Jae Sung Bae

Summary

Affiliation: Kyungpook National University
Country: Korea

Publications

  1. ncbi request reprint Intracerebellar transplantation of neural stem cells into mice with neurodegeneration improves neuronal networks with functional synaptic transmission
    Ji Min Lee
    Stem Cell Neuroplasticity Research Group, Department of Laboratory Animal Medicine, Kyungpook National University, Daegu, Korea
    J Vet Med Sci 72:999-1009. 2010
  2. pmc Bone marrow-derived mesenchymal stem cells improve the functioning of neurotrophic factors in a mouse model of diabetic neuropathy
    Bae Jin Kim
    Stem Cell Neuroplasticity Research Group, Kyungpook National University, Daegu, Republic of Korea
    Lab Anim Res 27:171-6. 2011
  3. doi request reprint Adipose tissue-derived stem cells rescue Purkinje neurons and alleviate inflammatory responses in Niemann-Pick disease type C mice
    Jae Sung Bae
    Department of Physiology, Cell and Matrix Research Institute, BSEI, World Class University Program, School of Medicine, Kyungpook National University, Daegu, Korea
    Cell Tissue Res 340:357-69. 2010
  4. ncbi request reprint Neurodegeneration augments the ability of bone marrow-derived mesenchymal stem cells to fuse with Purkinje neurons in Niemann-Pick type C mice
    Jae Sung Bae
    College of Veterinary Medicine, Kyungpook National University, Daegu, South Korea
    Hum Gene Ther 16:1006-11. 2005
  5. ncbi request reprint The therapeutic potential of human umbilical cord blood-derived mesenchymal stem cells in Alzheimer's disease
    Hyun Ju Lee
    Stem Cell Neuroplasticity Research Group, Kyungpook National University, Daegu, South Korea
    Neurosci Lett 481:30-5. 2010
  6. doi request reprint Human umbilical cord blood-derived mesenchymal stem cells improve neuropathology and cognitive impairment in an Alzheimer's disease mouse model through modulation of neuroinflammation
    Hyun Ju Lee
    Stem Cell Neuroplasticity Research Group, Kyungpook National University, Daegu, Korea
    Neurobiol Aging 33:588-602. 2012
  7. ncbi request reprint Human umbilical cord blood-derived mesenchymal stem cells improve neurological abnormalities of Niemann-Pick type C mouse by modulation of neuroinflammatory condition
    Hyun Lee
    Stem Cell Neuroplasticity Research Group, Kyungpook National University, Korea
    J Vet Med Sci 72:709-17. 2010
  8. doi request reprint Recombinant soluble neprilysin reduces amyloid-beta accumulation and improves memory impairment in Alzheimer's disease mice
    Min Hee Park
    Stem Cell Neuroplasticity Research Group, Kyungpook National University, Daegu, South Korea
    Brain Res 1529:113-24. 2013
  9. pmc Bone-marrow-derived mesenchymal stem cells promote proliferation and neuronal differentiation of Niemann-Pick type C mouse neural stem cells by upregulation and secretion of CCL2
    Hyun Lee
    Stem Cell Neuroplasticity Research Group, Kyungpook National University, Daegu 702 701, South Korea
    Hum Gene Ther 24:655-69. 2013
  10. ncbi request reprint Polysaccharides isolated from Phellinus gilvus enhances dermal wound healing in streptozotocin-induced diabetic rats
    Jae Sung Bae
    College of Veterinary Medicine, Kyungpook National University, Daegu, Korea
    J Vet Sci 6:161-4. 2005

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Intracerebellar transplantation of neural stem cells into mice with neurodegeneration improves neuronal networks with functional synaptic transmission
    Ji Min Lee
    Stem Cell Neuroplasticity Research Group, Department of Laboratory Animal Medicine, Kyungpook National University, Daegu, Korea
    J Vet Med Sci 72:999-1009. 2010
    ..These findings suggest that NSC, MHP36 transplantation may have therapeutic effects in the treatment of NP-C and other neurodegenerative diseases...
  2. pmc Bone marrow-derived mesenchymal stem cells improve the functioning of neurotrophic factors in a mouse model of diabetic neuropathy
    Bae Jin Kim
    Stem Cell Neuroplasticity Research Group, Kyungpook National University, Daegu, Republic of Korea
    Lab Anim Res 27:171-6. 2011
    ..Also, BM-MSCs ameliorated nerve conduction velocity in streptozotocin-treated mice. These results may help to elucidate the mechanism by which BM-MSCs function as a cell therapy agent in diabetic neuropathy...
