YoungJoo Lee

Summary

Affiliation: Sejong University
Country: Korea

Publications

  1. ncbi request reprint Effects of estrogen receptor and estrogen on the chromatin structure in estrogen receptor stable transfectants
    Young Joo Lee
    Institute of Bioscience, Department of Bioscience and Biotechnology, College of Engineering, Sejong University, Seoul, Korea
    Exp Mol Med 34:95-9. 2002
  2. doi request reprint Hypoxia-inducible factor 1 alpha activates and is inhibited by unoccupied estrogen receptor beta
    WonChung Lim
    College of Life Science, Institute of Biotechnology, Department of Bioscience and Biotechnology, Sejong University, Kwang Jin Gu, Seoul 143 747, Republic of Korea
    FEBS Lett 583:1314-8. 2009
  3. ncbi request reprint Estrogen receptor mediated effects of Cimicifuga extracts on human breast cancer cells
    Joonwoo Park
    College of Life Science, Institute of Biotechnology, Department of Bioscience and Biotechnology, Sejong University, Seoul, Korea
    Pharmazie 67:947-50. 2012
  4. pmc Estrogen receptor is activated by korean red ginseng in vitro but not in vivo
    Myeong Kuk Shim
    Department of Bioscience and Biotechnology, Institute of Biotechnology, College of Life Science, Sejong University, Seoul 143 747, Korea
    J Ginseng Res 36:169-75. 2012
  5. ncbi request reprint Ginsenoside Rc and Re stimulate c-fos expression in MCF-7 human breast carcinoma cells
    Young Joo Lee
    College of Engineering, Institute of Biotechnology, Department of Bioscience and Biotechnology, Sejong University, Seoul, Korea
    Arch Pharm Res 26:53-7. 2003
  6. ncbi request reprint Ginsenoside-Rb1 acts as a weak phytoestrogen in MCF-7 human breast cancer cells
    Young Joo Lee
    College of Engineering, Institute of Biotechnology, Department of Bioscience and Biotechnology, Sejong University, Seoul, Korea
    Arch Pharm Res 26:58-63. 2003
  7. ncbi request reprint A ginsenoside-Rh1, a component of ginseng saponin, activates estrogen receptor in human breast carcinoma MCF-7 cells
    YoungJoo Lee
    Department of Bioscience and Biotechnology, College of Engineering, Institute of Biotechnology, Sejong University, Seoul, South Korea
    J Steroid Biochem Mol Biol 84:463-8. 2003
  8. pmc Estrogen receptor beta inhibits transcriptional activity of hypoxia inducible factor-1 through the downregulation of arylhydrocarbon receptor nuclear translocator
    WonChung Lim
    Department of Bioscience and Biotechnology, College of Life Science, Institute of Biotechnology, Sejong University, Kwangjingu, Kunjadong, Seoul 143 747, Korea
    Breast Cancer Res 13:R32. 2011
  9. ncbi request reprint Ginsenoside-Rb1 from Panax ginseng C.A. Meyer activates estrogen receptor-alpha and -beta, independent of ligand binding
    Jungyoon Cho
    College of Life Science, Institute of Biotechnology, Department of Bioscience and Biotechnology, Sejong University, Kwang Jin Gu, Seoul 143 747, Korea
    J Clin Endocrinol Metab 89:3510-5. 2004
  10. ncbi request reprint Improved lipid profile in ovariectomized rats by red ginseng extract
    Yeomyeong Park
    Department of Bioscience and Biotechnologyl, Institute of Biotechnology, College of Life Science, Sejong University, Seoul, Korea
    Pharmazie 66:450-3. 2011

