Research Topics


Hyuncheol Oh


Country: Korea


  1. Yoon C, Kim D, Park J, Kim K, Kim Y, Oh H. Isolation of Novel Sesquiterpeniods and Anti-neuroinflammatory Metabolites from Nardostachys jatamansi. Molecules. 2018;23: pubmed publisher
  2. Kim K, Yoon C, Kim Y, Oh H. Desoxo-narchinol A and Narchinol B Isolated from Nardostachys jatamansi Exert Anti-neuroinflammatory Effects by Up-regulating of Nuclear Transcription Factor Erythroid-2-Related Factor 2/Heme Oxygenase-1 Signaling. Neurotox Res. 2019;35:230-243 pubmed publisher
    ..In conclusion, desoxo-narchinol A and narchinol B are potential candidates for the development of preventive agents for the regulation of neuroinflammation in neurodegenerative diseases. ..
  3. Lee D, Kim K, Ko W, Li B, Jeong G, Jang J, et al. The cytoprotective effect of sulfuretin against tert-butyl hydroperoxide-induced hepatotoxicity through Nrf2/ARE and JNK/ERK MAPK-mediated heme oxygenase-1 expression. Int J Mol Sci. 2014;15:8863-77 pubmed publisher
    ..Therefore, sulfuretin could be advantageous as a bioactive source for the prevention of oxidative injury. ..
  4. Quang T, Ngan N, Ko W, Kim D, Yoon C, Sohn J, et al. Tanzawaic acid derivatives from a marine isolate of Penicillium sp. (SF-6013) with anti-inflammatory and PTP1B inhibitory activities. Bioorg Med Chem Lett. 2014;24:5787-5791 pubmed publisher
    ..7 and BV2 cells. In addition, compounds 2 and 5 significantly inhibited the activity of protein tyrosine phosphatase 1B (PTP1B) with the same IC50 value (8.2 μM). ..
  5. Quang T, Ngan N, Yoon C, Cho K, Kang D, Lee H, et al. Protein Tyrosine Phosphatase 1B Inhibitors from the Roots of Cudrania tricuspidata. Molecules. 2015;20:11173-83 pubmed publisher
    ..Furthermore, kinetic analyses indicated that compounds 1 and 13 inhibited PTP1B in a noncompetitive manner; therefore, they may be potential lead compounds in the development of anti-obesity and -diabetic agents. ..
  6. Yoon C, Kim D, Lee D, Kim K, Ko W, Sohn J, et al. Anti-neuroinflammatory effect of aurantiamide acetate from the marine fungus Aspergillus sp. SF-5921: inhibition of NF-κB and MAPK pathways in lipopolysaccharide-induced mouse BV2 microglial cells. Int Immunopharmacol. 2014;23:568-74 pubmed publisher
    ..These results suggest that compound 1 has an anti-neuroinflammatory effect on LPS stimulation through its inhibition of the NF-κB, JNK and p38 pathways. ..
  7. Kim K, Cui X, Lee D, Ko W, Sohn J, Yim J, et al. Inhibitory effects of benzaldehyde derivatives from the marine fungus Eurotium sp. SF-5989 on inflammatory mediators via the induction of heme oxygenase-1 in lipopolysaccharide-stimulated RAW264.7 macrophages. Int J Mol Sci. 2014;15:23749-65 pubmed publisher
    ..Thus, the anti-inflammatory effects of compounds 1 and 2 also correlated with their ability of inducing HO-1 expression. ..
  8. Quang T, Kim D, Van Kiem P, Van Minh C, Nhiem N, Tai B, et al. Macrolide and phenolic metabolites from the marine-derived fungus Paraconiothyrium sp. VK-13 with anti-inflammatory activity. J Antibiot (Tokyo). 2018;71:826-830 pubmed publisher
    ..Furthermore, both compounds 7 and 9 inhibited the mRNA expression of proinflammatory cytokines, including TNF-?, IL-1?, IL-6, and IL-12, with IC50 values in a range of 2.4-12.5?µM. ..
  9. Yoon C, Kim D, Quang T, Seo J, Kang D, Lee H, et al. A Prenylated Xanthone, Cudratricusxanthone A, Isolated from Cudrania tricuspidata Inhibits Lipopolysaccharide-Induced Neuroinflammation through Inhibition of NF-κB and p38 MAPK Pathways in BV2 Microglia. Molecules. 2016;21: pubmed publisher
    ..Our data suggests that cudratricusxanthone A (1) may be a useful therapeutic agent in the treatment of neurodegenerative diseases caused by neuroinflammation. ..

