Sung Hee Baek

Summary

Affiliation: Seoul National University
Country: Korea

Publications

  1. Pyo K, Kim C, Lee M, Kim J, Kim K, Baek S. ULK1 O-GlcNAcylation Is Crucial for Activating VPS34 via ATG14L during Autophagy Initiation. Cell Rep. 2018;25:2878-2890.e4 pubmed publisher
    ..Our findings provide insights into the crosstalk between dephosphorylation and O-GlcNAcylation during autophagy and specify a molecular framework for potential therapeutic intervention in autophagy-related diseases. ..
  2. Kim H, Kim D, Choi S, Kim C, Oh S, Pyo K, et al. KDM3A histone demethylase functions as an essential factor for activation of JAK2-STAT3 signaling pathway. Proc Natl Acad Sci U S A. 2018;115:11766-11771 pubmed publisher
    ..Together, our findings demonstrate that inhibition of KDM3A phosphorylation could be a potent therapeutic strategy to control oncogenic effect of JAK2-STAT3 signaling pathway. ..
  3. Lee J, Choi H, Baek S. Sumoylation and Its Contribution to Cancer. Adv Exp Med Biol. 2017;963:283-298 pubmed publisher
    ..This chapter summarizes the mechanisms and functions of the deregulated SUMO pathway affecting oncogenes and tumor suppressor genes. ..
  4. Baek S, Kim K. Epigenetic Control of Autophagy: Nuclear Events Gain More Attention. Mol Cell. 2017;65:781-785 pubmed publisher
    ..It is becoming more important to propose a "whole-cell view" of autophagy embracing both cytoplasmic and nuclear events. Thus, it is great timing to summarize current status and discuss future direction. ..
  5. Kim D, Nam H, Lee W, Yim H, Ahn J, Park S, et al. PKCα-LSD1-NF-κB-Signaling Cascade Is Crucial for Epigenetic Control of the Inflammatory Response. Mol Cell. 2018;69:398-411.e6 pubmed publisher
  6. request reprint
    Baek S. A novel link between SUMO modification and cancer metastasis. Cell Cycle. 2006;5:1492-5 pubmed
    ..Here I overview these findings and discuss biological importance of protein SUMOylation in cancer metastasis. ..
  7. Nam H, Boo K, Kim D, Han D, Choe H, Kim C, et al. Phosphorylation of LSD1 by PKC? is crucial for circadian rhythmicity and phase resetting. Mol Cell. 2014;53:791-805 pubmed publisher
    ..These data demonstrate that LSD1 is a key component of the molecular circadian oscillator, which plays a pivotal role in rhythmicity and phase resetting of the circadian clock. ..
  8. Boo K, Baek S, Lee H. Pontin is required for pre-TCR signaling at the ?-selection checkpoint in T cell development. Biochem Biophys Res Commun. 2014;447:44-50 pubmed publisher
    ..Intriguingly, the developmental block of ?? T cells can be partially rescued by loss of p53. Together, our data demonstrate a novel role of Pontin as a crucial regulator in pre-TCR signaling during T cell development. ..
  9. Hur J, Choi J, Lee H, Nham P, Kim T, Chae C, et al. CD82/KAI1 Maintains the Dormancy of Long-Term Hematopoietic Stem Cells through Interaction with DARC-Expressing Macrophages. Cell Stem Cell. 2016;18:508-21 pubmed publisher
    ..A similar interaction appears to be relevant for human HSPCs. Thus, CD82 is a functional surface marker of LT-HSCs that maintains quiescence through interaction with DARC-expressing macrophages in the BM stem cell niche. ..

More Information

Publications12

  1. Lim C, Nam H, Lee J, Kim D, Choi J, Kang S, et al. PKCα-mediated phosphorylation of LSD1 is required for presynaptic plasticity and hippocampal learning and memory. Sci Rep. 2017;7:4912 pubmed publisher
    ..These results suggest that LSD1 is involved in the regulation of presynaptic gene expression and subsequently regulates the hippocampus-dependent memory in phosphorylation-dependent manner. ..
  2. Kim K, Boo K, Yu Y, Oh S, Kim H, Jeon Y, et al. ROR? controls hepatic lipid homeostasis via negative regulation of PPAR? transcriptional network. Nat Commun. 2017;8:162 pubmed publisher
    ..Here Kim et al. show that the nuclear receptor ROR? inhibits PPAR?-mediated transcriptional activity by interacting with HDAC3 and competing for the promoters of lipogenic genes. ..
  3. Kim K, Lee J, Yu Y, Kim H, Nam H, Moon H, et al. ROR?2 requires LSD1 to enhance tumor progression in breast cancer. Sci Rep. 2017;7:11994 pubmed publisher
    ..Therefore, our data establish that suppression of LSD1-mediated ROR?2 transcriptional activity may be potent therapeutic strategy to attenuate tumor cell migration in human breast cancer. ..