Yuseok Moon

Summary

Affiliation: Pusan National University
Country: Korea

Publications

  1. ncbi request reprint Vomitoxin-induced cyclooxygenase-2 gene expression in macrophages mediated by activation of ERK and p38 but not JNK mitogen-activated protein kinases
    Yuseok Moon
    Department of Food Science and Human Nutrition, Institute for Environmental Toxicology, Michigan State University, 234 G M Trout Bldg, East Lansing, MI 48824 1224, USA
    Toxicol Sci 69:373-82. 2002
  2. pmc Export of recombinant proteins in Escherichia coli using ABC transporter with an attached lipase ABC transporter recognition domain (LARD)
    Chan Woo Chung
    Korea Science Academy, 899, Tanggam 3 Dong, Busanjin Gu, Busan, 614 822, Korea
    Microb Cell Fact 8:11. 2009
  3. ncbi request reprint Up-regulation of early growth response gene 1 (EGR-1) via ERK1/2 signals attenuates sulindac sulfide-mediated cytotoxicity in the human intestinal epithelial cells
    Yuseok Moon
    Department of Microbiology and Immunology and Medical Research Institute, Pusan National University School of Medicine, Busan, 602 739, Republic of Korea
    Toxicol Appl Pharmacol 223:155-63. 2007
  4. ncbi request reprint Involvement of early growth response gene 1 in the modulation of microsomal prostaglandin E synthase 1 by epigallocatechin gallate in A549 human pulmonary epithelial cells
    Yuseok Moon
    Department of Microbiology and Immunology and Medical Research Institute, Pusan National University School of Medicine, Busan 602 739, Republic of Korea
    Biochem Pharmacol 73:125-35. 2007
  5. pmc Growth compensatory role of sulindac sulfide-induced thrombospondin-1 linked with ERK1/2 and RhoA GTPase signaling pathways
    Yuseok Moon
    Department of Microbiology and Immunology and Medical Research Institute, Pusan National University School of Medicine, Busan, 602 739, Republic of Korea
    Life Sci 82:591-9. 2008
  6. doi request reprint Hypo-responsiveness of interleukin-8 production in human embryonic epithelial intestine 407 cells independent of NF-kappaB pathway: new lessons from endotoxin and ribotoxic deoxynivalenol
    Yuseok Moon
    Department of Microbiology and Immunology, Medical Research Institute, Pusan National University School of Medicine, Busan 602 739, Korea
    Toxicol Appl Pharmacol 231:94-102. 2008
  7. ncbi request reprint Toxic alterations in chick embryonic liver and spleen by acute exposure to Fusarium-producing mycotoxin deoxynivalenol
    Yuseok Moon
    Department of Microbiology and Immunology, Medical Research Institute, Pusan National University School of Medicine, Busan 602 739, Korea
    Biol Pharm Bull 30:1808-12. 2007
  8. doi request reprint Repression of peroxisome proliferator-activated receptor gamma by mucosal ribotoxic insult-activated CCAAT/enhancer-binding protein homologous protein
    Seong Hwan Park
    Department of Microbiology and Immunology, Pusan National University School of Medicine, Yangsan, Korea
    J Immunol 185:5522-30. 2010
  9. doi request reprint Mechanism-based alternative monitoring of endoplasmic reticulum stress by 8-keto-trichothecene mycotoxins using human intestinal epithelial cell line
    Hyun Yang
    Department of Microbiology and Immunology, and Medical Research Institute, Pusan National University School of Medicine, Yangsan 626 813, Republic of Korea
    Toxicol Lett 198:317-23. 2010
  10. doi request reprint Chronic Nod2 stimulation potentiates activating transcription factor 3 and paradoxical superinduction of epithelial proinflammatory chemokines by mucoactive ribotoxic stressors via RNA-binding protein human antigen R
    Seong Hwan Park
    Laboratory of Systems Mucosal Biomodulation, Department of Microbiology and Immunology and Medical Research Institute, Pusan National University School of Medicine, Yangsan 626 813, Korea
    Toxicol Sci 125:116-25. 2012

Collaborators

Detail Information

Publications41

  1. ncbi request reprint Vomitoxin-induced cyclooxygenase-2 gene expression in macrophages mediated by activation of ERK and p38 but not JNK mitogen-activated protein kinases
    Yuseok Moon
    Department of Food Science and Human Nutrition, Institute for Environmental Toxicology, Michigan State University, 234 G M Trout Bldg, East Lansing, MI 48824 1224, USA
    Toxicol Sci 69:373-82. 2002
    ..These data provide insight into possible general mechanisms by which VT and other trichlothecenes upregulate proinflammatory genes and impart immunotoxicity...
