Jong Sup Bae

Summary

Affiliation: Kyungpook National University
Country: Korea

Publications

  1. Ku S, Jeong S, Yang S, Kim K, Choi H, Bae J. Suppressive effects of collismycin C on polyphosphate-mediated vascular inflammatory responses. Fitoterapia. 2019;134:447-453 pubmed publisher
    ..In conclusion, based on the anti-inflammatory effects of collismycins C in PolyP-mediated septic response, collismycins C have therapeutic potential for various systemic inflammatory diseases. ..
  2. Lee W, Yang S, Lee C, Park E, Kim K, Ku S, et al. Aloin reduces inflammatory gene iNOS via inhibition activity and p-STAT-1 and NF-κB. Food Chem Toxicol. 2019;126:67-71 pubmed publisher
    ..In LPS-treated mice, aloin significantly reduced iNOS protein in lung tissues, and TNF-α levels in the BALF. We concluded that aloin may be beneficial for treatment of lung injury. ..
  3. Lee B, Lee C, Yang S, Park E, Ku S, Bae J. Suppressive effects of pelargonidin on lipopolysaccharide-induced inflammatory responses. Chem Biol Interact. 2019;302:67-73 pubmed publisher
  4. Ku S, Bae J. Antithrombotic activities of wogonin and wogonoside via inhibiting platelet aggregation. Fitoterapia. 2014;98:27-35 pubmed publisher
    ..In addition, treatment with WGN(S) resulted in significant reduction of the PAI-1 to t-PA ratio. Collectively, WGN(S) possesses antithrombotic activities and offers a basis for development of a novel anticoagulant. ..
  5. Kim J, Lee W, Yang S, Cho S, Baek M, Song G, et al. Suppressive effects of rare ginsenosides, Rk1 and Rg5, on HMGB1-mediated septic responses. Food Chem Toxicol. 2019;124:45-53 pubmed publisher
    ..Our results indicate that SB1 and SB2 might be useful in the treatment of sepsis by targeting HMGB1. ..
  6. Yang S, Lee C, Lee B, Park E, Kim K, Bae J. Renal protective effects of aspalathin and nothofagin from rooibos (Aspalathus linearis) in a mouse model of sepsis. Pharmacol Rep. 2018;70:1195-1201 pubmed publisher
    ..Our results suggest that Aspt and Not protect mice against sepsis-triggered renal injury. ..
  7. Bae J. Barrier protective activities of phloroglucinol on lipopolysaccharide (LPS)-induced barrier disruption in human endothelial cells. Inflammation. 2012;35:920-6 pubmed publisher
    ..Given these results, phloroglucinol could be a candidate as a therapeutic agent for various systemic inflammatory diseases. ..
  8. Lee W, Ku S, Min B, Lee S, Jee J, Kim J, et al. Vascular barrier protective effects of pellitorine in LPS-induced inflammation in vitro and in vivo. Fitoterapia. 2014;92:177-87 pubmed publisher
  9. Baek M, Jung B, Kang H, Lee H, Bae J. Novel insight into drug repositioning: Methylthiouracil as a case in point. Pharmacol Res. 2015;99:185-93 pubmed publisher

More Information

Publications58

  1. Lee W, Kwak S, Lee H, Na D, Lee Y, Bae J. Inhibitory effect of exendin-4 on secretory group IIA phospholipase A2. Biochem Biophys Res Commun. 2015;459:650-4 pubmed publisher
    ..Therefore, these results show that EX4 inhibited LPS-induced expression of sPLA2-IIA by suppressing cPLA2 and ERK 1/2. ..
  2. Ku S, Lee H, Bae J. Inhibitory effect of baicalin, baicalein and wogonin on secretory group IIA phospholipase A2. Arch Pharm Res. 2015;38:1865-72 pubmed publisher
    ..Therefore, these results suggest that baicalin, baicalein, and wogonin inhibited LPS mediated expression of sPLA2-IIA by suppression of cPLA2 and ERK 1/2. ..
