Kyoungho Suk

Summary

Affiliation: Kyungpook National University
Country: Korea

Publications

  1. pmc Lipocalin-2 Is a chemokine inducer in the central nervous system: role of chemokine ligand 10 (CXCL10) in lipocalin-2-induced cell migration
    Shinrye Lee
    Department of Pharmacology, School of Life Sciences and Biotechnology, Kyungpook National University, Daegu, Korea
    J Biol Chem 286:43855-70. 2011
  2. doi request reprint TL1A induces the expression of TGF-β-inducible gene h3 (βig-h3) through PKC, PI3K, and ERK in THP-1 cells
    Seung Hee Lee
    Kyungpook National University, Daegu, Republic of Korea
    Cell Immunol 266:61-6. 2010
  3. ncbi request reprint Functional selection of phagocytosis-promoting genes: cell sorting-based selection
    Hyejin Jeon
    Department of Pharmacology, Brain Science and Engineering Institute, CMRI, Kyungpook National University School of Medicine, Daegu, Korea
    J Biomol Screen 15:949-55. 2010
  4. ncbi request reprint Clinopodium gracile inhibits mast cell-mediated allergic inflammation: involvement of calcium and nuclear factor-kappaB
    Seung Bin Park
    CMRI, Department of Pharmacology, School of Medicine, Kyungpook National University Medical School, Daegu 700 422, South Korea
    Exp Biol Med (Maywood) 235:606-13. 2010
  5. doi request reprint Suppressive effects of flavonoid fisetin on lipopolysaccharide-induced microglial activation and neurotoxicity
    Long Tai Zheng
    Department of Pharmacology, School of Medicine, Brain Science and Engineering Institute, CMRI, Kyungpook National University, Daegu, Republic of Korea
    Int Immunopharmacol 8:484-94. 2008
  6. ncbi request reprint Management of glia-mediated neuroinflammation and related patents
    Mithilesh Kumar Jha
    Department of Pharmacology, Kyungpook National University School of Medicine, 680 Gukchaebosang Street, Joong Gu, Daegu, 700 422, Republic of Korea
    Recent Pat Inflamm Allergy Drug Discov 8:118-24. 2014
  7. pmc Proteomic analysis of glioma chemoresistance
    Kyoungho Suk
    Department of Pharmacology, Brain Science and Engineering Institute, Kyungpook National University School of Medicine, Daegu, Korea
    Curr Neuropharmacol 10:72-9. 2012
  8. pmc Glia as a Link between Neuroinflammation and Neuropathic Pain
    Mithilesh Kumar Jha
    Department of Pharmacology, Brain Science and Engineering Institute, Kyungpook National University School of Medicine, Daegu 700 422, Korea
    Immune Netw 12:41-7. 2012
  9. pmc Pyruvate Dehydrogenase Kinases in the Nervous System: Their Principal Functions in Neuronal-glial Metabolic Interaction and Neuro-metabolic Disorders
    Mithilesh Kumar Jha
    Department of Pharmacology, Brain Science and Engineering Institute, Kyungpook National University School of Medicine, Daegu, Korea
    Curr Neuropharmacol 10:393-403. 2012
  10. pmc Modulation of glial and neuronal migration by lipocalin-2 in zebrafish
    Ho Kim
    Department of Medical Science, Korea University Ansan Hospital, Ansan 425 707, Korea
    Immune Netw 11:342-7. 2011

Collaborators

Detail Information

Publications124 found, 100 shown here

  1. pmc Lipocalin-2 Is a chemokine inducer in the central nervous system: role of chemokine ligand 10 (CXCL10) in lipocalin-2-induced cell migration
    Shinrye Lee
    Department of Pharmacology, School of Life Sciences and Biotechnology, Kyungpook National University, Daegu, Korea
    J Biol Chem 286:43855-70. 2011
    ..Thus, the LCN2 proteins, secreted under inflammatory conditions, may amplify neuroinflammation by inducing CNS cells to secrete chemokines such as CXCL10, which recruit additional inflammatory cells...
  2. doi request reprint TL1A induces the expression of TGF-β-inducible gene h3 (βig-h3) through PKC, PI3K, and ERK in THP-1 cells
    Seung Hee Lee
    Kyungpook National University, Daegu, Republic of Korea
    Cell Immunol 266:61-6. 2010
    ....
  3. ncbi request reprint Functional selection of phagocytosis-promoting genes: cell sorting-based selection
    Hyejin Jeon
    Department of Pharmacology, Brain Science and Engineering Institute, CMRI, Kyungpook National University School of Medicine, Daegu, Korea
    J Biomol Screen 15:949-55. 2010
    ....
  4. ncbi request reprint Clinopodium gracile inhibits mast cell-mediated allergic inflammation: involvement of calcium and nuclear factor-kappaB
    Seung Bin Park
    CMRI, Department of Pharmacology, School of Medicine, Kyungpook National University Medical School, Daegu 700 422, South Korea
    Exp Biol Med (Maywood) 235:606-13. 2010
    ..Our findings provide evidence that WECG inhibits mast cell-derived allergic inflammation and involvement of calcium and NF-kappaB in these effects...
  5. doi request reprint Suppressive effects of flavonoid fisetin on lipopolysaccharide-induced microglial activation and neurotoxicity
    Long Tai Zheng
    Department of Pharmacology, School of Medicine, Brain Science and Engineering Institute, CMRI, Kyungpook National University, Daegu, Republic of Korea
    Int Immunopharmacol 8:484-94. 2008
    ..These results indicate that fisetin has a strong anti-inflammatory activity in brain microglia, and could be a potential therapeutic agent for the treatment of neuroinflammatory diseases...
  6. ncbi request reprint Management of glia-mediated neuroinflammation and related patents
    Mithilesh Kumar Jha
    Department of Pharmacology, Kyungpook National University School of Medicine, 680 Gukchaebosang Street, Joong Gu, Daegu, 700 422, Republic of Korea
    Recent Pat Inflamm Allergy Drug Discov 8:118-24. 2014
    ..This review focuses on recent patents and emerging therapeutics related to the management of glia-mediated neuroinflammation. ..