  2. pmc Export of recombinant proteins in Escherichia coli using ABC transporter with an attached lipase ABC transporter recognition domain (LARD)
    Chan Woo Chung
    Korea Science Academy, 899, Tanggam 3 Dong, Busanjin Gu, Busan, 614 822, Korea
    Microb Cell Fact 8:11. 2009
    ..abstract:..
  3. ncbi request reprint Up-regulation of early growth response gene 1 (EGR-1) via ERK1/2 signals attenuates sulindac sulfide-mediated cytotoxicity in the human intestinal epithelial cells
    Yuseok Moon
    Department of Microbiology and Immunology and Medical Research Institute, Pusan National University School of Medicine, Busan, 602 739, Republic of Korea
    Toxicol Appl Pharmacol 223:155-63. 2007
    ....
  4. ncbi request reprint Involvement of early growth response gene 1 in the modulation of microsomal prostaglandin E synthase 1 by epigallocatechin gallate in A549 human pulmonary epithelial cells
    Yuseok Moon
    Department of Microbiology and Immunology and Medical Research Institute, Pusan National University School of Medicine, Busan 602 739, Republic of Korea
    Biochem Pharmacol 73:125-35. 2007
    ..Induced EGR-1 then stimulated the induction of mPGES-1 gene expression and this effect mechanistically can be linked to the pharmacological or toxicological actions after human exposure to green tea catechins...
  5. pmc Growth compensatory role of sulindac sulfide-induced thrombospondin-1 linked with ERK1/2 and RhoA GTPase signaling pathways
    Yuseok Moon
    Department of Microbiology and Immunology and Medical Research Institute, Pusan National University School of Medicine, Busan, 602 739, Republic of Korea
    Life Sci 82:591-9. 2008
    ..These findings suggest the possible mechanism through which tumor cells can survive the chemopreventive action of NSAIDs or the normal epithelium can reconstitute after NSAID-mediated ulceration in a compensatory way...
  6. doi request reprint Hypo-responsiveness of interleukin-8 production in human embryonic epithelial intestine 407 cells independent of NF-kappaB pathway: new lessons from endotoxin and ribotoxic deoxynivalenol
    Yuseok Moon
    Department of Microbiology and Immunology, Medical Research Institute, Pusan National University School of Medicine, Busan 602 739, Korea
    Toxicol Appl Pharmacol 231:94-102. 2008
    ..Taken together, endotoxin induced hypo-production of pro-inflammatory cytokine IL-8 in the human epithelial cells, which was associated with the delayed activation of PPAR-gamma expression by pre-existing endotoxin...
  7. ncbi request reprint Toxic alterations in chick embryonic liver and spleen by acute exposure to Fusarium-producing mycotoxin deoxynivalenol
    Yuseok Moon
    Department of Microbiology and Immunology, Medical Research Institute, Pusan National University School of Medicine, Busan 602 739, Korea
    Biol Pharm Bull 30:1808-12. 2007
    ..Conclusively, acute direct exposure to deoxynivalenol in the chick embryo caused toxic histological alterations in the liver and spleen and suppressed in vitro lymphoblastogenesis...
  8. doi request reprint Repression of peroxisome proliferator-activated receptor gamma by mucosal ribotoxic insult-activated CCAAT/enhancer-binding protein homologous protein
    Seong Hwan Park
    Department of Microbiology and Immunology, Pusan National University School of Medicine, Yangsan, Korea
    J Immunol 185:5522-30. 2010
    ....
