Se Kwon Kim

Summary

Affiliation: Pukyong National University
Country: Korea

Publications

  1. doi request reprint Medicinal effects of peptides from marine microalgae
    Se Kwon Kim
    Department of Chemistry, Pukyong National University, Busan, Republic of Korea
    Adv Food Nutr Res 64:313-23. 2011
  2. pmc Fumigaclavine C from a marine-derived fungus Aspergillus fumigatus induces apoptosis in MCF-7 breast cancer cells
    Yong Xin Li
    Marine Bioprocess Research Center, Pukyong National University, Busan 608 737, Korea
    Mar Drugs 11:5063-86. 2013
  3. ncbi request reprint Floridoside suppresses pro-inflammatory responses by blocking MAPK signaling in activated microglia
    Minjeong Kim
    Department of Chemistry Marine Bioprocess Research Center, Pukyong National University, Busan 608 737, Korea
    BMB Rep 46:398-403. 2013
  4. doi request reprint Triterpenoids of marine origin as anti-cancer agents
    Yong Xin Li
    Marine Bioprocess Research Center, Pukyong National University, Busan 608 737, Korea
    Molecules 18:7886-909. 2013
  5. ncbi request reprint Beneficial effect of peptides from microalgae on anticancer
    Kyong Hwa Kang
    Marine Bioprocess Research Center, Pukyong National University, Busan 608 737, Republic of Korea
    Curr Protein Pept Sci 14:212-7. 2013
  6. ncbi request reprint Potential beneficial effects of marine peptide on human neuron health
    BoMi Ryu
    School of Pharmacy, The University of Queensland, Brisbane, QLD 4072, Australia
    Curr Protein Pept Sci 14:173-6. 2013
  7. ncbi request reprint Marine bioactive peptides as potential antioxidants
    Dai Hung Ngo
    Marine Bioprocess Research Center, Pukyong National University, Busan 608 737, Republic of Korea
    Curr Protein Pept Sci 14:189-98. 2013
  8. ncbi request reprint Bioactive peptides from marine sources as potential anti-inflammatory therapeutics
    Jung Ae Kim
    Marine Bioprocess Research Center, Pukyong National University, Busan 608 737, Republic of Korea
    Curr Protein Pept Sci 14:177-82. 2013
  9. ncbi request reprint Natural flora and anticancer regime: milestones and roadmap
    Ira Bhatnagar
    Marine Bioprocess Research Center, Pukyong National University, Busan, Korea
    Anticancer Agents Med Chem 13:910-22. 2013
  10. pmc Beneficial effects of marine algal compounds in cosmeceuticals
    Noel Vinay Thomas
    Marine Biochemistry Lab, Department of Chemistry, Pukyong National University, Busan 608 737, Korea
    Mar Drugs 11:146-64. 2013

Collaborators

Detail Information

Publications128 found, 100 shown here

  1. doi request reprint Medicinal effects of peptides from marine microalgae
    Se Kwon Kim
    Department of Chemistry, Pukyong National University, Busan, Republic of Korea
    Adv Food Nutr Res 64:313-23. 2011
    ..Hence, in this chapter, we discussed the importance of marine microalgae in relation to their medicinal value...
  2. pmc Fumigaclavine C from a marine-derived fungus Aspergillus fumigatus induces apoptosis in MCF-7 breast cancer cells
    Yong Xin Li
    Marine Bioprocess Research Center, Pukyong National University, Busan 608 737, Korea
    Mar Drugs 11:5063-86. 2013
    ..Moreover, fumigaclavine C significantly down-regulated the NF-kappa-B cell survival pathway. Collectively, data suggest that fumigaclavine C has a potential to be developed as a therapeutic candidate for breast cancer. ..
  3. ncbi request reprint Floridoside suppresses pro-inflammatory responses by blocking MAPK signaling in activated microglia
    Minjeong Kim
    Department of Chemistry Marine Bioprocess Research Center, Pukyong National University, Busan 608 737, Korea
    BMB Rep 46:398-403. 2013
    ..Collectively, these results indicate that floridoside has the potential to be developed as an active agent for the treatment of neuro-inflammation...
  4. doi request reprint Triterpenoids of marine origin as anti-cancer agents
    Yong Xin Li
    Marine Bioprocess Research Center, Pukyong National University, Busan 608 737, Korea
    Molecules 18:7886-909. 2013
    ..In this review efforts have been taken to review the structural features and the potential use of triterpenoids of marine origin to be used in the pharmaceutical industry as potential anti-cancer drug leads. ..
  5. ncbi request reprint Beneficial effect of peptides from microalgae on anticancer
    Kyong Hwa Kang
    Marine Bioprocess Research Center, Pukyong National University, Busan 608 737, Republic of Korea
    Curr Protein Pept Sci 14:212-7. 2013
    ..This review focuses about the anticancer activating of peptides were prepared from microalgae in detail...
  6. ncbi request reprint Potential beneficial effects of marine peptide on human neuron health
    BoMi Ryu
    School of Pharmacy, The University of Queensland, Brisbane, QLD 4072, Australia
    Curr Protein Pept Sci 14:173-6. 2013
    ..This contribution presents an overview of marine proteins and peptides neuro-protective effect and their potential application in neuro-protection. ..
  7. ncbi request reprint Marine bioactive peptides as potential antioxidants
    Dai Hung Ngo
    Marine Bioprocess Research Center, Pukyong National University, Busan 608 737, Republic of Korea
    Curr Protein Pept Sci 14:189-98. 2013
    ..This chapter presents an overview of the antioxidant peptides derived marine resources with the potential utilization in the food as well as pharmaceutical industries. ..
  8. ncbi request reprint Bioactive peptides from marine sources as potential anti-inflammatory therapeutics
    Jung Ae Kim
    Marine Bioprocess Research Center, Pukyong National University, Busan 608 737, Republic of Korea
    Curr Protein Pept Sci 14:177-82. 2013
    ..Moreover, novel bioactive peptides from sponges, bacterium and microalgae are also described with their pharmacological effects in relation with anti-inflammation. ..
