Affiliation: Samsung Medical Center
- Severe growth defect in a Schizosaccharomyces pombe mutant defective in intron lariat degradationK Nam
Laboratory of Molecular Genetics II, Samsung Biomedical Research Institute, Kangnam Ku, Seoul, Republic of Korea
Mol Cell Biol 17:809-18. 1997..The growth defect of the S. pombe dbr1::leu1+ strain suggests that debranching activity is critical for efficient intron RNA degradation and that blocking this pathway interferes with cell growth...
- Human RNA lariat debranching enzyme cDNA complements the phenotypes of Saccharomyces cerevisiae dbr1 and Schizosaccharomyces pombe dbr1 mutantsJ W Kim
Department of Biochemistry, Inha University College of Medicine, Inchon, Republic of Korea, Clinical Research Center, Samsung Biomedical Research Institute, 50 Ilwon Dong, Kangnam Ku, Seoul 135 230, Republic of Korea
Nucleic Acids Res 28:3666-73. 2000..Comparison of the amino acid sequence of hDBR1 with the other DBR protein sequences showed several conserved regions, with 40, 44 and 43% identity to the S. cerevisiae, S. pombe and C. elegans debranching enzymes, respectively...
- Arginine in the beginning of the 1A rod domain of the keratin 10 gene is the hot spot for the mutation in epidermolytic hyperkeratosisJ M Yang
Department of Dermatology, College of Medicine, Sungkyunkwan University, Samsung Medical Center, Seoul, South Korea
J Dermatol Sci 19:126-33. 1999..Our results are compatible with the above classification and suggest that the arginine in the beginning of the 1A rod domain is the hot spot for the mutation of the keratin 10 gene...