  3. Jung B, Ku S, Bae J. Ameliorative effect of methylthiouracil on TGFBIp-induced septic responses. Biochem Biophys Res Commun. 2015;463:661-6 pubmed publisher
    ..Collectively, these results indicate that MTU could be a potential therapeutic agent for treatment of various severe vascular inflammatory diseases via inhibition of the TGFBIp signaling pathway. ..
  4. Bae J. Inhibitory Effect of Orientin on Secretory Group IIA Phospholipase A2. Inflammation. 2015;38:1631-8 pubmed publisher
    ..Therefore, these results suggest that orientin may inhibit LPS-mediated expression of sPLA2-IIA by suppression of cPLA2 and ERK 1/2. ..
  5. Bae J, Rezaie A. Activated protein C inhibits high mobility group box 1 signaling in endothelial cells. Blood. 2011;118:3952-9 pubmed publisher
  6. Lee W, Park E, Kwak S, Kim Y, Na D, Bae J. PEGylated lysozymes with anti-septic effects in human endothelial cells and in mice. Biochem Biophys Res Commun. 2015;459:662-7 pubmed publisher
    ..Collectively, these results suggest P5-K(1)-LYZ as a candidate therapeutic agent for the treatment of vascular inflammatory diseases via inhibition of the HMGB1 signaling pathway. ..
  7. Kwak S, Han M, Bae J. Aspalathin and nothofagin from rooibos (Aspalathus linearis) inhibit endothelial protein C receptor shedding in vitro and in vivo. Fitoterapia. 2015;100:179-86 pubmed publisher
    ..These results demonstrate the potential of Asp and Not as an anti-sEPCR shedding reagent against PMA and CLP-mediated EPCR shedding. ..
  8. Ku S, Lee I, Kim J, Bae J. Antithrombotic activities of pellitorine in vitro and in vivo. Fitoterapia. 2013;91:1-8 pubmed publisher
    ..Collectively, PLT possesses antithrombotic activities and offers bases for development of a novel anticoagulant. ..
  9. Ku S, Lee J, O Y, Lee W, Song G, Bae J. Vascular barrier protective effects of 3-N- or 3-O-cinnamoyl carbazole derivatives. Bioorg Med Chem Lett. 2015;25:4304-7 pubmed publisher
    ..These results suggest that the number of methoxy groups substituted on the cinnamamide or cinnamate moiety of the 9H-3-carbazole derivative is an important pharmacophore for the barrier protective effects of these compounds. ..
  10. Lee W, Ku S, Bae J. Vascular barrier protective effects of orientin and isoorientin in LPS-induced inflammation in vitro and in vivo. Vascul Pharmacol. 2014;62:3-14 pubmed publisher
  11. Ku S, Baek M, Bae J. Anti-inflammatory effects of methylthiouracil in vitro and in vivo. Toxicol Appl Pharmacol. 2015;288:374-86 pubmed publisher
  12. Bae J. Effects of lower concentration thrombin on high-mobility group box 1 protein-mediated inflammatory responses. Inflammation. 2012;35:1078-86 pubmed publisher
    ..Given these results, lower concentration thrombin could be a strong candidate as a therapeutic agent for various systemic inflammatory diseases. ..
  13. Jeong S, Ku S, Min G, Choi H, Park D, Bae J. Suppressive effects of three diketopiperazines from marine-derived bacteria on polyphosphate-mediated septic responses. Chem Biol Interact. 2016;257:61-70 pubmed publisher
    ..Therefore, these results indicated the therapeutic potential of diketopiperazine on various systemic inflammatory diseases, such as sepsis or septic shock. ..
  14. Min G, Ku S, Park M, Park T, Lee H, Bae J. Anti-septic effects of pelargonidin on HMGB1-induced responses in vitro and in vivo. Arch Pharm Res. 2016;39:1726-1738 pubmed publisher
    ..Collectively, these results indicate that PEL could be used to treat various severe vascular inflammatory diseases via the inhibition of the HMGB1 signaling pathway. ..
