J H Jung

Summary

Affiliation: Pusan National University
Country: Korea

Publications

  1. pmc Potent anti-diabetic effects of MHY908, a newly synthesized PPAR α/γ dual agonist in db/db mice
    Min Hi Park
    Molecular Inflammation Research Center for Aging Intervention MRCA, College of Pharmacy, Pusan National University, Busan, Korea Laboratory of Biochemistry, Pusan National University, Busan, Korea
    PLoS ONE 8:e78815. 2013
  2. pmc Computational approach to identify enzymes that are potential therapeutic candidates for psoriasis
    Daeui Park
    Interdisciplinary Research Program of Bioinformatics and Longevity Science, Pusan National University, Kumjeong gu, Busan 609 735, Republic of Korea
    Enzyme Res 2011:826784. 2011
  3. pmc Inhibitory effect of mTOR activator MHY1485 on autophagy: suppression of lysosomal fusion
    Yeon Ja Choi
    Molecular Inflammation Research Center for Aging Intervention MRCA, College of Pharmacy, Pusan National University, Busan, Korea
    PLoS ONE 7:e43418. 2012
  4. pmc Molecular study of dietary heptadecane for the anti-inflammatory modulation of NF-kB in the aged kidney
    Dae Hyun Kim
    Department of Pharmacy, College of Pharmacy, Aging Tissue Bank, Pusan National University, Busan, Republic of Korea
    PLoS ONE 8:e59316. 2013
  5. pmc Ginsenoside Rd inhibits the expressions of iNOS and COX-2 by suppressing NF-κB in LPS-stimulated RAW264.7 cells and mouse liver
    Dae Hyun Kim
    Molecular Inflammation Research Center for Aging Intervention MRCA, College of Pharmacy, Pusan National University, Busan 609 735, Korea
    J Ginseng Res 37:54-63. 2013
  6. pmc Anti-wrinkle and anti-inflammatory effects of active garlic components and the inhibition of MMPs via NF-κB signaling
    So Ra Kim
    Molecular Inflammation Research Center for Aging Intervention MRCA, College of Pharmacy, Pusan National University, Busan, Republic of Korea
    PLoS ONE 8:e73877. 2013
  7. ncbi request reprint Molecular inflammation hypothesis of aging based on the anti-aging mechanism of calorie restriction
    Hae Young Chung
    College of Pharmacy, Pusan National University, Pusan 609 735, Korea
    Microsc Res Tech 59:264-72. 2002
  8. doi request reprint Molecular inflammation as an underlying mechanism of the aging process and age-related diseases
    H Y Chung
    Molecular Inflammation Research Center for Aging Intervention, Pusan National University, Busan 609 735, Korea
    J Dent Res 90:830-40. 2011
  9. pmc Molecular inflammation: underpinnings of aging and age-related diseases
    Hae Young Chung
    Department of Pharmacy, Longevity Science and Technology Institutes, Research Institute for Drug Development, Pusan National University, Geumjeong Gu, Busan 609 735, South Korea
    Ageing Res Rev 8:18-30. 2009
  10. ncbi request reprint The molecular inflammatory process in aging
    Hae Young Chung
    College of Pharmacy, Pusan National University, Busan, Korea
    Antioxid Redox Signal 8:572-81. 2006

