Ai Young Lee

Summary

Country: Korea

Publications

  1. doi request reprint The regulation of epidermal melanogenesis via cAMP and/or PKC signaling pathways: insights for the development of hypopigmenting agents
    Ai Young Lee
    Department of Dermatology, Dongguk University Seoul, Graduate School of Medicine, 814 Siksa dong, Ilsandong gu, Goyang si, Gyeonggi Do, 410 773, South Korea
    Arch Pharm Res 36:792-801. 2013
  2. pmc Role of keratinocytes in the development of vitiligo
    Ai Young Lee
    Department of Dermatology, Dongguk University Ilsan Hospital, Dongguk University Graduate School of Medicine, Goyang, Korea
    Ann Dermatol 24:115-25. 2012
  3. doi request reprint Co-culture of melanocytes with adipose-derived stem cells as a potential substitute for co-culture with keratinocytes
    Ji Young Kim
    Department of Dermatology, Dongguk University Ilsan Hospital, Gyeonggi Do, South Korea
    Acta Derm Venereol 92:16-23. 2012
  4. doi request reprint Light-emitting diodes at 830 and 850 nm inhibit melanin synthesis in vitro
    Jeong Mo Kim
    Dongguk University Research Institute of Biotechnology Medical Science Research Center, Gyeonggi Do, Korea
    Acta Derm Venereol 92:675-80. 2012
  5. doi request reprint PDZK1 upregulation in estrogen-related hyperpigmentation in melasma
    Nan Hyung Kim
    Department of Dermatology, Dongguk University Ilsan Hospital, Goyang si, Gyenggi do, South Korea
    J Invest Dermatol 132:2622-31. 2012
  6. doi request reprint Reduced WIF-1 expression stimulates skin hyperpigmentation in patients with melasma
    Ji Young Kim
    Department of Dermatology, Dongguk University Ilsan Hospital, Goyang si, Gyeonggi Do, South Korea
    J Invest Dermatol 133:191-200. 2013
  7. doi request reprint Reduced aquaporin3 expression and survival of keratinocytes in the depigmented epidermis of vitiligo
    Nan Hyung Kim
    Department of Dermatology, Dongguk University, Ilsan Hospital, Gyenggi do, South Korea
    J Invest Dermatol 130:2231-9. 2010
  8. doi request reprint Histamine effect on melanocyte proliferation and vitiliginous keratinocyte survival
    Nan Hyung Kim
    Department of Dermatology, Dongguk University, Ilsan Hospital, Ilsandong gu, Gyenggi do, Korea
    Exp Dermatol 19:1073-9. 2010
  9. pmc Three new single nucleotide polymorphisms identified by a genome-wide association study in Korean patients with vitiligo
    Kyung Ah Cheong
    Department of Dermatology, Dongguk University Ilsan Hospital, Goyang, Korea
    J Korean Med Sci 28:775-9. 2013
  10. doi request reprint Mechanism underlying the effect of combined therapy using glucosamine and low-dose cyclosporine A on the development of atopic dermatitis-like skin lesions in NC/Nga mice
    Chang Hyun Kim
    Department of Dermatology, Dongguk University Ilsan Hospital, Dongguk University Graduate School of Medicine, Goyang 410 773, South Korea
    Int Immunopharmacol 15:424-32. 2013

