Sang Hyun Kim


Affiliation: Kyungpook National University
Country: Korea


  1. Je I, Kim H, Park P, Kwon T, Seo S, Shin T, et al. SG-HQ2 inhibits mast cell-mediated allergic inflammation through suppression of histamine release and pro-inflammatory cytokines. Exp Biol Med (Maywood). 2015;240:631-8 pubmed publisher
    ..Our results indicate that SG-HQ2, an analogue of gallic acid, might be a possible therapeutic candidate for mast cell-mediated allergic inflammatory diseases through suppression of histamine release and pro-inflammatory cytokines. ..
  2. Fei X, Je I, Shin T, Kim S, Seo S. Synthesis of Gallic Acid Analogs as Histamine and Pro-Inflammatory Cytokine Inhibitors for Treatment of Mast Cell-Mediated Allergic Inflammation. Molecules. 2017;22: pubmed publisher
    ..Further optimization yielded several (S)- and (R)-phenylglycine analogs that inhibited histamine release in vitro. Our findings suggest that some gallamides could be used as a treatment for allergic inflammatory diseases. ..
  3. Choi Y, Yu J, Jung H, Lee S, Park P, Lee H, et al. Inhibitory effect of ethanol extract of Ampelopsis brevipedunculata rhizomes on atopic dermatitis-like skin inflammation. J Ethnopharmacol. 2019;238:111850 pubmed publisher
  4. Jeon M, Min K, Woo S, Seo S, Choi Y, Kim S, et al. Maritoclax Enhances TRAIL-Induced Apoptosis via CHOP-Mediated Upregulation of DR5 and miR-708-Mediated Downregulation of cFLIP. Molecules. 2018;23: pubmed publisher
    ..Ectopic expression of cFLIP prevented combined maritoclax and TRAIL-induced apoptosis. Taken together, maritoclax sensitized TRAIL-induced apoptosis through CHOP-mediated DR5 upregulation and miR-708-mediated cFLIP downregulation. ..
  5. Kang B, Kim M, Lee S, Choi Y, Park P, Shin T, et al. Nothofagin suppresses mast cell-mediated allergic inflammation. Chem Biol Interact. 2019;298:1-7 pubmed publisher
    ..Topical administration of nothofagin suppressed local pigmentation and ear thickness. Taken together, these results suggest nothofagin as a potential candidate for the treatment of mast cell-involved allergic inflammatory diseases. ..
  6. Ji Y, Chae S, Lee H, Park I, Kim C, Ismail T, et al. Peroxiredoxin5 controls vertebrate ciliogenesis by modulating mitochondrial ROS. Antioxid Redox Signal. 2018;: pubmed publisher
    ..The loss of Prdx5 is associated with excessive production of ROS resulting in mitochondrial dysfunction and aberrant ciliogenesis. ..
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    Kim S, Lee S, Kim I, Kwon T, Moon J, Park W, et al. Suppression of mast cell-mediated allergic reaction by Amomum xanthiodes. Food Chem Toxicol. 2007;45:2138-44 pubmed
    ..Our findings provide evidence that AXE inhibits mast cell-derived allergic reactions, and that intracellular calcium, TNF-alpha, and p38 MAPK are involved in these effects. ..
  8. Kwon H, Jeong N, Jun S, Son J, Kim S, Jeon H, et al. Thymol attenuates the worsening of atopic dermatitis induced by Staphylococcus aureus membrane vesicles. Int Immunopharmacol. 2018;59:301-309 pubmed publisher
    ..aureus MVs. Our results suggest that thymol is a possible candidate for the management of AD aggravation induced by S. aureus colonization or infection in the lesions. ..
  9. Choi J, Oh H, Park J, Choi J, Sa K, Kang Y, et al. Salvia plebeia extract inhibits the inflammatory response in human rheumatoid synovial fibroblasts and a murine model of arthritis. Phytomedicine. 2015;22:415-22 pubmed publisher
    ..Taken together, these results indicate that SPE is therapeutically efficacious against chronic inflammatory arthritis, suggesting that SPE is a candidate for treating RA. ..

