statistical probabilistic anatomical map, and subtraction ictal SPET
    Jong Jin Lee
    Department of Nuclear Medicine, Seoul National University College of Medicine, 28 Yeongeon dong, Jongno gu, Seoul 110 744, South Korea
    Seizure 14:213-20. 2005
    ..SPM analysis of PET or ictal SPET could be used as an aid to visual assessment. Moreover, SISCOM was equal visual assessment of ictal SPET images in terms of lesion localizations...
  64. doi Prognostic value of preoperative metabolic tumor volume and total lesion glycolysis in patients with epithelial ovarian cancer
    Hyun Hoon Chung
    Department of Obstetrics and Gynecology, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea
    Ann Surg Oncol 19:1966-72. 2012
    ..The purpose of this study was to investigate the relationship between functional tumor parameters (MTV and TLG) and clinical outcomes in patients with epithelial ovarian cancer (EOC)...
  65. ncbi Nanoparticles modified by encapsulation of ligands with a long alkyl chain to affect multispecific and multimodal imaging
    Young Kyoung Lee
    Department of Nuclear Medicine, Institute of Radiation Medicine, Seoul National University College of Medicine, Seoul, South Korea
    J Nucl Med 53:1462-70. 2012
    ..Thus, we developed a method for modifying nanoparticles by encapsulation with specific ligand-conjugated amphiphiles...
  66. ncbi Stable aluminium fluoride chelates with triazacyclononane derivatives proved by X-ray crystallography and 18F-labeling study
    Dinesh Shetty
    Department of Nuclear Medicine, Institute of Radiation Medicine, Seoul National University College of Medicine, Seoul, Korea
    Chem Commun (Camb) 47:9732-4. 2011
    ..Series of ligands with an extra carboxylic acid linker for biomolecule conjugation were studied for improved (18)F-labeling applications...
  67. doi Synthesis and evaluation of macrocyclic amino acid derivatives for tumor imaging by gallium-68 positron emission tomography
    Dinesh Shetty
    Department of Nuclear Medicine, Institute of Radiation Medicine, Seoul National University College of Medicine, South Korea
    Bioorg Med Chem 18:7338-47. 2010
    ..These results might motivate the use of (68)Ga amino acid PET for tumor diagnosis...
  68. doi Cancer screening using 18F-FDG PET/CT in Korean asymptomatic volunteers: a preliminary report
    Jeong Won Lee
    Department of Nuclear Medicine, Seoul National University College of Medicine, Jongno gu, Seoul 110 744, Korea
    Ann Nucl Med 23:685-91. 2009
    ..This study was performed to evaluate the clinical value of (18)F-fluorodeoxyglucose (FDG) positron-emission tomography (PET)/computed tomography (CT) for cancer screening in Korean asymptomatic people...
  69. doi Tumor-targeted radionuclide imaging and therapy based on human sodium iodide symporter gene driven by a modified telomerase reverse transcriptase promoter
    Seung Hoo Kim
    Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul 110 744, South Korea
    Hum Gene Ther 19:951-7. 2008
    ..hTERT-positive tumors were successfully targeted by the NIS gene under the control of the 5mmTERT promoter. The described system could be useful for targeted molecular imaging and as a radioiodine gene therapy for cancer...
  70. doi In vivo imaging of sentinel nodes using fluorescent silica nanoparticles in living mice
    Yong Hyun Jeon
    Department of Nuclear Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Jongno gu, Seoul, South Korea
    Mol Imaging Biol 12:155-62. 2010
    ..We examine the feasibility of fluorescent imaging system for sentinel lymph node detection by using functionalized silica nanoparticles...
  71. doi Combined therapy with 131I and retinoic acid in Korean patients with radioiodine-refractory papillary thyroid cancer
    So Won Oh
    Department of Nuclear Medicine, Seoul National University College of Medicine, 101 Daehang ro, Jongno gu, Seoul, 110 744, Republic of Korea
    Eur J Nucl Med Mol Imaging 38:1798-805. 2011
    ....
