Research Topics
Genomes and GenesSpecies | Gou Young KohSummaryAffiliation: Pohang University of Science and Technology Country: Korea Publications
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Detail Information
Publications
Designed angiopoietin-1 variant, COMP-Ang1, protects against radiation-induced endothelial cell apoptosisChung-Hyun Cho
Biomedical Research Center and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea
Proc Natl Acad Sci U S A 101:5553-8. 2004..Thus, COMP-Ang1 could be used as a therapeutic protein for specific protection against endothelial cell injury...
Shear stress activates Tie2 receptor tyrosine kinase in human endothelial cellsHyuek Jong Lee
National Creative Research Initiatives Center for Endothelial Cells and Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, 790 784, Republic of Korea
Biochem Biophys Res Commun 304:399-404. 2003..Taken together, our results indicated that activation of Tie2/PI 3-kinase/Akt in response to shear stress could be an important signaling cascade for maintaining endothelial survival and integrity in blood vessels...- Biomedical significance of endothelial cell specific growth factor, angiopoietinGou Young Koh
National Creative Research Initiatives Center for Endothelial Cells, Division of Molecular and Life Sciences, Pohang University of Science and Technology, Republic of Korea
Exp Mol Med 34:1-11. 2002..Therefore, in this review, we describe the biomedical significance of these endothelial cell growth factors, the angiopoietins, in the vascular system under normal and pathological states... - Localization of Tie2 and phospholipase D in endothelial caveolae is involved in angiopoietin-1-induced MEK/ERK phosphorylation and migration in endothelial cellsMi Jeong Yoon
National Creative Research Initiatives Center for Endothelial Cells, Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang 790 784, Republic of Korea
Biochem Biophys Res Commun 308:101-5. 2003.... - Localization of VEGFR-2 and PLD2 in endothelial caveolae is involved in VEGF-induced phosphorylation of MEK and ERKChung Hyun Cho
National Creative Research Initiatives Center for Endothelial Cells, Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, 790 784, Republic of Korea
Am J Physiol Heart Circ Physiol 286:H1881-8. 2004..These results indicate that intact caveolae are required for the VEGF/VEGFR-2-mediated MEK/ERK signaling cascade... - EphB ligand, ephrinB2, suppresses the VEGF- and angiopoietin 1-induced Ras/mitogen-activated protein kinase pathway in venous endothelial cellsInjune Kim
National Creative Research Initiatives Center for Endothelial Cells and Department of Life Science, Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, 790 784, Republic of Korea
FASEB J 16:1126-8. 2002.... - Betacellulin induces angiogenesis through activation of mitogen-activated protein kinase and phosphatidylinositol 3'-kinase in endothelial cellHoe Suk Kim
National Creative Research Initiatives Center for Endothelial Cells and Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, 790-784, Republic of Korea
FASEB J 17:318-20. 2003..Taken together, these data show that BTC exerts potent angiogenic activity through activation of EGF receptors, mitogen-activated protein kinase, and PtdIns 3'-kinase/Akt in endothelial cells... - Betacellulin and amphiregulin induce upregulation of cyclin D1 and DNA synthesis activity through differential signaling pathways in vascular smooth muscle cellsHyoung Seek Shin
National Creative Research Initiatives Center for Endothelial Cells, Division of Molecular and Life Sciences, Pohang University of Science and Technology, Hyoja-dong, Pohang, Republic of Korea
Circ Res 93:302-10. 2003..Taken together, BTC and AR could be potent growth factors in proliferative vascular diseases... - Angiopoietin-1 negatively regulates expression and activity of tissue factor in endothelial cellsInjune Kim
National Creative Research Initiatives Center for Endothelial Cells and Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea
FASEB J 16:126-8. 2002..Ang1 may be useful as an inhibitor of VEGF- and TNF-a-induced coagulation, inflammation, and cancer progression... - Angiopoietin-1 promotes LYVE-1-positive lymphatic vessel formationTohru Morisada
Department of Cell Differentiation, The Sakaguchi Laboratory, School of Medicine, Keio University, Tokyo, Japan
Blood 105:4649-56. 2005..On the basis of these observations, we propose that Ang signaling regulates lymphatic vessel formation through Tie2... - Cooperative interaction of Angiopoietin-like proteins 1 and 2 in zebrafish vascular developmentYoshiaki Kubota
Department of Cell Differentiation, The Sakaguchi Laboratory, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
Proc Natl Acad Sci U S A 102:13502-7. 2005..These results provide a physiological demonstration of the cooperative interaction of Angptl1 and Angptl2 in endothelial cells through phosphatidylinositol 3-kinase/Akt mediated antiapoptotic activities... 
Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2Pipsa Saharinen
Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, University of Helsinki, Finland
J Cell Biol 169:239-43. 2005..These results should be important in dissecting the signal transduction pathways and biological functions of Tie1...- Oligomerization and multimerization are critical for angiopoietin-1 to bind and phosphorylate Tie2Kyung Tae Kim
Biomedical Research Center and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon
J Biol Chem 280:20126-31. 2005..Thus, our data shed a light on the structure-function relationships of Ang1 with Tie2... - Combined angiopoietin-1 and vascular endothelial growth factor gene transfer restores cavernous angiogenesis and erectile function in a rat model of hypercholesterolemiaJi-Kan Ryu
Department of Urology, Inha University School of Medicine, Incheon 400-711, Republic of Korea
Mol Ther 13:705-15. 2006.... - Hydrogen peroxide produced by angiopoietin-1 mediates angiogenesisYoung Mee Kim
Centre for Cell Signaling Research, Division of Molecular Life Sciences and College of Pharmacy, Ewha Womans University, Seoul, Korea
Cancer Res 66:6167-74. 2006..These results show that Ang1-induced H2O2 plays an important role in Ang1-mediated angiogenesis by modulating p44/42 MAPK activity... 
Differential function of Tie2 at cell-cell contacts and cell-substratum contacts regulated by angiopoietin-1Shigetomo Fukuhara
Department of Structural Analysis, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
Nat Cell Biol 10:513-26. 2008....- Systemic analysis of tyrosine phosphorylated proteins in angiopoietin-1 induced signaling pathway of endothelial cellsYoung Mee Kim
Center for Cell Signaling and Drug Discovery Research, College of Pharmacy and Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul 120 750, Korea
J Proteome Res 6:3278-90. 2007..Of these, p54nrb was validated as a molecule involved in cell migration. These results suggest that Ang1 induces stabilization of neo-vessel network by regulating the phosphorylations of metabolic and structural proteins... - Regulated proteolytic processing of Tie1 modulates ligand responsiveness of the receptor-tyrosine kinase Tie2Marie B Marron
Department of Cardiovascular Sciences, University of Leicester, Robert Kilpatrick Clinical Sciences Bld, P O Box 65, Leicester, LE2 7LX United Kingdom
J Biol Chem 282:30509-17. 2007..Furthermore the data suggest that regulated processing of Tie1 may be an important mechanism for controlling signaling by Tie2... - Angiopoietin-1 prevents hypertension and target organ damage through its interaction with endothelial Tie2 receptorJung Sun Lee
Department of Medicine, Samsung Medical Center, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, 50 Ilwon Dong, Kangnam Ku, Seoul 135 710, Korea
Cardiovasc Res 78:572-80. 2008.... - Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contactsPipsa Saharinen
Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki, University of Helsinki, Haartmaninkatu 8, P O B 63, 00014 Helsinki, Finland
Nat Cell Biol 10:527-37. 2008..This novel type of cellular microenvironment-dependent receptor tyrosine kinase activation may explain some of the effects of angiopoietins in angiogenesis and vessel stabilization... - Biological characterization of angiopoietin-3 and angiopoietin-4Hyuek Jong Lee
Biomedical Research Center and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea
FASEB J 18:1200-8. 2004..Ang3 and Ang4 both produced potent corneal angiogenesis extending from the limbus across the mouse cornea in vivo. Thus, Ang3 and Ang4 are agonists of Tie2, but mouse Ang3 has strong activity only on endothelial cells of its own species... - Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow nicheFumio Arai
Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University, 35 Shinano machi, Shinjuku ku, Tokyo, 160 8582, Japan
Cell 118:149-61. 2004..These data suggest that the Tie2/Ang-1 signaling pathway plays a critical role in the maintenance of HSCs in a quiescent state in the BM niche... - Protective effect of adrenomedullin in mannitol-induced apoptosisWon Kim
Department of Internal Medicine, Research Institute of Clinical Medicine, Chonbuk National University Medical School, Chonju, Republic of Korea
Apoptosis 7:527-36. 2002..Therefore, pretreatment with AM might help to maintain normal endothelial integrity during systemic mannitol therapy... - Dose-dependent biphasic activity of tRNA synthetase-associating factor, p43, in angiogenesisSang Gyu Park
National Creative Research Initiatives Center for ARS Network, College of Pharmacy, Seoul National University, Korea