  3. doi request reprint Adipose tissue-derived stem cells rescue Purkinje neurons and alleviate inflammatory responses in Niemann-Pick disease type C mice
    Jae Sung Bae
    Department of Physiology, Cell and Matrix Research Institute, BSEI, World Class University Program, School of Medicine, Kyungpook National University, Daegu, Korea
    Cell Tissue Res 340:357-69. 2010
    ....
  4. ncbi request reprint Neurodegeneration augments the ability of bone marrow-derived mesenchymal stem cells to fuse with Purkinje neurons in Niemann-Pick type C mice
    Jae Sung Bae
    College of Veterinary Medicine, Kyungpook National University, Daegu, South Korea
    Hum Gene Ther 16:1006-11. 2005
    ..The results suggest that the degenerative microenvironment of Purkinje neurons in the NP-C cerebellum modulates the cell fate switch of BM-MSCs via cell fusion...
  5. ncbi request reprint The therapeutic potential of human umbilical cord blood-derived mesenchymal stem cells in Alzheimer's disease
    Hyun Ju Lee
    Stem Cell Neuroplasticity Research Group, Kyungpook National University, Daegu, South Korea
    Neurosci Lett 481:30-5. 2010
    ..Interestingly, hUCB-MSCs treated AD mice demonstrated cognitive rescue with restoration of learning/memory function. These data suggest that hUCB-MSCs warrant further investigation as a potential therapeutic agent in AD...
  6. doi request reprint Human umbilical cord blood-derived mesenchymal stem cells improve neuropathology and cognitive impairment in an Alzheimer's disease mouse model through modulation of neuroinflammation
    Hyun Ju Lee
    Stem Cell Neuroplasticity Research Group, Kyungpook National University, Daegu, Korea
    Neurobiol Aging 33:588-602. 2012
    ....
  7. ncbi request reprint Human umbilical cord blood-derived mesenchymal stem cells improve neurological abnormalities of Niemann-Pick type C mouse by modulation of neuroinflammatory condition
    Hyun Lee
    Stem Cell Neuroplasticity Research Group, Kyungpook National University, Korea
    J Vet Med Sci 72:709-17. 2010
    ..This study provides the first evidence that hUCB-MSCs can improve neurological symptoms in NP-C disease, suggesting it as a potential therapeutic agent against neurodegenerative diseases...
  8. doi request reprint Recombinant soluble neprilysin reduces amyloid-beta accumulation and improves memory impairment in Alzheimer's disease mice
    Min Hee Park
    Stem Cell Neuroplasticity Research Group, Kyungpook National University, Daegu, South Korea
    Brain Res 1529:113-24. 2013
    ....
  9. pmc Bone-marrow-derived mesenchymal stem cells promote proliferation and neuronal differentiation of Niemann-Pick type C mouse neural stem cells by upregulation and secretion of CCL2
    Hyun Lee
    Stem Cell Neuroplasticity Research Group, Kyungpook National University, Daegu 702 701, South Korea
    Hum Gene Ther 24:655-69. 2013
    ..These effects suggest that soluble CCL2 derived from BM-MSCs can modulate endogenous NP-C NSCs, resulting in their improved proliferation and neuronal differentiation in mice...
  10. ncbi request reprint Polysaccharides isolated from Phellinus gilvus enhances dermal wound healing in streptozotocin-induced diabetic rats
    Jae Sung Bae
    College of Veterinary Medicine, Kyungpook National University, Daegu, Korea
    J Vet Sci 6:161-4. 2005
    ..05). These results show that polysaccharides isolated from PG enhanced wound repair in diabetic impaired healing, and could be developed as a wound healing agent in such clinical settings...
  11. doi request reprint Bone marrow-derived mesenchymal stem cells prevent the loss of Niemann-Pick type C mouse Purkinje neurons by correcting sphingolipid metabolism and increasing sphingosine-1-phosphate
    Hyun Lee
    Stem Cell Neuroplasticity Research Group, Daegu, Korea
    Stem Cells 28:821-31. 2010
    ..These effects suggest that BM-MSCs modulate sphingolipid metabolism of endogenous NP-C PNs, resulting in their survival and improved clinical outcome in mice...
  12. doi request reprint Intracerebral transplantation of bone marrow-derived mesenchymal stem cells reduces amyloid-beta deposition and rescues memory deficits in Alzheimer's disease mice by modulation of immune responses
    Jong Kil Lee
    Stem Cell Neuroplasticity Research Group, Kyungpook National University, Daegu, Korea
    Stem Cells 28:329-43. 2010
    ..These results demonstrate that BM-MSCs are a potential new therapeutic agent for AD...