More Information


  1. Jeong N, Yang E, Jin M, Lee J, Choi Y, Park P, et al. Esculetin from Fraxinus rhynchophylla attenuates atopic skin inflammation by inhibiting the expression of inflammatory cytokines. Int Immunopharmacol. 2018;59:209-216 pubmed publisher
    ..Taken together, these results imply that esculetin attenuated atopic skin inflammation, suggesting that esculetin could be a potential therapeutic candidate for the treatment of AD. ..
  2. Kim G, Lee J, Choi H, Kim S, Kim E, Shim S, et al. Cinnamomulactone, a new butyrolactone from the twigs of Cinnamomum cassia and its inhibitory activity of matrix metalloproteinases. Arch Pharm Res. 2017;40:304-310 pubmed publisher
    ..Among them, compound 1 has been revealed to suppress the gene expression of MMP-3 and interleukin (IL)-1? as well as MMP-1 in tumor necrosis factor (TNF)-? stimulated rheumatoid arthritis synovial fibroblasts. ..
  3. Choi J, Kim S, Kim D, Lee J, Lee S, Oh H, et al. Oleanolic acid acetate inhibits rheumatoid arthritis by modulating T cell immune responses and matrix-degrading enzymes. Toxicol Appl Pharmacol. 2016;290:1-9 pubmed publisher
    ..The immunosuppressive effects of OAA were comparable to dexamethasone and ketoprofen. We provide evidences that OAA could be a potential therapeutic candidate for RA. ..
  4. Je I, Choi H, Kim H, Lee S, Choi J, Kim S, et al. Inhibitory effect of 1,2,4,5-tetramethoxybenzene on mast cell-mediated allergic inflammation through suppression of IκB kinase complex. Toxicol Appl Pharmacol. 2015;287:119-27 pubmed publisher
    ..Our results suggest that TMB is a possible therapeutic candidate for allergic inflammatory diseases that acts through the inhibition of mast cell degranulation and expression of pro-inflammatory cytokines. ..
  5. Kim M, Kim E, Pun N, Chang J, Kim J, Jeong J, et al. Globular Adiponectin Inhibits Lipopolysaccharide-Primed Inflammasomes Activation in Macrophages via Autophagy Induction: The Critical Role of AMPK Signaling. Int J Mol Sci. 2017;18: pubmed publisher
    ..Taken together, these results indicate that adiponectin inhibits LPS-primed inflammasomes activation in macrophages via autophagy induction and AMPK signaling-dependent mechanisms. ..
  6. Jang Y, Choi J, Jin M, Choi Y, Ryoo Z, Lee H, et al. House Dust Mite Increases pro-Th2 Cytokines IL-25 and IL-33 via the Activation of TLR1/6 Signaling. J Invest Dermatol. 2017;137:2354-2361 pubmed publisher
    ..We found that DFE-induced activation of TLR1 and TLR6 may cause polarization toward a T helper type 2 immune response via the release of IL-25 and IL-33. ..
  7. Kim Y, Lee S, Kim M, Kang B, Dhakal H, Choi Y, et al. Tyrosol attenuates lipopolysaccharide-induced acute lung injury by inhibiting the inflammatory response and maintaining the alveolar capillary barrier. Food Chem Toxicol. 2017;109:526-533 pubmed publisher
    ..7 macrophages. These results suggested that tyrosol is a potential therapeutic agent for treating inflammatory lung diseases. ..
  8. Choi J, Jang Y, Lee S, Lee S, Choi Y, Jin M, et al. Chrysin attenuates atopic dermatitis by suppressing inflammation of keratinocytes. Food Chem Toxicol. 2017;110:142-150 pubmed publisher
    ..Taken together, the results indicate that chrysin suppressed AD symptoms, suggesting that chrysin might be a candidate for the treatment of AD and skin allergic diseases. ..
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    Kim S, Kim S, Shin H, Lim J, Chae B, Park J, et al. Effects of Prunella vulgaris on mast cell-mediated allergic reaction and inflammatory cytokine production. Exp Biol Med (Maywood). 2007;232:921-6 pubmed
    ..Our findings provide evidence that PVAE inhibits mast cell-derived immediate-type allergic reactions and involvement of proinflammatory cytokines and NF-kappaB in these effects...
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    Kim S, Lee S, Suk K, Bark H, Jun C, Kim D, et al. Discoidin domain receptor 1 mediates collagen-induced nitric oxide production in J774A.1 murine macrophages. Free Radic Biol Med. 2007;42:343-52 pubmed
  11. Lee J, Choi J, Jeong N, Yoo J, Ha Y, Lee B, et al. Anti-inflammatory effects of ursolic acid-3-acetate on human synovial fibroblasts and a murine model of rheumatoid arthritis. Int Immunopharmacol. 2017;49:118-125 pubmed publisher
    ..The effects of UAA were comparable with those of the positive control drug, dexamethasone. In summary, all the evidence presented in this paper suggest that UAA could be a therapeutic candidate for the treatment of RA. ..