  9. ncbi request reprint Natural flora and anticancer regime: milestones and roadmap
    Ira Bhatnagar
    Marine Bioprocess Research Center, Pukyong National University, Busan, Korea
    Anticancer Agents Med Chem 13:910-22. 2013
    ..This is a comprehensive review covering major aspects of cancer mediation and utilization of marine flora for remediation of this deadly disease...
  10. pmc Beneficial effects of marine algal compounds in cosmeceuticals
    Noel Vinay Thomas
    Marine Biochemistry Lab, Department of Chemistry, Pukyong National University, Busan 608 737, Korea
    Mar Drugs 11:146-64. 2013
    ..The proper development of marine algae compounds will be helpful in cosmeceutical product development and in the development of the cosmeceutical industry...
  11. pmc Cell survival and apoptosis signaling as therapeutic target for cancer: marine bioactive compounds
    Senthilkumar Kalimuthu
    Marine Bioprocess Research Center, Department of Chemistry, Pukyong National University, Busan 608 737, Korea
    Int J Mol Sci 14:2334-54. 2013
    ..This review discusses the signaling of apoptosis and cell survival, as well as the potential contribution of marine bioactive compounds, suggesting that new therapeutic strategies might follow...
  12. doi request reprint Phlorotannins and fucoidans from marine macroalgae as matrix metalloproteinase inhibitory substances and their possible application as medicinal foods
    Se Kwon Kim
    Marine Biochemistry Laboratory, Department of Chemistry, Pukyong National University, Busan, Republic of Korea
    Adv Food Nutr Res 64:129-41. 2011
    ....
  13. doi request reprint Antiallergic benefit of marine algae in medicinal foods
    Se Kwon Kim
    Department of Chemistry, Pukyong National University, Busan, Republic of Korea
    Adv Food Nutr Res 64:267-75. 2011
    ..This contribution focuses on antiallergic agents derived from marine algae and presents an overview of their potential application in medicinal foods for the treatment of allergic disorders...
  14. doi request reprint Medicinal benefits of sulfated polysaccharides from sea vegetables
    Se Kwon Kim
    Marine Biochemistry Laboratory, Department of Chemistry, Pukyong National University, Busan, Republic of Korea
    Adv Food Nutr Res 64:391-402. 2011
    ..This chapter presents an overview of biological activities and potential medicinal benefits of SPs derived from sea vegetables...
  15. doi request reprint Potential beneficial effects of marine algal sterols on human health
    Se Kwon Kim
    Marine Bioprocess Research Center, Pukyong National University, Busan, Republic of Korea
    Adv Food Nutr Res 64:191-8. 2011
    ..This chapter focuses on biological activities of marine algae derived sterols with potential health beneficial applications in functional foods and pharmaceuticals...
  16. doi request reprint Medicinal effects of phlorotannins from marine brown algae
    Se Kwon Kim
    Marine Biochemistry Laboratory, Department of Chemistry, Pukyong National University, Busan, Republic of Korea
    Adv Food Nutr Res 64:97-109. 2011
    ..In this chapter, attempts have taken to examine and categorize the reports available on active phlorotannins which have shown strong bioactivities...
  17. doi request reprint Potential application of marine algae as antiviral agents in medicinal foods
    Se Kwon Kim
    Department of Chemistry, Pukyong National University, Busan, Republic of Korea
    Adv Food Nutr Res 64:245-54. 2011
    ..This contribution focuses on antiherpes virus therapeutic agents derived from marine algae which are considered as novel functional ingredients in antiherpes virus therapy...
  18. doi request reprint Anticoagulant effect of marine algae
    Se Kwon Kim
    Marine Biochemistry Laboratory, Department of Chemistry, Pukyong National University, Busan, Republic of Korea
    Adv Food Nutr Res 64:235-44. 2011
    ..This chapter focuses on the potential anticoagulant agents in marine algae and presents an overview of their anticoagulant effect...
  19. doi request reprint Marine algae: natural product source for gastrointestinal cancer treatment
    Se Kwon Kim
    Department of Chemistry, Pukyong National University, Busan, Republic of Korea
    Adv Food Nutr Res 64:225-33. 2011
    ..Hence investigation of bioactive compounds against gastrointestinal cancer cells has recently become an important field for researchers...
  20. doi request reprint Biological activities and potential health benefits of fucoxanthin derived from marine brown algae
    Se Kwon Kim
    Marine Biochemistry Laboratory, Department of Chemistry, Pukyong National University, Busan, Republic of Korea
    Adv Food Nutr Res 64:111-28. 2011
    ..In this chapter, the currently available scientific literatures regarding the most significant activities of fucoxanthin are summarized...
  21. doi request reprint Physical, chemical, and biological properties of wonder kelp--Laminaria
    Se Kwon Kim
    Department of Chemistry, Pukyong National University, Busan, Republic of Korea
    Adv Food Nutr Res 64:85-96. 2011
    ..A deeper insight into the physical, biological, and chemical properties of this wonder kelp would lead to further exploitation of Laminaria for medicinal and cosmeceutical purpose...
  22. doi request reprint Potential role of marine algae on female health, beauty, and longevity
    Se Kwon Kim
    Marine Biochemistry Laboratory, Department of Chemistry, Pukyong National University, Busan, Republic of Korea
    Adv Food Nutr Res 64:41-55. 2011
    ..This contribution presents an overview of marine algal potential effect in promoting female health, beauty, and longevity...
  23. doi request reprint Sea lettuces: culinary uses and nutritional value
    Se Kwon Kim
    Marine Biochemistry Laboratory, Department of Chemistry, Pukyong National University, Busan, Republic of Korea
    Adv Food Nutr Res 64:57-70. 2011
    ..This contributions presents information on the currently culinary use of sea lettuces worldwide and nutritional aspects of sea lettuces...