  15. Kang H, Ku S, Choi H, Bae J. Three diketopiperazines from marine-derived bacteria inhibit LPS-induced endothelial inflammatory responses. Bioorg Med Chem Lett. 2016;26:1873-6 pubmed publisher
  16. Lee D, Kim D, Lee S, Kim T, Kim J, Kim S, et al. Efficient Syntheses of 1,2,3-Triazoloamide Derivatives Using Solid- and Solution-Phase Synthetic Approaches. Molecules. 2015;20:19984-20013 pubmed publisher
    ..The target secondary and tertiary 1,2,3-triazoloamide derivatives were obtained with three-diversity points in excellent overall yields and purities using the reported solid- and solution-phase synthetic routes, respectively. ..
  17. Lee W, Hwang M, Lee Y, Bae J. Protective effects of zingerone on lipopolysaccharide-induced hepatic failure through the modulation of inflammatory pathways. Chem Biol Interact. 2018;281:106-110 pubmed publisher
    ..Our results suggest that ZGR protects against LPS-induced liver damage by inhibiting the TLR-mediated inflammatory pathway, indicating its potential to treat liver diseases. ..
  18. Lee S, Lee W, Bae J, Ma E. Synthesis and in Vitro and in Vivo Anticoagulant and Antiplatelet Activities of Amidino- and Non-Amidinobenzamides. Molecules. 2016;21: pubmed publisher
    ..Collectively, 1 and 2 possess some antiplatelet and anticoagulant activities and offer a basis for development of a novel antithrombotic product. ..
  19. Ku S, Kim J, Kim S, Bae J. Suppressive effects of dabrafenib on endothelial protein C receptor shedding. Arch Pharm Res. 2017;40:282-290 pubmed publisher
    ..These results demonstrate the potential of DAB as an anti-EPCR shedding reagent against PMA-mediated and CLP-mediated EPCR shedding. ..
  20. Kulkarni R, Lee W, Jang T, Lee J, Kwak S, Park M, et al. Caffeoyl glucosides from Nandina domestica inhibit LPS-induced endothelial inflammatory responses. Bioorg Med Chem Lett. 2015;25:5367-71 pubmed publisher
  21. Kwak S, Ku S, Kang H, Baek M, Bae J. Methylthiouracil, a new treatment option for sepsis. Vascul Pharmacol. 2017;88:1-10 pubmed publisher
    ..Our results indicate that MTUs could be candidate therapeutic agents for various severe vascular inflammatory diseases via the inhibition of the HMGB1 signaling pathway. ..
  22. Bae J, Rezaie A. Thrombin inhibits HMGB1-mediated proinflammatory signaling responses when endothelial protein C receptor is occupied by its natural ligand. BMB Rep. 2013;46:544-9 pubmed
  23. Kang H, Ku S, Kim J, Chung J, Kim S, Zhou W, et al. Anti-vascular inflammatory effects of pentacyclic triterpenoids from Astilbe rivularis in vitro and in vivo. Chem Biol Interact. 2017;261:127-138 pubmed publisher
    ..Therefore, these compounds can be considered as a potential therapy for vascular inflammatory diseases. ..
  24. Lee I, Bae J. Suppressive effects of pelargonidin on PolyPhosphate-mediated vascular inflammatory responses. Arch Pharm Res. 2017;40:258-267 pubmed publisher
    ..These anti-inflammatory functions of PEL were confirmed in PolyP injected mice. These results suggest that PEL have therapeutic potential for various systemic inflammatory diseases. ..
  25. Kwak S, Ku S, Han M, Bae J. Vascular barrier protective effects of baicalin, baicalein and wogonin in vitro and in vivo. Toxicol Appl Pharmacol. 2014;281:30-8 pubmed publisher
    ..These results indicate that BCL, BCN, and WGN could be candidate therapeutic agents for various severe vascular inflammatory diseases owing to their inhibition of the HMGB1 signaling pathway. ..
  26. Lee W, Yang E, Park D, Bae J. Suppressive effects of polyozellin on endothelial protein C receptor shedding via inhibiting TACE activity and MAP kinases. Fitoterapia. 2016;108:26-32 pubmed publisher
    ..These results demonstrate the potential of polyozellin as an anti-EPCR shedding reagent against PMA-mediated and CLP-mediated EPCR shedding. ..