  7. pmc Proteomic analysis of glioma chemoresistance
    Kyoungho Suk
    Department of Pharmacology, Brain Science and Engineering Institute, Kyungpook National University School of Medicine, Daegu, Korea
    Curr Neuropharmacol 10:72-9. 2012
    ..LCN2, ITGB3, and other proteins identified by proteomic analysis could be utilized to overcome glioma chemoresistance...
  8. pmc Glia as a Link between Neuroinflammation and Neuropathic Pain
    Mithilesh Kumar Jha
    Department of Pharmacology, Brain Science and Engineering Institute, Kyungpook National University School of Medicine, Daegu 700 422, Korea
    Immune Netw 12:41-7. 2012
    ..This review will briefly discuss the recent findings that have shed light on the molecular and cellular mechanisms of glia as a connecting link between neuropathic pain and neuroinflammation...
  9. pmc Pyruvate Dehydrogenase Kinases in the Nervous System: Their Principal Functions in Neuronal-glial Metabolic Interaction and Neuro-metabolic Disorders
    Mithilesh Kumar Jha
    Department of Pharmacology, Brain Science and Engineering Institute, Kyungpook National University School of Medicine, Daegu, Korea
    Curr Neuropharmacol 10:393-403. 2012
    ..Here, the authors review the results of recent research efforts that have shed light on the functions of PDKs in the nervous system, particularly on neuron-glia metabolic interactions and neuro-metabolic disorders...
  10. pmc Modulation of glial and neuronal migration by lipocalin-2 in zebrafish
    Ho Kim
    Department of Medical Science, Korea University Ansan Hospital, Ansan 425 707, Korea
    Immune Netw 11:342-7. 2011
    ..The secreted protein lipocalin-2 (LCN2) has been previously implicated in regulation of diverse cellular processes of glia and neurons, including cell migration and morphology...
  11. pmc Molecular and cellular pathways as a target of therapeutic hypothermia: pharmacological aspect
    Hyung Soo Han
    Department of Physiology, Brain Science and Engineering Institute, Kyungpook National University School of Medicine, Daegu, 700 422, Korea
    Curr Neuropharmacol 10:80-7. 2012
    ..Along with the mechanism-based drug targets, applications of therapeutic hypothermia in combination with drug treatment will also be discussed in this review...
  12. pmc Hypothermia enhances induction of protective protein metallothionein under ischemia
    Youn Hee Park
    Department of Physiology, Kyungpook National University School of Medicine, 101 Dongin 2 Ga, Jung Gu, Daegu 700 422, Korea
    J Neuroinflammation 10:21. 2013
    ..This protein was found to exert protective effects in models of brain injury as well. In the present study, we investigated the effect of hypothermia on MT expression and the underlying mechanisms...
  13. ncbi request reprint The neurovascular protection afforded by delayed local hypothermia after transient middle cerebral artery occlusion
    Jong Heon Kim
    Department of Pharmacology, Kyungpook National University School of Medicine, 101 Dong In, Joonggu, Daegu, 700 422, Korea
    Curr Neurovasc Res 10:134-43. 2013
    ....
  14. ncbi request reprint Effects of therapeutic hypothermia on the glial proteome and phenotype
    Jong Heon Kim
    Department of Pharmacology, Brain Science and Engineering Institute, Kyungpook National University School of Medicine, Daegu, Republic of Korea
    Curr Protein Pept Sci 14:51-60. 2013
    ..Therefore, hypothermia-modulated glial proteins and subsequent phenotypic changes may form the basis of the therapeutic effects of hypothermia...
  15. pmc Unexpected role of lipocalin-type prostaglandin D synthase in brain: regulation of glial cell migration and morphology
    Kyoungho Suk
    Department of Pharmacology, Brain Science and Engineering Institute, Kyungpook National University School of Medicine, Daegu, Korea
    Cell Adh Migr 6:160-3. 2012
    ..L-PGDS is a potential drug target that can be exploited for therapeutic intervention of glia-driven neuroinflammation and related diseases...
  16. doi request reprint Delivering alcohol neurotoxicity into nucleus, when clusterin meets BclXL: a commentary
    Kyoungho Suk
    Department of Pharmacology, Brain Science and Engineering Institute, Kyungpook National University School of Medicine, Daegu, Korea
    Alcohol Clin Exp Res 36:745-7. 2012
    ..The study provides novel insights into the molecular mechanisms underlying fetal alcohol spectrum disorders...
  17. doi request reprint Chemical genetics of neuroinflammation: natural and synthetic compounds as microglial inhibitors
    Kyoungho Suk
    Department of Pharmacology, Brain Science and Engineering Institute, CMRI, Kyungpook National University School of Medicine, 680 Gukchaebosang Street, Joong Gu, Daegu 700 422, Korea
    Inflammopharmacology 20:151-8. 2012
    ....
  18. ncbi request reprint Minocycline suppresses hypoxic activation of rodent microglia in culture
    Kyoungho Suk
    Department of Pharmacology, School of Medicine, Kyungpook National University, 101 Dong In, Joong Gu, Daegu 700 422, South Korea
    Neurosci Lett 366:167-71. 2004
    ..Thus, the known neuroprotective effects of minocycline in animal models of cerebral ischemia may be partly due to its direct actions on brain microglia...
  19. pmc Reconstitution of human RNA interference in budding yeast
    Kyoungho Suk
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA
    Nucleic Acids Res 39:e43. 2011
    ..Thus, human Ago2, Dicer and TRBP can functionally reconstitute human RNAi in S. cerevisiae, in vivo, enabling the study and use of the human RNAi pathway in a facile genetic model organism...
  20. ncbi request reprint Neuropeptide PACAP inhibits hypoxic activation of brain microglia: a protective mechanism against microglial neurotoxicity in ischemia
    Kyoungho Suk
    Department of Pharmacology, School of Medicine, Kyungpook National University, 101 Dong In, Joong Gu, Daegu, 700 422 South Korea
    Brain Res 1026:151-6. 2004
    ..The neuroprotective effects of PACAP in animal models of cerebral hypoxia/ischemia may be partly due to its direct actions on brain microglia and neurotoxic inflammation...