  24. doi request reprint Anti-HIV activity of extracts and compounds from marine algae
    Se Kwon Kim
    Department of Chemistry, Pukyong National University, Busan, Republic of Korea
    Adv Food Nutr Res 64:255-65. 2011
    ..Up to date, several types of compounds such as tannins, polysaccharides, lectins, and derivatives have been isolated, identified, and reported to possess significant anti-HIV-1 activity...
  25. doi request reprint Anticancer compounds from marine macroalgae and their application as medicinal foods
    Se Kwon Kim
    Marine Biochemistry Laboratory, Department of Chemistry, Pukyong National University, Busan, Republic of Korea
    Adv Food Nutr Res 64:213-24. 2011
    ..In this chapter, we have discussed the anticancer activities of marine algae-derived SPs, phlorotannins, and carotenoids and the possibilities of marine algae as potential medicinal foods in the management of cancer...
  26. doi request reprint Triterpene glycosides from sea cucumbers and their biological activities
    Se Kwon Kim
    Department of Chemistry, Pukyong National University, Busan, Republic of Korea
    Adv Food Nutr Res 65:297-319. 2012
    ..The structural significance and the application limitations of triterpene glycosides are also discussed...
  27. doi request reprint Bioactive sterols from marine resources and their potential benefits for human health
    Se Kwon Kim
    Department of Chemistry, Marine Biochemistry Laboratory, Pukyong National University, Busan, Republic of Korea
    Adv Food Nutr Res 65:261-8. 2012
    ..This chapter focuses on biological activities of marine animal and microbe sterols with potential health beneficial applications in functional foods and pharmaceuticals...
  28. doi request reprint Biological activities and health effects of terpenoids from marine fungi
    Se Kwon Kim
    Department of Chemistry, Pukyong National University, Busan, Republic of Korea
    Adv Food Nutr Res 65:409-13. 2012
    ..These secondary metabolites serve many biopharmaceutical purposes. This chapter discusses about marine fungi-derived terpenoids and presents an overview of their beneficial health effects...
  29. doi request reprint Medicinal foods from marine animals: current status and prospects
    Se Kwon Kim
    Department of Chemistry, Pukyong National University, Busan, Republic of Korea
    Adv Food Nutr Res 65:1-9. 2012
    ..In addition, this chapter encourages the new researchers as well as various health communities to implement the marine animal-based medicinal foods and their applications...
  30. doi request reprint Bioactive compounds from marine sponges and their symbiotic microbes: a potential source of nutraceuticals
    Se Kwon Kim
    Department of Chemistry, Pukyong National University, Busan, Republic of Korea
    Adv Food Nutr Res 65:137-51. 2012
    ..This overview discusses the potentials of marine sponge-derived bioactivities as natural health-promoting compounds...
  31. doi request reprint Biological importance and applications of squalene and squalane
    Se Kwon Kim
    Department of Chemistry, Pukyong National University, Busan, Republic of Korea
    Adv Food Nutr Res 65:223-33. 2012
    ..According to promising results from recent studies, squalene and squalane are considered important substances in practical and clinical uses with a huge potential in nutraceutical and pharmaceutical industries...
  32. doi request reprint Marine fish-derived bioactive peptides as potential antihypertensive agents
    Se Kwon Kim
    Department of Chemistry, Pukyong National University, Busan, Republic of Korea
    Adv Food Nutr Res 65:249-60. 2012
    ..This contribution presents an overview of the ACE inhibitory peptides derived from marine fishes and discusses their future prospects to be used as potential drug candidates for preventing and treating high blood pressure...
  33. doi request reprint Development of marine probiotics: prospects and approach
    Se Kwon Kim
    Department of Chemistry, Pukyong National University, Busan, Republic of Korea
    Adv Food Nutr Res 65:353-62. 2012
    ..This chapter is an attempt to shift the paradigm of research in probiotic area to the marine environment and to find ways of expanding the research in marine probiotics development...
  34. doi request reprint Applications of calcium and its supplement derived from marine organisms
    Se Kwon Kim
    Department of Chemistry, Pukyong National University, Busan, Republic of Korea
    Crit Rev Food Sci Nutr 52:469-74. 2012
    ..In this paper, we report various marine sources of calcium, solubilizing the calcium to improve the bioavailability and the applications of calcium as an important mineral in controlling different diseases...
  35. doi request reprint Anti-adipogenic effect of dioxinodehydroeckol via AMPK activation in 3T3-L1 adipocytes
    Se Kwon Kim
    Marine Bioprocess Research Center, Pukyong National University, Busan, Republic of Korea
    Chem Biol Interact 186:24-9. 2010
    ..Therefore, these results suggest that DHE exerts anti-adipogenic effect on adipocyte differentiation through the activation and modulation of the AMPK signaling pathway...
  36. doi request reprint Neoechinulin A suppresses amyloid-β oligomer-induced microglia activation and thereby protects PC-12 cells from inflammation-mediated toxicity
    Pradeep Dewapriya
    Marine Biochemistry Laboratory, Department of Chemistry, Pukyong National University, Busan 608 737, Republic of Korea
    Neurotoxicology 35:30-40. 2013
    ..Collectively, these results suggest that with further studies neoechinulin A have a potential to be developed as a modulator of neuroinflammatory process in AD...
  37. doi request reprint Free radical scavenging and angiotensin-I converting enzyme inhibitory peptides from Pacific cod (Gadus macrocephalus) skin gelatin
    Dai Hung Ngo
    Department of Chemistry, Pukyong National University, Busan 608 737, Republic of Korea
    Int J Biol Macromol 49:1110-6. 2011
    ..The present study demonstrated that the peptides derived from Pacific cod (G. macrocephalus) skin gelatin could be used in the food industry as functional ingredients with potent antioxidative and antihypertensive benefits...