More Information


  1. Lee S, Kim D, Baek H, Lee K, Kim Y, Oh H. Anti-neuroinflammatory effects of tryptanthrin from Polygonum tinctorium Lour. in lipopolysaccharide-stimulated BV2 microglial cells. Arch Pharm Res. 2018;41:419-430 pubmed publisher
    ..Taken together, it was suggested that tryptanthrin (1) have anti-neuroinflammatory effect by regulating TLR4-MyD88-mediated several inflammatory pathways including p38 and NF-?B pathways in LPS-induced BV2 microglial cells. ..
  2. Kim K, Lee D, Kim D, Yoon C, Ko W, Oh H, et al. Anti-Inflammatory Effects and Mechanisms of Action of Coussaric and Betulinic Acids Isolated from Diospyros kaki in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages. Molecules. 2016;21: pubmed publisher
    ..g., NO, PGE₂, TNF-α, IL-1β, IL-6), by partial reversal of this effect by SnPP, an inhibitor of HO-1. These findings further elucidate the anti-inflammatory mechanism of CA and BA isolated from D. kaki. ..
  3. Lee Y, Lee S, Cui X, Yoon J, Oh H, Kim Y, et al. Quantitative evaluation of Oryeongsan and its action on water regulation in renal inner medullary collecting duct cells. J Ethnopharmacol. 2016;185:310-8 pubmed publisher
    ..The present data suggest that the beneficial effect of ORS in water balance and apoptosis against hypertonic stress of renal collecting ducts. ..
  4. Kim D, Yoon C, Quang T, Ko W, Kim J, Oh H, et al. Prenylated Flavonoids from Cudrania tricuspidata Suppress Lipopolysaccharide-Induced Neuroinflammatory Activities in BV2 Microglial Cells. Int J Mol Sci. 2016;17:255 pubmed publisher
    ..In addition, cudraflavanone D (1) suppressed the phosphorylation of c-Jun N-terminal kinase (JNK) and p38 MAPK pathways. This study indicated that cudraflavanone D (1) can be a potential drug candidate for the cure of neuroinflammation. ..
  5. Ko W, Sohn J, Jang J, Ahn J, Kang D, Lee H, et al. Inhibitory effects of alternaramide on inflammatory mediator expression through TLR4-MyD88-mediated inhibition of NF-кB and MAPK pathway signaling in lipopolysaccharide-stimulated RAW264.7 and BV2 cells. Chem Biol Interact. 2016;244:16-26 pubmed publisher
    ..7 and BV2 cells. Taken together, the results of the present study suggest that 1 modulates several TLR4-mediated inflammatory pathways, demonstrating its potential in the treatment of inflammatory and neuroinflammatory conditions. ..
  6. Park J, Quang T, Yoon C, Kim H, Sohn J, Oh H. Furanoaustinol and 7-acetoxydehydroaustinol: new meroterpenoids from a marine-derived fungal strain Penicillium sp. SF-5497. J Antibiot (Tokyo). 2018;71:557-563 pubmed publisher
    ..0, 30.1, 58.3, 37.6, and 40.2??M, respectively. ..
  7. Lee S, Kim D, Park J, Son J, Hak Sohn J, Liu L, et al. Penicillospirone from a marine isolate of Penicillium sp. (SF-5292) with anti-inflammatory activity. Bioorg Med Chem Lett. 2017;27:3516-3520 pubmed publisher
    ..Overall, the anti-inflammatory effect of 1 was suggested to be mediated through the negative regulation of NF-?B pathway. ..
  8. Ha T, Ko W, Lee S, Kim Y, Son J, Sohn J, et al. Anti-Inflammatory Effects of Curvularin-Type Metabolites from a Marine-Derived Fungal Strain Penicillium sp. SF-5859 in Lipopolysaccharide-Induced RAW264.7 Macrophages. Mar Drugs. 2017;15: pubmed publisher
  9. Kim D, Quang T, Oh H, Kim Y. Steppogenin Isolated from Cudrania tricuspidata Shows Antineuroinflammatory Effects via NF-κB and MAPK Pathways in LPS-Stimulated BV2 and Primary Rat Microglial Cells. Molecules. 2017;22: pubmed publisher
  10. Yoon C, Kim K, Lee S, Kim Y, Oh H. Anti-neuroinflammatory effects of sesquiterpenoids isolated from Nardostachys jatamansi. Bioorg Med Chem Lett. 2018;28:140-144 pubmed publisher
  11. Kim D, Lee H, Ko W, Lee D, Sohn J, Yim J, et al. Anti-inflammatory effect of methylpenicinoline from a marine isolate of Penicillium sp. (SF-5995): inhibition of NF-κB and MAPK pathways in lipopolysaccharide-induced RAW264.7 macrophages and BV2 microglia. Molecules. 2014;19:18073-89 pubmed publisher
    ..Taken together, the results suggest that compound 1 might be a valuable therapeutic agent for the treatment of anti-inflammatory and anti-neuroinflammatory diseases. ..