  21. ncbi request reprint Microglial signal transduction as a target of alcohol action in the brain
    Kyoungho Suk
    Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, 700 422 Korea
    Curr Neurovasc Res 4:131-42. 2007
    ..Deregulation by ethanol of the inflammatory activation signaling of microglia may contribute to the derangement of CNS immune and inflammatory responses...
  22. ncbi request reprint Combined analysis of the glia secretome and the CSF proteome: neuroinflammation and novel biomarkers
    Kyoungho Suk
    Department of Pharmacology, Brain Science and Engineering Institute, Kyungpook National University School of Medicine, 101 Dong In, Joong Gu, Daegu, 700 422, South Korea
    Expert Rev Proteomics 7:263-74. 2010
    ..Omics and systems biology approaches to glia and neuroinflammation will be a focus of future investigation and will enable an integrative understanding of inflammatory CNS disorders, such as neurodegenerative disease...
  23. pmc A novel functional gene selection method provides a systematic view of cell migration
    Kyoungho Suk
    Department of Pharmacology, Brain Science and Engineering Institute, Kyungpook National University School of Medicine, Joong Gu, Daegu, Korea
    Cell Adh Migr 4:207-10. 2010
    ..The gain-of-function selection method described here can be combined with RNAi-mediated loss-of-function screen or selection to be a more powerful tool for the systems biology research of cell migration...
  24. doi request reprint The antipsychotic spiperone attenuates inflammatory response in cultured microglia via the reduction of proinflammatory cytokine expression and nitric oxide production
    Long Tai Zheng
    Department of Pharmacology, School of Medicine, Brain Science and Engineering Institute, CMRI, Kyungpook National University, Daegu, Korea
    J Neurochem 107:1225-35. 2008
    ..These results imply that the antipsychotic spiperone has anti-inflammatory and neuroprotective effects in the central nervous system by modulating glial activation...
  25. ncbi request reprint Analysis of glial secretome: the long pentraxin PTX3 modulates phagocytic activity of microglia
    Hyejin Jeon
    Department of Pharmacology, Brain Science and Engineering Institute, CMRI, Kyungpook National University School of Medicine, Joong Gu, Daegu, Republic of Korea
    J Neuroimmunol 229:63-72. 2010
    ..Our results indicate that glia-derived PTX3 may modulate phagocytic functions of microglia, and this may have important implications in the regulation of microglial activity in health and disease...
  26. doi request reprint Decursinol angelate blocks transmigration and inflammatory activation of cancer cells through inhibition of PI3K, ERK and NF-kappaB activation
    Won Jung Kim
    School of Life Sciences and Biotechnology, Kyungpook National University, Daegu 702 701, Republic of Korea
    Cancer Lett 296:35-42. 2010
    ..These results demonstrate that DA suppresses invasion and inflammatory activation of cancer cells through modulation of PI3K/AKT, ERK and NF-kappaB. These anti-inflammatory activities of DA may contribute to its anti-cancer activity...
  27. doi request reprint Microglia-inhibiting activity of Parkinson's disease drug amantadine
    Jong Heon Kim
    Department of Pharmacology, Kyungpook National University School of Medicine, Daegu, Korea
    Neurobiol Aging 33:2145-59. 2012
    ..These results provide a molecular basis of the glia-targeted mechanism of action for amantadine...
  28. doi request reprint 2'-Hydroxycinnamaldehyde targets low-density lipoprotein receptor-related protein-1 to inhibit lipopolysaccharide-induced microglial activation
    Heehong Hwang
    Department of Pharmacology, Brain Science and Engineering Institute, CMRI, Kyungpook National University School of Medicine, Daegu, Republic of Korea
    J Neuroimmunol 230:52-64. 2011
    ..Our results suggest that HCA/BCA be anti-inflammatory and neuroprotective in the CNS by targeting LRP1, and may have a therapeutic potential against neuroinflammatory diseases...
  29. doi request reprint Lipocalin-2 is an autocrine mediator of reactive astrocytosis
    Shinrye Lee
    Department of Pharmacology, Brain Science and Engineering Institute, Cell Matrix Research Institute, Kyungpook National University School of Medicine, Daegu 700 422, Korea
    J Neurosci 29:234-49. 2009
    ....
  30. ncbi request reprint NF-κB as a common signaling pathway in ganglioside-induced autophagic cell death and activation of astrocytes
    Jaegyu Hwang
    Department of Pharmacology, Brain Science and Engineering Institute, CMRI, Kyungpook National University School of Medicine, Daegu, Republic of Korea
    J Neuroimmunol 226:66-72. 2010
    ....
  31. ncbi request reprint Inhibition of glial inflammatory activation and neurotoxicity by tricyclic antidepressants
    Jaegyu Hwang
    Department of Pharmacology, School of Medicine, Brain Science and Engineering Institute, Kyungpook National University, Joong Gu, Daegu 700 422, Republic of Korea
    Neuropharmacology 55:826-34. 2008
    ..Therefore, these results imply that clomipramine and imipramine have antiinflammatory and neuroprotective effects in the central nervous system by modulating glial activation...
  32. doi request reprint Anti-inflammatory effects of catechols in lipopolysaccharide-stimulated microglia cells: inhibition of microglial neurotoxicity
    Long Tai Zheng
    Department of Pharmacology, Brain Science and Engineering Institute, CMRI, Kyungpook National University School of Medicine, 101 Dong In, Joong Gu, Daegu, 700 422, Republic of Korea
    Eur J Pharmacol 588:106-13. 2008
    ....
  33. doi request reprint Secreted protein lipocalin-2 promotes microglial M1 polarization
    Eunha Jang
    Department of Pharmacology, Kyungpook National University School of Medicine, 680 Gukchaebosang St, Joong Gu, Daegu 700 422, Korea
    FASEB J 27:1176-90. 2013
    ..These findings suggest that LCN2 is an M1-amplifier in brain microglial cells...
