Affiliation: Kyungpook National University
Shrestha J, Ki S, Shin S, Kim S, Lee J, Jun H, et al
. Synthesis of Novel FTY720 Analogs with Anticancer Activity through PP2A Activation. Molecules. 2018;23: pubmed publisher
..In the docking study of compound 7 and PP2A, the amide chain of compound 7 showed an interaction with Asn61 that was different from FTY720, which is expected to affect the activity of the compound. ..
Cho P, Paudel S, Lee D, Jin Y, Jo G, Jeong T, et al
. Characterization of CYPs and UGTs Involved in Human Liver Microsomal Metabolism of Osthenol. Pharmaceutics. 2018;10: pubmed publisher
..We also found that glucuronidation is the dominant metabolic pathway of osthenol in HLMs. ..
Lee T, Gong Y. Solid-phase parallel synthesis of drug-like artificial 2H-benzopyran libraries. Molecules. 2012;17:5467-96 pubmed publisher
Lee D, Kim D, Lee S, Kim T, Kim J, Kim S, et al
. Efficient Syntheses of 1,2,3-Triazoloamide Derivatives Using Solid- and Solution-Phase Synthetic Approaches. Molecules. 2015;20:19984-20013 pubmed publisher
..The target secondary and tertiary 1,2,3-triazoloamide derivatives were obtained with three-diversity points in excellent overall yields and purities using the reported solid- and solution-phase synthetic routes, respectively. ..
Kim Y, Jung D, Oh S, Lee T, Lee I, Lee K, et al
. Protective effects of 1,2,3-triazole derivative KPR-A020 against cisplatin-induced ototoxicity in murine cochlear cultures. Int J Pediatr Otorhinolaryngol. 2017;96:59-64 pubmed publisher
..The results of this study suggest that KPR-A020 can be used as an antioxidant and antiapoptotic agent to prevent hearing loss caused by cisplatin induced-oxidative stress. ..
Min G, Ku S, Lee T, Bae J. Suppressive effects of zingerone on TGFBIp-mediated septic responses. Arch Pharm Res. 2018;41:276-287 pubmed publisher
..Therefore, ZGR could be a potential therapeutic agent for treatment of various severe vascular inflammatory diseases via inhibition of the TGFBIp signaling pathway. ..