Beom Sik Kang
Affiliation: Kyungpook National University
Cho H, Lee H, Cho H, Park J, Lee D, Lee H, et al
. Structural basis for substrate binding to human pyridoxal 5'-phosphate phosphatase/chronophin by a conformational change. Int J Biol Macromol. 2019;131:912-924 pubmed publisher
..However, a change to the cap-open conformation is required for binding of larger substrates such as phosphopeptides to the active site. ..
Kim M, Kang J, Kang Y, Kang B, Jin E. Loss of Function in Zeaxanthin Epoxidase of Dunaliella tertiolecta Caused by a Single Amino Acid Mutation within the Substrate-Binding Site. Mar Drugs. 2018;16: pubmed publisher
Seo U, Kim K, Kang B. An Algorithm for Computing Side Chain Conformational Variations of a Protein Tunnel/Channel. Molecules. 2018;23: pubmed publisher
..With the exception of certain cases, experimental results show that the algorithm finds up to 327,680 valid side chain conformations from 12⁸~1233 conformation candidates within three seconds. ..
Ji Y, Chae S, Lee H, Park I, Kim C, Ismail T, et al
. Peroxiredoxin5 controls vertebrate ciliogenesis by modulating mitochondrial ROS. Antioxid Redox Signal. 2018;: pubmed publisher
..The loss of Prdx5 is associated with excessive production of ROS resulting in mitochondrial dysfunction and aberrant ciliogenesis. ..
Cho H, Cho H, Park J, Kwon O, Lee H, Huh T, et al
. NADP+-dependent cytosolic isocitrate dehydrogenase provides NADPH in the presence of cadmium due to the moderate chelating effect of glutathione. J Biol Inorg Chem. 2018;23:849-860 pubmed publisher
..The ability of IDH to utilise Cd2+ to generate NADPH could allow cells to protect themselves against Cd2+. ..
Lee S, Nam M, Lee D, Park J, Kang B, Lee D, et al
. Silibinin Ameliorates O-GlcNAcylation and Inflammation in a Mouse Model of Nonalcoholic Steatohepatitis. Int J Mol Sci. 2018;19: pubmed publisher
..Therefore, silibinin is a promising therapeutic agent for hyper-O-GlcNAcylation as well as NASH. ..
Cho H, Kang B. Serine 83 in DosR, a response regulator from Mycobacterium tuberculosis, promotes its transition from an activated, phosphorylated state to an inactive, unphosphorylated state. Biochem Biophys Res Commun. 2014;444:651-5 pubmed publisher
..Structural comparison with a histidinol phosphate phosphatase suggests that the hydroxyl group of DosR S83 could play a role in activating the water molecule involved in the triggering of autodephosphorylation. ..
Cho H, Maeng S, Cho H, Choi Y, Chung J, Lee S, et al
. Assembly of Multi-tRNA Synthetase Complex via Heterotetrameric Glutathione Transferase-homology Domains. J Biol Chem. 2015;290:29313-28 pubmed publisher
..Considering prevalence of the GST-like domains, this tetramer can also provide a tool for the communication of the MSC with other GST-containing cellular factors. ..
Kang B, Pugalendhi G, Kim K. Binding Direction-Based Two-Dimensional Flattened Contact Area Computing Algorithm for Protein-Protein Interactions. Molecules. 2017;22: pubmed publisher