Jeen Woo Park


Affiliation: Kyungpook National University
Country: Korea


  1. Kim S, Kil I, Kwon O, Kang B, Lee D, Lee H, et al. Oxalomalate reduces tumor progression in melanoma via ROS-dependent proapoptotic and antiangiogenic effects. Biochimie. 2019;158:165-171 pubmed publisher
    ..Thus, OMA might be a potential candidate drug for melanoma skin cancer therapy. ..
  2. Kim Y, Baek J, Kim S, Kim M, Lee B, Ryu N, et al. Therapeutic potential of the mitochondria-targeted antioxidant MitoQ in mitochondrial-ROS induced sensorineural hearing loss caused by Idh2 deficiency. Redox Biol. 2018;20:544-555 pubmed publisher
  3. Ji Y, Chae S, Lee H, Park I, Kim C, Ismail T, et al. Peroxiredoxin5 controls vertebrate ciliogenesis by modulating mitochondrial ROS. Antioxid Redox Signal. 2018;: pubmed publisher
    ..The loss of Prdx5 is associated with excessive production of ROS resulting in mitochondrial dysfunction and aberrant ciliogenesis. ..
  4. Cha H, Lee S, Lee J, Park J. Protective effects of p-coumaric acid against acetaminophen-induced hepatotoxicity in mice. Food Chem Toxicol. 2018;121:131-139 pubmed publisher
    ..These findings indicate that the administration of PCA protects against AAP-induced hepatotoxicity, suggesting it could be a novel therapeutic strategy for AAP-induced liver injury. ..
  5. Choi S, Piao S, Nagar H, Jung S, Kim S, Lee I, et al. Isocitrate dehydrogenase 2 deficiency induces endothelial inflammation via p66sh-mediated mitochondrial oxidative stress. Biochem Biophys Res Commun. 2018;503:1805-1811 pubmed publisher
    ..These findings suggest that IDH2 deficiency induced endothelial inflammation via p66shc-mediated mitochondrial oxidative stress. ..
  6. Lee J, Park J. Attenuated mitochondrial NADP+-dependent isocitrate dehydrogenase activity induces apoptosis and hypertrophy of H9c2 cardiomyocytes. Biochimie. 2014;99:110-8 pubmed publisher
    ..Taken together, our results suggest that the suppression of IDPm expression by siRNA induces apoptosis and hypertrophy of cultured cardiomyocytes through the disruption of cellular redox balance. ..
  7. Lee S, Nam M, Lee D, Park J, Kang B, Lee D, et al. Silibinin Ameliorates O-GlcNAcylation and Inflammation in a Mouse Model of Nonalcoholic Steatohepatitis. Int J Mol Sci. 2018;19: pubmed publisher
    ..Therefore, silibinin is a promising therapeutic agent for hyper-O-GlcNAcylation as well as NASH. ..
  8. Kim J, Park J, Ku H, Kim S, Lim Y, Park J, et al. Naringin protects acrolein-induced pulmonary injuries through modulating apoptotic signaling and inflammation signaling pathways in mice. J Nutr Biochem. 2018;59:10-16 pubmed publisher
    ..Naringin provided protection against the environmental toxicant, acrolein, in mice lung via modulating MAPK, p53, and NF-?B signaling pathways and our data may provide significant implications considering the prevalence of acrolein. ..
  9. Park J, Ku H, Kim J, Park J, Lee J. Amelioration of High Fructose-Induced Cardiac Hypertrophy by Naringin. Sci Rep. 2018;8:9464 pubmed publisher
    ..These findings indicate a novel role for naringin in protecting against fructose-induced cardiac hypertrophy and suggest unique therapeutic strategies for prevention of cardiovascular diseases. ..

