Research Topics
Genomes and Genes | Sang Soo KimSummaryAffiliation: National Cancer Center Country: Korea Publications
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Detail Information
Publications
The yin-yang of DNA damage response: roles in tumorigenesis and cellular senescenceXiaoman Li
Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang 110001, China
Int J Mol Sci 14:2431-48. 2013..Emphasis is placed on discussing DDR outcome in the light of in vivo models. This information is critical as it can help make better decisions for clinical treatments of cancer patients...
Impaired skin and mammary gland development and increased gamma-irradiation-induced tumorigenesis in mice carrying a mutation of S1152-ATM phosphorylation site in Brca1Sang Soo Kim
Radiation Medicine Branch, National Cancer Center, Goyang, Korea
Cancer Res 69:9291-300. 2009..These observations indicate that ATM-mediated phosphorylation of S1189 is required for BRCA1 functions in the modulation of DNA damage response and in the suppression of tumor formation by regulating p53 and apoptosis...
ATM is required for rapid degradation of cyclin D1 in response to gamma-irradiationDong Wan Choo
Radiation Medicine Branch, National Cancer Center, Goyang si, Gyeonggi Do, South Korea
Biochem Biophys Res Commun 378:847-50. 2009..Our data indicate that communication between ATM and cyclin D1 may be required for maintenance of genomic integrity achieved by rapid arrest of the cell-cycle, and that disruption of this crosstalk may increase susceptibility to cancer...
In vivo radiobiological characterization of proton beam at the National Cancer Center in Korea: effect of the Chk2 mutationSang Soo Kim
Radiation Medicine Branch, National Cancer Center, Goyang, Korea
Int J Radiat Oncol Biol Phys 79:559-62. 2011..The relative biological effectiveness (RBE) in the presence or absence of CHK2 was estimated at the Korean National Cancer Center Proton Therapy Center (NCCPTC)...
A prospective observational study with dose volume parameters predicting rectosigmoidoscopic findings and late rectosigmoid bleeding in patients with uterine cervical cancer treated by definitive radiotherapyTae Hyun Kim
Research Institute and Hospital, National Cancer Center, Goyang, Gyeonggi, South Korea
Radiat Oncol 8:28. 2013..We assessed the value of dose-volumetric parameters predicting rectosigmoid mucosal changes (RMC) and late rectosigmoid complications (LRC)...
Transforming growth factor-β adaptor, β2-spectrin, modulates cyclin dependent kinase 4 to reduce development of hepatocellular cancerHye Jung Baek
Radiation Medicine Branch, National Cancer Center, Goyang, Korea
Hepatology 53:1676-84. 2011..Our data highlight CDK4 as an attractive target for the pharmacologic inhibition of HCC and demonstrate the importance of β2sp(+/-) mice as a model of preclinical efficacy in the treatment of HCC...
Radiobiological characterization of proton beam at the National Cancer Center in KoreaHye Jung Baek
Radiation Medicine Branch, National Cancer Center, Goyang, Korea
J Radiat Res 49:509-15. 2008..1 for protons of the majority of centers. Due to the recommendation of a generic RBE of 1.1 for protons, a representative RBE value of 1.1 was assigned for clinical application for proton beams at the NCCPTC...
Role of adjuvant chemoradiotherapy for resected extrahepatic biliary tract cancerTae Hyun Kim
Center for Liver Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Republic of Korea
Int J Radiat Oncol Biol Phys 81:e853-9. 2011..To evaluate the effect of adjuvant chemoradiotherapy (CRT) on locoregional control (LRC), disease-free survival (DFS), and overall survival (OS) for patients with extrahepatic biliary tract cancer treated with curative resection...
Combined primary tumor and extracranial metastasis status as constituent factor of prognostic indices for predicting the overall survival in patients with brain metastasesYoung Hee Park
Research Institute and Hospital, National Cancer Center, Goyang, Korea
J Korean Med Sci 28:205-12. 2013....
The effect of a contrast agent on proton beam range in radiotherapy planning using computed tomography for patients with locoregionally advanced lung cancerUi Jung Hwang
Research Institute and Hospital, National Cancer Center, Goyang, Gyeonggi, Korea
Int J Radiat Oncol Biol Phys 81:e317-24. 2011..We evaluated the effect of a contrast agent (CA) on proton beam range in a treatment planning system (TPS) for patients with locoregionally advanced lung cancer...
Hepatocellular cancer arises from loss of transforming growth factor beta signaling adaptor protein embryonic liver fodrin through abnormal angiogenesisHye Jung Baek
Radiation Medicine Branch, National Cancer Center, Goyang, Korea
Hepatology 48:1128-37. 2008..Our studies propose that ELF is potentially a powerful target for mimetics enhancing the TGF-beta pathway tumor suppression of HCC...
The effect of external beam radiotherapy volume on locoregional control in patients with locoregionally advanced or recurrent nonanaplastic thyroid cancerTae Hyun Kim
Center for Thyroid Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Korea
Radiat Oncol 5:69. 2010..We evaluated outcomes of patients treated with external beam radiotherapy (EBRT) for locoregionally advanced or recurrent nonanaplastic thyroid cancer and analyzed the effect of EBRT volume on locoregional control...