  72. doi Evaluation of surgical completeness in endoscopic thyroidectomy compared with open thyroidectomy with regard to remnant ablation
    Hyung Jun Im
    Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea
    Clin Nucl Med 37:148-51. 2012
    ..To assure the surgical completeness of the bilateral axillo-breast approach (BABA) endoscopic thyroidectomy (ET), we compared ET and open thyroidectomy (OT) by means of the radioactive iodine (RAI) uptake of remnant thyroid...
  73. doi Comparison of FDG-PET findings of brain metastasis from non-small-cell lung cancer and small-cell lung cancer
    Ho Young Lee
    Department of Nuclear Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul, Korea
    Ann Nucl Med 22:281-6. 2008
    ..We compared the F-18 fluorodeoxyglucose positron emission tomography (FDG-PET) findings of brain metastasis between patients with non-small-cell lung cancer (NSCLC) and small cell lung cancer (SCLC)...
  74. doi The clinical impact of [(18)F]FDG PET/CT for the management of recurrent endometrial cancer: correlation with clinical and histological findings
    Hyun Hoon Chung
    Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Chongno Gu, Seoul, 110 744, South Korea
    Eur J Nucl Med Mol Imaging 35:1081-8. 2008
    ..The purpose of this study was to evaluate the accuracy of integrated positron emission tomography (PET) and computed tomography (CT) for the identification of suspected recurrent endometrial cancer after treatment...
  75. doi Prognostic value of metabolic tumor volume measured by FDG-PET/CT in patients with cervical cancer
    Hyun Hoon Chung
    Department of Obstetrics and Gynecology, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea
    Gynecol Oncol 120:270-4. 2011
    ....
  76. doi Synthesis of novel 68Ga-labeled amino acid derivatives for positron emission tomography of cancer cells
    Dinesh Shetty
    Department of Nuclear Medicine, Institute of Radiation Medicine, Seoul National University College of Medicine, Seoul 110 744, South Korea
    Nucl Med Biol 37:893-902. 2010
    ....
  77. doi Tumor targeting and imaging using cyclic RGD-PEGylated gold nanoparticle probes with directly conjugated iodine-125
    Young Hwa Kim
    Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul 110 744, South Korea
    Small 7:2052-60. 2011
    ..These promising results show that radioactive-iodine-labeled gold nanoprobes have potential for highly specific and sensitive tumor imaging or for use as angiogenesis-targeted SPECT/CT imaging probes...
  78. doi Radioiodine gene therapy of hepatocellular carcinoma targeted human alpha fetoprotein
    Yong Nan Jin
    Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea
    Cancer Biother Radiopharm 23:551-60. 2008
    ..We conducted a molecular imaging and gene therapy method in alpha-fetoprotein (AFP)-producing hepatocellular carcinoma (HCC) by tumor-specific expression of the human sodium/iodide symporter (hNIS) using an AFP promoter...
  79. doi Metabolic and metastatic characteristics of ALK-rearranged lung adenocarcinoma on FDG PET/CT
    Hongyoon Choi
    Department of Nuclear Medicine, Seoul National University Hospital, Seoul, Republic of Korea
    Lung Cancer 79:242-7. 2013
    ..In this study, we evaluated metabolic and metastatic features of lung adenocarcinoma by using FDG PET/CT, with regard to specific genotypes of ALK and EGFR mutation...
  80. doi Thyroglobulin in washout fluid from lymph node fine-needle aspiration biopsy in papillary thyroid cancer: large-scale validation of the cutoff value to determine malignancy and evaluation of discrepant results
    Jae Hoon Moon
    Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul, Korea
    J Clin Endocrinol Metab 98:1061-8. 2013
    ....
  81. doi Total lesion glycolysis in positron emission tomography is a better predictor of outcome than the International Prognostic Index for patients with diffuse large B cell lymphoma
    Tae Min Kim
    Department of Internal Medicine, Seoul National University Hospital, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Cancer 119:1195-202. 2013
    ..This study was undertaken to evaluate the prognostic value of quantitative metabolic parameters in [(18) F]2-fluoro-2-deoxyglucose (FDG)-positron emission tomography (PET) for diffuse large B cell lymphoma (DLBCL)...