  27. Jung B, Ku S, Gao M, Kim K, Han M, Choi H, et al. Suppressive effects of three diketopiperazines from marine-derived bacteria on TGFBIp-mediated septic responses in human endothelial cells and mice. Arch Pharm Res. 2016;39:843-54 pubmed publisher
    ..Therefore, 1-3 could be a potential therapeutic agent for treatment of various severe vascular inflammatory diseases via inhibition of the TGFBIp signaling pathway. ..
  28. Lee W, Ku S, Choi H, Bae J. Inhibitory effects of three diketopiperazines from marine-derived bacteria on endothelial protein C receptor shedding in human endothelial cells and mice. Fitoterapia. 2016;110:181-8 pubmed publisher
    ..These results demonstrate the potential of 1-3 as an anti-EPCR shedding reagent against PMA-mediated and CLP-mediated EPCR shedding. ..
  29. Jung B, Yang E, Bae J. Suppressive effects of polyozellin on TGFBIp-mediated septic responses in human endothelial cells and mice. Nutr Res. 2016;36:380-389 pubmed publisher
    ..Therefore, polyozellin could be a potential therapeutic agent for treatment of various severe vascular inflammatory diseases via inhibition of the TGFBIp signaling pathway. ..
  30. Ku S, Yoon E, Lee W, Kwon S, Lee T, Bae J. Antithrombotic and antiplatelet activities of pelargonidin in vivo and in vitro. Arch Pharm Res. 2016;39:398-408 pubmed publisher
    ..Collectively, these results indicate that the anthocyanin pelargonidin possesses antithrombotic activity, and can be beneficial in preventing thrombus formation, thus improving blood circulation. ..
  31. Yang E, Lee W, Song K, Bae J. Ameliorative effect of a rarely occurring C-methylrotenoid on HMGB1-induced septic responses in vitro and in vivo. Biochem Pharmacol. 2016;110-111:58-70 pubmed publisher
    ..Collectively, these results indicate that comp 1 could be potential therapeutic agents for the treatment of various severe vascular inflammatory diseases via inhibition of the HMGB1 signaling pathway. ..
  32. Lee I, Bae J. Anti-inflammatory effects of vicenin-2 and scolymoside on polyphosphate-mediated vascular inflammatory responses. Inflamm Res. 2016;65:203-12 pubmed publisher
    ..These anti-inflammatory functions of vicenin-2 and scolymoside were confirmed in polyP-injected mice. These results suggest that vicenin-2 and scolymoside have therapeutic potential for various systemic inflammatory diseases. ..
  33. Lee W, Lee S, Choi J, Park J, Kim K, Jee J, et al. Antithrombotic properties of JJ1, a potent and novel thrombin inhibitor. Sci Rep. 2017;7:14862 pubmed publisher
    ..It also exhibited anticoagulant effects in mice. Collectively, these results demonstrated that JJ1 was a potent, direct, and selective thrombin inhibitor that may be useful in the management of various thrombotic disorders. ..
  34. Lee W, Kim M, Park I, Hwang J, Na M, Bae J. Novel direct factor Xa inhibitory compounds from Tenebrio molitor with anti-platelet aggregation activity. Food Chem Toxicol. 2017;109:19-27 pubmed publisher
    ..Therefore, 1-2 could serve as candidates and provide scaffolds for the development of new anti-FXa and anti-platelet drugs. ..
  35. Lee W, Ku S, Bae J. Zingerone reduces HMGB1-mediated septic responses and improves survival in septic mice. Toxicol Appl Pharmacol. 2017;329:202-211 pubmed publisher
    ..In addition, treatment with ZGR reduced the CLP-induced release of HMGB1, sepsis-related mortality, and tissue injury in vivo. Our results indicated that ZGR might be useful in the treatment of sepsis by targeting HMGB1. ..
  36. Lee W, Ku S, Bae J. Factor Xa inhibits HMGB1-induced septic responses in human umbilical vein endothelial cells and in mice. Thromb Haemost. 2014;112:757-69 pubmed publisher
    ..Collectively, these results suggest that FXa may be regarded as a candidate therapeutic agent for treating vascular inflammatory diseases by inhibiting the HMGB1 signalling pathway. ..
  37. Lee W, Ku S, Kim M, Bae J. Anti-factor Xa activities of zingerone with anti-platelet aggregation activity. Food Chem Toxicol. 2017;105:186-193 pubmed publisher
    ..Collectively, these results show that ZGR could serve as candidates and provide scaffolds for the development of new anti-FXa and anti-platelet drugs. ..
