Research Topics
Genomes and GenesSpecies | Yuseok MoonSummaryAffiliation: Pusan National University Country: Korea Publications
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Publications
Vomitoxin-induced cyclooxygenase-2 gene expression in macrophages mediated by activation of ERK and p38 but not JNK mitogen-activated protein kinasesYuseok Moon
Department of Food Science and Human Nutrition, Institute for Environmental Toxicology, Michigan State University, 234 G.M. Trout Bldg, East Lansing, MI 48824-1224, USA
Toxicol Sci 69:373-82. 2002..These data provide insight into possible general mechanisms by which VT and other trichlothecenes upregulate proinflammatory genes and impart immunotoxicity...
Export of recombinant proteins in Escherichia coli using ABC transporter with an attached lipase ABC transporter recognition domain (LARD)Chan Woo Chung
Korea Science Academy, 899, Tanggam 3 Dong, Busanjin Gu, Busan, 614 822, Korea
Microb Cell Fact 8:11. 2009..abstract:..- Growth compensatory role of sulindac sulfide-induced thrombospondin-1 linked with ERK1/2 and RhoA GTPase signaling pathwaysYuseok Moon
Department of Microbiology and Immunology and Medical Research Institute, Pusan National University School of Medicine, Busan, 602 739, Republic of Korea
Life Sci 82:591-9. 2008..These findings suggest the possible mechanism through which tumor cells can survive the chemopreventive action of NSAIDs or the normal epithelium can reconstitute after NSAID-mediated ulceration in a compensatory way... - Toxic alterations in chick embryonic liver and spleen by acute exposure to Fusarium-producing mycotoxin deoxynivalenolYuseok Moon
Department of Microbiology and Immunology, Medical Research Institute, Pusan National University School of Medicine, Busan 602 739, Korea
Biol Pharm Bull 30:1808-12. 2007..Conclusively, acute direct exposure to deoxynivalenol in the chick embryo caused toxic histological alterations in the liver and spleen and suppressed in vitro lymphoblastogenesis... - Up-regulation of early growth response gene 1 (EGR-1) via ERK1/2 signals attenuates sulindac sulfide-mediated cytotoxicity in the human intestinal epithelial cellsYuseok Moon
Department of Microbiology and Immunology and Medical Research Institute, Pusan National University School of Medicine, Busan, 602 739, Republic of Korea
Toxicol Appl Pharmacol 223:155-63. 2007.... 
Hypo-responsiveness of interleukin-8 production in human embryonic epithelial intestine 407 cells independent of NF-kappaB pathway: new lessons from endotoxin and ribotoxic deoxynivalenolYuseok Moon
Department of Microbiology and Immunology, Medical Research Institute, Pusan National University School of Medicine, Busan 602 739, Korea
Toxicol Appl Pharmacol 231:94-102. 2008..Taken together, endotoxin induced hypo-production of pro-inflammatory cytokine IL-8 in the human epithelial cells, which was associated with the delayed activation of PPAR-gamma expression by pre-existing endotoxin...- Involvement of early growth response gene 1 in the modulation of microsomal prostaglandin E synthase 1 by epigallocatechin gallate in A549 human pulmonary epithelial cellsYuseok Moon
Department of Microbiology and Immunology and Medical Research Institute, Pusan National University School of Medicine, Busan 602 739, Republic of Korea
Biochem Pharmacol 73:125-35. 2007..Induced EGR-1 then stimulated the induction of mPGES-1 gene expression and this effect mechanistically can be linked to the pharmacological or toxicological actions after human exposure to green tea catechins... - Repression of peroxisome proliferator-activated receptor gamma by mucosal ribotoxic insult-activated CCAAT/enhancer-binding protein homologous proteinSeong Hwan Park
Department of Microbiology and Immunology, Pusan National University School of Medicine, Yangsan, Korea
J Immunol 185:5522-30. 2010.... - Mechanism-based alternative monitoring of endoplasmic reticulum stress by 8-keto-trichothecene mycotoxins using human intestinal epithelial cell lineHyun Yang
Department of Microbiology and Immunology, and Medical Research Institute, Pusan National University School of Medicine, Yangsan 626 813, Republic of Korea
Toxicol Lett 198:317-23. 2010..The mechanism-based monitoring of 8-keto trichothecenes is promising as a supplementary analysis means of the presence of bioactive 8-keto trichothecenes, which are potentially exposed in human gut epithelia... - Chronic Nod2 stimulation potentiates activating transcription factor 3 and paradoxical superinduction of epithelial proinflammatory chemokines by mucoactive ribotoxic stressors via RNA-binding protein human antigen RSeong Hwan Park