Collaborators

  • WonChung Lim
  • Mee Ra Rhyu
  • Hiroyasu Inoue
  • Suhn Hee Kim
  • Hyunsung Park
  • DooSeok Choi
  • Choa Park
  • Jungyoon Cho
  • Myeongkuk Shim
  • Joonwoo Park
  • N P Aditya
  • Wankyu Park
  • Myeong Kuk Shim
  • Byung Koo Yoon
  • Yeomyung Park
  • Kwanghee Ryu
  • Yeomyeong Park
  • Hyeok yi Kwon
  • Mi Kyung Park
  • Seungki Lee
  • Inae Lee
  • Moo Hyeog Im
  • Sanghoon Ko
  • Yiseul Kim
  • Won Jong Oh
  • Dong Yun Lee
  • Kyungwon Park
  • Duk Kyung Kim
  • Young Hee Kang
  • Byung Chul Oh
  • Wansup Kim
  • Chanyoung Shin
  • Myeong Kuk Shimi
  • Woong Shick Ahn
  • SuMi Bae
  • Dukkyung Kim
  • Woongshick Ahn
  • Siyoul Jang

Detail Information

Publications23

  1. ncbi request reprint Effects of estrogen receptor and estrogen on the chromatin structure in estrogen receptor stable transfectants
    Young Joo Lee
    Institute of Bioscience, Department of Bioscience and Biotechnology, College of Engineering, Sejong University, Seoul, Korea
    Exp Mol Med 34:95-9. 2002
    ..Our results suggest that under certain circumstances unoccupied estrogen receptors may play some role in reorganizing the repressive chromatin structure to induce gene activation...
  2. doi request reprint Hypoxia-inducible factor 1 alpha activates and is inhibited by unoccupied estrogen receptor beta
    WonChung Lim
    College of Life Science, Institute of Biotechnology, Department of Bioscience and Biotechnology, Sejong University, Kwang Jin Gu, Seoul 143 747, Republic of Korea
    FEBS Lett 583:1314-8. 2009
    ..Taken together, these data show that HIF-1 alpha activates ER beta-mediated transcription in the absence of a ligand, and ER beta inhibits HIF-1 alpha-mediated transcription...
  3. ncbi request reprint Estrogen receptor mediated effects of Cimicifuga extracts on human breast cancer cells
    Joonwoo Park
    College of Life Science, Institute of Biotechnology, Department of Bioscience and Biotechnology, Sejong University, Seoul, Korea
    Pharmazie 67:947-50. 2012
    ..These results suggested that C-Ex does not activate or inactivate ERalpha in a direct manner, but the extracts may affect factors in ER signal transduction pathway...
  4. pmc Estrogen receptor is activated by korean red ginseng in vitro but not in vivo
    Myeong Kuk Shim
    Department of Bioscience and Biotechnology, Institute of Biotechnology, College of Life Science, Sejong University, Seoul 143 747, Korea
    J Ginseng Res 36:169-75. 2012
    ..These results show that KRG does contain estrogenic activity as manifested by in vitro study but the activity is not strong enough to elicit physiological responses...
  5. ncbi request reprint Ginsenoside Rc and Re stimulate c-fos expression in MCF-7 human breast carcinoma cells
    Young Joo Lee
    College of Engineering, Institute of Biotechnology, Department of Bioscience and Biotechnology, Sejong University, Seoul, Korea
    Arch Pharm Res 26:53-7. 2003
    ..These data demonstrate that ginsenoside Rc and Re act via other transcription factors and not via estrogen receptor in c-Fos expression...
  6. ncbi request reprint Ginsenoside-Rb1 acts as a weak phytoestrogen in MCF-7 human breast cancer cells
    Young Joo Lee
    College of Engineering, Institute of Biotechnology, Department of Bioscience and Biotechnology, Sejong University, Seoul, Korea
    Arch Pharm Res 26:58-63. 2003
    ..These data support our hypothesis that ginsenoside-Rb1 acts a weak phytoestrogen, presumably by binding and activating the estrogen receptor...
  7. ncbi request reprint A ginsenoside-Rh1, a component of ginseng saponin, activates estrogen receptor in human breast carcinoma MCF-7 cells
    YoungJoo Lee
    Department of Bioscience and Biotechnology, College of Engineering, Institute of Biotechnology, Sejong University, Seoul, South Korea
    J Steroid Biochem Mol Biol 84:463-8. 2003