Collaborators

  • Byung Pal Yu
  • Emanuele Marzetti
  • J Lee
  • Matteo Cesari
  • Christiaan Leeuwenburgh
  • H S Kim
  • Jae Sue Choi
  • Sik Yoon
  • Sataro Goto
  • Takako Yokozawa
  • Ryoya Takahashi
  • Naoki Maruyama
  • Hae Young Chung
  • Kyung Jin Jung
  • Dae Hyun Kim
  • Yani Zou
  • Ji Young Kim
  • Min Hi Park
  • Yeon Ja Choi
  • Chul Hong Kim
  • Eun Kyung Go
  • Chan Hum Park
  • Hyoung Oh Jeong
  • Young Mi Ha
  • Daeui Park
  • Bokyung Sung
  • Min Sun Kim
  • You Jung Kim
  • Tae Gen Son
  • Eun Ji Jang
  • Hye Jin An
  • So Ra Kim
  • Ki Wung Chung
  • Akihito Ishigami
  • Ji Young Park
  • Hyung Ryong Moon
  • Pusoon Chun
  • Eun Kyeong Lee
  • H Y Chung
  • Hyoung Sam Heo
  • Jae Heun Chung
  • Ji Min Kim
  • Min Ju Kang
  • Jeong Hwan Je
  • Zsolt Radak
  • Kyu Won Kim
  • Chong Gun Cho
  • Nam Deuk Kim
  • Mi Kyung Kim
  • Yung Whan Choi
  • Ji Sung Yoon
  • Ha Ram Bae
  • Hye Jin Lee
  • Kyoung Mi Moon
  • Yu Ri Jung
  • Sungjin Bae
  • Yun Jung Park
  • Yu Min Song
  • C H Kim
  • Y J Choi
  • J M Kim
  • Byoung Chul Kim
  • D H Kim
  • N D Kim
  • Y Zou
  • E K Lee
  • Christy Carter
  • Hyung Suk Baik
  • Silvia Giovannini
  • Arnold Young Seo
  • Stephen Anton
  • Hyeang Kwan Lim
  • Won Gun An
  • Hyunae Lim
  • Hyun Seok Song
  • Myung Jin Son
  • Hyung Suck Baik
  • Mie Ae Yoo
  • Bo Kyung Sung
  • Jung Won Kim
  • Hisashi Naito
  • Dae Ui Park
  • An Sung Chung
  • Junji Yodoi
  • Kyung Hee Shim
  • Sang Woon Chung