Collaborators

  • Minsoo Noh
  • Songhee Jeon
  • Chang Hyun Kim
  • Soo Cheon Chae
  • Seung Won Park
  • Hee Kang
  • Joon Lee
  • Kyu Han Kim
  • Nan Hyung Kim
  • Kyung Ah Cheong
  • Hyok Bu Kwon
  • Yunseok Choi
  • Ji Young Kim
  • Yu Shun Tian
  • Chang Hoon Lee
  • Seung Ho Lee
  • Tae Ryong Lee
  • Jeong Mo Kim
  • Byung Jin Ahn
  • Chan Do Park
  • Sang S Lee
  • Won Jun Choi
  • Joo Young Roh
  • Yun Seok Choi
  • Sang Yun Jin
  • Seong Eon Kim
  • Won Young Chey
  • Sang Y Jin
  • Kyung A Cheong
  • Hwa Jung Kim
  • Chang K Hong
  • Cheol Heon Lee
  • Sang W Lee
  • Dong Jae Kim
  • Young Min Park
  • Myeung Nam Kim
  • Jin Wou Kim
  • Hae Y Park
  • Nam J Jeong
  • Hae Y Choi
  • Ga Young Lee
  • Jee Ho Choi
  • Dong K Hong
  • Jun Mo Yang
  • Joo Yeon Ko
  • Hee C Eun
  • Byung Rok Do
  • Young Lip Park
  • Kwang Hoon Lee
  • Young Suck Ro
  • Chun Wook Park
  • Sang Hyun Cho
  • Yang Won Lee
  • Seong J Seo
  • Kee Chan Moon
  • Seong Jun Seo
  • Youn Min Park
  • Bum Jun Kim
  • Beom Joon Kim
  • Nam Doo Kim
  • Santosh Rani Agrawal
  • Myung Nam Kim
  • Yoon Seok Chang
  • Hai Jin Park
  • Yeon Soon Ahn
  • Yong Shin Kim
  • Hun Taeg Chung
  • Jong Sun Choi
  • Hyun Joo Lee
  • Tae Yeon Yoo

