In Kyu Lee


Affiliation: Kyungpook National University
Country: Korea


  1. Park B, Jeon J, Go Y, Ham H, Kim J, Yoo E, et al. PDK4 Deficiency Suppresses Hepatic Glucagon Signaling by Decreasing cAMP Levels. Diabetes. 2018;67:2054-2068 pubmed publisher
    ..The latter were abrogated by the FAO inhibitor etomoxir, suggesting a critical role for PDK4 in FAO stimulation and the regulation of cAMP levels. This finding strengthens the possibility of PDK4 as a target against diabetes. ..
  2. Kim J, Choi Y, Do J, Choi Y, Ha C, Lee S, et al. Estrogen-Related Receptor γ Plays a Key Role in Vascular Calcification Through the Upregulation of BMP2 Expression. Arterioscler Thromb Vasc Biol. 2015;35:2384-90 pubmed publisher
  3. Park S, Kang H, Jeon J, Kim M, Lee I. Recent advances in the pathogenesis of microvascular complications in diabetes. Arch Pharm Res. 2019;42:252-262 pubmed publisher
  4. Karunakaran U, Elumalai S, Moon J, Jeon J, Kim N, Park K, et al. Myricetin Protects Against High Glucose-Induced β-Cell Apoptosis by Attenuating Endoplasmic Reticulum Stress via Inactivation of Cyclin-Dependent Kinase 5. Diabetes Metab J. 2019;43:192-205 pubmed publisher
    ..Myricetin protects the β-cells against HG-induced apoptosis by inhibiting ER stress, possibly through inactivation of CDK5 and consequent upregulation of PDX1 and SERCA2b. ..
  5. Thoudam T, Ha C, Leem J, Chanda D, Park J, Kim H, et al. PDK4 Augments ER-Mitochondria Contact to Dampen Skeletal Muscle Insulin Signaling During Obesity. Diabetes. 2019;68:571-586 pubmed publisher
    ..Overall, our findings demonstrate a critical mediatory role of PDK4 in the development of skeletal muscle insulin resistance via enhancement of MAM formation. ..
  6. Jeong S, Byun J, Cho S, Chin J, Lee I, Choi Y, et al. Transcription Factor Eb Is Required for Macropinocytosis-Mediated Growth Recovery of Nutrient-Deprived Kras-Mutant Cells. Nutrients. 2018;10: pubmed publisher
    ..Collectively, our results show that TFEB plays a role in macropinocytosis-mediated KRAS-mutant cell growth under nutrient deprivation by promoting lysosomal degradation of extracellular proteins. ..
  7. Park J, Jeong G, Lee I, Yoon Y, Liu K, Gu N, et al. A Pharmacometabolomic Approach to Predict Response to Metformin in Early-Phase Type 2 Diabetes Mellitus Patients. Molecules. 2018;23: pubmed publisher
    ..These results might facilitate a better understanding and prediction of metformin response and its variability in individual patients. ..
  8. Karunakaran U, Park S, Jun D, Sim T, Park K, Kim M, et al. Non-receptor tyrosine kinase inhibitors enhances β-cell survival by suppressing the PKCδ signal transduction pathway in streptozotocin-induced β-cell apoptosis. Cell Signal. 2015;27:1066-74 pubmed publisher
    ..These findings suggest that non-receptor tyrosine kinase inhibitors provide a new approach for the treatment of new-onset Type I and Type II diabetes. ..
  9. Lee S, Hong J, Park H, Park J, Kim B, Lee J, et al. Colorectal cancer-derived tumor spheroids retain the characteristics of original tumors. Cancer Lett. 2015;367:34-42 pubmed publisher