Detail Information

Publications32

  1. pmc Potent anti-diabetic effects of MHY908, a newly synthesized PPAR α/γ dual agonist in db/db mice
    Min Hi Park
    Molecular Inflammation Research Center for Aging Intervention MRCA, College of Pharmacy, Pusan National University, Busan, Korea Laboratory of Biochemistry, Pusan National University, Busan, Korea
    PLoS ONE 8:e78815. 2013
    ....
  2. pmc Computational approach to identify enzymes that are potential therapeutic candidates for psoriasis
    Daeui Park
    Interdisciplinary Research Program of Bioinformatics and Longevity Science, Pusan National University, Kumjeong gu, Busan 609 735, Republic of Korea
    Enzyme Res 2011:826784. 2011
    ..We adopted a computational approach to detect potential therapeutic targets; this approach may become an effective strategy for the discovery of new drug targets for psoriasis...
  3. pmc Inhibitory effect of mTOR activator MHY1485 on autophagy: suppression of lysosomal fusion
    Yeon Ja Choi
    Molecular Inflammation Research Center for Aging Intervention MRCA, College of Pharmacy, Pusan National University, Busan, Korea
    PLoS ONE 7:e43418. 2012
    ..The significance of this study is the finding of a novel inhibitor of autophagy with an mTOR activating effect...
  4. pmc Molecular study of dietary heptadecane for the anti-inflammatory modulation of NF-kB in the aged kidney
    Dae Hyun Kim
    Department of Pharmacy, College of Pharmacy, Aging Tissue Bank, Pusan National University, Busan, Republic of Korea
    PLoS ONE 8:e59316. 2013
    ..We conclude that heptadecane suppresses age-related increases in pro-inflammatory gene expressions then travel upstream set by step by reducing NF-kB activity by downregulating the NIK/IKK and MAPKs pathways induced by RS...
  5. pmc Ginsenoside Rd inhibits the expressions of iNOS and COX-2 by suppressing NF-κB in LPS-stimulated RAW264.7 cells and mouse liver
    Dae Hyun Kim
    Molecular Inflammation Research Center for Aging Intervention MRCA, College of Pharmacy, Pusan National University, Busan 609 735, Korea
    J Ginseng Res 37:54-63. 2013
    ..Taken together, our results suggest that the anti-inflammatory effects of ginsenoside Rd are due to the down-regulation of NF-κB and the consequent expressional suppressions of iNOS and COX-2...
  6. pmc Anti-wrinkle and anti-inflammatory effects of active garlic components and the inhibition of MMPs via NF-κB signaling
    So Ra Kim
    Molecular Inflammation Research Center for Aging Intervention MRCA, College of Pharmacy, Pusan National University, Busan, Republic of Korea
    PLoS ONE 8:e73877. 2013
    ..Summarizing, caffeic acid, S-allyl cysteine, and uracil inhibited UVB-induced wrinkle formation by modulating MMP via NF-κB signaling. ..
  7. ncbi request reprint Molecular inflammation hypothesis of aging based on the anti-aging mechanism of calorie restriction
    Hae Young Chung
    College of Pharmacy, Pusan National University, Pusan 609 735, Korea
    Microsc Res Tech 59:264-72. 2002
    ..It was further proposed that CR's major force of the regulation of redox-sensitive inflammation may well be its life-prolonging action...
  8. doi request reprint Molecular inflammation as an underlying mechanism of the aging process and age-related diseases
    H Y Chung
    Molecular Inflammation Research Center for Aging Intervention, Pusan National University, Busan 609 735, Korea
    J Dent Res 90:830-40. 2011
    ..The final section discusses calorie restriction as an aging-retarding intervention that also exhibits extraordinarily effective anti-inflammatory activity by modulating GSH redox, NF-κB, SIRT1, PPARs, and FOXOs...
  9. pmc Molecular inflammation: underpinnings of aging and age-related diseases
    Hae Young Chung
    Department of Pharmacy, Longevity Science and Technology Institutes, Research Institute for Drug Development, Pusan National University, Geumjeong Gu, Busan 609 735, South Korea
    Ageing Res Rev 8:18-30. 2009
    ....
  10. ncbi request reprint The molecular inflammatory process in aging
    Hae Young Chung
    College of Pharmacy, Pusan National University, Busan, Korea
    Antioxid Redox Signal 8:572-81. 2006
    ....
  11. ncbi request reprint Significance of protein tyrosine kinase/protein tyrosine phosphatase balance in the regulation of NF-kappaB signaling in the inflammatory process and aging
    Kyung Jin Jung
    Department of Pharmacy, College of Pharmacy and Molecular Inflammation Research Center for Aging Intervention, Pusan National University, Busan 609 735, Korea
    Free Radic Biol Med 47:983-91. 2009
    ..Thus, our data suggest, for the first time, that the delicate balance between PTK and PTP is disturbed during aging and inflammation, both of which lead to NF-kappaB activation via NIK/IKK and MAPKs...