Laboratory of Systems Mucosal Biomodulation, Department of Microbiology and Immunology and Medical Research Institute, Pusan National University School of Medicine, Yangsan 626 813, Korea
Toxicol Sci 125:116-25. 2012..This paradoxical superinduction of chemokines was also mediated by enhanced mRNA stabilization by HuR protein in spite of ATF3-mediated suppression of NF-κB signal in human intestinal epithelial cells... - Pro-inflammatory NF-κB and early growth response gene 1 regulate epithelial barrier disruption by food additive carrageenan in human intestinal epithelial cellsHye Jin Choi
Laboratory of Systems Mucosal Biomodulation, Department of Microbiology and Immunology, Pusan National University School of Medicine, Yangsan, Republic of Korea
Toxicol Lett 211:289-95. 2012..Suppression of NF-κB or EGR-1 aggravated barrier disruption by CGN, which was associated with the reduced gene expression of tight junction component zonula occludens 1 and its irregular localization in the epithelial monolayer... - Ribotoxic mycotoxin deoxynivalenol induces G2/M cell cycle arrest via p21Cip/WAF1 mRNA stabilization in human epithelial cellsHyun Yang
Department of Microbiology and Immunology and Medical Research Institute, Pusan National University School of Medicine, Busan 602 739, Republic of Korea
Toxicology 243:145-54. 2008..Particularly, ERK1/2 signal was associated with DON-induced p21 mRNA stabilization in the human epithelial cells. Taken together, deoxynivalenol arrested epithelial cell cycle at G(2)/M phase via elevated p21 gene expression... - Two in-and-out modulation strategies for endoplasmic reticulum stress-linked gene expression of pro-apoptotic macrophage-inhibitory cytokine 1Seong Hwan Park
Laboratory of Systems Mucosal Biomodulation, Department of Microbiology and Immunology, Pusan National University School of Medicine, Yangsan 626 870, Korea
J Biol Chem 287:19841-55. 2012..We propose that these two sequential in-and-out modulations can account for stabilized transcription and subsequent translation of pro-apoptotic MIC-1 gene in human cancer cells under ER stress... - Epithelial cell survival by activating transcription factor 3 (ATF3) in response to chemical ribosome-inactivating stressHyun Yang
Department of Microbiology and Immunology, Medical Research Institute, Pusan National University School of Medicine, 1 10 Ami dong Seo Ku, Busan 602 739, Republic of Korea
Biochem Pharmacol 77:1105-15. 2009..The results of this study showed that enhanced ATF3 production was associated with cellular defenses by maintaining the epithelial survival after ribotoxic mucosal insults... - Ambivalent roles of early growth response 1 in inflammatory signaling following ribosomal insult in human enterocytesKee Hun Do
Laboratory of Systems Mucosal Biomodulation, Department of Microbiology and Immunology and Medical Research Institute, Pusan National University School of Medicine, Yangsan 626 870, South Korea
Biochem Pharmacol 84:513-21. 2012..It can be thus concluded that EGR-1 regulates pro-inflammatory NF-κB activation by LPS via PPARγ although EGR-1 is a positive mediator of chemokine expression following ribosomal insult in intestinal epithelial cells... - Modulation of early growth response gene 1 and interleukin-8 expression by ribotoxin deoxynivalenol (vomitoxin) via ERK1/2 in human epithelial intestine 407 cellsYuseok Moon
Department of Microbiology and Immunology and Medical Research Institute, Pusan National University School of Medicine, 1 10 Ami dong, Busan, Republic of
Biochem Biophys Res Commun 362:256-62. 2007..These findings will provide insight into the possible mechanism associated with the early epithelial inflammation by ribotoxic insults... - Involvement of epidermal growth factor receptor-linked signaling responses in Pseudomonas fluorescens-infected alveolar epithelial cellsHye Jin Choi
Department of Microbiology and Immunology, Pusan National University School of Medicine, Yangsan 626 813, South Korea
Infect Immun 79:1998-2005. 2011..Thus, airway epithelial exposure to P. fluorescens can trigger antiapoptotic responses via EGFR and proinflammatory responses via TLR4-independent NF-κB signaling pathway in human pneumocytes... - The integrated stress response-associated signals modulates intestinal tumor cell growth by NSAID-activated gene 1 (NAG-1/MIC-1/PTGF-beta)Hyun Yang
