Duk Hee Lee

..Restricted to non-diabetic participants, we now investigate the relationship between POPs and the metabolic syndrome, a prediabetic state...

..Therefore, we explored barriers to and predictors of gastric cancer screening participation among a nationally representative sample...

..In animal experiments, persistent organic pollutants (POPs) have induced visceral obesity. To address this possibility in humans, we evaluated associations between POPs and abdominal obesity both cross-sectionally and prospectively...

..S population with background exposure to POPs. Here, we investigated POPs and insulin resistance, a frequent pathogenic precursor of type 2 diabetes...

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..Our hypothesis can be tested in both prospective studies and toxicological studies...

..This study was performed to explore whether POPs are associated with peripheral neuropathy, a common long-term complication of diabetes, in people with glucose abnormalities...

..As a marker of the amount of conjugated xenobiotics, recent epidemiological findings about serum GGT imply the possibility of harmful effects of various environmental pollutants at background levels currently regarded as safe...

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..If the associations of serum GGT with environmental chemicals were confirmed, it could have an enormous impact on public health because it would indicate that exposure to mixed chemicals at very low levels may not actually be safe...

..However, these two environmental factors cannot be separated from each other in the real world because a number of chemical agents contaminate food chains...

..Low-level exposure to some persistent organic pollutants (POPs) has recently become a focus because of their possible link with the risk of diabetes...

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..This study examined if serum GGT predicted coronary heart disease (CHD), especially differentiating non-fatal myocardial infarction (MI) and fatal CHD event, among the general population or participants with type-2 diabetes...

..In conclusion, in women as well as men, serum GGT level within its normal range predicted type 2 diabetes and may modify the well-known association between body mass index and type 2 diabetes...

..Even though studies on serum and/or cellular GGT is at a beginning stage, our epidemiological findings suggest that serum GGT might be useful in studying oxidative stress-related issues in both epidemiological and clinical settings...

..Since oxidative stress plays a crucial role in the pathogenesis of various liver diseases, serum GGT may predict development of liver damage...

..9, and BMI> or =30. The strong association of serum GGT and CRP suggest that further studies on cellular and/or serum GGT might help to elucidate the association between oxidative stress and inflammation...

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..03). Our data supported the hypothesis that the effect of age on the development of hypertension differed by baseline GGT level, although the underlying mechanism for this interaction is unclear...

..Because vitamin C may cause oxidative stress in the presence of redox active iron, we hypothesized that non-transferrin-bound iron (NTBI), a form of iron susceptible to redox activity, may be present in patients with type 2 diabetes...

..This study was performed to investigate if organochlorine pesticides (OCPs) were associated with metabolic syndrome and insulin resistance among non-diabetes...

..We investigated possible interactions between serum GGT and body mass index (BMI) and their effects on the risk of prevalent type 2 diabetes and homeostasis model assessment (HOMA) insulin resistance...

..We found that telomere length was increasing across low doses of exposure to POPs in which the majority of study subjects were found, suggesting that low-dose POPs may act as a tumour promoter in carcinogenesis in humans...

..This prospective cohort study was performed to examine if serum gamma-glutamyltrasferase (GGT) within a normal range can predict the future risk of hypertension among prehypertensive adults...

..0 (1.1-14.6) for OC pesticides; corresponding ORs for those ≥ 95th percentile were 7.8 (2.1-29.6) and 9.5 (2.3-38.9). Background exposure to POPs may play an important role in development or progression of stroke in the elderly...

..Whether these associations extend to a population with much lower concentrations of POPs is not known...

..The current study examined if low dose POPs predicted future adiposity, dyslipidemia, and insulin resistance among controls without diabetes in that study...

..These associations were similarly observed among most subgroups. In conclusion, the current and previous studies strongly suggest that serum GGT level within its normal range may be an early marker of oxidative stress...

..In addition, as metabolic change due to obesity has been proposed as one mechanism of osteoarthritis (OA), POPs stored in adipose tissue may be also associated with OA...

..There is now increasing evidence that exposure to persistent organic pollutants (POPs) can contribute to the development of inflammatory diseases such as atherosclerosis...

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..Although serum gamma-glutamyltransferase (GGT) predicted cardiovascular diseases (CVD) in prospective studies and may be useful in risk assessment, prediction in older adults was weaker in several studies...

..However, evidence from prospective studies is sparse. This study was performed to evaluate prospective associations of type 2 diabetes with selected POPs among the elderly...

..Cross-sectional associations of serum concentrations of BFRs with diabetes and metabolic syndrome were studied...

..Surprisingly, CAC risk was higher with BMI loss and lower with BMI gain, whereas associations with IMT were as expected...

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..Low doses of some persistent organic pollutants (POPs) associate cross-sectionally with type 2 diabetes, whereas associations with high POP exposures are inconsistent...

..Persistent organic pollutants (POPs), which are endocrine disruptors that accumulate in adipose tissue, can increase the risk of periodontal disease through the disturbance of the immune system...

..This study was performed to examine the association of serum ferritin and transferrin saturation (%TS) with all-cause, cancer, and cardiovascular mortality...

..This may help to explain the excess cardiovascular mortality seen in diabetic patients with CAN...

..This study was conducted to investigate the associations of non alcoholic fatty liver with metabolic syndrome and the serum carotenoids...

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..In this study, we examined the interactions between micronutrients and blood lead on homocysteine levels...

..This study was performed to examine if serum concentrations of OC pesticides were associated with serum concentrations of 25-hydroxyvitamin D (25(OH)D) in the U.S. general population...

..The present study strongly suggests that intracellular AA plays critical roles in vascular physiology through enhancing endothelial NO production...

..To estimate the current cancer burden in Korea, newly diagnosed cancer cases and cancer incidence rates were calculated for the years 2003~2005...

..This paper presents data on levels of three biomarkers, oxidized low-density lipoproteins (LDL), carbonyl, and 8-hydroxy-2'-deoxyguanosine (8-OHdG), and a number of life style factors associated with oxidative stress in healthy adults...

..The latent period might be helpful for clinicians in choosing a treatment method for patients. LEVEL OF EVIDENCE: Prognostic study, Level IV (case series). See the Guidelines for Authors for a complete description of levels of evidence...