Sang Ho Choi
Affiliation: Seoul National University
Lee Z, Kim B, Jang K, Bang Y, Kim S, Ha N, et al
. Small-molecule inhibitor of HlyU attenuates virulence of Vibrio species. Sci Rep. 2019;9:4346 pubmed publisher
..Together, this molecule could be an anti-virulence agent against HlyU-harboring Vibrio species with a low selective pressure for the emergence of resistance. ..
Lim J, Bang Y, Choi S. Characterization of the Vibrio vulnificus 1-Cys peroxiredoxin Prx3 and regulation of its expression by the Fe-S cluster regulator IscR in response to oxidative stress and iron starvation. J Biol Chem. 2014;289:36263-74 pubmed publisher
..vulnificus during pathogenesis. ..
Jang K, Gil S, Lim J, Choi S. Regulatory Characteristics of Vibrio vulnificus gbpA Gene Encoding a Mucin-binding Protein Essential for Pathogenesis. J Biol Chem. 2016;291:5774-87 pubmed publisher
..Consequently, the combined results indicated that IscR, CRP, and SmcR cooperate for precise regulation of gbpA during the V. vulnificus pathogenesis. ..
Bang Y, Lee Z, Kim D, Jo I, Ha N, Choi S. OxyR2 Functions as a Three-state Redox Switch to Tightly Regulate Production of Prx2, a Peroxiredoxin of Vibrio vulnificus. J Biol Chem. 2016;291:16038-47 pubmed publisher
..We further provide evidence that another OxyR homolog, OxyR1, displays similar three-state behavior, inviting further exploration of this phenomenon as a potentially general regulatory mechanism. ..
Park J, Lee B, Jo Y, Choi S. Role of extracellular matrix protein CabA in resistance of Vibrio vulnificus biofilms to decontamination strategies. Int J Food Microbiol. 2016;236:123-9 pubmed publisher
..vulnificus biofilms possibly by forming filaments in the matrix and thus rendering the biofilms robust, suggesting that CabA could be a target to control V. vulnificus biofilms on oyster. ..
Jo I, Kim D, Bang Y, Ahn J, Choi S, Ha N. The hydrogen peroxide hypersensitivity of OxyR2 in Vibrio vulnificus depends on conformational constraints. J Biol Chem. 2017;292:7223-7232 pubmed publisher
Jang K, Lee Z, Kim B, Jung Y, Han H, Kim M, et al
. Identification and characterization of Vibrio vulnificus plpA encoding a phospholipase A2 essential for pathogenesis. J Biol Chem. 2017;292:17129-17143 pubmed publisher
..Taken together, this study demonstrated that VvPlpA is a type II secretion system-dependent secretory phospholipase A2 regulated by HlyU and CRP and is essential for the pathogenicity of V. vulnificus. ..