  9. doi request reprint Mechanism-based alternative monitoring of endoplasmic reticulum stress by 8-keto-trichothecene mycotoxins using human intestinal epithelial cell line
    Hyun Yang
    Department of Microbiology and Immunology, and Medical Research Institute, Pusan National University School of Medicine, Yangsan 626 813, Republic of Korea
    Toxicol Lett 198:317-23. 2010
    ..The mechanism-based monitoring of 8-keto trichothecenes is promising as a supplementary analysis means of the presence of bioactive 8-keto trichothecenes, which are potentially exposed in human gut epithelia...
  10. doi request reprint Chronic Nod2 stimulation potentiates activating transcription factor 3 and paradoxical superinduction of epithelial proinflammatory chemokines by mucoactive ribotoxic stressors via RNA-binding protein human antigen R
    Seong Hwan Park
    Laboratory of Systems Mucosal Biomodulation, Department of Microbiology and Immunology and Medical Research Institute, Pusan National University School of Medicine, Yangsan 626 813, Korea
    Toxicol Sci 125:116-25. 2012
    ..This paradoxical superinduction of chemokines was also mediated by enhanced mRNA stabilization by HuR protein in spite of ATF3-mediated suppression of NF-κB signal in human intestinal epithelial cells...
  11. doi request reprint Pro-inflammatory NF-κB and early growth response gene 1 regulate epithelial barrier disruption by food additive carrageenan in human intestinal epithelial cells
    Hye Jin Choi
    Laboratory of Systems Mucosal Biomodulation, Department of Microbiology and Immunology, Pusan National University School of Medicine, Yangsan, Republic of Korea
    Toxicol Lett 211:289-95. 2012
    ..Suppression of NF-κB or EGR-1 aggravated barrier disruption by CGN, which was associated with the reduced gene expression of tight junction component zonula occludens 1 and its irregular localization in the epithelial monolayer...
  12. ncbi request reprint Ribotoxic mycotoxin deoxynivalenol induces G2/M cell cycle arrest via p21Cip/WAF1 mRNA stabilization in human epithelial cells
    Hyun Yang
    Department of Microbiology and Immunology and Medical Research Institute, Pusan National University School of Medicine, Busan 602 739, Republic of Korea
    Toxicology 243:145-54. 2008
    ..Particularly, ERK1/2 signal was associated with DON-induced p21 mRNA stabilization in the human epithelial cells. Taken together, deoxynivalenol arrested epithelial cell cycle at G(2)/M phase via elevated p21 gene expression...
  13. doi request reprint SOCS3 regulates BAFF in human enterocytes under ribosomal stress
    Kee Hun Do
    Laboratory of Mucosal Exposome and Biomodulation, Department of Microbiology and Immunology, Pusan National University School of Medicine, Yangsan 626 870, South Korea
    J Immunol 190:6501-10. 2013
    ....
  14. pmc Two in-and-out modulation strategies for endoplasmic reticulum stress-linked gene expression of pro-apoptotic macrophage-inhibitory cytokine 1
    Seong Hwan Park
    Laboratory of Systems Mucosal Biomodulation, Department of Microbiology and Immunology, Pusan National University School of Medicine, Yangsan 626 870, Korea
    J Biol Chem 287:19841-55. 2012
    ..We propose that these two sequential in-and-out modulations can account for stabilized transcription and subsequent translation of pro-apoptotic MIC-1 gene in human cancer cells under ER stress...
  15. doi request reprint Epithelial cell survival by activating transcription factor 3 (ATF3) in response to chemical ribosome-inactivating stress
    Hyun Yang
    Department of Microbiology and Immunology, Medical Research Institute, Pusan National University School of Medicine, 1 10 Ami dong Seo Ku, Busan 602 739, Republic of Korea
    Biochem Pharmacol 77:1105-15. 2009
    ..The results of this study showed that enhanced ATF3 production was associated with cellular defenses by maintaining the epithelial survival after ribotoxic mucosal insults...
  16. doi request reprint Novel regulatory action of ribosomal inactivation on epithelial Nod2-linked proinflammatory signals in two convergent ATF3-associated pathways
    Seong Hwan Park
    Laboratory of Mucosal Exposome and Biomodulation, Department of Microbiology and Immunology, Medical Research Institute, Pusan National University School of Medicine, Yangsan 626 870, Korea
    J Immunol 191:5170-81. 2013
    ..These findings demonstrate that ribosomal stress-induced ATF3 is a critical regulator in the convergent pathways between EGR-1 and NF-κB, which contributes to the suppression of Nod2-activated proinflammatory gene expression. ..