  12. ncbi request reprint Upregulation of aortic adhesion molecules during aging
    Yani Zou
    College of Pharmacy, Pusan National University, Gumjung gu, Busan 609 735, Korea
    J Gerontol A Biol Sci Med Sci 61:232-44. 2006
    ..Our study documented that aortic upregulated AMs with age are closely related to activation of NIK/IKK/IkappaB/nuclear factor-kappaB pathway brought on by oxidative stress...
  13. ncbi request reprint Modulation of redox-sensitive transcription factors by calorie restriction during aging
    Hyon Jeen Kim
    Department of Pharmacy, College of Pharmacy, Pusan National University, Gumjung gu, Busan 609 735, South Korea
    Mech Ageing Dev 123:1589-95. 2002
    ..Data on cellular regulation provide better molecular insights into the mechanisms underlying cellular redox maintenance, which may be the cross-talk between normal aging and age-associated pathogenic processes...
  14. ncbi request reprint The redox-sensitive DNA binding sites responsible for age-related downregulation of SMP30 by ERK pathway and reversal by calorie restriction
    Kyung Jin Jung
    Department of Pharmacy, College of Pharmacy, Pusan National University, Busan, Korea
    Antioxid Redox Signal 8:671-80. 2006
    ..Perhaps a more significant finding of the present study is that the downregulation of SMP30 is likely involved in ERK signal pathway...
  15. ncbi request reprint Effect of short-term, low dose aspirin supplementation on the activation of pro-inflammatory NF-kappaB in aged rats
    Kyung Jin Jung
    Department of Pharmacy, College of Pharmacy, Aging Tissue Bank, Pusan National University, Gumjung gu, Busan 609 735, Republic of Korea
    Mech Ageing Dev 127:223-30. 2006
    ..These findings showed for the first time that in aged rat short-term low dose dietary aspirin feeding modulates the molecular signal transduction involved in the inflammatory process...
  16. ncbi request reprint Betaine modulates age-related NF-kappaB by thiol-enhancing action
    Eun Kyung Go
    Department of Pharmacy, College of Pharmacy, Pusan National University, Gumjung ku, Busan 609 735, Korea
    Biol Pharm Bull 30:2244-9. 2007
    ..Based on both in vivo and in vitro data, we concluded that betaine exerts its efficacy by maintaining thiol status in the regulation of COX-2 and TNFalpha via NF-kappaB activation during aging...
  17. ncbi request reprint Suppression of age-related inflammatory NF-kappaB activation by cinnamaldehyde
    Dae Hyun Kim
    College of Pharmacy, Pusan National University, San 30, Jangjun dong, Gumjung gu, Busan 609 735, Korea
    Biogerontology 8:545-54. 2007
    ..Thus, the significance of the current study is the new information revealing the anti-inflammatory properties of CNA and the role it plays in the regulation of age-related alterations in signal transduction pathways...
  18. ncbi request reprint Alteration of soluble adhesion molecules during aging and their modulation by calorie restriction
    Yani Zou
    College of Pharmacy, Pusan National University, Busan 609 735, Korea
    FASEB J 18:320-2. 2004
    ..These findings suggest that the altered expressions of sAMs may be due to increased oxidative stress with advanced age and that these increases were prevented by CR through its antioxidative action...
  19. ncbi request reprint Modulation of the age-related nuclear factor-kappaB (NF-kappaB) pathway by hesperetin
    Ji Young Kim
    College of Pharmacy, Pusan National University, Busan, Korea
    Aging Cell 5:401-11. 2006
    ..The most significant findings of the current study report new information on the use of hesperetin as a potential anti-aging agent...
  20. ncbi request reprint cDNA representational difference analysis used in the identification of genes related to the aging process in rat kidney
    Bokyung Sung
    College of Pharmacy, Aging Tissue Bank, Pusan National University, Jangjeon Dong, Geumjeong ku, Busan 609 735, South Korea
    Mech Ageing Dev 126:882-91. 2005
    ..These data suggested that the inflammatory process is a plausible cause of the aging process...
  21. ncbi request reprint Suppression of apoptosis by calorie restriction in aged kidney
    Ji Hyeon Lee
    Department of Pharmacy, Aging Tissue Bank, Pusan National University, Gumjung ku, Busan 609 735, South Korea
    Exp Gerontol 39:1361-8. 2004
    ..Thus, our present data strongly suggest that the apoptotic activity observed in the aged kidney is likely modulated by the age-related oxidative status, and reversed by CR as a result of its anti-oxidative and anti-aging actions...
  22. ncbi request reprint The effect of age and calorie restriction on HIF-1-responsive genes in aged liver