  34. ncbi request reprint Identification of KT-15073 as an inhibitor of lipopolysaccharide-induced microglial activation
    Jiyeon Ock
    Department of Pharmacology, School of Medicine, Brain Science and Engineering Institute, CMRI, Kyungpook National University, Daegu, 700 412, Korea
    Biol Pharm Bull 33:461-7. 2010
    ..Thus, KT-15073 has an anti-inflammatory activity in microglia, and may have a therapeutic potential for the treatment of neuroinflammatory or neurodegenerative diseases...
  35. ncbi request reprint Anti-inflammatory effects of synthetic compound KT-14480 in lipopolysaccharide-stimulated microglia cells
    Jiyeon Ock
    Department of Pharmacology, Brain Science and Engineering Institute, Kyungpook National University School of Medicine, Daegu, Korea
    J Pharm Pharmacol 62:279-85. 2010
    ..Several synthetic fluorovinyloxyacetamide derivatives were screened by microglia cell-based assay in order to identify novel compounds that inhibit the inflammatory activation of microglia...
  36. doi request reprint Phenotypic polarization of activated astrocytes: the critical role of lipocalin-2 in the classical inflammatory activation of astrocytes
    Eunha Jang
    Department of Pharmacology, Brain Science and Engineering Institute, Cell and Matrix Research Institute, Kyungpook National University School of Medicine, Daegu 700 422, Korea
    J Immunol 191:5204-19. 2013
    ....
  37. ncbi request reprint Regulation of Toll-like receptor 4 expression and its signaling by hypoxia in cultured microglia
    Jiyeon Ock
    Department of Pharmacology, Kyungpook National University School of Medicine, Daegu, Korea
    J Neurosci Res 85:1989-95. 2007
    ..Taken together, although hypoxia up-regulates TLR4 expression, its downstream signaling pathways appear to be differentially modulated by hypoxia...
  38. doi request reprint Neurotoxicity of microglial cathepsin D revealed by secretome analysis
    Sangseop Kim
    Department of Pharmacology, Kyungpook National University School of Medicine, Daegu, Korea
    J Neurochem 103:2640-50. 2007
    ....
  39. doi request reprint Anti-inflammatory effects of a fluorovinyloxyacetamide compound KT-15087 in microglia cells
    Jiyeon Ock
    Department of Pharmacology, Brain Science and Engineering Institute, CMRI, Kyungpook National University School of Medicine, 101 Dong In, Joong Gu, Daegu 700 422, South Korea
    Pharmacol Res 59:414-22. 2009
    ..Taken collectively, KT-15087 has an anti-inflammatory activity in microglia, and might have a therapeutic potential for the treatment of neuroinflammatory diseases...
  40. ncbi request reprint Reverse signaling initiated from GITRL induces NF-kappaB activation through ERK in the inflammatory activation of macrophages
    Eun Mi Bae
    Department of Genetic Engineering, School of Life Sciences and Biotechology, Kyungpook National University, Taegu 702 701, Republic of Korea
    Mol Immunol 45:523-33. 2008
    ..These observations raise the possibility that the GITRL-mediated inflammatory activation of macrophages is involved in the pathogenesis of inflammatory diseases...
  41. pmc Obovatol attenuates microglia-mediated neuroinflammation by modulating redox regulation
    Jiyeon Ock
    Department of Pharmacology, Brain Science and Engineering Institute, CMRI, Kyungpook National University, Daegu, Korea
    Br J Pharmacol 159:1646-62. 2010
    ..Here, the effect of obovatol and its mechanism of action on microglial activation, neuroinflammation and neurodegeneration were investigated...
  42. ncbi request reprint Down-regulation of lipocalin 2 contributes to chemoresistance in glioblastoma cells
    Long Tai Zheng
    Department of Pharmacology, Brain Science and Engineering Institute, CMRI, Kyungpook National University School of Medicine, Daegu, Korea
    J Neurochem 111:1238-51. 2009
    ..These results suggest that LCN2 protein may be involved in glioma drug resistance and may provide a new approach to sensitizing glioblastoma to chemotherapy...
  43. doi request reprint Reverse signaling through BAFF differentially regulates the expression of inflammatory mediators and cytoskeletal movements in THP-1 cells
    Sung Tak Jeon
    School of Life Sciences and Biotechnology, Kyungpook National University, Daegu, Korea
    Immunol Cell Biol 88:148-56. 2010
    ..These observations show that the reverse signaling initiated from BAFF induces the expression of inflammatory mediators while suppressing the cytoskeletal movements associated with phagocytosis and transmigration...
  44. doi request reprint Regulation by lipocalin-2 of neuronal cell death, migration, and morphology
    Shinrye Lee
    Department of Pharmacology, Brain Science and Engineering Institute, CMRI, Kyungpook National University School of Medicine, Daegu, Korea
    J Neurosci Res 90:540-50. 2012
    ....
  45. ncbi request reprint Anti-inflammatory effects of m-chlorophenylpiperazine in brain glia cells
    Jaegyu Hwang
    Department of Pharmacology, School of Medicine, Brain Science and Engineering Institute, CMRI, Kyungpook National University, Daegu, South Korea
    Int Immunopharmacol 8:1686-94. 2008
    ..These findings suggest that m-CPP may have important implications in the treatment of neuroinflammatory diseases...
  46. doi request reprint A novel anti-neuroinflammatory pyridylimidazole compound KR-31360
    Jiyeon Ock
    Department of Pharmacology, School of Medicine, Brain Science and Engineering Institute, CMRI, Kyungpook National University, 101 Dong In, Joong Gu, Daegu 700 422, Republic of Korea
    Biochem Pharmacol 79:596-609. 2010
    ..In addition to being a new drug candidate against neuroinflammatory diseases, the compound may be a powerful tool for the better understanding of microglia biology and neuroinflammation...
  47. ncbi request reprint Discoidin domain receptor 1 mediates collagen-induced inflammatory activation of microglia in culture
    Min Chul Seo
    Department of Pharmacology, Brain Science and Engineering Institute, Kyungpook National University School of Medicine, Daegu, Korea
    J Neurosci Res 86:1087-95. 2008
    ..Our results suggest that collagen can induce inflammatory activation of brain microglia and that DDR1 mediates this effect of collagen in an integrin-independent manner...
