Byeong Cheol Ahn


Affiliation: Kyungpook National University
Country: Korea


  1. Son S, Gangadaran P, Ahn B. A novel strategy of transferring NIS protein to cells using extracellular vesicles leads to increase in iodine uptake and cytotoxicity. Int J Nanomedicine. 2019;14:1779-1787 pubmed publisher
    ..This is the first-of-its-kind demonstration of successful transportation of the NIS protein to cells via EVs, which increased radioiodine uptake. This approach can revert radioiodine-resistant cancers into radioiodine-sensitive cancers. ..
  2. Jung J, Ahn B. Current Radiopharmaceuticals for Positron Emission Tomography of Brain Tumors. Brain Tumor Res Treat. 2018;6:47-53 pubmed publisher
    ..PET with various tracers including FDG, ¹¹C-methionine, and FDOPA has improved the management of patients with brain tumors. To evaluate the exact value of PET, however, additional prospective large sample studies are needed. ..
  3. Zhu L, Kalimuthu S, Oh J, Gangadaran P, Baek S, Jeong S, et al. Enhancement of antitumor potency of extracellular vesicles derived from natural killer cells by IL-15 priming. Biomaterials. 2018;190-191:38-50 pubmed publisher
    ..In addition, both NK-EVs and NK-EVsIL-15 were not significantly toxic to either normal cells or mice. IL-15 may improve the immunotherapeutic effects of NK-EVs, thus improving the applications of NK-EVs in the future. ..
  4. Gangadaran P, Li X, Kalimuthu S, Min O, Hong C, Rajendran R, et al. New Optical Imaging Reporter-labeled Anaplastic Thyroid Cancer-Derived Extracellular Vesicles as a Platform for In Vivo Tumor Targeting in a Mouse Model. Sci Rep. 2018;8:13509 pubmed publisher
    ..Here, we successfully monitored the tumor targeting ability of tumor cell-derived EVs by optical imaging. Based on these results, tumor cell-derived EVs are highly effective natural carriers for drug delivery for cancer therapies. ..
  5. Ahn B, Ahn G, Kim D, Kim K, Jeong S, Lee S, et al. Size measurement of the thyroid gland on a magnified pinhole thyroid scan using an ultrasonic device measuring distance from the pinhole to the thyroid gland. Ann Nucl Med. 2015;29:111-7 pubmed publisher
    ..The TSM system can be applied to obtain accurate size of the thyroid gland or lesions in the thyroid gland on pinhole thyroid scan. ..
  6. Kalimuthu S, Zhu L, Oh J, Lee H, Gangadaran P, Rajendran R, et al. Regulated Mesenchymal Stem Cells Mediated Colon Cancer Therapy Assessed by Reporter Gene Based Optical Imaging. Int J Mol Sci. 2018;19: pubmed publisher
    ..In addition, our results provide an innovative therapeutic approach using the Tet-On system to eradicate tumors by administration of MSC-Tet-TK cells with DOX and GCV. ..
  7. Oh E, Lee H, Kalimuthu S, Kim T, Kim H, Baek S, et al. In vivo migration of mesenchymal stem cells to burn injury sites and their therapeutic effects in a living mouse model. J Control Release. 2018;279:79-88 pubmed publisher
    ..Our observations suggested that MSCs might assist burn wound healing and that MSCs expressing Fluc could be a useful tool for optimizing MSC-based therapeutic strategies for burn wound healing. ..
  8. Kavitha M, Kurita T, Ahn B. Critical texture pattern feature assessment for characterizing colonies of induced pluripotent stem cells through machine learning techniques. Comput Biol Med. 2018;94:55-64 pubmed publisher
  9. Li X, Gangadaran P, Kalimuthu S, Oh J, Zhu L, Jeong S, et al. Role of pulmonary macrophages in initiation of lung metastasis in anaplastic thyroid cancer. Int J Cancer. 2016;139:2583-92 pubmed publisher
    ..New therapeutic strategies that preclude initiation of pulmonary metastasis could potentially be developed by targeting pulmonary macrophages. ..

More Information


  1. Hong C, Kim C, Son S, Jung J, Lee C, Jeong J, et al. I-131 biokinetics of remnant normal thyroid tissue and residual thyroid cancer in patients with differentiated thyroid cancer: comparison between recombinant human TSH administration and thyroid hormone withdrawal. Ann Nucl Med. 2017;31:582-589 pubmed publisher
    ..549, p = 0.571). Radioiodine therapy using rhTSH delivered an at least similar radiation dose to target lesions compared to using THW in thyroid remnants and metastatic lymph nodes. ..
  2. Kalimuthu S, Jeong J, Oh J, Ahn B. Drug Discovery by Molecular Imaging and Monitoring Therapy Response in Lymphoma. Int J Mol Sci. 2017;18: pubmed publisher
    ..Further, we discuss the different molecular imaging modalities for lymphoma therapy and their preclinical and clinical applications. ..
  3. Gangadaran P, Rajendran R, Lee H, Kalimuthu S, Hong C, Jeong S, et al. Extracellular vesicles from mesenchymal stem cells activates VEGF receptors and accelerates recovery of hindlimb ischemia. J Control Release. 2017;264:112-126 pubmed publisher
    ..MSC-EVs enhance angiogenesis in ischemic limbs, most likely via the overexpression of VEGFR1 and VEGFR2 in endothelial cells. These findings reveal a novel mechanism of activating receptors by MSC-EVs influence the angiogenesis. ..
  4. Lee H, Lee H, La Lee Y, Jeon Y, Jeong S, Lee S, et al. Optimization of Dendritic Cell-Mediated Cytotoxic T-Cell Activation by Tracking of Dendritic Cell Migration Using Reporter Gene Imaging. Mol Imaging Biol. 2018;20:398-406 pubmed publisher
    ..The optimization of DC-mediated cytotoxic T-cell activation could be applied for the future DC-based immunotherapy. ..
  5. Oh J, Lee H, Kalimuthu S, Gangadaran P, Baek S, Han M, et al. Development of an athyroid mouse model using 131I ablation after preparation with a low-iodine diet. Sci Rep. 2017;7:13284 pubmed publisher
    ..Scintigraphy images showed that tumor uptake was statically higher in athyroid mice than in control mice. These data suggest that these optimized conditions for thyroid ablation could be helpful to establish an in vivo mouse model. ..
  6. Rajendran R, Gangadaran P, Bak S, Oh J, Kalimuthu S, Lee H, et al. Extracellular vesicles derived from MSCs activates dermal papilla cell in vitro and promotes hair follicle conversion from telogen to anagen in mice. Sci Rep. 2017;7:15560 pubmed publisher
    ..The first time our results suggest that MSC-EVs have a potential to activate DP cells, prolonged survival, induce growth factor activation in vitro, and promotes hair growth in vivo. ..
  7. Son S, Kim D, Hong C, Kim C, Jeong S, Lee S, et al. Prognostic implication of intratumoral metabolic heterogeneity in invasive ductal carcinoma of the breast. BMC Cancer. 2014;14:585 pubmed publisher
    ..Intratumoral metabolic heterogeneity correlated closely with the MTV and significantly affected the OS in IDC patients. The HF may act as a robust surrogate marker for the prediction of OS in IDC patients. ..