  38. ncbi request reprint In vitro antioxidant activity of 5-HMF isolated from marine red alga Laurencia undulata in free-radical-mediated oxidative systems
    Yong Xin Li
    Department of Chemistry, Pukyong National University, Busan 608 737, Korea
    J Microbiol Biotechnol 19:1319-27. 2009
    ..The results demonstrated that 5-HMF could be developed as a novel marine natural antioxidant or potential precursor for practical applications in the food, cosmetic, and pharmaceutical fields...
  39. doi request reprint Chitooligosaccharides attenuate UVB-induced damages in human dermal fibroblasts
    Byul Nim Ahn
    Department of Chemistry, Pukyoung National University, Busan, 608 737, Republic of Korea
    Naunyn Schmiedebergs Arch Pharmacol 385:95-102. 2012
    ..The photoprotective activity of COS (3-5 kDa) was confirmed by transcriptional phosphorylation of mitogen-activated protein kinase-responsive signaling pathways...
  40. doi request reprint Effect of Sargassum thunbergii on ROS mediated oxidative damage and identification of polyunsaturated fatty acid components
    Jung Ae Kim
    Department of Chemistry, Pukyong National University, 599 1 Daeyon 3 dong, Busan, Republic of Korea
    Food Chem Toxicol 48:1243-9. 2010
    ..thunbergii has nutraceutical effectiveness in prevention of ROS-induced tissue damage and potential natural antioxidant related to oxidative stress, which can be traceable to polyunsaturated fatty acids contained in S. thunbergii...
  41. ncbi request reprint Purification and in vitro antioxidative effects of giant squid muscle peptides on free radical-mediated oxidative systems
    Niranjan Rajapakse
    Department of Chemistry, Pukyong National University, Busan 608 737, South Korea
    J Nutr Biochem 16:562-9. 2005
    ....
  42. doi request reprint Effect of phloroglucinol on oxidative stress and inflammation
    Moon Moo Kim
    Department of Chemistry, Dong Eui University, Busan 614 714, Republic of Korea
    Food Chem Toxicol 48:2925-33. 2010
    ..These results suggest that phloroglucinol can provide a therapeutic potential for prevention of chronic inflammation...
  43. ncbi request reprint Inhibition of free radical-mediated oxidation of cellular biomolecules by carboxylated chitooligosaccharides
    Niranjan Rajapakse
    Department of Chemistry, Pukyong National University, Busan 608 737, Republic of Korea
    Bioorg Med Chem 15:997-1003. 2007
    ..Direct radical scavenging studies carried out with DCFH-DA fluorescence probe concluded that CCOS can act as a potent radical scavenger in cells...
  44. doi request reprint Protective effect of (2'S)-columbianetin from Corydalis heterocarpa on UVB-induced keratinocyte damage
    Byul Nim Ahn
    Department of Chemistry, Pukyoung National University, Busan 608 737, Republic of Korea
    J Photochem Photobiol B 109:20-7. 2012
    ..These results suggest that (2'S)-columbianetin could be effectively used to protect human keratinocytes from UVB induced damage...
  45. ncbi request reprint Angiotensin I converting enzyme (ACE) inhibitory peptide derived from the sauce of fermented blue mussel, Mytilus edulis
    Jae Young Je
    Department of Chemistry, Pukyong National University, Busan 608 737, Republic of Korea
    Bioresour Technol 96:1624-9. 2005
    ..Blood pressure significantly decreased after peptide ingestion. This result suggested that FBMS may have beneficial effects on hypertension...
  46. ncbi request reprint Strong electronic charge as an important factor for anticancer activity of chitooligosaccharides (COS)
    Ronghua Huang
    Department of Chemistry, Pukyong National University, Busan 608 737, South Korea
    Life Sci 78:2399-408. 2006
    ..However, the exact molecular mechanism for anticancer activity of strongly charged COS compared to their poorly charged counterparts is not clear...
  47. ncbi request reprint An in vitro cellular analysis of the radical scavenging efficacy of chitooligosaccharides
    Eresha Mendis
    Marine Bioprocess Research Center, Pukyong National University, Busan 608 737, South Korea
    Life Sci 80:2118-27. 2007
    ..Moreover, induction of intracellular glutathione (GSH) level in the presence of COS promoted the effectiveness of COS to act against cellular oxidative stress...
  48. doi request reprint Antioxidant effects of phlorotannins isolated from Ishige okamurae in free radical mediated oxidative systems
    Yanping Zou
    Marine Bioprocess Research Center, Pukyong National University, Busan 608 737, South Korea
    J Agric Food Chem 56:7001-9. 2008
    ..In conclusion, these results suggested that phlorotannins could be used as novel functional foodstuffs or antioxidants in the cosmetic and drug industries...
  49. ncbi request reprint Differentiation of human osteosarcoma cells by isolated phlorotannins is subtly linked to COX-2, iNOS, MMPs, and MAPK signaling: implication for chronic articular disease
    BoMi Ryu
    Department of Chemistry, Pukyong National University, Busan 608 737, Republic of Korea
    Chem Biol Interact 179:192-201. 2009
    ..These results suggested the phlorotannin derivatives (1, 2) could promote cell differentiation, attenuate MMP-1, MMP-3, MMP-13 expressions, and inflammatory response via MAPK pathway in chronic articular diseases...
  50. doi request reprint Protective effect of chitin oligosaccharides against lipopolysaccharide-induced inflammatory response in BV-2 microglia
    Thanh Sang Vo
    Department of Chemistry, Pukyong National University, Busan 608 737, Republic of Korea
    Cell Immunol 277:14-21. 2012
    ..These findings provide mechanistic insights into the anti-inflammatory and neuroprotective actions of NA-COS in BV-2 microglia...