    ..These data support our hypothesis that ginsenoside-Rh1 acts as a weak phytoestrogen, presumably by binding and activating the estrogen receptor...
  8. pmc Estrogen receptor beta inhibits transcriptional activity of hypoxia inducible factor-1 through the downregulation of arylhydrocarbon receptor nuclear translocator
    WonChung Lim
    Department of Bioscience and Biotechnology, College of Life Science, Institute of Biotechnology, Sejong University, Kwangjingu, Kunjadong, Seoul 143 747, Korea
    Breast Cancer Res 13:R32. 2011
    ..We have shown previously that ERβ inhibits hypoxia inducible factor (HIF)-1α mediated transcription, but the mechanism by which ERβ works to exert this effect is not understood...
  9. ncbi request reprint Ginsenoside-Rb1 from Panax ginseng C.A. Meyer activates estrogen receptor-alpha and -beta, independent of ligand binding
    Jungyoon Cho
    College of Life Science, Institute of Biotechnology, Department of Bioscience and Biotechnology, Sejong University, Kwang Jin Gu, Seoul 143 747, Korea
    J Clin Endocrinol Metab 89:3510-5. 2004
    ..Our results indicate that the estrogen-like activity of ginsenoside-Rb1 is independent of direct estrogen receptor association...
  10. ncbi request reprint Improved lipid profile in ovariectomized rats by red ginseng extract
    Yeomyeong Park
    Department of Bioscience and Biotechnologyl, Institute of Biotechnology, College of Life Science, Sejong University, Seoul, Korea
    Pharmazie 66:450-3. 2011
    ....
  11. ncbi request reprint Estrogen activities and the cellular effects of natural progesterone from wild yam extract in mcf-7 human breast cancer cells
    Mi Kyung Park
    Department of Bioscience and Biotechnolgy, College of Engineering, Institute of Biotechnology, Sejong University, Seoul, Korea
    Am J Chin Med 37:159-67. 2009
    ..Wild yam extract also inhibited proliferation of MCF-7 cells. These data indicate that wild yam extract acts as a weak phytoestrogen and protects against proliferation in human breast carcinoma MCF-7 cells...
  12. ncbi request reprint Cobalt chloride-induced estrogen receptor alpha down-regulation involves hypoxia-inducible factor-1alpha in MCF-7 human breast cancer cells
    Jungyoon Cho
    College of Life Science, Institute of Biotechnology, Department of Bioscience and Biotechnology, Sejong University, Kwang Jin Gu, Seoul 143 747, Korea
    Mol Endocrinol 19:1191-9. 2005
    ..These results suggest that ERalpha down-regulation under hypoxia involves protein-protein interactions between the ERalpha and HIF-1alpha...
  13. ncbi request reprint Inhibitory effects of ginsenoside-Rb1 on activation of the 12-O-tetradecanoylphorbol 13-acetate-induced cyclooxygenase-2 promoter
    Wankyu Park
    College of Life Science, Institute of Biotechnology, Department of Bioscience and Biotechnology, Sejong University, Seoul, Korea
    Planta Med 72:272-5. 2006
    ..In conclusion, ginsenoside-Rb1 inhibits TPA-induced COX-2 promoter activity through the nuclear factor interleukin-6 binding site and not through the nuclear factor-kappaB or cAMP-responsive elements...
  14. doi request reprint Curcumin and genistein coloaded nanostructured lipid carriers: in vitro digestion and antiprostate cancer activity
    N P Aditya
    Department of Food Science and Technology, Sejong University, Seoul, Republic of Korea
    J Agric Food Chem 61:1878-83. 2013
    ..Collectively, these results have shown that coloaded lipid based carriers are promising vehicles for oral delivery of poorly bioaccessible molecules like curcumin and genistein...
  15. doi request reprint Hypoxia-inducible factor 1 alpha represses the transcription of the estrogen receptor alpha gene in human breast cancer cells
    Kwanghee Ryu
    College of Life Science, Institute of Biotechnology, Department of Bioscience and Biotechnology, Sejong University, Seoul 143 747, Republic of Korea