  82. doi In vivo bioluminescent imaging of α-fetoprotein-producing hepatocellular carcinoma in the diethylnitrosamine-treated mouse using recombinant adenoviral vector
    Kwang Il Kim
    Molecular Imaging Research Center, Korea Institute of Radiological and Medical Sciences, Seoul, Korea
    J Gene Med 14:513-20. 2012
    ..The present study aimed to visualize spontaneously developing α-fetoprotein (AFP)-producing HCC through targeted gene expression in tumors using recombinant adenoviral vector...
  83. doi Molecular-genetic imaging based on reporter gene expression
    Joo Hyun Kang
    Department of Nuclear Medicine, Cancer Research Institute, Tumor Immunity Medical Research Center, College of Medicine, Seoul National University, Seoul, Korea
    J Nucl Med 49:164S-79S. 2008
    ....
  84. doi The assessment of breast cancer response to neoadjuvant chemotherapy: comparison of magnetic resonance imaging and 18F-fluorodeoxyglucose positron emission tomography
    Jeong Seon Park
    Department of Radiology, College of Medicine Seoul National University and The Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul, Korea
    Acta Radiol 52:21-8. 2011
    ..For assessment of the tumor response after chemotherapy, both magnetic resonance imaging (MRI) and (18)F-fluorodeoxyglucose positron emission tomography (PET) are promising methods...
  85. doi Development of a dual-luciferase reporter system for in vivo visualization of MicroRNA biogenesis and posttranscriptional regulation
    Ji Young Lee
    Interdisciplinary Program in Brain Science, Seoul National University, Seoul, Korea
    J Nucl Med 49:285-94. 2008
    ..Here, we developed a dual-luciferase reporter system for monitoring in vivo endogenous transcription of primary miRNA (pri-miRNA) and also the mature miRNA activity simultaneously...
  86. doi Preoperative [18F]FDG PET/CT maximum standardized uptake value predicts recurrence of uterine cervical cancer
    Hyun Hoon Chung
    Department of Obstetrics and Gynecology, Cancer Research Institute, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 744, Republic of Korea
    Eur J Nucl Med Mol Imaging 37:1467-73. 2010
    ..To determine if preoperative [(18)F]FDG-PET/CT imaging has prognostic significance in patients with uterine cervical cancer...
  87. ncbi Differential receptor targeting of liver cells using 99mTc-neoglycosylated human serum albumins
    Sungeun Kim
    Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul 110 744, Korea
    Arch Pharm Res 31:60-6. 2008
    ....
  88. ncbi Cationic complex: (99m)Tc-N,N'-dimethyldiaminedithiol
    Jae Min Jeong
    Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, South Korea
    Nucl Med Biol 29:711-7. 2002
    ..Increased heart-uptake in mice suggests that this compound or its derivatives can be used as a myocardial-imaging agent...
  89. ncbi Site-specific 99mTc-labeling of antibody using dihydrazinophthalazine (DHZ) conjugation to Fc region of heavy chain
    Jae Min Jeong
    Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul 110 744, Korea
    Arch Pharm Res 27:961-7. 2004
    ..Moreover, 99mTc labeled antibody via DHZ was found to have excellent chemical and biological properties for nuclear medicine imaging...
  90. doi Post-treatment [¹⁸F]FDG maximum standardized uptake value as a prognostic marker of recurrence in endometrial carcinoma
    Hyun Hoon Chung
    Department of Obstetrics and Gynecology, Cancer Research Institute, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul, 110 744, Republic of Korea
    Eur J Nucl Med Mol Imaging 38:74-80. 2011
    ....
  91. doi Predictive role of post-treatment [18F]FDG PET/CT in patients with uterine cervical cancer
    Hyun Hoon Chung
    Department of Obstetrics and Gynecology, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 744, Republic of Korea
    Eur J Radiol 81:e817-22. 2012
    ....