Department of Microbiology and Immunology and Medical Research Institute, Pusan National University School of Medicine, Yangsan 626 813, Korea
Carcinogenesis 31:703-11. 2010..PKR-ERK1/2 activation may thus contribute to the defensive cellular response to cytotoxic NSAIDs while drug-mediated ER stress triggers the pro-apoptotic NAG-1 production in human colon cancer cells... - Enhanced wound healing by recombinant Escherichia coli Nissle 1917 via human epidermal growth factor receptor in human intestinal epithelial cells: therapeutic implication using recombinant probioticsHye Jin Choi
Laboratory of Systems Mucosal Biomodulation, Department of Microbiology and Immunology, Pusan National University School of Medicine, Yangsan, South Korea
Infect Immun 80:1079-87. 2012..The present study provides a basis for the clinical application of human recombinant biotherapeutics via an efficient, safe probiotic vehicle... - Macrophage inhibitory cytokine-1 (MIC-1) and subsequent urokinase-type plasminogen activator mediate cell death responses by ribotoxic anisomycin in HCT-116 colon cancer cellsHyun Yang
Department of Microbiology and Immunology and Medical Research Institute, Pusan National University School of Medicine, Yangsan, Republic of Korea
Biochem Pharmacol 78:1205-13. 2009..The results of this study provide mechanistic insight into tumor cell decision for death or survival pathways in response to ribosome-disrupting stresses from chemotherapeutics... - Endoplasmic reticulum stress-activated C/EBP homologous protein enhances nuclear factor-kappaB signals via repression of peroxisome proliferator-activated receptor gammaSeong Hwan Park
Laboratory of Systems Mucosal Biomodulation, Department of Microbiology and Immunology, Pusan National University School of Medicine, Yangsan 626 813, Korea
J Biol Chem 285:35330-9. 2010.... - Induction of human microsomal prostaglandin E synthase 1 by activated oncogene RhoA GTPase in A549 human epithelial cancer cellsHye Jin Choi
Laboratory of Systems Mucosal Biomodulation, Department of Microbiology and Immunology, Pusan National University School of Medicine, Yangsan, Republic of Korea
Biochem Biophys Res Commun 413:448-53. 2011..Since oncogene-triggered PGE(2) production is a critical modulator of epithelial tumor cells, RhoA-associated mPGES-1 represents a promising chemo-preventive or therapeutic target for epithelial inflammation and its associated cancers... - HuR/ELAVL1 RNA binding protein modulates interleukin-8 induction by muco-active ribotoxin deoxynivalenolHye Jin Choi
Department of Microbiology and Immunology and Medical Research Institute, Pusan National University School of Medicine, Yangsan, 626 813, Republic of Korea
Toxicol Appl Pharmacol 240:46-54. 2009.... - Identification of the minimal region in lipase ABC transporter recognition domain of Pseudomonas fluorescens for secretion and fluorescence of green fluorescent proteinYeonwoo Park
Korea Science Academy of KAIST, 899 Tanggam 3 Dong, Busanjin Gu, Busan, 614 822, Korea
Microb Cell Fact 11:60. 2012..Each LARD was fused to epidermal growth factor (EGF) or green fluorescent protein (GFP), and the secretion of EGF-LARD or GFP-LARD fusion proteins was assessed in Escherichia coli with ABC transporter... - Integrated stress response-altered pro-inflammatory signals in mucosal immune-related cellsSeong Hwan Park
Laboratory of Mucosal Exposome and Biomodulation, Department of Microbiology and Immunology, Pusan National University School of Medicine, Yangsan, South Korea
Immunopharmacol Immunotoxicol 35:205-14. 2013..Understanding ISR-modulated cellular alterations will provide progressive insights into approaches for treating human mucosal inflammatory and metabolic disorders... - Protective effect of irradiated renal carcinoma expressing hepatitis B surface antigen against renal-cell carcinoma-mediated tumorsYuseok Moon
Department of Microbiology and Immunology, Medical Research Institute, Pusan National University Medical School, Busan, Korea
Cancer Biother Radiopharm 21:211-6. 2006..These results confirm the postulate that RENCA/HBS vaccination elicits an antitumor immune response to some putative antigens or enhances the general immune competence in immunosuppressed renal tumor patients... - Regulation of EP4 expression via the Sp-1 transcription factor: inhibition of expression by anti-cancer agentsAtsushi Kambe
Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, North Carolina 27709, USA