Detail Information

Publications33

  1. doi request reprint The regulation of epidermal melanogenesis via cAMP and/or PKC signaling pathways: insights for the development of hypopigmenting agents
    Ai Young Lee
    Department of Dermatology, Dongguk University Seoul, Graduate School of Medicine, 814 Siksa dong, Ilsandong gu, Goyang si, Gyeonggi Do, 410 773, South Korea
    Arch Pharm Res 36:792-801. 2013
    ..Here, factors involved in melanogenesis regulation via cAMP and/or PKC pathways are reviewed with their action mechanisms. ..
  2. pmc Role of keratinocytes in the development of vitiligo
    Ai Young Lee
    Department of Dermatology, Dongguk University Ilsan Hospital, Dongguk University Graduate School of Medicine, Goyang, Korea
    Ann Dermatol 24:115-25. 2012
    ..Apoptotic keratinocytes induced a lower expression of keratinocyte-derived factors, including stem cell factor, in depigmented epidermis, resulting in passive melanocyte death...
  3. doi request reprint Co-culture of melanocytes with adipose-derived stem cells as a potential substitute for co-culture with keratinocytes
    Ji Young Kim
    Department of Dermatology, Dongguk University Ilsan Hospital, Gyeonggi Do, South Korea
    Acta Derm Venereol 92:16-23. 2012
    ..Our data show that co-culturing with ADSCs results in increased melanocyte proliferation and migration while reducing differentiation, and could provide a means to treat disorders such as vitiligo...
  4. doi request reprint Light-emitting diodes at 830 and 850 nm inhibit melanin synthesis in vitro
    Jeong Mo Kim
    Dongguk University Research Institute of Biotechnology Medical Science Research Center, Gyeonggi Do, Korea
    Acta Derm Venereol 92:675-80. 2012
    ..These results indicate that LEDs could potentially be used to treat melanin-overproducing skin conditions...
  5. doi request reprint PDZK1 upregulation in estrogen-related hyperpigmentation in melasma
    Nan Hyung Kim
    Department of Dermatology, Dongguk University Ilsan Hospital, Goyang si, Gyenggi do, South Korea
    J Invest Dermatol 132:2622-31. 2012
    ..Collectively, upregulation of PDZK1 could have an important role in the development of melasma in connection with estrogen through NHE, CFTR, and SLC26A3...
  6. doi request reprint Reduced WIF-1 expression stimulates skin hyperpigmentation in patients with melasma
    Ji Young Kim
    Department of Dermatology, Dongguk University Ilsan Hospital, Goyang si, Gyeonggi Do, South Korea
    J Invest Dermatol 133:191-200. 2013
    ....
  7. doi request reprint Reduced aquaporin3 expression and survival of keratinocytes in the depigmented epidermis of vitiligo
    Nan Hyung Kim
    Department of Dermatology, Dongguk University, Ilsan Hospital, Gyenggi do, South Korea
    J Invest Dermatol 130:2231-9. 2010
    ..Moreover, AQP3 knockdown induced no increase in differentiating markers at high calcium concentrations and reduced survival of KCs, suggesting that reduced AQP3 in vitiliginous KCs might be responsible for their reduced survival...
  8. doi request reprint Histamine effect on melanocyte proliferation and vitiliginous keratinocyte survival
    Nan Hyung Kim
    Department of Dermatology, Dongguk University, Ilsan Hospital, Ilsandong gu, Gyenggi do, Korea
    Exp Dermatol 19:1073-9. 2010
    ..Overall, histamine stimulated the proliferation and migration of melanocytes and the vitiliginous keratinocyte survival, providing the basis for novel therapeutic approaches to vitiligo repigmentation...
  9. pmc Three new single nucleotide polymorphisms identified by a genome-wide association study in Korean patients with vitiligo
    Kyung Ah Cheong
    Department of Dermatology, Dongguk University Ilsan Hospital, Goyang, Korea
    J Korean Med Sci 28:775-9. 2013
    ..DNAH5 (rs2277046), STRN3 (rs2273171), and KIAA1005 (rs3213758) may be new vitiligo-related SNPs in Korean patients, either non-segmental or segmental type...
  10. doi request reprint Mechanism underlying the effect of combined therapy using glucosamine and low-dose cyclosporine A on the development of atopic dermatitis-like skin lesions in NC/Nga mice
    Chang Hyun Kim
    Department of Dermatology, Dongguk University Ilsan Hospital, Dongguk University Graduate School of Medicine, Goyang 410 773, South Korea
    Int Immunopharmacol 15:424-32. 2013
    ..These results suggest that this combined immunosuppressive treatment may provide important implications for the design of therapeutic strategies aimed at AD treatment...
  11. doi request reprint Antiphotoaging effects of light-emitting diode irradiation on narrow-band ultraviolet B-exposed cultured human skin cells
    Yu Shun Tian
    Department of Dermatology, Dongguk University Ilsan Hospital, Goyang si, Gyeonggi Do, South Korea
    Dermatol Surg 38:1695-703. 2012
    ..Antiaging effects of light-emitting diodes (LEDs) have been clinically demonstrated using one or two wavelengths. The mechanism is unclear...
  12. doi request reprint A novel function of Siglec-9 A391C polymorphism on T cell receptor signaling