  92. doi Imaging sensitivity of dedicated positron emission mammography in relation to tumor size
    Jae Seon Eo
    Department of Nuclear Medicine, Seoul National University College of Medicine, Republic of Korea
    Breast 21:66-71. 2012
    ..In conclusion, PEM had higher imaging sensitivity than PET/CT, particularly in small tumors. The results suggest that PEM may be used for diagnosis and characterization of small lesions as a supplementary imaging modality for PET/CT...
  93. pmc Early metabolic response using FDG PET/CT and molecular phenotypes of breast cancer treated with neoadjuvant chemotherapy
    Bhumsuk Keam
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    BMC Cancer 11:452. 2011
    ....
  94. ncbi Comparison of the cost-effectiveness of stress myocardial SPECT and stress echocardiography in suspected coronary artery disease considering the prognostic value of false-negative results
    Dong Soo Lee
    Department of Nuclear Medicine, Seoul National University College of Medicine, Korea
    J Nucl Cardiol 9:515-22. 2002
    ....
  95. ncbi Criteria for definition of regional functional improvement on quantitative post-stress gated myocardial SPET after bypass surgery in patients with ischaemic cardiomyopathy
    Dong Soo Lee
    Department of Nuclear Medicine, Seoul National University College of Medicine, 110 744, Chongno Gu, Yongun dong 28, Seoul, Korea
    Eur J Nucl Med Mol Imaging 29:1078-82. 2002
    ..The most reliable regional criterion of myocardial viability was improvement in regional wall thickening by > or = 15% on quantitative gated SPET...
  96. ncbi Altered gene expression profiles by sodium/iodide symporter gene transfection in a human anaplastic thyroid carcinoma cell line using a radioactive complementary DNA microarray
    Jae Gol Choe
    Department of Nuclear Medicine, Korea University Medical School, Seoul, South Korea
    Nucl Med Commun 26:1155-62. 2005
    ..NIS gene transfection, a gene-therapy modality, has been introduced in many types of cancer, such as prostate cancer and breast cancer, and has demonstrated a high potential for the treatment of non-thyroidal cancers...
  97. ncbi Development of acetylated HDD kit for preparation of 188Re-HDD/lipiodol
    Yun Sang Lee
    Department of Nuclear Medicine and Institute of Radiation Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Jongno gu, Seoul 110 744, Korea
    Appl Radiat Isot 65:64-9. 2007
    ..We found that AHDD kit can replace HDD kit due to an increased stability for formulation, the better radiolabeling efficiency (78%) and the equivalent biodistribution pattern in mice...
  98. doi Formulation of 68Ga BAPEN kit for myocardial positron emission tomography imaging and biodistribution study
    Bo Yeun Yang
    Department of Nuclear Medicine, Institute of Radiation Medicine, Seoul National University College of Medicine, 110 744 Seoul, South Korea
    Nucl Med Biol 37:149-55. 2010
    ..However, its labeling requires complicated and time-consuming procedures. In this study, the authors formulated a new BAPEN kit for convenient (68)Ga labeling...
  99. doi Papillary microcarcinoma in comparison with larger papillary thyroid carcinoma in BRAF(V600E) mutation, clinicopathological features, and immunohistochemical findings
    Young Joo Park
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Head Neck 32:38-45. 2010
    ..Papillary thyroid microcarcinoma (PMC; <or=1 cm) is thought to take a benign course during the lifetime. However, recent studies showed high recurrence rates for PMC...
  100. doi Use of granulocyte colony-stimulating factor for fluorine-18-fluorodeoxyglucose labeling in human leukocytes
    Seung Hwan Moon
    Department of Nuclear Medicine, Seoul National University College of Medicine, Korea
    Nucl Med Commun 32:186-91. 2011
    ..This study was conducted to evaluate the feasibility of using granulocyte colony-stimulating factor (G-CSF) to improve ¹⁸F-FDG labeling in human leukocytes...
  101. doi Synergistic tumoricidal effect of combined hMUC1 vaccination and hNIS radioiodine gene therapy
    Yong Hyun Jeon
    Department of Nuclear Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 744, Korea
    Mol Cancer Ther 7:2252-60. 2008
    ..Our data suggest that phMUC1 + (131)I combination therapy synergistically generates marked tumoricidal effects against established hMUC1-expressing cancers...