More Information


  1. Pan J, Kim H, Beane K, Montalbano A, Lee J, Kim Y, et al. IDH2 Deficiency Aggravates Fructose-Induced NAFLD by Modulating Hepatic Fatty Acid Metabolism and Activating Inflammatory Signaling in Female Mice. Nutrients. 2018;10: pubmed publisher
    ..For the first time, we report our novel findings that IDH2 KO female mice may be more susceptible to fructose-induced NAFLD and the associated inflammatory response, suggesting a mechanistic role of IDH2 in metabolic diseases. ..
  2. request reprint
    Chae U, Park N, Kim E, Choi J, Yim M, Lee H, et al. IDH2-deficient mice develop spinal deformities with aging. Physiol Res. 2018;67:487-494 pubmed
    ..This indicates that IDH2 might be a potent target for the development of therapies for spinal deformities. Our findings also provide a novel animal model for vertebral disease research. ..
  3. Kim H, Pan J, Kim S, Lee J, Park J. Chlorogenic acid ameliorates alcohol-induced liver injuries through scavenging reactive oxygen species. Biochimie. 2018;150:131-138 pubmed publisher
    ..These findings suggest that CGA treatment can be an effective approach to attenuate ALD through the suppression of oxidative stress. ..
  4. Park J, Ku H, Lee J, Park J. IDH2 deficiency accelerates skin pigmentation in mice via enhancing melanogenesis. Redox Biol. 2018;17:16-24 pubmed publisher
    ..Together, our findings highlight the role of IDH2 in skin melanogenesis in association with mitochondrial ROS and suggest unique therapeutic strategies for the prevention of skin pigmentation. ..
  5. Park J, Ku H, Lee J, Park J. Disruption of IDH2 attenuates lipopolysaccharide-induced inflammation and lung injury in an α-ketoglutarate-dependent manner. Biochem Biophys Res Commun. 2018;503:798-802 pubmed publisher
    ..The present study supports the rationale for targeting IDH2 as an important therapeutic strategy for the treatment of systemic inflammatory response syndromes, particularly ALI. ..
  6. Ku H, Park J, Kim S, Park J. Isocitrate dehydrogenase 2 deficiency exacerbates dermis damage by ultraviolet-B via ?Np63 downregulation. Biochim Biophys Acta Mol Basis Dis. 2018;1864:1138-1147 pubmed publisher
    ..In the present study, we provided a role for IDH2 in protection against UVB-induced skin damage and a new connection between IDH2 and ?Np63. ..
  7. Kim S, Kim H, Ku H, Park J, Cha H, Lee S, et al. Oxalomalate reduces expression and secretion of vascular endothelial growth factor in the retinal pigment epithelium and inhibits angiogenesis: Implications for age-related macular degeneration. Redox Biol. 2016;10:211-220 pubmed publisher
    ..These findings reveal a novel role for OMA in inhibiting RPE-derived VEGF expression and angiogenesis, and suggest unique therapeutic strategies for treating pathological angiogenesis and AMD development. ..
  8. Lee S, Cha H, Lee S, Kim H, Ku H, Kim S, et al. Idh2 deficiency accelerates renal dysfunction in aged mice. Biochem Biophys Res Commun. 2017;493:34-39 pubmed publisher
    ..These data support a significant role for increased oxidative stress as a result of compromised mitochondrial antioxidant defenses in modulating life span in mice, and thus support the oxidative stress theory of aging. ..
  9. Ku H, Ahn Y, Lee J, Park K, Park J. IDH2 deficiency promotes mitochondrial dysfunction and cardiac hypertrophy in mice. Free Radic Biol Med. 2015;80:84-92 pubmed publisher
    ..Our results suggest that IDH2 plays an important role in maintaining both baseline mitochondrial function and cardiac contractile function following pressure-overload hypertrophy, by preventing oxidative stress. ..
  10. Cha H, Lee S, Hwan Kim S, Kim H, Lee D, Lee H, et al. Increased susceptibility of IDH2-deficient mice to dextran sodium sulfate-induced colitis. Redox Biol. 2017;13:32-38 pubmed publisher
    ..The present study supported the rationale for targeting IDH2 as an important cancer chemoprevention strategy, particularly in the prevention of colorectal cancer. ..
  11. Lee S, Kim S, Park K, Lee J, Park J. Increased obesity resistance and insulin sensitivity in mice lacking the isocitrate dehydrogenase 2 gene. Free Radic Biol Med. 2016;99:179-188 pubmed publisher
  12. Kim S, Kim S, Ku H, Jeon Y, Lee H, Lee J, et al. Suppression of tumorigenesis in mitochondrial NADP(+)-dependent isocitrate dehydrogenase knock-out mice. Biochim Biophys Acta. 2014;1842:135-43 pubmed publisher
    ..These results support the hypothesis that redox status-associated changes in the host environment of tumor-bearing mice may contribute to cancer progression. ..