  51. doi request reprint Anti-HIV-1 activity of low molecular weight sulfated chitooligosaccharides
    Murat Artan
    Department of Chemistry, Pukyong National University, Busan 608 737, Republic of Korea
    Carbohydr Res 345:656-62. 2010
    ..These results suggest that sulfated chitooligosaccharides represent novel candidates for the development of anti-HIV-1 agent...
  52. ncbi request reprint Purification and characterization of antioxidant peptide from hoki (Johnius belengerii) frame protein by gastrointestinal digestion
    Soo Yong Kim
    Department of Chemistry, Pukyong National University, Busan 608 737, Korea
    J Nutr Biochem 18:31-8. 2007
    ..99 microM) and superoxide radicals (IC(50)=172.10 microM). Furthermore, APHPH decreased t-butylhydroperoxide-induced cytotoxicity on human embryonic lung fibroblasts and efficiently protected free-radical-induced DNA damage...
  53. doi request reprint 1-(3',5'-dihydroxyphenoxy)-7-(2'',4'',6-trihydroxyphenoxy)-2,4,9-trihydroxydibenzo-1,4-dioxin inhibits adipocyte differentiation of 3T3-L1 fibroblasts
    Chang Suk Kong
    Marine Bioprocess Research Center, Pukyong National University, Busan, 608 737, South Korea
    Mar Biotechnol (NY) 12:299-307. 2010
    ..Furthermore, compound 1 could be developed as a functional agent effective in improving obesity...
  54. doi request reprint Prevention of hydrogen peroxide-induced oxidative stress in HDF cells by peptides derived from seaweed pipefish, Syngnathus schlegeli
    BoMi Ryu
    Department of Chemistry, Pukyong National University, Busan 608 737, Republic of Korea
    Peptides 32:639-47. 2011
    ..These finding indicate the potential antioxidant effects of SPPs as response to H(2)O(2) stimulation...
  55. doi request reprint 1-(5-bromo-2-hydroxy-4-methoxyphenyl)ethanone [SE1] suppresses pro-inflammatory responses by blocking NF-κB and MAPK signaling pathways in activated microglia
    S W A Himaya
    Biochemistry and Molecular Biology Laboratory, Department of Chemistry, Pukyong National University, Busan 608 737, Republic of Korea
    Eur J Pharmacol 670:608-16. 2011
    ..These results suggest that SE1 has the potential to be further developed as therapeutic against neuro-inflammation...
  56. ncbi request reprint Free radical scavenging activity of a novel antioxidative peptide isolated from in vitro gastrointestinal digests of Mytilus coruscus
    Won Kyo Jung
    Department of Chemistry, Pukyong National University, Busan, Republic of Korea
    J Med Food 10:197-202. 2007
    ....
  57. doi request reprint An antihypertensive peptide from tilapia gelatin diminishes free radical formation in murine microglial cells
    Thanh Sang Vo
    Department of Chemistry, Pukyong National University, Busan 608 737, Republic of Korea
    J Agric Food Chem 59:12193-7. 2011
    ..These results suggest that the peptide isolated from Nile tilapia (O. niloticus) gelatin acts as a candidate against hypertension and oxidative stress and could be used in health-functional foods...
  58. doi request reprint Anti-inflammatory action of sulfated glucosamine on cytokine regulation in LPS-activated PMA-differentiated THP-1 macrophages
    Jung Ae Kim
    Department of Chemistry, Pukyong National University, Busan 608 737, Republic of Korea
    Inflamm Res 60:1131-8. 2011
    ..Changes in the inflammatory profiles of lipopolysaccharide (LPS)-activated phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1 macrophage models were investigated following SGlc treatment...
  59. doi request reprint Production and characterization of an extracellular polysaccharide from Streptomyces violaceus MM72
    Panchanathan Manivasagan
    Marine Biotechnology Laboratory, Department of Chemistry and Marine Bioprocess Research Center, Pukyong National University, Busan 608 737, Republic of Korea
    Int J Biol Macromol 59:29-38. 2013
    ..violaceus MM72 could be used in industry in place of synthetic compounds. The EPS from S. violaceus MM72 may be a new source of natural antioxidants with potential value for health, food and therapeutics...
  60. ncbi request reprint Phlorotannins in Ecklonia cava extract inhibit matrix metalloproteinase activity
    Moon Moo Kim
    Marine Bioprocess Research Center, Pukyong National University, Busan 608 737, Republic of Korea
    Life Sci 79:1436-43. 2006
    ..More interestingly, EC extract did not exert any cytotoxic effect even at 100 microg/ml anticipating its potential use as a safe MMP inhibitor...
  61. ncbi request reprint Investigation of jumbo squid (Dosidicus gigas) skin gelatin peptides for their in vitro antioxidant effects
    Eresha Mendis
    Department of Chemistry, Pukyong National University, Busan 608 737, South Korea
    Life Sci 77:2166-78. 2005
    ..Based on our results we suggest that hydrophobic amino acids present in peptide sequences contributed greatly for observed antioxidant activities...
  62. ncbi request reprint Golmaenone, a new diketopiperazine alkaloid from the marine-derived fungus Aspergillus sp
    Yong Li
    Department of Chemistry, Pukyong National University, Busan, Korea
    Chem Pharm Bull (Tokyo) 52:375-6. 2004
    ..Compounds 1 and 2 also showed an ultraviolet-A (UV-A) (320--390 nm) protecting activity with ED(50) values of 90 and 170 microM, respectively, which are more active than oxybenzone (ED(50), 350 microM) currently being used as sunscreen...
  63. ncbi request reprint Free radical scavenging activity of chitooligosaccharides by electron spin resonance spectrometry
    Pyo Jam Park
    Department of Chemistry, Pukyong National University, Busan 608 737, Korea
    J Agric Food Chem 51:4624-7. 2003
    ..These results suggest that the scavenging activity of COSs is dependent on their molecular weights and tested radicals...