J Biol Chem 277:45243-8. 2002..In contrast, p43 at high concentration activated Jun N-terminal kinase, which mediated apoptosis of endothelial cells. These results suggest that p43 is a novel cytokine playing a dose-dependent biphasic role in angiogenesis... - Overexpression of VEGF and angiopoietin 2: a key to high vascularity of hepatocellular carcinoma?Woo Sung Moon
Department of Pathology and Institute for Medical Sciences, Chonbuk National University, Medical School, Chonju, Korea
Mod Pathol 16:552-7. 2003..Our findings also suggest that interaction between VEGF and Ang2 may play a critical role in tumor angiogenesis in HCC... - Nuclear factor kappaB dependency of platelet-activating factor-induced angiogenesisHyun-Mi Ko
Department of Biological Sciences, The Institute of Basic Sciences, Research Institute of Medical Science, Chonnam National University, Kwangju 500-757, Japan
Cancer Res 62:1809-14. 2002..These data indicate that PAF enhances angiogenesis through inducing NFkappaB activation, which in turn promotes the production of angiogenic factors such as VEGF... - RANKL regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathwayHong-Hee Kim
Department of Cell and Developmental Biology, College of Dentistry, Seoul National University, Seoul 110-749, Korea
FASEB J 17:2163-5. 2003..These findings indicate that RANK, in response to the paracrine stimulus of RANKL, may play an important role in maintaining endothelial cell integrity through the PI 3'-kinase/Akt signal transduction pathway... - COMP-Ang1: a designed angiopoietin-1 variant with nonleaky angiogenic activityChung-Hyun Cho
Biomedical Research Center and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea
Proc Natl Acad Sci U S A 101:5547-52. 2004..Thus, COMP-Ang1 is an effective alternative to native Ang1 for therapeutic angiogenesis in vivo... - Suppression of angiogenesis by the plant alkaloid, sanguinarineJong-Pil Eun
Department of Neurosurgery, Chonbuk National University Hospital, Jeonju 560-180, Republic of Korea
Biochem Biophys Res Commun 317:618-24. 2004..Thus, in addition to antibacterial, antifungal, and anti-inflammatory activities, sanguinarine has a novel antiangiogenic role... - Expression and purification of recombinant human angiopoietin-1 produced in Chinese hamster ovary cellsSu Jeong Hwang
Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 373 1 Kusong Dong, Yuseong Gu, Daejon 305 701, South Korea
In Vitro Cell Dev Biol Anim 43:162-7. 2007..Therefore, the rhAng1 produced from CHO cells could be useful for clarifying the biological effects of exogenous rhAng1 in the future... - A novel zinc finger protein that inhibits osteoclastogenesis and the function of tumor necrosis factor receptor-associated factor 6Jin Na Shin
National Research Laboratory for Bone Metabolism and School of Dentistry, Chosun University, Gwangju 501 759, Korea
J Biol Chem 277:8346-53. 2002..7 reduced the RANK ligand-induced osteoclastogenesis of this cell line. Our findings suggest that the novel zinc finger protein TIZ may play a role during osteoclast differentiation by modulating TRAF6 signaling activity... - Cartilage oligometric matrix protein-angiopoietin-1 promotes revascularization through increased survivin expression in dermal endothelial cells of skin grafts in miceSeung Jae Byun
Institute for Radiological Imaging Science, Wonkwang University School of Medicine, Jeonbuk, Korea
Am J Pathol 171:1682-90. 2007..Therefore, we believe that COMP-Ang1 provides the therapeutic benefit of enhancing the survival of vascular endothelial cells during transplantation of skin graft... - Blockade of airway inflammation and hyper-responsiveness by an angiopoietin-1 variant, COMP-Ang1Kyung Sun Lee
Department of Internal Medicine, Airway Remodeling Laboratory, Chonbuk National University Medical School, JeonJu 561 180, Korea
Exp Mol Med 39:733-45. 2007..These results suggest that COMP-Ang1 attenuates airway inflammation and hyper-responsiveness, prevents vascular leakage, and may be used as a therapeutic agent in allergic airway disease... - Profound but dysfunctional lymphangiogenesis via vascular endothelial growth factor ligands from CD11b+ macrophages in advanced ovarian cancerBong Hyun Jeon
National Research Laboratory of Vascular Biology and Biomedical Research Center, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea
Cancer Res 68:1100-9. 2008..These findings provide additional therapeutic targets to ameliorate chylous ascites formation in patients with advanced OVCA... - COMP-Ang1, angiopoietin-1 variant protects radiation-induced bone marrow damage in C57BL/6 miceHae June Lee
Division of Radiation Effect, Korea Institute of Radiological and Medical Sciences, Seoul, Korea
