Genomes and Genes

Species

Kwang Hyeon Liu

Summary

Affiliation: Kyungpook National University
Country: Korea

Publications

  1. Phuc N, Wu Z, O Y, Lee J, Oh S, Song G, et al. LKY-047: First Selective Inhibitor of Cytochrome P450 2J2. Drug Metab Dispos. 2017;45:765-769 pubmed publisher
    ..These in vitro data support the use of LKY-047 as a selective CYP2J2 inhibitor with potential application in the identification of P450 isoforms responsible for drug metabolism in reaction phenotyping assays. ..
  2. Lee E, Wu Z, Shon J, Liu K. Danazol Inhibits Cytochrome P450 2J2 Activity in a Substrate-independent Manner. Drug Metab Dispos. 2015;43:1250-3 pubmed publisher
    ..Taken together, these data suggest that danazol may be used as a CYP2J2 index inhibitor in reaction phenotyping studies. ..
  3. Jeon Y, Kim J, Hwang G, Wu Z, Han H, Park S, et al. Inhibition of cytochrome P450 2J2 by tanshinone IIA induces apoptotic cell death in hepatocellular carcinoma HepG2 cells. Eur J Pharmacol. 2015;764:480-8 pubmed publisher
    ..Thus, our data strongly suggest that tanshinone IIA exerts its anticancer effect by inhibiting CYP2J2 activity. ..
  4. Lee E, Kim J, Shon J, Wu Z, Kim H, Gim M, et al. Terfenadone is a strong inhibitor of CYP2J2 present in the human liver and intestinal microsomes. Drug Metab Pharmacokinet. 2018;33:159-163 pubmed publisher
    ..93-1.95 μM). Our data suggest that terfenadone may be used as a general CYP2J2 inhibitor in reaction phenotyping study using HLMs and HIMs regardless of the substrate used. ..
  5. Heo J, Kim H, Lee G, Ohk B, Lee S, Song K, et al. Simultaneous Determination of Five Cytochrome P450 Probe Substrates and Their Metabolites and Organic Anion Transporting Polypeptide Probe Substrate in Human Plasma Using Liquid Chromatography-Tandem Mass Spectrometry. Pharmaceutics. 2018;10: pubmed publisher
    ..This analytical method provides a simple, sensitive, and accurate tool for the determination of OATP1B1 and five major P450 activities in vivo drug interaction studies. ..
  6. Lee B, Ji H, Lee T, Liu K. Simultaneous Screening of Activities of Five Cytochrome P450 and Four Uridine 5'-Diphospho-glucuronosyltransferase Enzymes in Human Liver Microsomes Using Cocktail Incubation and Liquid Chromatography-Tandem Mass Spectrometry. Drug Metab Dispos. 2015;43:1137-46 pubmed publisher
    ..This new method will also be useful in the drug discovery process and for advancing the mechanistic understanding of drug interactions. ..
  7. Park S, Lee J, Shon J, Phuc N, Jee J, Liu K. The inhibitory potential of Broussochalcone A for the human cytochrome P450 2J2 isoform and its anti-cancer effects via FOXO3 activation. Phytomedicine. 2018;42:199-206 pubmed publisher
    ..Overall, this was the first report of the inhibitory effects of BCA on CYP2J2 in HLMs. The present data suggest that BCA is a potential candidate for further evaluation for its CYP2J2 targeting anti-cancer activities. ..
  8. Lee D, Kim D, Lee S, Kim T, Kim J, Kim S, et al. Efficient Syntheses of 1,2,3-Triazoloamide Derivatives Using Solid- and Solution-Phase Synthetic Approaches. Molecules. 2015;20:19984-20013 pubmed publisher
    ..The target secondary and tertiary 1,2,3-triazoloamide derivatives were obtained with three-diversity points in excellent overall yields and purities using the reported solid- and solution-phase synthetic routes, respectively. ..
  9. Lee E, Shon J, Liu K. Simultaneous evaluation of substrate-dependent CYP3A inhibition using a CYP3A probe substrates cocktail. Biopharm Drug Dispos. 2016;37:366-72 pubmed publisher
    ..This new method could be an effective tool for the robust and accurate screening of the CYP3A inhibition potential of NCEs in drug discovery. Copyright © 2016 John Wiley & Sons, Ltd. ..

More Information

Publications14

  1. request reprint
    Wu Z, Shon J, Kim J, Cho Y, Liu K. Structural identification of skin ceramides containing ?-hydroxy acyl chains using mass spectrometry. Arch Pharm Res. 2016;39:1426-1432 pubmed
    ..In addition, we have also developed a method for identifying and profiling O-type ceramides in the mouse and guinea pig SC. This information may be used to identify O-type ceramides in the SC of animal skin. ..
  2. Park K, Shon J, Kim J, Park G, Choi H, Liu K. Sulfatides Primarily Exist in the Substantia Nigra Region of Mouse Brain Tissue. Lipids. 2017;52:179-187 pubmed publisher
    ..In particular, sulfatides were mainly distributed in the SN region. Our results could be used to help understand the functions and mechanisms of lipids in various brain diseases. ..
  3. Park H, Park K, Park E, Kim S, Choi M, Liu K, et al. Mass Spectrometry-Based Metabolomic and Lipidomic Analyses of the Effects of Dietary Platycodon grandiflorum on Liver and Serum of Obese Mice under a High-Fat Diet. Nutrients. 2017;9: pubmed publisher
    ..We suggest that further studies on these metabolites could help us gain a better understanding of both HFD-induced obesity and the effects of PG. ..
  4. Park S, Phuc N, Lee J, Wu Z, Kim J, Kim H, et al. Identification of acetylshikonin as the novel CYP2J2 inhibitor with anti-cancer activity in HepG2 cells. Phytomedicine. 2017;24:134-140 pubmed publisher
    ..Taken together, our present study elucidates acetylshikonin displays the inhibitory effects against CYP2J2 in HLMs and anti-cancer activity in human hepatocellular carcinoma HepG2 cells. ..
  5. Heo J, Nguyen P, Kim W, Phuc N, Liu K. Inhibitory Effect of Selaginellins from Selaginella tamariscina (Beauv.) Spring against Cytochrome P450 and Uridine 5'-Diphosphoglucuronosyltransferase Isoforms on Human Liver Microsomes. Molecules. 2017;22: pubmed publisher
    ..This information might be helpful to predict possible drug interaction potential of between selaginellins and co-administered drugs. ..