    Min Ju Kang
    College of Pharmacy, Aging Tissue Bank, Pusan National University, Busan, Korea
    Biogerontology 6:27-37. 2005
    ..We propose that age-related HIF-1 binding activity may well be influenced by the increased pro-oxidative conditions of aged animals, which up-regulate HIF-1-dependent gene expression...
  23. ncbi request reprint Betaine suppresses proinflammatory signaling during aging: the involvement of nuclear factor-kappaB via nuclear factor-inducing kinase/IkappaB kinase and mitogen-activated protein kinases
    Eun Kyung Go
    Department of Pharmacy, College of Pharmacy, Pusan National University, Jang Jun dong, Gumjung ku, Busan, Korea
    J Gerontol A Biol Sci Med Sci 60:1252-64. 2005
    ..Thus, betaine might be useful as a preventive agent against the activation of NF-kappaB induced during inflammation and aging...
  24. ncbi request reprint Modulation of gene expression of SMP-30 by LPS and calorie restriction during aging process
    Kyung Jin Jung
    Department of Pharmacy, Aging Tissue Bank, Pusan National University, Gumjung ku, Busan 609 735, Republic of South Korea
    Exp Gerontol 39:1169-77. 2004
    ..The potent anti-aging and anti-oxidative action of CR effectively suppressed the age-related down-regulation of SMP-30 by ROS reduction...
  25. ncbi request reprint NF-kappaB activation mechanism of 4-hydroxyhexenal via NIK/IKK and p38 MAPK pathway
    Jeong Hwan Je
    Department of Pharmacy, College of Pharmacy, Pusan National University, Busan 609 735, Republic of Korea
    FEBS Lett 566:183-9. 2004
    ..These findings strongly suggest that HHE induces NF-kappaB activation through IKK/NIK pathway and/or p38 MAPK and ERK activation associated with oxidative stress in endothelial cells...
  26. ncbi request reprint Proteomic analysis of post-mitochondrial fractions of young and old rat kidney
    Chul Hong Kim
    Interdisciplinary Research Program of Bioinformatics, Pusan National University, Gumjung ku, Busan 609 735, South Korea
    Exp Gerontol 39:1155-68. 2004
    ..Thus, our results demonstrated that proteomic analysis can be effectively applied to the assessment of the age status of protein expression, and thereby provide valuable information on age-related changes of proteome...
  27. doi request reprint Lysophosphatidylcholine enhances oxidative stress via the 5-lipoxygenase pathway in rat aorta during aging
    Yani Zou
    College of Pharmacy, Aging Tissue Bank, Busan, South Korea
    Rejuvenation Res 12:15-24. 2009
    ..LPC may well be an important contributor to age-related oxidative stress in aging aorta...
  28. ncbi request reprint Influence of aging and calorie restriction on MAPKs activity in rat kidney
    Hyon Jeen Kim
    Department of Pharmacy, College of Pharmacy, Pusan National University, Gumjung ku, Pusan 609 735, South Korea
    Exp Gerontol 37:1041-53. 2002
    ..Based on these data, we concluded that an age-related increase in MAPK activity is associated with increased ROS, which was effectively suppressed by the anti-oxidative action of CR...
  29. ncbi request reprint Age-associated increase in oxidative stress and nuclear factor kappaB activation are attenuated in rat liver by regular exercise
    Zsolt Radak
    Laboratory of Exercise Physiology, School of Sport Science, Semmelweis University, Budapest, Hungary
    FASEB J 18:749-50. 2004
    ....
  30. ncbi request reprint Modulation of glutathione and thioredoxin systems by calorie restriction during the aging process
    Chong Gun Cho
    Department of Molecular Pathology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Exp Gerontol 38:539-48. 2003
    ..Our conclusion is that a redox imbalance occurs during aging and that redox changes are minimized through the anti-oxidative action of CR...
  31. ncbi request reprint SMP30 deficiency causes increased oxidative stress in brain
    Tae Gen Son
    Department of Pharmacy, College of Pharmacy and Research Institute for Drug Development, Longevity Life Science and Technology Institutes, Pusan National University, Geumjeong Gu, Busan, South Korea
    Mech Ageing Dev 127:451-7. 2006
    ..Our results documented that brain SMP30 has a protective action against oxidative damage, without influencing antioxidant enzyme status...
  32. ncbi request reprint Hesperetin: a potent antioxidant against peroxynitrite
    Ji Young Kim
    College of Pharmacy, Aging Tissue Bank, Pusan National University, Gumjung gu, Busan 609 735, South Korea
    Free Radic Res 38:761-9. 2004
    ..The present study suggests that hesperetin is a powerful ONOO- scavenger and promotes cellular defense activity in the protection against ONOO- involved diseases...