Kyung Sik Song


Affiliation: Kyungpook National University
Country: Korea


  1. Yang E, Song I, Song K. Ethanol extract of Glycyrrhizae Radix modulates the responses of antigen-specific splenocytes in experimental autoimmune encephalomyelitis. Phytomedicine. 2018;54:56-65 pubmed publisher
    ..These results could be helpful for the discovery of drug candidates for MS by focusing on IFN-γ-related autoimmune responses. ..
  2. Jeong N, Yang E, Jin M, Lee J, Choi Y, Park P, et al. Esculetin from Fraxinus rhynchophylla attenuates atopic skin inflammation by inhibiting the expression of inflammatory cytokines. Int Immunopharmacol. 2018;59:209-216 pubmed publisher
    ..Taken together, these results imply that esculetin attenuated atopic skin inflammation, suggesting that esculetin could be a potential therapeutic candidate for the treatment of AD. ..
  3. Heo J, Kim H, Lee G, Ohk B, Lee S, Song K, et al. Simultaneous Determination of Five Cytochrome P450 Probe Substrates and Their Metabolites and Organic Anion Transporting Polypeptide Probe Substrate in Human Plasma Using Liquid Chromatography-Tandem Mass Spectrometry. Pharmaceutics. 2018;10: pubmed publisher
    ..This analytical method provides a simple, sensitive, and accurate tool for the determination of OATP1B1 and five major P450 activities in vivo drug interaction studies. ..
  4. Yang E, Song K. Polyozellin, a key constituent of the edible mushroom Polyozellus multiplex, attenuates glutamate-induced mouse hippocampal neuronal HT22 cell death. Food Funct. 2015;6:3678-86 pubmed publisher
    ..These data suggest that PM and its constituent PZ might be useful for prevention and treatment of neurodegenerative disorders. ..
  5. Lee D, Kim D, Lee S, Kim T, Kim J, Kim S, et al. Efficient Syntheses of 1,2,3-Triazoloamide Derivatives Using Solid- and Solution-Phase Synthetic Approaches. Molecules. 2015;20:19984-20013 pubmed publisher
    ..The target secondary and tertiary 1,2,3-triazoloamide derivatives were obtained with three-diversity points in excellent overall yields and purities using the reported solid- and solution-phase synthetic routes, respectively. ..
  6. Lee J, Ji S, Kim G, Song K, Um Y, Kim O, et al. Global Profiling of Various Metabolites in Platycodon grandiflorum by UPLC-QTOF/MS. Int J Mol Sci. 2015;16:26786-96 pubmed publisher
    ..grandiflorum. This metabolomics approach can also be applied to evaluate the overall quality of P. grandiflorum, as well as to discriminate the cultivars for the medicinal plant industry. ..
  7. Yang E, Lee W, Song K, Bae J. Ameliorative effect of a rarely occurring C-methylrotenoid on HMGB1-induced septic responses in vitro and in vivo. Biochem Pharmacol. 2016;110-111:58-70 pubmed publisher
    ..Collectively, these results indicate that comp 1 could be potential therapeutic agents for the treatment of various severe vascular inflammatory diseases via inhibition of the HMGB1 signaling pathway. ..
  8. Chon S, Yang E, Lee T, Song K. ?-Secretase (BACE1) inhibitory and neuroprotective effects of p-terphenyls from Polyozellus multiplex. Food Funct. 2016;7:3834-42 pubmed publisher
    ..Thus, P. multiplex and the isolated p-terphenyls might be useful in the development of lead compounds for the prevention of neurodegenerative diseases, especially AD. ..
  9. Yang E, Kim M, Woo J, Lee T, Jung J, Song K. The comparison of neuroprotective effects of isoliquiritigenin and its Phase I metabolites against glutamate-induced HT22 cell death. Bioorg Med Chem Lett. 2016;26:5639-5643 pubmed publisher
    ..Our study suggests that the neuroprotective effect of isoliquiritigenin could be elevated by its active metabolite 4, which is a chalcone containing a catechol group in the B ring. ..

More Information


  1. Park S, Phuc N, Lee J, Wu Z, Kim J, Kim H, et al. Identification of acetylshikonin as the novel CYP2J2 inhibitor with anti-cancer activity in HepG2 cells. Phytomedicine. 2017;24:134-140 pubmed publisher
    ..Taken together, our present study elucidates acetylshikonin displays the inhibitory effects against CYP2J2 in HLMs and anti-cancer activity in human hepatocellular carcinoma HepG2 cells. ..