  48. ncbi request reprint The pivotal role played by lipocalin-2 in chronic inflammatory pain
    Mithilesh Kumar Jha
    Department of Pharmacology, Brain Science and Engineering Institute, BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University School of Medicine, Daegu, Republic of Korea
    Exp Neurol 254:41-53. 2014
    ..Taken together, our results show that inflammatory cell-derived LCN2 at the sites of inflammation plays important roles in central sensitization and the subsequent nociceptive behavior in the rodent model of chronic inflammatory pain. ..
  49. pmc Role of lipocalin-2-chemokine axis in the development of neuropathic pain following peripheral nerve injury
    Sangmin Jeon
    Department of Pharmacology, Brain Science and Engineering Institute, Kyungpook National University School of Medicine, Daegu 700 422, Korea
    J Biol Chem 288:24116-27. 2013
    ....
  50. pmc Plasminogen activator inhibitor type 1 regulates microglial motility and phagocytic activity
    Hyejin Jeon
    Department of Pharmacology, Brain Science and Engineering Institute, CMRI, Kyungpook National University School of Medicine, 101 Dong In, Daegu, Joong Gu, 700 422, South Korea
    J Neuroinflammation 9:149. 2012
    ..PAI-1 is also involved in the innate immunity by regulating cell migration and phagocytosis. However, little is known about the role of PAI-1 in the central nervous system...
  51. ncbi request reprint Comparative analysis of the expression patterns of various TNFSF/TNFRSF in atherosclerotic plaques
    Won Jung Kim
    Department of Genetic Engineering, School of Life Sciences and Biotechnology School of Medicine, Kyungpook National University, Daegu, Korea
    Immunol Invest 37:359-73. 2008
    ....
  52. ncbi request reprint Role of protein kinase Cdelta in paraquat-induced glial cell death
    Sangseop Kim
    Department of Pharmacology, Brain Science and Engineering Institute, CMRI, Kyungpook National University School of Medicine, Daegu, Korea
    J Neurosci Res 86:2062-70. 2008
    ..Last, Rac1 appeared to antagonize paraquat toxicity in glia. These results indicate a gliotoxic effect of paraquat and an opposing role of PKCdelta and Rac1 in paraquat-induced glial cell death...
  53. doi request reprint Stimulation of CD107 affects LPS-induced cytokine secretion and cellular adhesion through the ERK signaling pathway in the human macrophage-like cell line, THP-1
    Byong Keol Min
    School of Life Sciences and Biotechnology, Kyungpook National University, Daegu 702 701, Republic of Korea
    Cell Immunol 281:122-8. 2013
    ..These results suggest that stimulation of THP-1 cells through CD107 affects macrophage-associated functions such as cytokine secretion and cellular adhesion through activation of ERK...
  54. doi request reprint Pro-apoptotic role of integrin β3 in glioma cells
    Jong Heon Kim
    Department of Pharmacology, Brain Science and Engineering Institute, CMRI, Kyungpook National University School of Medicine, Daegu, Korea
    J Neurochem 117:494-503. 2011
    ..These results implicate ITGB3 in glioma cell death/survival and drug resistance...
  55. ncbi request reprint Sequential induction of heme oxygenase-1 and manganese superoxide dismutase protects cultured astrocytes against nitric oxide
    Eunyung Son
    Department of Pharmacology, Kyungpook National University School of Medicine, 101 Dong In, Joong Gu, Daegu, 700 422 Korea
    Biochem Pharmacol 70:590-7. 2005
    ....
  56. doi request reprint Suppression of the lipopolysaccharide-induced expression of MARCKS-related protein (MRP) affects transmigration in activated RAW264.7 cells
    Kwang Rok Chun
    Department of Genetic Engineering, Kyungpook National University, Daegu, Republic of Korea
    Cell Immunol 256:92-8. 2009
    ..Furthermore, pharmacological inhibitors of PKC significantly inhibited the chemotaxis in RAW264.7 cells. These data reveals the pivotal role of MRP in the transmigration of activated RAW264.7 cells...
  57. pmc Lipocalin-type prostaglandin D2 synthase protein regulates glial cell migration and morphology through myristoylated alanine-rich C-kinase substrate: prostaglandin D2-independent effects
    Shinrye Lee
    Department of Pharmacology, Brain Science and Engineering Institute, CMRI, Kyungpook National University School of Medicine, Kyungpook National University, Daegu, Korea
    J Biol Chem 287:9414-28. 2012
    ..The results also indicate that L-PGDS may participate in reactive gliosis in an autocrine or paracrine manner, and may have pathological implications in neuroinflammatory diseases...
  58. pmc CD300a and CD300f differentially regulate the MyD88 and TRIF-mediated TLR signalling pathways through activation of SHP-1 and/or SHP-2 in human monocytic cell lines
    Eun Ju Kim
    School of Life Sciences and Biotechnology, Kyungpook National University, Daegu, Department of Pharmacology, Brain Science and Engineering Institute, School of Medicine, Kyungpook National University, Daegu, Korea
    Immunology 135:226-35. 2012
    ..These data indicate that CD300a and CD300f regulate the MyD88 and TRIF-mediated TLR signalling pathways through differential activation of SHP-1 and SHP-2...
  59. ncbi request reprint Microglia signaling as a target of donepezil
    Jaegyu Hwang
    Department of Pharmacology, Brain Science and Engineering Institute, CMRI, Kyungpook National University School of Medicine, 101 Dong In, Joong Gu, Daegu 700 422, Republic of Korea
    Neuropharmacology 58:1122-9. 2010
    ..It should be noted, however, that there is a large gap between the therapeutic dose of the drug used clinically and the concentration of the drug that exerts the direct action on microglial cells...
  60. doi request reprint Comparative analysis of the role of small G proteins in cell migration and cell death: cytoprotective and promigratory effects of RalA
    Hyejin Jeon
    Department of Pharmacology, Brain Science and Engineering Institute, Kyungpook National University School of Medicine, Daegu, Republic of Korea
    Exp Cell Res 317:2007-18. 2011
    ..Our study provides a framework for further systematic investigation of small G proteins in the perspectives of cell death/survival and motility in inflammation and cancer...