  17. doi request reprint Ambivalent roles of early growth response 1 in inflammatory signaling following ribosomal insult in human enterocytes
    Kee Hun Do
    Laboratory of Systems Mucosal Biomodulation, Department of Microbiology and Immunology and Medical Research Institute, Pusan National University School of Medicine, Yangsan 626 870, South Korea
    Biochem Pharmacol 84:513-21. 2012
    ..It can be thus concluded that EGR-1 regulates pro-inflammatory NF-κB activation by LPS via PPARγ although EGR-1 is a positive mediator of chemokine expression following ribosomal insult in intestinal epithelial cells...
  18. ncbi request reprint Modulation of early growth response gene 1 and interleukin-8 expression by ribotoxin deoxynivalenol (vomitoxin) via ERK1/2 in human epithelial intestine 407 cells
    Yuseok Moon
    Department of Microbiology and Immunology and Medical Research Institute, Pusan National University School of Medicine, 1 10 Ami dong, Busan, Republic of
    Biochem Biophys Res Commun 362:256-62. 2007
    ..These findings will provide insight into the possible mechanism associated with the early epithelial inflammation by ribotoxic insults...
  19. pmc Involvement of epidermal growth factor receptor-linked signaling responses in Pseudomonas fluorescens-infected alveolar epithelial cells
    Hye Jin Choi
    Department of Microbiology and Immunology, Pusan National University School of Medicine, Yangsan 626 813, South Korea
    Infect Immun 79:1998-2005. 2011
    ..Thus, airway epithelial exposure to P. fluorescens can trigger antiapoptotic responses via EGFR and proinflammatory responses via TLR4-independent NF-κB signaling pathway in human pneumocytes...
  20. doi request reprint The integrated stress response-associated signals modulates intestinal tumor cell growth by NSAID-activated gene 1 (NAG-1/MIC-1/PTGF-beta)
    Hyun Yang
    Department of Microbiology and Immunology and Medical Research Institute, Pusan National University School of Medicine, Yangsan 626 813, Korea
    Carcinogenesis 31:703-11. 2010
    ..PKR-ERK1/2 activation may thus contribute to the defensive cellular response to cytotoxic NSAIDs while drug-mediated ER stress triggers the pro-apoptotic NAG-1 production in human colon cancer cells...
  21. pmc Enhanced wound healing by recombinant Escherichia coli Nissle 1917 via human epidermal growth factor receptor in human intestinal epithelial cells: therapeutic implication using recombinant probiotics
    Hye Jin Choi
    Laboratory of Systems Mucosal Biomodulation, Department of Microbiology and Immunology, Pusan National University School of Medicine, Yangsan, South Korea
    Infect Immun 80:1079-87. 2012
    ..The present study provides a basis for the clinical application of human recombinant biotherapeutics via an efficient, safe probiotic vehicle...
  22. doi request reprint Macrophage inhibitory cytokine-1 (MIC-1) and subsequent urokinase-type plasminogen activator mediate cell death responses by ribotoxic anisomycin in HCT-116 colon cancer cells
    Hyun Yang
    Department of Microbiology and Immunology and Medical Research Institute, Pusan National University School of Medicine, Yangsan, Republic of Korea
    Biochem Pharmacol 78:1205-13. 2009
    ..The results of this study provide mechanistic insight into tumor cell decision for death or survival pathways in response to ribosome-disrupting stresses from chemotherapeutics...
  23. pmc Endoplasmic reticulum stress-activated C/EBP homologous protein enhances nuclear factor-kappaB signals via repression of peroxisome proliferator-activated receptor gamma
    Seong Hwan Park
    Laboratory of Systems Mucosal Biomodulation, Department of Microbiology and Immunology, Pusan National University School of Medicine, Yangsan 626 813, Korea
    J Biol Chem 285:35330-9. 2010
    ....
