Affiliation: Seoul National University
Hwang S, Bang S, Kang K, Kang D, Chung J. ULK1 negatively regulates Wnt signaling by phosphorylating Dishevelled. Biochem Biophys Res Commun. 2019;508:308-313 pubmed publisher
..Based on these results, we propose that ULK1 plays a pivotal role in the regulation of Wnt/β-catenin signaling pathway by phosphorylating Dsh. ..
Kim W, Kim H, Jung Y, Kim J, Chung J. Drosophila Low Temperature Viability Protein 1 (LTV1) Is Required for Ribosome Biogenesis and Cell Growth Downstream of Drosophila Myc (dMyc). J Biol Chem. 2015;290:13591-604 pubmed publisher
..Importantly, the loss of LTV1 blocked the cell growth and endoreplication induced by dMyc. Combined, these results suggest that LTV1 is a key downstream factor of dMyc-induced cell growth by properly maintaining ribosome biogenesis. ..
Kim H, Yang J, Kim M, Choi S, Chung J, Kim J, et al
. Tumor Necrosis Factor Receptor-associated Protein 1 (TRAP1) Mutation and TRAP1 Inhibitor Gamitrinib-triphenylphosphonium (G-TPP) Induce a Forkhead Box O (FOXO)-dependent Cell Protective Signal from Mitochondria. J Biol Chem. 2016;291:1841-53 pubmed publisher
..These results strongly suggest that inhibition of the mitochondrial chaperone TRAP1 generates a retrograde cell protective signal from mitochondria to the nucleus in a FOXO-dependent manner. ..
Ham S, Lee S, Song S, Chung J, Choi S, Chung J. Interaction between RING1 (R1) and the Ubiquitin-like (UBL) Domains Is Critical for the Regulation of Parkin Activity. J Biol Chem. 2016;291:1803-16 pubmed publisher
Min S, Chae H, Jang Y, Choi S, Lee S, Jeong Y, et al
. Identification of a Peptidergic Pathway Critical to Satiety Responses in Drosophila. Curr Biol. 2016;26:814-20 pubmed publisher
..Together, our results reveal a novel anorexigenic pathway that controls satiety in Drosophila and provide a new avenue to study how the brain actively maintains a constant BW. ..
Bae J, Bang S, Min S, Lee S, Kwon S, Lee Y, et al
. Positive geotactic behaviors induced by geomagnetic field in Drosophila. Mol Brain. 2016;9:55 pubmed publisher
..These findings provide a novel concept with the neurogenetic basis on the regulation of vertical movement by GMF in the flying animals. ..
Choi S, Quan X, Bang S, Yoo H, Kim J, Park J, et al
. Mitochondrial calcium uniporter in Drosophila transfers calcium between the endoplasmic reticulum and mitochondria in oxidative stress-induced cell death. J Biol Chem. 2017;292:14473-14485 pubmed publisher
..Taken together, these results support the idea that Drosophila MCU is responsible for endoplasmic reticulum-to-mitochondrial calcium transfer and for cell death due to mitochondrial dysfunction under oxidative stress. ..
Kim W, Jang Y, Yang J, Chung J. Spatial Activation of TORC1 Is Regulated by Hedgehog and E2F1 Signaling in the Drosophila Eye. Dev Cell. 2017;42:363-375.e4 pubmed publisher
..Based on this evolutionarily conserved regulation of TORC1 by Hh signaling, we propose that Hh-dependent developmental signaling pathways spatially regulate TORC1 activity in multicellular organisms. ..
Min S, Yoon W, Cho H, Chung J. Misato underlies visceral myopathy in Drosophila. Sci Rep. 2017;7:17700 pubmed publisher
..Taken together, we propose the impairment of actomyosin structures induced by mst depletion in the visceral muscle as a pathogenic mechanism for VM. ..