  61. ncbi request reprint Effects of 3',4'-dihydroxyflavonol on vascular contractions of rat aortic rings
    Min Ji Song
    Department of Pharmacology, Kyungpook National University School of Medicine, Daegu, Korea
    Clin Exp Pharmacol Physiol 37:803-10. 2010
    ..These results suggest that DiOHF may have therapeutic potential in the treatment of cardiovascular diseases...
  62. doi request reprint Signaling pathways of bisphenol A-induced apoptosis in hippocampal neuronal cells: role of calcium-induced reactive oxygen species, mitogen-activated protein kinases, and nuclear factor-kappaB
    Soyoung Lee
    CMRI, Department of Pharmacology, School of Medicine, Kyungpook National University, Joong Gu, Daegu, Republic of Korea
    J Neurosci Res 86:2932-42. 2008
    ..The results suggest that calcium, ROS, ERK, and JNK are involved in BPA-induced apoptotic cell death in HT-22 cells. In contrast, an NF-kappaB cascade was activated for survival signaling after BPA treatment...
  63. doi request reprint Neuroprotective effect of methyl lucidone against microglia-mediated neurotoxicity
    Yanji Cui
    Department of Physiology, Jeju national University School of Medicine, 66 Jejudaehakno, Jeju Si, Jeju do 690 756, Republic of Korea
    Eur J Pharmacol 690:4-12. 2012
    ..Taken together, these results suggest that methyl lucidone may have a neuroprotective potential via inhibition of neurotoxic microglial activation implicated in neurodegeneration...
  64. doi request reprint Role of soluble CD14 in cerebrospinal fluid as a regulator of glial functions
    Guo Nan Yin
    Department of Pharmacology, Brain Science and Engineering Institute, CMRI, Kyungpook National University School of Medicine, Daegu, Korea
    J Neurosci Res 87:2578-90. 2009
    ..These results suggest that microglia-derived soluble CD14 is a candidate CSF biomarker for AD and PD, and the soluble CD14 may inhibit glial activation by interfering with LPS effects...
  65. ncbi request reprint A novel derivative of decursin, CSL-32, blocks migration and production of inflammatory mediators and modulates PI3K and NF-κB activities in HT1080 cells
    Seung Hee Lee
    School of Life Sciences and Biotechnology, Kyungpook National University, Daegu 702701, Korea
    Cell Biol Int 36:683-8. 2012
    ..The analyses show that CSL-32 inhibits processes associated with inflammation, such as the production of pro-inflammatory mediators, as well as adhesion, migration and invasion in HT1080 cells...
  66. pmc Glucocorticoid-induced tumour necrosis factor receptor family related protein (GITR) mediates inflammatory activation of macrophages that can destabilize atherosclerotic plaques
    Won Jung Kim
    Department of Genetic Engineering, School of Life Sciences and Biotechnology, Kyungpook National University, Daegu, Korea
    Immunology 119:421-9. 2006
    ....
  67. doi request reprint Natural flavone jaceosidin is a neuroinflammation inhibitor
    Youngpyo Nam
    Department of Pharmacology, Brain Science and Engineering Institute, CMRI, Kyungpook National University School of Medicine, Daegu, Korea
    Phytother Res 27:404-11. 2013
    ..These results indicate that plant flavone jaceosidin is a microglial inhibitor with anti-neuroinflammation activity...
  68. doi request reprint Stimulation of Fas (CD95) induces production of pro-inflammatory mediators through ERK/JNK-dependent activation of NF-κB in THP-1 cells
    Sang Min Lee
    School of Life Sciences and Biotechnology, Kyungpook National University, Daegu 702 701, Republic of Korea
    Cell Immunol 271:157-62. 2011
    ....
  69. ncbi request reprint Gallotannin isolated from Euphorbia species, 1,2,6-tri-O-galloyl-beta-D-allose, decreases nitric oxide production through inhibition of nuclear factor-kappa>B and downstream inducible nitric oxide synthase expression in macrophages
    Mi Sun Kim
    CMRI, IHBR, Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea
    Biol Pharm Bull 32:1053-6. 2009
    ..Our results suggest that gallotannins possess an inhibitory effect on the LPS-induced inflammatory reaction...
  70. ncbi request reprint Stimulation of glucocorticoid-induced tumor necrosis factor receptor family-related protein ligand (GITRL) induces inflammatory activation of microglia in culture
    Heehong Hwang
    Department of Pharmacology, Brain Science and Engineering Institute, CMRI, Kyungpook National University School of Medicine, Daegu, Korea
    J Neurosci Res 88:2188-96. 2010
    ..The GITR/GITRL system may play an important role in neuroinflammation...
  71. doi request reprint The secretome signature of reactive glial cells and its pathological implications
    Mithilesh Kumar Jha
    Department of Pharmacology, Brain Science and Engineering Institute, CMRI, Kyungpook National University School of Medicine, Daegu, South Korea
    Biochim Biophys Acta 1834:2418-28. 2013
    ..This review focuses on reactive glial cells and the uniqueness of their secretome during diverse neuropathological conditions. This article is part of a Special Issue entitled: An Updated Secretome. ..
  72. ncbi request reprint A dual role of lipocalin 2 in the apoptosis and deramification of activated microglia
    Shinrye Lee
    Department of Pharmacology, Kyungpook National University School of Medicine, 101 Dong In, Joong Gu, Daegu 700 422, Korea
    J Immunol 179:3231-41. 2007
    ....
  73. pmc Time-dependent effects of hypothermia on microglial activation and migration
    Jung Wan Seo
    Department of Pharmacology, Brain Science and Engineering Institute, CMRI, Kyungpook National University School of Medicine, 101 Dong In, Daegu, Joong Gu, 700 422, South Korea
    J Neuroinflammation 9:164. 2012
    ..The aim of this study was to determine the time-dependent effects of hypothermia on microglial cell activation and migration, which are accompanied by neuroinflammation...