  24. pmc Prolonged NF-κB activation by a macrophage inhibitory cytokine 1-linked signal in enteropathogenic Escherichia coli-infected epithelial cells
    Hye Jin Choi
    Laboratory of Mucosal Exposome and Biomodulation, Department of Microbiology and Immunology, Medical Research Institute, Pusan National University School of Medicine, Yangsan, South Korea
    Infect Immun 81:1860-9. 2013
    ..In summary, the results of the present study suggest that MIC-1 serves as a mediator of prolonged NF-κB activation, which is critical in maintaining gut epithelial integrity in response to infection-induced injuries...
  25. doi request reprint Induction of human microsomal prostaglandin E synthase 1 by activated oncogene RhoA GTPase in A549 human epithelial cancer cells
    Hye Jin Choi
    Laboratory of Systems Mucosal Biomodulation, Department of Microbiology and Immunology, Pusan National University School of Medicine, Yangsan, Republic of Korea
    Biochem Biophys Res Commun 413:448-53. 2011
    ..Since oncogene-triggered PGE(2) production is a critical modulator of epithelial tumor cells, RhoA-associated mPGES-1 represents a promising chemo-preventive or therapeutic target for epithelial inflammation and its associated cancers...
  26. pmc Mucosal injuries due to ribosome-inactivating stress and the compensatory responses of the intestinal epithelial barrier
    Yuseok Moon
    Laboratory of Systems Mucosal Biomodulation, Department of Microbiology and Immunology, Medical Research Institute, Pusan National University School of Medicine, Yangsan 626 870, Korea
    Toxins (Basel) 3:1263-77. 2011
    ....
  27. doi request reprint HuR/ELAVL1 RNA binding protein modulates interleukin-8 induction by muco-active ribotoxin deoxynivalenol
    Hye Jin Choi
    Department of Microbiology and Immunology and Medical Research Institute, Pusan National University School of Medicine, Yangsan, 626 813, Republic of Korea
    Toxicol Appl Pharmacol 240:46-54. 2009
    ....
  28. pmc Identification of the minimal region in lipase ABC transporter recognition domain of Pseudomonas fluorescens for secretion and fluorescence of green fluorescent protein
    Yeonwoo Park
    Korea Science Academy of KAIST, 899 Tanggam 3 Dong, Busanjin Gu, Busan, 614 822, Korea
    Microb Cell Fact 11:60. 2012
    ..Each LARD was fused to epidermal growth factor (EGF) or green fluorescent protein (GFP), and the secretion of EGF-LARD or GFP-LARD fusion proteins was assessed in Escherichia coli with ABC transporter...
  29. doi request reprint Integrated stress response-altered pro-inflammatory signals in mucosal immune-related cells
    Seong Hwan Park
    Laboratory of Mucosal Exposome and Biomodulation, Department of Microbiology and Immunology, Pusan National University School of Medicine, Yangsan, South Korea
    Immunopharmacol Immunotoxicol 35:205-14. 2013
    ..Understanding ISR-modulated cellular alterations will provide progressive insights into approaches for treating human mucosal inflammatory and metabolic disorders...
  30. ncbi request reprint Protective effect of irradiated renal carcinoma expressing hepatitis B surface antigen against renal-cell carcinoma-mediated tumors
    Yuseok Moon
    Department of Microbiology and Immunology, Medical Research Institute, Pusan National University Medical School, Busan, Korea
    Cancer Biother Radiopharm 21:211-6. 2006
    ..These results confirm the postulate that RENCA/HBS vaccination elicits an antitumor immune response to some putative antigens or enhances the general immune competence in immunosuppressed renal tumor patients...
  31. ncbi request reprint Cyclooxygenase-2 mediates interleukin-6 upregulation by vomitoxin (deoxynivalenol) in vitro and in vivo
    Yuseok Moon
    Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI 48824 1224, USA
    Toxicol Appl Pharmacol 187:80-8. 2003
    ....
  32. ncbi request reprint The anti-invasive activity of cyclooxygenase inhibitors is regulated by the transcription factor ATF3 (activating transcription factor 3)
    Frank G Bottone
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, NIH, P O Box 12233, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
    Mol Cancer Ther 4:693-703. 2005
    ..In conclusion, ATF3 represents a novel mechanism in which NSAIDs exert their anti-invasive activity, thereby linking ATF3 and its gene regulatory activity to the biological activity of these compounds...
