Jun Goo Jee
Affiliation: Kyungpook National University
Lee P, Woo S, Jee J, Sung S, Kim H. Bisdemethoxycurcumin Induces apoptosis in activated hepatic stellate cells via cannabinoid receptor 2. Molecules. 2015;20:1277-92 pubmed publisher
Park S, Lee J, Shon J, Phuc N, Jee J, Liu K. The inhibitory potential of Broussochalcone A for the human cytochrome P450 2J2 isoform and its anti-cancer effects via FOXO3 activation. Phytomedicine. 2018;42:199-206 pubmed publisher
..Overall, this was the first report of the inhibitory effects of BCA on CYP2J2 in HLMs. The present data suggest that BCA is a potential candidate for further evaluation for its CYP2J2 targeting anti-cancer activities. ..
Hwang G, Ryu J, Jeon Y, Choi J, Han H, Lee Y, et al
. The role of thioredoxin reductase and glutathione reductase in plumbagin-induced, reactive oxygen species-mediated apoptosis in cancer cell lines. Eur J Pharmacol. 2015;765:384-93 pubmed publisher
..In conclusion, plumbagin exerted its anticancer effect by directly interacting with TrxR and GR, and thus increasing intracellular ROS levels. ..
Choi J, Park S, Jee J. Analogues of ethionamide, a drug used for multidrug-resistant tuberculosis, exhibit potent inhibition of tyrosinase. Eur J Med Chem. 2015;106:157-66 pubmed publisher
..Our results suggest that carbothioamide can be a central moiety for the development of new and potent tyrosinase inhibitors. ..
Choi J, Jee J. Repositioning of Thiourea-Containing Drugs as Tyrosinase Inhibitors. Int J Mol Sci. 2015;16:28534-48 pubmed publisher
..These data were consistent with the results of enzyme assays with the analogues of thiourea. ..
Kim H, Hyun J, Choi J, Choi K, Jee J, Park S. Structural ensemble-based docking simulation and biophysical studies discovered new inhibitors of Hsp90 N-terminal domain. Sci Rep. 2018;8:368 pubmed publisher
..Cheminformatics revealed that the molecules share limited chemical similarities with known inhibitors. Molecular dynamics simulations detailed the putative binding modes of the inhibitors. ..
Lee W, Lee S, Choi J, Park J, Kim K, Jee J, et al
. Antithrombotic properties of JJ1, a potent and novel thrombin inhibitor. Sci Rep. 2017;7:14862 pubmed publisher
..It also exhibited anticoagulant effects in mice. Collectively, these results demonstrated that JJ1 was a potent, direct, and selective thrombin inhibitor that may be useful in the management of various thrombotic disorders. ..
Choi J, Lee Y, Jee J. Thiopurine Drugs Repositioned as Tyrosinase Inhibitors. Int J Mol Sci. 2017;19: pubmed publisher
..Particularly, 50 ?M thioguanine reduced the melanin content by 57%, without apparent cytotoxicity. Cheminformatics showed that the thiopurine drugs shared little chemical similarity with the known tyrosinase inhibitors. ..