  74. ncbi request reprint BAFF and APRIL induce inflammatory activation of THP-1 cells through interaction with their conventional receptors and activation of MAPK and NF-κB
    Sang Min Lee
    School of Life Sciences and Biotechnology, Kyungpook National University, Daegu, 702 701, Korea
    Inflamm Res 60:807-15. 2011
    ..Although these molecules have been under intense investigation in order to identify their role in immune reactions, the effect of BAFF and APRIL on macrophage function has not been tested...
  75. pmc Gangliosides induce autophagic cell death in astrocytes
    Jaegyu Hwang
    Department of Pharmacology, School of Medicine, Brain Science and Engineering Institute, CMRI, Kyungpook National University, Daegu, Korea
    Br J Pharmacol 159:586-603. 2010
    ..In this study, the pathological role of gangliosides in the extracellular milieu with respect to glial cell death and lipid raft/membrane disruption was investigated...
  76. ncbi request reprint Induction of microglial apoptosis by corticotropin-releasing hormone
    Jiyeon Ock
    Department of Pharmacology, Kyungpook National University School of Medicine, Daegu, Korea
    J Neurochem 98:962-72. 2006
    ..Taken together, our results indicate that the stress neuropeptide CRH may regulate neuroinflammation by inducing the apoptosis of microglia, the major cellular source of inflammatory mediators in the CNS...
  77. doi request reprint Neuronal pentraxin receptor in cerebrospinal fluid as a potential biomarker for neurodegenerative diseases
    Guo Nan Yin
    Department of Pharmacology, Brain Science and Engineering Institute, CMRI, Kyungpook National University School of Medicine, Joong Gu, Daegu, South Korea
    Brain Res 1265:158-70. 2009
    ..This study suggests that NCAM-120, alpha-dystroglycan, and NPR are candidate biomarkers in CSF for neurodegenerative diseases, and that the changes in the CSF level of NPR may be specific for AD...
  78. ncbi request reprint Discoidin domain receptor 1 mediates collagen-induced nitric oxide production in J774A.1 murine macrophages
    Sang Hyun Kim
    Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu 700 422, Korea
    Free Radic Biol Med 42:343-52. 2007
    ....
  79. ncbi request reprint Glial proteome changes in response to moderate hypothermia
    Jong Heon Kim
    Department of Pharmacology, Brain Science and Engineering Institute, Kyungpook National University School of Medicine, Daegu, Republic of Korea
    Proteomics 12:2571-83. 2012
    ..These proteins may be involved in the protective mechanism of hypothermia against brain injuries...
  80. doi request reprint Identification of novel cell migration-promoting genes by a functional genetic screen
    Minchul Seo
    Department of Pharmacology, School of Medicine, Brain Science and Engineering Institute, Kyungpook National University, Daegu, Korea
    FASEB J 24:464-78. 2010
    ..Thus, chchd2 is a novel cell migration determinant identified by an in vitro functional genetic selection strategy. The selection method can also be useful for the isolation of genes that give other phenotypes of interest...
  81. doi request reprint Stimulation of FasL induces production of proinflammatory mediators through activation of mitogen-activated protein kinases and nuclear factor-κB in THP-1 cells
    Sang Min Lee
    School of Life Sciences and Biotechnology, Kyungpook National University, Daegu, 702 701, South Korea
    Inflammation 35:1-10. 2012
    ..These data indicate that membrane expression of FasL and its interaction with its counterpart may contribute to the inflammatory activation of macrophages during immune reactions or pathogenesis of chronic inflammatory diseases...
  82. doi request reprint Amyloid neurotoxicity is attenuated by metallothionein: dual mechanisms at work
    Jong Heon Kim
    Department of Pharmacology, CMRI, Kyungpook National University School of Medicine, Daegu, Korea
    J Neurochem 121:751-62. 2012
    ..These findings broaden the understanding of neurotoxic mechanisms of Aβ and the crosstalk between Aβ and MT in AD...
  83. doi request reprint A novel pathway responsible for lipopolysaccharide-induced translational regulation of TNF-α and IL-6 expression involves protein kinase C and fascin
    Jae Kwan Kim
    School of Life Sciences and Biotechnology, Kyungpook National University, Daegu 702 701, Korea
    J Immunol 187:6327-34. 2011
    ..These data demonstrate the involvement of fascin in the PKC-mediated translational regulation of TNF-α and IL-6 expression during the LPS response...
  84. ncbi request reprint Flavone inhibits vascular contraction by decreasing phosphorylation of the myosin phosphatase target subunit
    Su Bun Jeon
    Department of Pharmacology, Kyungpook National University School of Medicine, Daegu, Republic of Korea
    Clin Exp Pharmacol Physiol 34:1116-20. 2007
    ..These results suggest that flavone causes endothelium-independent relaxation through, at least in part, the inhibition of p160 Rho-associated coiled-coil-containing protein kinase (ROCK) signalling...
  85. pmc Macrophages express membrane bound form of APRIL that can generate immunomodulatory signals
    Sang Min Lee
    School of Life Sciences and Biotechnology, Kyungpook National University, Daegu, Korea
    Immunology 131:350-6. 2010
    ..These observations demonstrate that macrophages express a membrane-bound form of APRIL which, upon stimulation, modulates the activities of macrophages through stimulation or inhibition of processes associated with inflammation...
  86. doi request reprint Synthetic peptides containing ITIM-like domains block expression of inflammatory mediators and migration/invasion of cancer cells through activation of SHP-1 and PI3K
    Jae Kwan Kim
    School of Life Sciences and Biotechnology, Kyungpook National University, Daegu, Korea
    Cancer Invest 30:364-71. 2012
    ..The inhibitory activities of the synthetic peptides required activation of SH2-containing protein tyrosine phosphatase-1 (SHP-1) and phosphoinositide 3-kinase (PI3K)...
  87. ncbi request reprint TLR4, but not TLR2, signals autoregulatory apoptosis of cultured microglia: a critical role of IFN-beta as a decision maker
    Dae Young Jung
    Department of Pharmacology, Kyungpook National University School of Medicine, Daegu, Korea
    J Immunol 174:6467-76. 2005
    ..Taken together, TLR4 appears to signal a microglial apoptosis via autocrine/paracrine IFN-beta production, which may act as an apoptotic sensitizer...