    Kyung Ah Cheong
    Department of Dermatology, Dongguk University Ilsan Hospital, Ilsandong gu, Goyang, Korea
    Int Arch Allergy Immunol 154:111-8. 2011
    ..In human Siglec-9, at least 8 nonsynonymous SNPs have been detected without functional studies. This study examined the SNP(s) related to TCR-mediated signaling...
  13. doi request reprint H19 RNA downregulation stimulated melanogenesis in melasma
    Nan Hyung Kim
    Department of Dermatology, Dongguk University School of Medicine, Ilsandong gu, Goyang si, Gyenggi do, South Korea
    Pigment Cell Melanoma Res 23:84-92. 2010
    ..These findings suggest that downregulation of H19 and a sufficient dose of estrogen might be involved in the development of melasma...
  14. ncbi request reprint All trans-retinoic acid (ATRA) elevated eukaryotic translation initiation factor 4A1 (eIF4A1) mRNA in ATRA-responsive vitiliginous epidermis
    Ai Young Lee
    Department of Dermatology, Eulji University School of Medicine, Seoul, South Korea
    Pigment Cell Res 17:659-67. 2004
    ..Therefore, eIF4A1 mRNA may be an important gene related to ATRA effects, although further studies are required...
  15. ncbi request reprint Less keratinocyte-derived factors related to more keratinocyte apoptosis in depigmented than normally pigmented suction-blistered epidermis may cause passive melanocyte death in vitiligo
    Ai Young Lee
    Department of Dermatology, Eulji University School of Medicine, Seoul, Korea
    J Invest Dermatol 124:976-83. 2005
    ....
  16. ncbi request reprint The therapeutic effects of a topical tretinoin and corticosteroid combination for vitiligo: a placebo-controlled, paired-comparison, left-right study
    Hyok Bu Kwon
    Department of Dermatology, Dongguk University Graduate School of Medicine, Goyang si, South Korea
    J Drugs Dermatol 12:e63-7. 2013
    ..Topical all-trans-retinoic acid (tretinoin) prevents skin atrophy induced by long-term use of topical corticosteroids, without abrogating their anti-inflammatory effects...
  17. doi request reprint Irradiation of light emitting diode at 850nm inhibits T cell-induced cytokine expression
    Kyung Ah Cheong
    Department of Dermatology, Dongguk University Ilsan Hospital, 814 Siksa dong, Ilsandong gu, Goyang si, Gyeonggi do 410 773, South Korea
    J Dermatol Sci 65:27-37. 2012
    ..An anti-inflammatory effect of light obtained from light-emitting diodes (LEDs) has been discovered, however, limited ranges of wavelengths have been used and the action mechanism has been rarely demonstrated...
  18. pmc Treatment of verrucous carcinoma of the lower lip with topical imiquimod (aldara®) and debulking therapy
    Hyok Bu Kwon
    Department of Dermatology, Dongguk University Ilsan Hospital, College of Medicine, Dongguk University, Goyang, Korea
    Ann Dermatol 23:S68-71. 2011
    ..We reported on 2 cases of verrucous carcinoma of the lip treated with topical imiquimod and debulking therapy...
  19. pmc Papular elastorrhexis: a case and differential diagnosis
    Yunseok Choi
    Department of Dermatology, Dongguk University Ilsan Hospital, College of Medicine, Dongguk University, Goyang, Korea
    Ann Dermatol 23:S53-6. 2011
    ..Histological examination revealed focal areas showing increased layers of collagen fibers and decreased and fragmented elastic fibers in the upper dermis...
  20. doi request reprint Patch test reactions in patients with the additional diagnosis of vitiligo
    Joon Ho Lee
    Department of Dermatology, Graduate School of Medicine, Dongguk University Seoul, Seoul, South KoreaMedical Science Research Center, Dongguk University Seoul, Seoul, South KoreaDepartment of Pharmacy, College of Pharmacy, Ajou University, Suwon, South Korea
    Int J Dermatol 53:187-91. 2014
    ..A positive correlation (P = 0.03) was also detected between avoidance of allergen and improvement of vitiligo lesions. Conclusions  Causative allergens of ACD may play a role in the development and/or aggravation of vitiligo. ..
  21. doi request reprint Greater collagen deposition with the microneedle therapy system than with intense pulsed light
    Seong Eon Kim
    Department of Dermatology, Graduate School of Medicine, Dongguk University, Seoul, Gyeonggi Do, South Korea
    Dermatol Surg 37:336-41. 2011
    ..Intense pulsed light (IPL) and the microneedle therapy system (MTS) are currently available for the treatment of scars. Greater collagen deposition has been proposed as a mechanism for the treatment of scars...
  22. doi request reprint Combination of glucosamine improved therapeutic effect of low-dose cyclosporin A in patients with atopic dermatitis: a pilot study
    Hyok Bu Kwon
    Department of Dermatology, Dongguk University Seoul, Graduate School of Medicine, Goyang si, Gyeonggi do 410 773, South Korea
    J Dermatol 40:207-10. 2013
    ..This study suggests that the C would produce better clinical outcomes than the S regimen in patients with atopic dermatitis, although confirmatory clinical trials are warranted to determine the effect of combination...