  38. Bae J. Role of high mobility group box 1 in inflammatory disease: focus on sepsis. Arch Pharm Res. 2012;35:1511-23 pubmed publisher
  39. Lee S, Ku S, Bae J. Anti-inflammatory effects of dabrafenib on polyphosphate-mediated vascular disruption. Chem Biol Interact. 2016;256:266-73 pubmed publisher
    ..Therefore, these results indicated the therapeutic potential of dabrafenib on various systemic inflammatory diseases, such as sepsis or septic shock. ..
  40. Lee W, Kwon O, Han M, Lee Y, Kim S, Kim K, et al. Role of moesin in HMGB1-stimulated severe inflammatory responses. Thromb Haemost. 2015;114:350-63 pubmed publisher
    ..Collectively, our findings demonstrate that the HMGB1-RAGE-moesin axis can elicit severe inflammatory responses, suggesting it to be a potential target for the development of diagnostics and therapeutics for sepsis. ..
  41. Lee W, Ku S, Bae J. Ameliorative Effect of Vicenin-2 and Scolymoside on TGFBIp-Induced Septic Responses. Inflammation. 2015;38:2166-77 pubmed publisher
    ..Collectively, these results indicate that vicenin-2 and scolymoside could be a potential therapeutic agent for treatment of various severe vascular inflammatory diseases via inhibition of the TGFBIp signaling pathway. ..
  42. Bae J. Antithrombotic and profibrinolytic activities of phloroglucinol. Food Chem Toxicol. 2011;49:1572-7 pubmed publisher
  43. Lee W, Lee Y, Jeong G, Ku S, Bae J. Cudratricusxanthone A attenuates renal injury in septic mice. Food Chem Toxicol. 2017;106:404-410 pubmed publisher
    ..The present results suggested that CTXA could protect against sepsis-triggered renal injury in mice. ..
  44. Lee I, Bae J. Antiseptic effects of dabrafenib on TGFBIp-induced septic responses. Chem Biol Interact. 2017;278:92-100 pubmed publisher
    ..These results suggest that DAB exerts anti-inflammatory effects by inhibiting hyperpermeability, CAM expression, and leukocyte adhesion and migration, indicating its utility for treating vascular inflammatory diseases...
  45. Lee W, Lee H, Kim M, Choi J, Kim K, Hwang J, et al. Evaluation of novel factor Xa inhibitors from Oxya chinensis sinuosa with anti-platelet aggregation activity. Sci Rep. 2017;7:7934 pubmed publisher
    ..Collectively, these results suggest that compounds 1-4 could serve as candidates and provide scaffolds for development of new antithrombotic drugs. ..
  46. Min G, Ku S, Lee T, Bae J. Suppressive effects of zingerone on TGFBIp-mediated septic responses. Arch Pharm Res. 2018;41:276-287 pubmed publisher
    ..Therefore, ZGR could be a potential therapeutic agent for treatment of various severe vascular inflammatory diseases via inhibition of the TGFBIp signaling pathway. ..
  47. Ku S, Yang E, Kang H, Jung B, Bae J. Inhibitory effect of polyozellin on secretory group IIA phospholipase A2. Arch Pharm Res. 2016;39:271-278 pubmed publisher
    ..These results demonstrated that polyozellin might play an important role in the modulation of sPLA2-IIA expression and activity in response to the inflammatory diseases. ..
  48. Jung B, Chung J, Zhou W, Lee T, Na M, Bae J. Inhibitory effects of pentacyclic triterpenoids from Astilbe rivularis on TGFBIp-induced inflammatory responses in vitro and in vivo. Chem Biol Interact. 2016;254:179-90 pubmed publisher
  49. Chung J, Ku S, Lee S, Bae J. Suppressive effects of lysozyme on polyphosphate-mediated vascular inflammatory responses. Biochem Biophys Res Commun. 2016;474:715-721 pubmed publisher
    ..Therefore, these results indicated the therapeutic potential of lysozyme on various systemic inflammatory diseases, such as sepsis or septic shock. ..