  13. ncbi request reprint Bone marrow-derived mesenchymal stem cells promote neuronal networks with functional synaptic transmission after transplantation into mice with neurodegeneration
    Jae Sung Bae
    Departments of Physiology, College of Medicine, Kyungpook National University, Korea
    Stem Cells 25:1307-16. 2007
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  14. ncbi request reprint Synergistic vasculogenic effects of AMD3100 and stromal-cell-derived factor-1α in vasa nervorum of the sciatic nerve of mice with diabetic peripheral neuropathy
    Bae Jin Kim
    Stem Cell Neuroplasticity Research Group, Kyungpook National University, Daegu, South Korea
    Cell Tissue Res 354:395-407. 2013
    ..Thus, AMD3100 might be an effective EPC mobilization agent in diabetes, with local SDF-1α injection synergistically increasing vascularity in diabetic nerves. This represents a novel potential therapeutic option for DN patients. ..
  15. ncbi request reprint Bone marrow-derived mesenchymal stem cells contribute to the reduction of amyloid-β deposits and the improvement of synaptic transmission in a mouse model of pre-dementia Alzheimer's disease
    Jae Sung Bae
    Stem Cell Neuroplasticity Research Group, Kyungpook National University, Daegu, Korea
    Curr Alzheimer Res 10:524-31. 2013
    ..These findings suggest that BM-MSC transplantation warrants further investigation as a potential therapy for early intervention in pro-dromal AD...
  16. doi request reprint Soluble CCL5 derived from bone marrow-derived mesenchymal stem cells and activated by amyloid β ameliorates Alzheimer's disease in mice by recruiting bone marrow-induced microglia immune responses
    Jong Kil Lee
    Stem Cell Neuroplasticity Research Group, Kyungpook National University, Daegu, South Korea
    Stem Cells 30:1544-55. 2012
    ..The recruitment of the alternative microglia into the brain is driven by CCL5 secretion from the transplanted BM-MSCs, which itself is induced by Aβ deposition in the AD brain...
  17. doi request reprint Combined effects of hematopoietic progenitor cell mobilization from bone marrow by granulocyte colony stimulating factor and AMD3100 and chemotaxis into the brain using stromal cell-derived factor-1α in an Alzheimer's disease mouse model
    Ji woong Shin
    Stem Cell Neuroplasticity Research Group, Kyungpook National University, Daegu, Korea
    Stem Cells 29:1075-89. 2011
    ..This approach warrants further investigation as a potential therapeutic option for the treatment of AD patients in the future...
  18. ncbi request reprint Neuroglial activation in Niemann-Pick Type C mice is suppressed by intracerebral transplantation of bone marrow-derived mesenchymal stem cells
    Jae Sung Bae
    College of Veterinary Medicine, Kyungpook National University, Daegu 702 701, Korea
    Neurosci Lett 381:234-6. 2005
    ..These findings suggest that BM-MSC transplantation may have potential for a therapeutic role in the treatment of NP-C and other neurodegenerative brain disorders...
  19. pmc Proliferation and osteoblastic differentiation of bone marrow stem cells: comparison of vertebral body and iliac crest
    Woo Kie Min
    Department of Orthopedic Surgery, School of Medicine, Kyungpook National University, 50 Samduk 2 Ga, Jung Gu, Daegu 700 712, Korea
    Eur Spine J 19:1753-60. 2010
    ..Based on these findings, we suggest that BMSCs from VB would be comparable candidates for osseous graft supplementation especially in spinal fusion procedures...
  20. ncbi request reprint Comparative effects of recombinant acid sphingomyelinase administration by different routes in niemann-pick disease mice
    Jae Sung Bae
    Department of Laboratory Animal Medicine, College of Veterinary Medicine, Kyungpook National University, Daegu, Korea
    Exp Anim 53:417-21. 2004
    ..It was concluded that rhASM administered by subcutaneous injection is completely absorbed, and offers a similar efficacy to intravenously administered recombinant enzyme...
  21. ncbi request reprint Comparison of intraperitoneal anti-adhesive polysaccharides derived from Phellinus mushrooms in a rat peritonitis model
    Jae Sung Bae
    Department of Surgery, College of Veterinary Medicine, Kyungpook National University, Daegu 702 701, Republic of Korea
    World J Gastroenterol 11:810-6. 2005
    ..To assess the adhesion- and abscess-reducing capacities of various concentrations of polysaccharides derived from fungus, Phellinus gilvus (PG) or Phellinus linteus (PL) in a rat peritonitis model...