    Biochem Biophys Res Commun 407:831-6. 2011
    ..Our data show that hypoxia induces repression of the ESR1 gene, which may facilitate hormone insensitivity in the tumor microenvironment...
  16. doi request reprint Hypoxia enhances ligand-occupied androgen receptor activity
    Choa Park
    College of Life Science, Institute of Biotechnology, Department of Bioscience and Biotechnology, Sejong University, Kwang Jin Gu, Seoul 143 747, Republic of Korea
    Biochem Biophys Res Commun 418:319-23. 2012
    ..These results provide evidence that hypoxia may stimulate as yet unknown factors, which further stimulate AR signal transduction pathways...
  17. pmc Glucocorticoids suppress hypoxia-induced COX-2 and hypoxia inducible factor-1α expression through the induction of glucocorticoid-induced leucine zipper
    WonChung Lim
    Department of Bioscience and Biotechnology, College of Life Science, Institute of Biotechnology, Sejong University, Seoul, Korea
    Br J Pharmacol 171:735-45. 2014
    ..Hence, we explored the mechanisms underlying glucocorticoid-mediated inhibition of hypoxia-induced COX-2 in human distal lung epithelial A549 cells...
  18. doi request reprint Mammalian MST2 kinase and human Salvador activate and reduce estrogen receptor alpha in the absence of ligand
    Yeomyung Park
    College of Life Science, Institute of Biotechnology, Department of Bioscience and Biotechnology, Sejong University, Kwang Jin Gu, Seoul, 143 747, South Korea
    J Mol Med (Berl) 89:181-91. 2011
    ..This study suggests that MST and hSAV act as novel co-regulators of ERα and may play an important role in breast cancer pathogenesis...
  19. ncbi request reprint Hypertonic sodium chloride and mannitol induces COX-2 via different signaling pathways in mouse cortical collecting duct M-1 cells
    WonChung Lim
    College of Engineering, Institute of Biotechnology, Department of Bioscience and Biotechnology, Sejong University, Seoul, South Korea
    Life Sci 80:2085-92. 2007
    ..Furthermore, the signal transduction pathways that respond to hypertonic stress vary for different osmolytes in cortical collecting duct cells...
  20. ncbi request reprint Sodium chloride regulation of the alpha epithelial amiloride-sensitive sodium channel (alphaENaC) gene requires syntheses of new protein(s)
    WonChung Lim
    Department of Bioscience and Biotechnology, College of Engineering, Institute of Biotechnology, Sejong University, Seoul, South Korea
    J Steroid Biochem Mol Biol 88:305-10. 2004
    ..This indicates that synthesis of new, uncharacterized protein(s) is required for sodium chloride-mediated inhibition of alphaENaC gene transcription...
  21. ncbi request reprint Overexpression of ERβ is sufficient to inhibit hypoxia-inducible factor-1 transactivation
    Choa Park
    Department of Bioscience and Biotechnology, College of Life Science, Institute of Biotechnology, Sejong University, Kwangjingu, Kunjadong, Seoul 143 747, Republic of Korea
    Biochem Biophys Res Commun 450:261-6. 2014
    ..However, DPN did not additionally affect this suppression in MCF-7 cells transfected with ERβ. This result shows that unliganded ERβ is sufficient to inhibit HIF-1 in systems of overexpression. ..
  22. ncbi request reprint Development of an efficient endothelial cell specific vector using promoter and 5' untranslated sequences from the human preproendothelin-1 gene
    Jungyoon Cho
    Department of Bioscience and Biotechnology, College of Engineering, Sejong University, Seoul 143 747, Korea
    Exp Mol Med 35:269-74. 2003
    ....
  23. pmc Impact of lysophosphatidylcholine on the plasminogen activator system in cultured vascular smooth muscle cells
    Byung Koo Yoon
    Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    J Korean Med Sci 27:803-10. 2012
    ..Importantly, lysoPC stimulates the enzyme activity of PAI-1 and suppresses that of t-PA...