Biochim Biophys Acta 1783:1211-9. 2008..Thus, we propose that the expression of EP4 is regulated by Sp-1, but phosphorylation of Sp-1 induced by TGZ suppresses this expression. This represents a new and unique mechanism for the regulation of the EP4 receptor expression... - Cyclooxygenase-2 mediates interleukin-6 upregulation by vomitoxin (deoxynivalenol) in vitro and in vivoYuseok Moon
Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI 48824-1224, USA
Toxicol Appl Pharmacol 187:80-8. 2003.... - Deoxynivalenol-induced mitogen-activated protein kinase phosphorylation and IL-6 expression in mice suppressed by fish oilYuseok Moon
Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI 48824-1224, USA
J Nutr Biochem 14:717-26. 2003..Taken together, the capacity of FO and its component n-3 PUFAs to suppress IL-6 expression as well as ERK 1/2 and JNK 1/2 activation might explain, in part, the reported suppressive effects of these lipids on DON-induced IgA nephropathy... - The anti-invasive activity of cyclooxygenase inhibitors is regulated by the transcription factor ATF3 (activating transcription factor 3)Frank G Bottone
Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, NIH, P.O. Box 12233, 111 T.W. Alexander Drive, Research Triangle Park, NC 27709, USA
Mol Cancer Ther 4:693-703. 2005..In conclusion, ATF3 represents a novel mechanism in which NSAIDs exert their anti-invasive activity, thereby linking ATF3 and its gene regulatory activity to the biological activity of these compounds... - Transcriptional regulation of activating transcription factor 3 involves the early growth response-1 geneFrank G Bottone
Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
J Pharmacol Exp Ther 315:668-77. 2005..Therefore, this is a novel first report demonstrating that the expression of ATF3 occurs via Egr-1 downstream of Erk1/2... - Curcumin suppresses interleukin 1beta-mediated microsomal prostaglandin E synthase 1 by altering early growth response gene 1 and other signaling pathwaysYuseok Moon
Eicosanoid Biochemistry Section, Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
J Pharmacol Exp Ther 315:788-95. 2005..These results indicate that curcumin inhibits IL-1beta-induced PGE(2) formation by inhibiting the expression of mPGES-1 that is mediated by suppression of EGR-1 expression as well as NF-kappaB and JNK1/2... - Suppression of tumor cell invasion by cyclooxygenase inhibitors is mediated by thrombospondin-1 via the early growth response gene Egr-1Yuseok Moon
Eicosanoid Biochemistry Section, Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, 111 T.W. Alexander Drive, Research Triangle Park, NC 27709, USA
Mol Cancer Ther 4:1551-8. 2005..This is the first report suggesting that COX inhibitors suppress tumor cell invasion via TSP-1, which occurs downstream of Egr-1... - A GTPase-activating protein binds STAT3 and is required for IL-6-induced STAT3 activation and for differentiation of a leukemic cell lineYukio Tonozuka
Division of Cellular Therapy, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
Blood 104:3550-7. 2004..All together, our data not only reveal an important role for MgcRacGAP in STAT3 activation, but also demonstrate that MgcRacGAP regulates IL-6-induced cellular differentiation in which STAT3 plays a pivotal role... - Ionizing radiation enhances the expression of the nonsteroidal anti-inflammatory drug-activated gene (NAG1) by increasing the expression of TP53 in human colon cancer cellsRyuji Okazaki
Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Radiat Res 165:125-30. 2006..The findings reported here indicate that gamma radiation activates the TP53 tumor suppressor, which then increases the expression of NAG1. NAG1 mediates the induction of apoptosis in human colorectal cells... - Relationship of trichothecene structure to COX-2 induction in the macrophage: selective action of type B (8-keto) trichothecenesYuseok Moon
Department of Food Science and Human Nutrition and Institute for Environmental Toxicology, Michigan State University, East Lansing 48824, USA
J Toxicol Environ Health A 66:1967-83. 2003..Selective action on COX-2 might contribute to unique pathologic manifestations associated with Type B trichothecene-mediated immunotoxicity... - Rac1 and a GTPase-activating protein, MgcRacGAP, are required for nuclear translocation of STAT transcription factorsToshiyuki Kawashima
Division of Cellular Therapy, The Institute of Medical Science, University of Tokyo, Minato ku, Tokyo 108 8639, Japan
J Cell Biol 175:937-46. 2006..We conclude that GTP-bound Rac1 and MgcRacGAP function as a nuclear transport chaperone for activated STATs...