  64. ncbi request reprint Sulfated glucosamine inhibits oxidation of biomolecules in cells via a mechanism involving intracellular free radical scavenging
    Eresha Mendis
    Marine Bioprocess Research Center, Pukyong National University, Busan 608 737, South Korea
    Eur J Pharmacol 579:74-85. 2008
    ....
  65. doi request reprint Photoprotective effect of libanoridin isolated from Corydalis heterocarpa on UVB stressed human keratinocyte cells
    Byul Nim Ahn
    Department of Chemistry, Pukyoung National University, Busan, Korea
    Exp Dermatol 22:155-7. 2013
    ..Therefore, libanoridin may be used as an effective natural compound to prevent skin damage due to UVB exposure...
  66. doi request reprint Utilization of seafood processing by-products: medicinal applications
    Mahinda Senevirathne
    Marine Bioprocess Research Center, Pukyong National University, Busan, Republic of Korea
    Adv Food Nutr Res 65:495-512. 2012
    ..Hence, seafood by-products are valuable natural resources that show range of functionalities and hence potential materials for biomedical and nutraceutical industries...
  67. ncbi request reprint Glucosamine sulfate promotes osteoblastic differentiation of MG-63 cells via anti-inflammatory effect
    Moon Moo Kim
    Marine Bioprocess Research Center, Pukyong National University, Busan 608 737, Republic of Korea
    Bioorg Med Chem Lett 17:1938-42. 2007
    ..7 cells. In conclusion, these results suggest that SGlc can promote cell differentiation in cultured MG-63 osteoblast cells via anti-inflammatory effect...
  68. doi request reprint Inhibitors of oxidation and matrix metalloproteinases, floridoside, and D-isofloridoside from marine red alga Laurencia undulata
    Yong Xin Li
    Department of Chemistry, Pukyong National University, Busan 608 737, Republic of Korea
    J Agric Food Chem 58:578-86. 2010
    ..Furthermore, the structure-activity relationships were also suggested. Both isomers could be effective candidates for applications in food and pharmaceutical fields as natural marine antioxidants...
  69. doi request reprint Attenuation of pro-inflammatory mediators in LPS-stimulated BV2 microglia by chitooligosaccharides via the MAPK signaling pathway
    Ratih Pangestuti
    Marine Biochemistry Laboratory, Department of Chemistry, Pukyong National University, Busan, South Korea
    Int J Biol Macromol 49:599-606. 2011
    ..These results indicate that COS could be used as an inhibitor in regulating microglial inflammatory responses. Moreover, COS may assist therapeutic treatment of neurodegenerative diseases which accompanied with microglial activation...
  70. ncbi request reprint Sulfated glucosamine inhibits MMP-2 and MMP-9 expressions in human fibrosarcoma cells
    Niranjan Rajapakse
    Marine Bioprocess Research Center, Pukyong National University, Busan 608 737, South Korea
    Bioorg Med Chem 15:4891-6. 2007
    ..Since MMPs involve in joint inflammation, it can be presumed that inhibition of MMP-2 and MMP-9 can be one of the mechanisms of SGlc to be an effective drug in relieving the symptoms of osteoarthritis...
  71. doi request reprint Purification of a peptide from seahorse, that inhibits TPA-induced MMP, iNOS and COX-2 expression through MAPK and NF-kappaB activation, and induces human osteoblastic and chondrocytic differentiation
    BoMi Ryu
    Department of Chemistry, Pukyong National University, Busan 608 737, Republic of Korea
    Chem Biol Interact 184:413-22. 2010
    ....
  72. doi request reprint Phosphorylated glucosamine inhibits the inflammatory response in LPS-stimulated PMA-differentiated THP-1 cells
    Jung Ae Kim
    Department of Chemistry, Pukyong National University, Busan 608 737, Republic of Korea
    Carbohydr Res 345:1851-5. 2010
    ..Furthermore, we confirmed that the LPS-stimulated transcription of MAP kinases in PMA-differentiated THP-1 macrophages was inhibited by pGlc. According to this study, pGlc can be considered as a potential anti-inflammatory agent...
  73. pmc Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 in lipopolysaccharide-stimulated RAW264.7 cells by carboxybutyrylated glucosamine takes place via down-regulation of mitogen-activated protein kinase-mediated nuclear factor-kappaB signali
    Niranjan Rajapakse
    Marine Bioprocess Research Center, Pukyong National University, Busan, Korea
    Immunology 123:348-57. 2008
    ..Therefore, it can be concluded that CGlcN is capable of inhibiting iNOS and COX-2 expression in LPS-induced RAW264.7 cells via attenuation of NF-kappaB signaling by p38 MAPK and JNK, but not by ERK...
  74. ncbi request reprint Purification and characterization of a collagenase from the mackerel, Scomber japonicus
    Pyo Jam Park
    Department of Chemistry, Pukyong National University, Busan 608 737, Korea
    J Biochem Mol Biol 35:576-82. 2002
    ..The K(m) and V(max) of the enzyme for collagen Type I were approximately 1.1mM and 2,343 U, respectively. The purified enzyme was strongly inhibited by Hg2+, Zn2+, PMSF, TLCK, and the soybean-trypsin inhibitor...
  75. ncbi request reprint Antioxidant properties of a radical-scavenging peptide purified from enzymatically prepared fish skin gelatin hydrolysate
    Eresha Mendis
    Department of Chemistry, Pukyong National University, Busan 608 737, South Korea
    J Agric Food Chem 53:581-7. 2005
    ..Present data indicate that free-radical-scavenging activities of hoki skin gelatin peptides substantially contribute to their antioxidant properties measured in different oxidative systems...
  76. doi request reprint Antioxidant peptides from protein hydrolysate of microalgae Navicula incerta and their protective effects in HepG2/CYP2E1 cells induced by ethanol
    Kyong Hwa Kang
    Marine Bioprocess Research Center, Pukyong National University, Busan, Republic of Korea
    Phytother Res 26:1555-63. 2012
    ..Furthermore, this study demonstrated that NIPP-1 and NIPP-2 peptides inhibited ethanol-induced cytotoxicity in HepG2/CYP2E1 cells...