  33. ncbi request reprint Deoxynivalenol-induced mitogen-activated protein kinase phosphorylation and IL-6 expression in mice suppressed by fish oil
    Yuseok Moon
    Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI 48824 1224, USA
    J Nutr Biochem 14:717-26. 2003
    ..Taken together, the capacity of FO and its component n-3 PUFAs to suppress IL-6 expression as well as ERK 1/2 and JNK 1/2 activation might explain, in part, the reported suppressive effects of these lipids on DON-induced IgA nephropathy...
  34. ncbi request reprint Suppression of tumor cell invasion by cyclooxygenase inhibitors is mediated by thrombospondin-1 via the early growth response gene Egr-1
    Yuseok Moon
    Eicosanoid Biochemistry Section, Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
    Mol Cancer Ther 4:1551-8. 2005
    ..This is the first report suggesting that COX inhibitors suppress tumor cell invasion via TSP-1, which occurs downstream of Egr-1...
  35. ncbi request reprint Curcumin suppresses interleukin 1beta-mediated microsomal prostaglandin E synthase 1 by altering early growth response gene 1 and other signaling pathways
    Yuseok Moon
    Eicosanoid Biochemistry Section, Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Pharmacol Exp Ther 315:788-95. 2005
    ..These results indicate that curcumin inhibits IL-1beta-induced PGE(2) formation by inhibiting the expression of mPGES-1 that is mediated by suppression of EGR-1 expression as well as NF-kappaB and JNK1/2...
  36. ncbi request reprint Transcriptional regulation of activating transcription factor 3 involves the early growth response-1 gene
    Frank G Bottone
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    J Pharmacol Exp Ther 315:668-77. 2005
    ..Therefore, this is a novel first report demonstrating that the expression of ATF3 occurs via Egr-1 downstream of Erk1/2...
  37. pmc Regulation of EP4 expression via the Sp-1 transcription factor: inhibition of expression by anti-cancer agents
    Atsushi Kambe
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, North Carolina 27709, USA
    Biochim Biophys Acta 1783:1211-9. 2008
    ..Thus, we propose that the expression of EP4 is regulated by Sp-1, but phosphorylation of Sp-1 induced by TGZ suppresses this expression. This represents a new and unique mechanism for the regulation of the EP4 receptor expression...
  38. pmc Rac1 and a GTPase-activating protein, MgcRacGAP, are required for nuclear translocation of STAT transcription factors
    Toshiyuki Kawashima
    Division of Cellular Therapy, The Institute of Medical Science, University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    J Cell Biol 175:937-46. 2006
    ..We conclude that GTP-bound Rac1 and MgcRacGAP function as a nuclear transport chaperone for activated STATs...
  39. ncbi request reprint A GTPase-activating protein binds STAT3 and is required for IL-6-induced STAT3 activation and for differentiation of a leukemic cell line
    Yukio Tonozuka
    Division of Cellular Therapy, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Blood 104:3550-7. 2004
    ..All together, our data not only reveal an important role for MgcRacGAP in STAT3 activation, but also demonstrate that MgcRacGAP regulates IL-6-induced cellular differentiation in which STAT3 plays a pivotal role...
  40. ncbi request reprint Relationship of trichothecene structure to COX-2 induction in the macrophage: selective action of type B (8-keto) trichothecenes
    Yuseok Moon
    Department of Food Science and Human Nutrition and Institute for Environmental Toxicology, Michigan State University, East Lansing 48824, USA
    J Toxicol Environ Health A 66:1967-83. 2003
    ..Selective action on COX-2 might contribute to unique pathologic manifestations associated with Type B trichothecene-mediated immunotoxicity...
  41. ncbi request reprint Ionizing radiation enhances the expression of the nonsteroidal anti-inflammatory drug-activated gene (NAG1) by increasing the expression of TP53 in human colon cancer cells
    Ryuji Okazaki
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Radiat Res 165:125-30. 2006
    ..The findings reported here indicate that gamma radiation activates the TP53 tumor suppressor, which then increases the expression of NAG1. NAG1 mediates the induction of apoptosis in human colorectal cells...