  22. pmc Inhibition of GM3 synthase attenuates neuropathology of niemann-pick disease type C by affecting sphingolipid metabolism
    Hyun Lee
    Stem Cell Neuroplasticity Research Group, Kyungpook National University, Daegu 702 701, Korea Department of Laboratory Animal Medicine, College of Veterinary Medicine, Kyungpook National University, Daegu 702 701, Korea
    Mol Cells 37:161-71. 2014
    ..These findings indicate the crucial role of GM3 synthesis in the NP-C phenotype and progression of CNS pathologic abnormality, suggesting that well-controlled inhibition of GM3 synthesis could be used as a therapeutic strategy. ..
  23. ncbi request reprint Fabrication of microengineered templates and their applications into micropatterned cell culture
    Jin Ho Choi
    School of Mechanical Engineering, Kyungpook National University, Daegu, 702 701, Korea
    J Biomed Nanotechnol 9:377-81. 2013
    ..The results showed that cells could be cultured into micropatterns with precisely controlled manner at any shapes and specific size for bioscience study and bioengineering applications...
  24. pmc Human amniotic fluid stem cell injection therapy for urethral sphincter regeneration in an animal model
    Bum Soo Kim
    Department of Urology, School of Medicine, Kyungpook National University, Daegu, Korea
    BMC Med 10:94. 2012
    ..Recently, human amniotic fluid stem cells (hAFSCs) have been proposed as an ideal cell therapy source. In this study, we investigated whether periurethral injection of hAFSCs can restore urethral sphincter competency in a mouse model...
  25. ncbi request reprint Specific labeling of neurogenic, endothelial, and myogenic differentiated cells derived from human amniotic fluid stem cells with silica-coated magnetic nanoparticles
    Jong Kil Lee
    Stem Cell Neuroplasticity Research Group, Kyungpook National University, Daegu, Korea
    J Vet Med Sci 74:969-75. 2012
    ..These results suggest that the fluorescent dye incorporated MNPs@SiO2 are a useful tool for the cell labeling and in vivo tracking of differentiated cells derived from hAFSCs...
  26. ncbi request reprint Inhibitory effects of polysaccharides isolated from Phellinus gilvus on benzo(a)pyrene-induced forestomach carcinogenesis in mice
    Jae Sung Bae
    College of Veterinary Medicine, Kyungpook National University, Daegu 702 701, Republic of Korea
    World J Gastroenterol 11:577-9. 2005
    ..The modulating effect of polysaccharides isolated from PG on the benzo(a)pyrene (BaP)-induced forestomach carcinogenesis in ICR female mice was investigated in this study...
  27. doi request reprint MEGF10 functions as a receptor for the uptake of amyloid-β
    Thoudam Debraj Singh
    Department of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea
    FEBS Lett 584:3936-42. 2010
    ..Thus, the identification of the MEGF10 as a functional receptor that mediates the uptake of amyloid-β peptide will help elucidate the molecular mechanisms of amlyoid-β clearance in Alzheimer's disease...
  28. pmc Reliability of Triggered EMG for Prediction of Safety during Pedicle Screw Placement in Adolescent Idiopathic Scoliosis Surgery
    Woo Kie Min
    Department of Orthopaedic Surgery, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu, Korea
    Asian Spine J 5:51-8. 2011
    ..We performed a prospective study to evaluate the reliability of using triggered electromyography (EMG) for predicting pedicle wall breakthrough during the placement of pedicle screw in adolescent idiopathic scoliosis surgery...
  29. ncbi request reprint Promotion of dermal wound healing by polysaccharides isolated from Phellinus gilvus in rats
    Jae Sung Bae
    College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea
    J Vet Med Sci 67:111-4. 2005
    ..We conclude that polysaccharides isolated from PG have significant dermal wound healing effects, and this investigation suggests the potential clinical application of PG as a wound healing agent...
  30. doi request reprint Bone marrow-derived mesenchymal stem cells reduce brain amyloid-beta deposition and accelerate the activation of microglia in an acutely induced Alzheimer's disease mouse model
    Jong Kil Lee
    Stem Cell Neuroplasticity Research Group, Kyungpook National University, Daegu, South Korea
    Neurosci Lett 450:136-41. 2009
    ..This study provides evidence that BM-MSCs can promote the reduction of Abeta through the microglial activation in this acutely induced AD brain, suggesting a potential therapeutic agent against AD...