  77. doi request reprint Paeonol from Hippocampus kuda Bleeler suppressed the neuro-inflammatory responses in vitro via NF-κB and MAPK signaling pathways
    S W A Himaya
    Biochemistry and Molecular Biology Laboratory, Department of Chemistry, Pukyong National University, Busan 608 737, Republic of Korea
    Toxicol In Vitro 26:878-87. 2012
    ..7 cells via modulating MAPK and NF-κB signaling pathways. Therefore, paeonol could be a promising candidate to be used in neuro-inflammatory therapy...
  78. doi request reprint Protective effect of chromene isolated from Sargassum horneri against UV-A-induced damage in skin dermal fibroblasts
    Jung Ae Kim
    Department of Chemistry, Pukyong National University, Busan, Korea
    Exp Dermatol 21:630-1. 2012
    ..Furthermore, we confirmed that the UV-A-induced transcriptions of AP-1 signalling pathway were regulated by sargachromenol treatment in UV-A-irradiated dermal fibroblasts...
  79. ncbi request reprint Protective effect of an antioxidative peptide purified from gastrointestinal digests of oyster, Crassostrea gigas against free radical induced DNA damage
    Zhong Ji Qian
    Department of Chemistry, Pukyong National University, Busan 608 737, Republic of Korea
    Bioresour Technol 99:3365-71. 2008
    ..7), respectively. These results indicate that this peptide shows potent antioxidant...
  80. doi request reprint Protective effects of aminoethyl-chitooligosaccharides against oxidative stress in mouse macrophage RAW 264.7 cells
    Dai Nghiep Ngo
    Marine Bioprocess Research Center, Pukyong National University, Busan 608 737, South Korea
    Int J Biol Macromol 50:624-31. 2012
    ..AE-COS also inhibited myeloperoxidase (MPO) activity in human myeloid cells (HL-60). These results suggest that AE-COS acts as a potential free radical scavenger in RAW 264.7 cells...
  81. doi request reprint Antiphotoaging effect of chitooligosaccharides on human dermal fibroblasts
    Jung Ae Kim
    Marine Bioprocess Research Center, Pukyong National University, Busan, Korea
    Photodermatol Photoimmunol Photomed 28:299-306. 2012
    ....
  82. doi request reprint Peptide isolated from Japanese flounder skin gelatin protects against cellular oxidative damage
    S W A Himaya
    Marine Biochemistry Laboratory, Department of Chemistry, Pukyong National University, Busan 608 737, South Korea
    J Agric Food Chem 60:9112-9. 2012
    ..Collectively, it can be concluded that Japanese flounder skin, a processing byproduct of filleting, can be effectively used to produce a bioactive peptide with potent antioxidant capacity...
  83. doi request reprint Anti-allergic effects of phlorotannins on histamine release via binding inhibition between IgE and Fc epsilonRI
    Yong Li
    Marine Bioprocess Research Center, Pukyong National University, Busan 608 737, Republic of Korea
    J Agric Food Chem 56:12073-80. 2008
    ..These results suggested that compounds 1 and 3 could be the key effectors in the crude methanol extract of EC against allergy disease and used as novel candidates for development in the cosmetic and drug industries potentially...
  84. doi request reprint A comparative study of thermal calcination and an alkaline hydrolysis method in the isolation of hydroxyapatite from Thunnus obesus bone
    Jayachandran Venkatesan
    Department of Chemistry, Pukyong National University, Busan 608 737, Korea
    Biomed Mater 6:035003. 2011
    ..Biocompatibility of HAp crystals was evaluated by cytotoxicity and cell proliferation with human osteoblast-like cell MG-63...
  85. doi request reprint SHP-1, a novel peptide isolated from seahorse inhibits collagen release through the suppression of collagenases 1 and 3, nitric oxide products regulated by NF-kappaB/p38 kinase
    BoMi Ryu
    Department of Chemistry, Pukyong National University, Busan, Republic of Korea
    Peptides 31:79-87. 2010
    ..Inhibition of collagen release by SHP-1 is associated with restraining the phosphorylation of NF-kappaB and p38 kinase cascade. Therefore, it could be suggested that SHP-1 has a potential to be used in arthritis treatment...
  86. ncbi request reprint Inhibitory effect of chitooligosaccharides on matrix metalloproteinase-9 in human fibrosarcoma cells (HT1080)
    Quang Van Ta
    Department of Chemistry, Pukyong National University, Busan, 608 737, Republic of Korea
    Mar Biotechnol (NY) 8:593-9. 2006
    ..It was also found that COS-I was capable of inhibiting both gene and protein expression of MMP-9 (P<0.01). These results suggest that low molecular mass COS can be considered as a potent inhibitor of MMP-9...
  87. doi request reprint Anti-HIV-1 activity of phloroglucinol derivative, 6,6'-bieckol, from Ecklonia cava
    Murat Artan
    Department of Chemistry, Pukyong National University, Busan 608 737, Republic of Korea
    Bioorg Med Chem 16:7921-6. 2008
    ..Thus, it can be suggested that the potentially effective 6,6'-bieckol might be employed as a drug candidate for development of new generation therapeutic agents against HIV...
  88. doi request reprint Preparation and characterization of chitosan-carbon nanotube scaffolds for bone tissue engineering
    Jayachandran Venkatesan
    Department of Chemistry, Pukyong National University, Busan, Republic of Korea
    Int J Biol Macromol 50:393-402. 2012
    ..Herewith, we are suggesting that chitosan/f-MWCNT scaffolds are promising biomaterials for bone tissue engineering...
  89. doi request reprint Sulfated chitooligosaccharide II (SCOS II) suppress collagen degradation in TNF-induced chondrosarcoma cells via NF-κB pathway
    BoMi Ryu
    Marine Bioprocess Research Center, Pukyong National University, Busan, Republic of Korea
    Carbohydr Res 350:55-61. 2012
    ..We suggest that SCOS II can be further studied as a potential candidate for the treatment of arthritis...