J Radiat Res 49:313-20. 2008..Pre-treatment of Ang1 could be beneficial in protecting bone marrow from damage by radiation and COMP-Ang1 may be an effective alternative to native Ang1 for therapeutic purposes... - Tumor necrosis factor-alpha induces fractalkine expression preferentially in arterial endothelial cells and mithramycin A suppresses TNF-alpha-induced fractalkine expressionSo Young Ahn
Biomedical Research Center and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea
Am J Pathol 164:1663-72. 2004..NF-kappaB and Sp1 inhibitors such as mithramycin A may provide a pharmacological approach to suppressing these processes... - Stretch-activated atrial natriuretic peptide secretion in atria with heat shock protein 70 overexpressionSuhn Hee Kim
Department of Physiology, Institute for Medical Sciences, Chonbuk National University Medical School, JeonJu 561 180, Republic of Korea
Exp Biol Med (Maywood) 228:200-6. 2003..The results suggest that both atrial stretching and ET-1 are important stimuli to ANP secretion from mouse atria, and the responsiveness of the ANP system to those stimuli are unlikely coupled to the pathway involving HSP70... - A specific requirement for PDGF-C in palate formation and PDGFR-alpha signalingHao Ding
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
Nat Genet 36:1111-6. 2004..Our results also show that PDGF-C signaling is a new pathway in palatogenesis, different from, and independent of, those previously implicated... - Long-term and sustained COMP-Ang1 induces long-lasting vascular enlargement and enhanced blood flowChung-Hyun Cho
Biomedical Research Center and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea
Circ Res 97:86-94. 2005..Sustained overexpression of Tie2 could participate in the maintenance of vascular changes. Together, our findings indicate that sustained treatment with COMP-Ang1 can produce long-lasting vascular enlargement and increased blood flow... - Expression and purification of recombinant human angiopoietin-2 produced in Chinese hamster ovary cellsSu Jeong Hwang
Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 373 1 Kusong Dong, Yusong gu, Daejon 305 701, Republic of Korea
Protein Expr Purif 39:175-83. 2005..Furthermore, rhAng2 binds to the Tie2 receptor and phosphorylates Tie2 in a concentration-dependent manner. Therefore, our rhAng2 could be useful for clarifying biological effect of exogenous Ang2 in the future... - COMP-angiopoietin-1 promotes wound healing through enhanced angiogenesis, lymphangiogenesis, and blood flow in a diabetic mouse modelChung-Hyun Cho
Biomedical Research Center and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Guseong-dong, Daejeon 305-701, Korea
Proc Natl Acad Sci U S A 103:4946-51. 2006..Taken together, these findings indicate that COMP-Ang1 can promote wound healing in diabetes through enhanced angiogenesis, lymphangiogenesis, and blood flow... - Inhibition of phosphatidylinositol 3-kinase enhances mitogenic actions of insulin in endothelial cellsMonica Montagnani
Cardiology Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 277:1794-9. 2002..We conclude that inhibition of the metabolic branch of insulin signaling leads to an enhanced mitogenic action of insulin in endothelial cells... - COMP-angiopoietin-1 ameliorates renal fibrosis in a unilateral ureteral obstruction modelWon Kim
Renal Regeneration Laboratory and Department of Internal Medicine, Chonbuk National University Medical School, San 2-20 Keumam-dong, Jeonju, 561-180, South Korea
J Am Soc Nephrol 17:2474-83. 2006..These results demonstrate that COMP-Ang1 treatment can decrease the progression of renal fibrosis in unilateral ureteral obstruction. COMP-Ang1 may be an endothelium-specific therapeutic modality in fibrotic renal disease... - In vivo actions of angiopoietins on quiescent and remodeling blood and lymphatic vessels in mouse airways and skinKyung Eun Kim
National Research Laboratory of Vascular Biology and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea
Arterioscler Thromb Vasc Biol 27:564-70. 2007..We analyzed the microvasculature of trachea and ear skin, and compared quiescent skin microvasculature with that during wound healing... - Angiogenic role of LYVE-1-positive macrophages in adipose tissueChung Hyun Cho
National Research Laboratory of Vascular Biology and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea
Circ Res 100:e47-57. 2007.... - Gab family proteins are essential for postnatal maintenance of cardiac function via neuregulin-1/ErbB signalingYoshikazu Nakaoka
Department of Structural Analysis, National Cardiovascular Center Research Institute, Osaka, Japan
J Clin Invest 117:1771-81. 2007....