  23. doi request reprint Prevalence and risk factors for atopic dermatitis: a cross-sectional study of 6,453 Korean preschool children
    Won Jun Choi
    Department of Dermatology, College of Medicine, Hanyang University, Seoul, Korea
    Acta Derm Venereol 92:467-71. 2012
    ..9%). In addition, the prevalence of atopic dermatitis was lower when assessed by dermatological examination than by questionnaire...
  24. doi request reprint 850nm light-emitting-diode phototherapy plus low-dose tacrolimus (FK-506) as combination therapy in the treatment of dermatophagoides farinae-induced atopic dermatitis-like skin lesions in NC/Nga mice
    Chang Hyun Kim
    Department of Dermatology, Dongguk University Ilsan Hospital, Dongguk University Graduate School of Medicine, Goyang 410 773, South Korea
    J Dermatol Sci 72:142-8. 2013
    ..Tacrolimus (FK-506) is a potent immunomodulating agent, which has been used to treat AD. Combination therapy is often used in the treatment of AD to improve therapeutic efficacy or to reduce the dose of each drug...
  25. ncbi request reprint Impaired PI3K/Akt activation-mediated NF-kappaB inactivation under elevated TNF-alpha is more vulnerable to apoptosis in vitiliginous keratinocytes
    Nan Hyung Kim
    Department of Dermatology, Dongguk University School of Medicine, Gyenggi do, South Korea
    J Invest Dermatol 127:2612-7. 2007
    ..Thus, reduced activation of NF-kappaB via impaired PI3K/Akt activation under increased TNF-alpha levels could result in increased apoptosis of vitiliginous keratinocytes...
  26. pmc An NH2-terminal truncated cytochrome P450 CYP3A4 showing catalytic activity is present in the cytoplasm of human liver cells
    Songhee Jeon
    Department of Dermatology, Dongguk University School of Medicine, Goyang 410 773, Korea
    Exp Mol Med 40:254-60. 2008
    ..Our result shows, for the first time, that N-terminal truncated, catalytically active CYP3A4 is present principally in the cytoplasm of human liver cells...
  27. ncbi request reprint Allergic contact dermatitis to white petrolatum
    Hee Kang
    Department of Dermatology, Eulji University, School of Medicine, Seoul, Korea
    J Dermatol 31:428-30. 2004
    ..We herein report a case of allergic contact dermatitis to white petrolatum...
  28. ncbi request reprint Allergic contact dermatitis from hair dye and development of lichen simplex chronicus
    Won Young Chey
    Department of Dermatology, Eulji Hospital, Eulji University School of Medicine, Seoul 139 711, South Korea
    Contact Dermatitis 51:5-8. 2004
    ..The suggestion can therefore be made that hair dye could be a possible aetiologic agent causing LSC in those using hair dyes...
  29. pmc Lotus (Nelumbo nuficera) flower essential oil increased melanogenesis in normal human melanocytes
    Songhee Jeon
    Department of Dermatology, Dongguk University School of Medicine, Goyang 410 773, Korea
    Exp Mol Med 41:517-25. 2009
    ..Thus, our results indicate that lotus flower oil may prove useful in the development of gray hair prevention agents or tanning reagents...
  30. doi request reprint Multicenter study of preservative sensitivity in patients with suspected cosmetic contact dermatitis in Korea
    Sang S Lee
    Department of Dermatology, Chungnam National University College of Medicine, Daejeon, Seoul, Korea
    J Dermatol 39:677-81. 2012
    ..MCI/MI and thimerosal showed highly positive allergy reactions in our study. The optimum concentration of chlorphenesin to avoid skin reactions is less than 0.5%...
  31. pmc A case of argyria following colloidal silver ingestion
    Hyok Bu Kwon
    Department of Dermatology, Dongguk University International Hospital, College of Medicine, Dongguk University, Goyang, Korea
    Ann Dermatol 21:308-10. 2009
    ..The ingestion of colloidal silver appears to be increasing among patients using alternative health practices. We report this case to bring people's attention to the problems associated with the ingestion of colloidal silver...
  32. doi request reprint Validation of nested PCR and a selective biochemical method as alternatives for mycoplasma detection
    Kyung Ah Cheong
    Department of Dermatology, Dongguk University Ilsan Hospital, Goyang, Korea
    J Basic Microbiol 51:215-9. 2011
    ..Changes in the concentration of reagents, reagent lot, or individual analysts did not influence the results of the examined methods. The results of this study support nested PCR as a valuable alternative for mycoplasma detection...
  33. doi request reprint Association of thymic stromal lymphopoietin gene -847C>T polymorphism in generalized vitiligo
    Kyung Ah Cheong
    Department of Dermatology, Dongguk University School of Medicine, Goyang si, Gyeonggi Do, South Korea
    Exp Dermatol 18:1073-5. 2009
    ..013) compared with -847T, expecting lower TSLP mRNA levels in the polymorphism. Collectively, C allele at the TSLP -847C>T polymorphism may increase susceptibility to generalized vitiligo through decreasing TSLP mRNA expression levels...