  90. ncbi request reprint Chitooligosaccharides inhibit activation and expression of matrix metalloproteinase-2 in human dermal fibroblasts
    Moon Moo Kim
    Marine Bioprocess Research Center, Pukyong National University, Busan 608 737, Republic of Korea
    FEBS Lett 580:2661-6. 2006
    ..These results suggest that COS may play an important role in the prevention and treatment of MMP-2 mediated several health problems such as metastasis and wrinkle formation...
  91. doi request reprint Phosphorylated glucosamine inhibits adipogenesis in 3T3-L1 adipocytes
    Chang Suk Kong
    Marine Bioprocess Research Center, Pukyong National University, Busan, South Korea
    J Nutr Biochem 21:438-43. 2010
    ....
  92. doi request reprint Anti-inflammatory effect of coumarins isolated from Corydalis heterocarpa in HT-29 human colon carcinoma cells
    Kyong Hwa Kang
    Department of Chemistry, Pukyong National University, Busan 608 737, Republic of Korea
    Food Chem Toxicol 47:2129-34. 2009
    ..Furthermore, we confirmed that LPS-induced transcription activity of NF-kappaB was inhibited by compound B. As a result of this study, compound B can be considered as a potential anti-inflammatory agent...
  93. doi request reprint Potential pharmacological applications of polyphenolic derivatives from marine brown algae
    Noel Vinay Thomas
    Marine Biochemistry Laboratory, Department of Chemistry, Pukyong National University, Busan 608 737, Republic of Korea
    Environ Toxicol Pharmacol 32:325-35. 2011
    ..In this review, we have made an attempt to discuss the potential biological activities of phlorotannins from marine brown algae and their possible candidature in the pharmaceutical applications...
  94. ncbi request reprint A novel anticoagulant protein with high affinity to blood coagulation factor Va from Tegillarca granosa
    Won Kyo Jung
    Department of Chemistry, Pukyong National University, Busan 608 737, Republic of Korea
    J Biochem Mol Biol 40:832-8. 2007
    ..In addition, TGAP did not significantly (P < 0.05) show fibrinolytic activity and cytotoxicity on venous endothelial cell line (ECV 304)...
  95. ncbi request reprint Potential targets for anti-inflammatory and anti-allergic activities of marine algae: an overview
    Thanh Sang Vo
    Marine Biochemistry Laboratory, Department of Chemistry, Pukyong National University, Busan, Republic of Korea
    Inflamm Allergy Drug Targets 11:90-101. 2012
    ..This review presents an overview of potential anti-inflammatory and anti-allergic agents derived from marine algae and their promising applications in inflammation and allergy therapy...
  96. doi request reprint Factors affecting anti-inflammatory effect of chitooligosaccharides in lipopolysaccharides-induced RAW264.7 macrophage cells
    Sang Hoon Lee
    Department of Chemistry, Pukyong National University, Busan 606 737, Republic of Korea
    Bioorg Med Chem Lett 19:6655-8. 2009
    ..These results suggested that 90-HMWCOS may have anti-inflammatory effect via down-regulation of transcriptional and translational expression levels of TNF-alpha, IL-6 and iNOS and COX-2...
  97. doi request reprint Statistical optimization of microalgae Pavlova lutheri cultivation conditions and its fermentation conditions by yeast, Candida rugopelliculosa
    BoMi Ryu
    Marine Bioprocess Research Center, Pukyong National University, Busan 608 737, Republic of Korea
    Bioresour Technol 107:307-13. 2012
    ..01 Da) with hydroxyl radical scavenging activity. Collectively, these results indicated that microalgae P. lutheri can enhance the hydroxyl radical inhibiting effect through protein hydrolysis process under RSM optimal condition...
  98. ncbi request reprint Free radical scavenging activity of a novel antioxidative peptide purified from hydrolysate of bullfrog skin, Rana catesbeiana Shaw
    Zhong Ji Qian
    Department of Chemistry, Pukyong National University, Busan, Republic of Korea
    Bioresour Technol 99:1690-8. 2008
    ..8 microM), superoxide radical (IC(50)=34.0 microM) and peroxyl radical (IC(50)=32.6 microM). Moreover, MTT assay showed that this peptide does not exert any cytotoxicity on human embryonic lung fibroblasts cell line (MRC-5)...
  99. doi request reprint Chitooligosaccharides suppress the level of protein expression and acetylcholinesterase activity induced by Abeta25-35 in PC12 cells
    Sang Hoon Lee
    Department of Chemistry, Pukyong National University, Busan 608 737, Republic of Korea
    Bioorg Med Chem Lett 19:860-2. 2009
    ..Cell culture experiment revealed that 90-MMWCOS suppressed the level of AChE protein expression and AChE activity induced by Abeta(25-35) in PC12 cell lines...
  100. ncbi request reprint Purification and characterization of a collagenolytic protease from the filefish, Novoden modestrus
    Se Kwon Kim
    Department of Chemistry, Pukyong National University, Pusan 608 737, Korea
    J Biochem Mol Biol 35:165-71. 2002
    ..In addition, the purified collagenolytic enzyme was strongly inhibited by N-P-toluenesulfonyl-L-lysine chloromethyl ketone (TLCK), diisopropylfluorophosphate (DFP), and soybean trypsin inhibitor...
  101. doi request reprint Phlorotannins from Ecklonia cava (Phaeophyceae): biological activities and potential health benefits
    Isuru Wijesekara
    Marine Biochemistry Laboratory, Department of Chemistry, Pukyong National University, Busan, Republic of Korea
    Biofactors 36:408-14. 2010
    ..This review focuses on biological activities of phlorotannins with potential health beneficial applications in functional foods, pharmaceuticals, and cosmeceuticals...