Research Topics

Genomes and Genes


Jun Hyuck Lee


Country: Korea


  1. Lee J, Park H, Park S, Kim H, Eom S. The structural flexibility of the shank1 PDZ domain is important for its binding to different ligands. Biochem Biophys Res Commun. 2011;407:207-12 pubmed publisher
    ..Overall, our study provides a new level of understanding of the specificity and structural plasticity of the shank PDZ domain. ..
  2. Lee C, Park S, Jeong C, Cha S, Park H, Lee J. Structural basis of small RNA hydrolysis by oligoribonuclease (CpsORN) from Colwellia psychrerythraea strain 34H. Sci Rep. 2019;9:2649 pubmed publisher
    ..Moreover, the biochemical data support our suggested mechanism and identified the key residues responsible for enzymatic catalysis of CpsORN. ..
  3. Lee C, Park S, Koh H, Jeong C, Hwang J, Lee S, et al. Crystal structure of a transcription factor, GerE (PaGerE), from spore-forming bacterium Paenisporosarcina sp. TG-14. Biochem Biophys Res Commun. 2019;513:374-379 pubmed publisher
    ..Additionally, our structural comparison studies suggest that DNA binding by PaGerE causes a conformational change in the α4-helix region, which may strongly induce dimerization of PaGerE. ..
  4. Yoo W, Lee C, Kim B, Huong Luu Le L, Park S, Kim H, et al. Structural and functional analysis of a dimeric fumarylacetoacetate hydrolase (EaFAH) from psychrophilic Exiguobacterium antarcticum. Biochem Biophys Res Commun. 2019;: pubmed publisher
  5. Lee J, Park H, Park Y. Molecular mechanisms of host cytoskeletal rearrangements by Shigella invasins. Int J Mol Sci. 2014;15:18253-66 pubmed publisher
    ..These so-called Shigella invasins, including IpaA, IpaC, IpgB1, IpgB2 and IpgD, modulate the actin-regulatory system in a concerted manner to guarantee efficient entry of the bacteria into host cells. ..
  6. Lee C, Kim J, Do H, Kim R, Lee S, Park H, et al. Structural basis for the ligand-binding specificity of fatty acid-binding proteins (pFABP4 and pFABP5) in gentoo penguin. Biochem Biophys Res Commun. 2015;465:12-8 pubmed publisher
    ..In conclusion, our high-resolution structures and ligand-binding studies provide useful insights into the ligand-binding preferences of pFABPs based on key protein-ligand interactions. ..
  7. Lee C, Park S, Lee S, Park H, Kim H, Park H, et al. Crystal structure of dihydrodipicolinate reductase (PaDHDPR) from Paenisporosarcina sp. TG-14: structural basis for NADPH preference as a cofactor. Sci Rep. 2018;8:7936 pubmed publisher
    ..These findings provide insight into the mechanism of action and cofactor selectivity of this important bacterial enzyme. ..
  8. Lee C, Lee J, Rimal H, Park H, Lee J, Oh T. Crystal Structure of Cytochrome P450 (CYP105P2) from Streptomyces peucetius and Its Conformational Changes in Response to Substrate Binding. Int J Mol Sci. 2016;17: pubmed publisher
    ..These results provide useful insights into the structural changes involved in the recognition of different ligands by CYP105P2. ..
  9. Lee C, Yu S, Lee J, Park S, Park H, Oh T, et al. Crystal Structure of a Putative Cytochrome P450 Alkane Hydroxylase (CYP153D17) from Sphingomonas sp. PAMC 26605 and Its Conformational Substrate Binding. Int J Mol Sci. 2016;17: pubmed
    ..These results improve the understanding of the catalytic mechanism of CYP153D17 and provide valuable information for future protein engineering studies. ..

More Information


  1. Do H, Lee C, Lee S, Kang H, Park C, Kim H, et al. Crystal structure and modeling of the tetrahedral intermediate state of methylmalonate-semialdehyde dehydrogenase (MMSDH) from Oceanimonas doudoroffii. J Microbiol. 2016;54:114-21 pubmed publisher
    ..Our results provide useful insights into the substrate recognition site residues and catalytic mechanism of OdoMMSDH. ..
  2. Park A, Kim I, Jeon B, Roh S, Ryu M, Baek H, et al. Crystal structures of aldehyde deformylating oxygenase from Limnothrix sp. KNUA012 and Oscillatoria sp. KNUA011. Biochem Biophys Res Commun. 2016;477:395-400 pubmed publisher
    ..Moreover, our results provided a comprehensive structural basis for conformational changes induced by binding of the substrate and co-factor. ..
  3. Lee C, Park S, Lee S, Shin S, Han S, Kim H, et al. Crystal structure of the inactive state of the receiver domain of Spo0A from Paenisporosarcina sp. TG-14, a psychrophilic bacterium isolated from an Antarctic glacier. J Microbiol. 2017;55:464-474 pubmed publisher
    ..Collectively, these observations provide insight into the mechanism of phosphorylation-dependent activation unique to Spo0A. ..
  4. Lee J, An J, Park H, Kim H, Eom S. Crystallization and preliminary X-ray crystallographic analysis of the human kindlin-2 PH domain. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011;67:696-9 pubmed publisher
    ..A diffraction data set was collected at 2.8 Å resolution using synchrotron radiation on BL-4A at the Pohang Accelerator Laboratory (Pohang, Republic of Korea). ..
  5. Kim H, Lee J, Hur Y, Lee C, Park S, Koo B. Marine Antifreeze Proteins: Structure, Function, and Application to Cryopreservation as a Potential Cryoprotectant. Mar Drugs. 2017;15: pubmed publisher