  88. doi request reprint Increased plasma levels of lipocalin 2 in mild cognitive impairment
    Jihye Choi
    Department of Pharmacology, Brain Science and Engineering Institute, CMRI, Kyungpook National University School of Medicine, Daegu, Republic of Korea
    J Neurol Sci 305:28-33. 2011
    ..Therefore, we hypothesize that there may be a significant change in the plasma LCN2 levels in patients with MCI and AD when compared to healthy control subjects...
  89. doi request reprint Increases of pentraxin 3 plasma levels in patients with Parkinson's disease
    Ho Won Lee
    Department of Neurology, Brain Science and Engineering Institute, Kyungpook National University School of Medicine, Daegu, Korea
    Mov Disord 26:2364-70. 2011
    ..368; P = .003) and motor function (r = 0.358; P = .004). Plasma pentraxin 3 levels could be a new biochemical marker for PD, and they may be associated with the severity of motor dysfunction and other clinical symptoms in PD patients...
  90. doi request reprint Plasma level of chitinase 3-like 1 protein increases in patients with early Alzheimer's disease
    Jihye Choi
    Department of Pharmacology, Brain Science and Engineering Institute, CMRI, Kyungpook National University School of Medicine, 101 Dong In, Joong Gu, Daegu, Korea
    J Neurol 258:2181-5. 2011
    ..Our results demonstrate that CHI3L1 plasma levels are elevated in early AD compared to control or MCI patients. Thus, CHI3L1 plasma levels may be useful as a biomarker, reflecting disease severity in AD patients...
  91. doi request reprint Differential antiproliferation effect of 2'-benzoyloxycinnamaldehyde in K-ras-transformed cells via downregulation of thiol antioxidants
    Jiyeon Ock
    Department of Dental Microbiology, School of Dentistry, Kyungpook National University, Daegu, South Korea
    Cancer Sci 102:212-8. 2011
    ..Based on these findings, it seems that the therapeutic selectivity of BCA in RK3E-ras results from decreased thiol antioxidants via decreased DJ-1 and Nrf2 expression...
  92. ncbi request reprint Decursin inhibits induction of inflammatory mediators by blocking nuclear factor-kappaB activation in macrophages
    Jung Hee Kim
    Department of Genetic Engineering, College of Natural Sciences, Kyungpook National University, Taegu 702 701, Korea
    Mol Pharmacol 69:1783-90. 2006
    ..These data indicate that decursin is a novel inhibitor of NF-kappaB activation in signaling induced by TLR ligands and cytokines...
  93. ncbi request reprint Pro-apoptotic activity of N-myc in activation-induced cell death of microglia
    Dae Young Jung
    Department of Pharmacology, Kyungpook National University School of Medicine, Daegu, Korea
    J Neurochem 94:249-56. 2005
    ....
  94. ncbi request reprint Ethanol selectively modulates inflammatory activation signaling of brain microglia
    Heasuk Lee
    Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, 101 Dong In, Joong Gu, Daegu 700 422, Republic of Korea
    J Neuroimmunol 156:88-95. 2004
    ....
  95. ncbi request reprint Selective modulation of microglial signal transduction by PACAP
    Heasuk Lee
    Department of Pharmacology, School of Medicine, Kyungpook National University, 101 Dong In, Joong Gu, Daegu, 700 422 Korea
    Neuroreport 15:1469-74. 2004
    ..IFNgamma-induced STAT-1 activation or IRF-1 induction was not significantly influenced by PACAP. Therefore, PACAP appears to suppress inflammatory activation of BV-2 microglia via specific inhibition of LPS-induced p38 MAPK pathway...
  96. ncbi request reprint Therapeutic hypothermia in brain injuries and related diseases
    Jong Heon Kim
    Department of Pharmacology, Brain Science and Engineering Institute, Kyungpook National University School of Medicine, Daegu, Korea
    Recent Pat Inflamm Allergy Drug Discov 5:155-64. 2011
    ..Ultimately, we conclude that a localized hypothermia may overcome the limitations, risks, and side effects of systemic hypothermia, and the combination of local hypothermia and drug treatment may improve clinical benefits...
  97. doi request reprint L-theanine partially counteracts caffeine-induced sleep disturbances in rats
    Hwan Soo Jang
    Department of Pharmacology, School of Medicine, Kyungpook National University, 2 101 Dongin Dong, Jung gu Daegu 700 422, Republic of Korea
    Pharmacol Biochem Behav 101:217-21. 2012
    ..In conclusion, low doses of L-theanine can partially reverse caffeine-induced reductions in SWS; however, effects of L-theanine on caffeine-induced insomnia do not appear to increase dose-dependently...
  98. doi request reprint CD300F blocks both MyD88 and TRIF-mediated TLR signaling through activation of Src homology region 2 domain-containing phosphatase 1
    Sang Min Lee
    School of Life Sciences and Biotechnology, Kyungpook National University, Daegu 702 701, Korea
    J Immunol 186:6296-303. 2011
    ....
  99. ncbi request reprint Heme oxygenase-1 mediates cytoprotective effects of immunostimulation in microglia
    Shinrye Lee
    Department of Pharmacology, Kyungpook National University School of Medicine, 101 Dong In, Joong Gu, Daegu 700 422, Republic of Korea
    Biochem Pharmacol 74:723-9. 2007
    ..Taken together, our results suggest that immunostimulation of microglia with LPS provides cytoprotective effects via HO-1 induction followed by the generation of CO and iron...
  100. pmc Synthetic peptides containing ITIM-like sequences of IREM-1 inhibit BAFF-mediated regulation of interleukin-8 expression and phagocytosis through SHP-1 and/or PI3K
    Sang Min Lee
    School of Life Sciences and Biotechnology, Kyungpook National University, Daegu, Korea
    Immunology 134:224-33. 2011
    ..These data indicate that the synthetic peptides are capable of blocking BAFF-mediated regulation of macrophage activities through the activation of SHP-1 and PI3K as well as inhibition of nuclear factor-κB activation...