More Information


  1. request reprint
    Park S, Karunakaran U, Jeoung N, Jeon J, Lee I. Physiological effect and therapeutic application of alpha lipoic acid. Curr Med Chem. 2014;21:3636-45 pubmed
    ..In this review, we will discuss recent clinical studies that have investigated the beneficial effects of ?-lipoic acid on endothelial dysfunction and propose possible mechanisms involved. ..
  2. Kim J, Im C, Yoo E, Ma M, Kim S, Hong E, et al. Identification of Selective ERRγ Inverse Agonists. Molecules. 2016;21:80 pubmed publisher
    ..This novel class of ERRγ inverse agonists shows promise in the development of drugs targeting ERRγ-related diseases. ..
  3. Seo H, Jeon J, Jung Y, Jung G, Lee E, Choi Y, et al. Fyn deficiency attenuates renal fibrosis by inhibition of phospho-STAT3. Kidney Int. 2016;90:1285-1297 pubmed publisher
    ..Thus, Fyn plays an important role in renal fibrosis. Hence, Fyn kinase inhibitors may be therapeutically useful against renal fibrosis. ..
  4. Choi S, Park S, Oh C, Leem J, Park K, Lee I. Dipeptidyl peptidase-4 inhibition by gemigliptin prevents abnormal vascular remodeling via NF-E2-related factor 2 activation. Vascul Pharmacol. 2015;73:11-9 pubmed publisher
    ..Taken together, our data indicate that gemigliptin exerts a preventative effect on the proliferation and migration of VSMCs via Nrf2. ..
  5. Bae K, Min A, Kim J, Lee I, Park K. Alpha lipoic acid induces hepatic fibroblast growth factor 21 expression via up-regulation of CREBH. Biochem Biophys Res Commun. 2014;455:212-7 pubmed publisher
    ..Collectively, these results indicate that ALA increases hepatic FGF21 expression via up-regulation of CREBH, identifying ALA as a novel positive regulator of FGF21. ..
  6. Oh C, Kim J, Min A, Park K, Harris R, Kim H, et al. Sulforaphane attenuates hepatic fibrosis via NF-E2-related factor 2-mediated inhibition of transforming growth factor-?/Smad signaling. Free Radic Biol Med. 2012;52:671-682 pubmed publisher
    ..Collectively, these results show that SFN elicits an antifibrotic effect on hepatic fibrosis through Nrf2-mediated inhibition of the TGF-?/Smad signaling and subsequent suppression of HSC activation and fibrogenic gene expression. ..
  7. Kim Y, Jung D, Oh S, Lee T, Lee I, Lee K, et al. Protective effects of 1,2,3-triazole derivative KPR-A020 against cisplatin-induced ototoxicity in murine cochlear cultures. Int J Pediatr Otorhinolaryngol. 2017;96:59-64 pubmed publisher
    ..The results of this study suggest that KPR-A020 can be used as an antioxidant and antiapoptotic agent to prevent hearing loss caused by cisplatin induced-oxidative stress. ..
  8. Byun J, Choi Y, Kim J, Jeong J, Jeon H, Kim M, et al. A Positive Feedback Loop between Sestrin2 and mTORC2 Is Required for the Survival of Glutamine-Depleted Lung Cancer Cells. Cell Rep. 2017;20:586-599 pubmed publisher
    ..This study shows that differential Sestrin2-mediated regulation of mTORC1 and mTORC2 is necessary for the survival of glutamine-depleted lung cancer cells. ..
  9. Goodwin J, Choi H, Hsieh M, Neugent M, Ahn J, Hayenga H, et al. Targeting Hypoxia-Inducible Factor-1α/Pyruvate Dehydrogenase Kinase 1 Axis by Dichloroacetate Suppresses Bleomycin-induced Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2018;58:216-231 pubmed publisher
  10. Oh C, Ha C, Choi Y, Park S, Choe M, Jeoung N, et al. Pyruvate dehydrogenase kinase 4 deficiency attenuates cisplatin-induced acute kidney injury. Kidney Int. 2017;91:880-895 pubmed publisher
    ..Thus, PDK4 mediates cisplatin-induced acute kidney injury, suggesting that PDK4 might be a therapeutic target for attenuating cisplatin-induced acute kidney injury. ..